2型糖尿病左室舒张功能与血尿酸水平的关系
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摘要
(1)目的观察和探讨2型糖尿病(T2DM)左室舒张功能与血尿酸关系。(2)方法入选的126例T2DM患者均行心脏超声检查,依据二尖瓣口舒张早期峰值(E峰)/舒张晚期血流峰值(A峰)(E/A)将入选者分为左室舒张功能正常组(A组)和左室舒张功能减低组(B组);检测两组血尿酸(SUA)、相关生化及心脏超声指标。(3)结果两组病程、SBP、TG、HDL-C、UA、HbA1c、HOMA-IR、E峰、LVMI差异有统计学意义(P <0.05);TG、UA、HbA1c、HOMA-IR、LVMI与2型糖尿病心肌舒张功能减低呈正相关(OR> 1),E峰呈负相关(OR <1)。(4)结论 2型糖尿病左室舒张功能降低患者血尿酸水平升高,升高的血尿酸可使T2DM患心肌舒张功能减低的风险增加。
Objective To observe and explore the relationship between serum uric acid and left ventricular diastolic function in patients with type 2diabetes.Methods A total of 126 patients with diabetesunderwent echocardiography.According to the early peak diastolic peak diastolic peak(E peak)/late diastolic peak blood flow peak(A peak)(E/A),the candidates were divided into the normal left ventricular diastolic function group(group A)and the left ventricular diastolic function group(B group),and two groups of hematuria acid,related biochemical indexes and echocardiographic indexes were detected.Results There were significant differences in the course of disease,SBP,TG,HDL-C,UA,HbA1 c,HOMA-IR,E peak,and LVMI between the two groups(P <0.05);TG,UA,HbA1 c,HOMA-IR,LVMI were a positive correlation between myocardial diastolic dysfunction in type 2diabetes(OR>1)and negative correlation between E peak(OR <1).Conclusion The level of uric acid in patients with type 2diabetes mellitus with decreased left ventricular diastolic function was elevated,and elevated serum uric acid is associated with an increased risk of myocardial diastolic dysfunction in T2 DM.
Objective To observe and explore the relationship between serum uric acid and left ventricular diastolic function in patients with type 2diabetes.Methods A total of 126 patients with diabetesunderwent echocardiography.According to the early peak diastolic peak diastolic peak(E peak)/late diastolic peak blood flow peak(A peak)(E/A),the candidates were divided into the normal left ventricular diastolic function group(group A)and the left ventricular diastolic function group(B group),and two groups of hematuria acid,related biochemical indexes and echocardiographic indexes were detected.Results There were significant differences in the course of disease,SBP,TG,HDL-C,UA,HbA1 c,HOMA-IR,E peak,and LVMI between the two groups(P <0.05);TG,UA,HbA1 c,HOMA-IR,LVMI were a positive correlation between myocardial diastolic dysfunction in type 2diabetes(OR>1)and negative correlation between E peak(OR <1).Conclusion The level of uric acid in patients with type 2diabetes mellitus with decreased left ventricular diastolic function was elevated,and elevated serum uric acid is associated with an increased risk of myocardial diastolic dysfunction in T2 DM.
引文
[1]李晓涛,郭春超,夏岳,等.福辛普利钠治疗冠心病合并左室舒张功能不全疗效观察[J].武警后勤学院学报(医学版),2011,20(7):571-572
[2]李晓丽,刘玲玲,赵龙,等.2型糖尿病患者血浆TGF-β1水平及其与心脏结构和功能的关系[J].江苏大学学报(医学版),2015(4):317-321
[3]陈静,周翔海,庞梦端,等.住院2型糖尿病患者合并左心室舒张功能不全的相关因素分析[J].中国糖尿病杂志,2016,24(4):321-324
[4]张晓艳.2型糖尿病患者早期左室舒张功能的评价[D].石家庄:河北医科大学,2015
[5]Goyal Br,Mehta Aa.Diabetic cardiomyopathy:Pathophysiological mechanisms and cardiacdysfuntion[J].Hum ExpToxicol,2013,32(6):571-590
[6]高嵩,危春英,文渊,等.糖代谢紊乱患者左室舒张功能的早期评价[J].中国糖尿病杂志,2012,20(10):744-747
[7]Patil VC,Patil HV,Shah KB,et al.Diastolic dysfunction in asymptomatic type 2diabetes m ellitus with norm alsystolic function[J].J Cardiovasc Dis Res,2011,2(4):213-222
[8]H am eedullah,Faheem M,Bahadar S,et al.Effectofglycaemicstatus on left ventricular diastolic function in norm otensive type 2diabeticpatients[J].J Ayub Med Coll Abbottabad,2009,21(3):139-144
[9]刘挺松,吴宗贵,江时森,等.2型糖尿病患者血尿酸水平与心功能不全的关系研究[J].中华实用诊断与治疗杂志,2009,23(11):1056-1058
[10]唐建东,李清楚,任健,等.2型糖尿病患者左室舒张功能减退相关临床影响因素分析[J].现代预防医学,2014,41(24):4515-4517
[11] Matsuura F,Yamashita S,Nakamura T,et al.Effect of visceral fat accumulation on uric acid metabolism in male obesesubjects:visceral fat obesity is linked mo re closely tooverproduction of uric acid than subcutaneous fat obesity[J].Metabolism,1998,47(8):929-933
[12]黄芝,叶山东.2型糖尿病患者血尿酸水平及其有关因素的研究进展[J].安徽医学,2013,34(5):659-662
[13]H am eedullah,Faheem M,Bahadar S,et al.Effectofglycaemicstatus on left ventricular diastolic function in norm otensive type 2diabeticpatients[J].J Ayub Med Coll Abbottabad,2009,21(3):139-144
[14]吴祥梅.住院2型糖尿病患者血尿酸水平与代谢综合征的相关性分析[J].中国继续医学教育,2017,9(13):100-101
[15]雷友富,谢燕.高尿酸血症对2型糖尿病心功能及颈动脉粥样斑块形成的影响[J].现代临床医学,2017,43(6):442-444
[16]刘凤莲,陈莉,赵红强,等.血尿酸水平对老年2型糖尿病患者心脏结构与功能的影响[J].山东医药,2011,51(45):73-74
[17]黄艳玲,王铁建,蔺心敬,等.血尿酸与脑梗死患者颈动脉粥样硬化关系的研究[J].中国综合临床,2008,24(12):1249
[18]刘燕.高尿酸血症与2型糖尿病合并心血管并发症的相关性[J].吉林医学,2014(18):3941-3942
[19]Young ME,McNulty P,Taegtmeyer H.Adaptation and maladaptation of the heart in diabetes:PartⅡ:potentialmechanisms[J].Circulation,2002,105(15):1861-1870
[20]钱远宇,孟庆义,杨晓秋,等.老年2型糖尿病合并高尿酸与心室重构的关系[J].天津医药,2007,35(4):288-289
[2]李晓丽,刘玲玲,赵龙,等.2型糖尿病患者血浆TGF-β1水平及其与心脏结构和功能的关系[J].江苏大学学报(医学版),2015(4):317-321
[3]陈静,周翔海,庞梦端,等.住院2型糖尿病患者合并左心室舒张功能不全的相关因素分析[J].中国糖尿病杂志,2016,24(4):321-324
[4]张晓艳.2型糖尿病患者早期左室舒张功能的评价[D].石家庄:河北医科大学,2015
[5]Goyal Br,Mehta Aa.Diabetic cardiomyopathy:Pathophysiological mechanisms and cardiacdysfuntion[J].Hum ExpToxicol,2013,32(6):571-590
[6]高嵩,危春英,文渊,等.糖代谢紊乱患者左室舒张功能的早期评价[J].中国糖尿病杂志,2012,20(10):744-747
[7]Patil VC,Patil HV,Shah KB,et al.Diastolic dysfunction in asymptomatic type 2diabetes m ellitus with norm alsystolic function[J].J Cardiovasc Dis Res,2011,2(4):213-222
[8]H am eedullah,Faheem M,Bahadar S,et al.Effectofglycaemicstatus on left ventricular diastolic function in norm otensive type 2diabeticpatients[J].J Ayub Med Coll Abbottabad,2009,21(3):139-144
[9]刘挺松,吴宗贵,江时森,等.2型糖尿病患者血尿酸水平与心功能不全的关系研究[J].中华实用诊断与治疗杂志,2009,23(11):1056-1058
[10]唐建东,李清楚,任健,等.2型糖尿病患者左室舒张功能减退相关临床影响因素分析[J].现代预防医学,2014,41(24):4515-4517
[11] Matsuura F,Yamashita S,Nakamura T,et al.Effect of visceral fat accumulation on uric acid metabolism in male obesesubjects:visceral fat obesity is linked mo re closely tooverproduction of uric acid than subcutaneous fat obesity[J].Metabolism,1998,47(8):929-933
[12]黄芝,叶山东.2型糖尿病患者血尿酸水平及其有关因素的研究进展[J].安徽医学,2013,34(5):659-662
[13]H am eedullah,Faheem M,Bahadar S,et al.Effectofglycaemicstatus on left ventricular diastolic function in norm otensive type 2diabeticpatients[J].J Ayub Med Coll Abbottabad,2009,21(3):139-144
[14]吴祥梅.住院2型糖尿病患者血尿酸水平与代谢综合征的相关性分析[J].中国继续医学教育,2017,9(13):100-101
[15]雷友富,谢燕.高尿酸血症对2型糖尿病心功能及颈动脉粥样斑块形成的影响[J].现代临床医学,2017,43(6):442-444
[16]刘凤莲,陈莉,赵红强,等.血尿酸水平对老年2型糖尿病患者心脏结构与功能的影响[J].山东医药,2011,51(45):73-74
[17]黄艳玲,王铁建,蔺心敬,等.血尿酸与脑梗死患者颈动脉粥样硬化关系的研究[J].中国综合临床,2008,24(12):1249
[18]刘燕.高尿酸血症与2型糖尿病合并心血管并发症的相关性[J].吉林医学,2014(18):3941-3942
[19]Young ME,McNulty P,Taegtmeyer H.Adaptation and maladaptation of the heart in diabetes:PartⅡ:potentialmechanisms[J].Circulation,2002,105(15):1861-1870
[20]钱远宇,孟庆义,杨晓秋,等.老年2型糖尿病合并高尿酸与心室重构的关系[J].天津医药,2007,35(4):288-289