磁共振生理成像对膝软骨损伤诊断的应用进展
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摘要
随着社会日趋老龄化,膝关节骨性关节炎成了危害人类健康的主要疾病之一。膝关节骨性关节炎早期病变损伤的是关节软骨,所以对于软骨早期损伤的诊断,对于临床延缓骨性关节炎的发生意义重大,磁共振成像是目前检查关节软骨损伤的首选方法。近年来,磁共振技术不断进步发展,特别是生理成像技术的产生,不仅能显示关节软骨形态学的改变,还能对软骨内部生化成分、组织学特点和生物力学方面变化进行检测,更有利于为膝关节骨性关节炎早期病损诊断。
With the aging society, knee osteoarthritis has become one of the major diseases that endanger human health. The early lesions of knee osteoarthritis are articular cartilage, so the diagnosis of early cartilage lesions is of great significance for the clinical delay of osteoarthritis. Magnetic resonance imaging is currently the method of choice for examining articular cartilage injuries. In recent years, the development of magnetic resonance technology, especially the development of physiological imaging technology, can not only show the changes in the morphology of articular cartilage, but also detect changes in the biochemical composition, histological characteristics and biomechanics of cartilage, and is more conducive to Diagnosis of early lesions of knee osteoarthritis.
With the aging society, knee osteoarthritis has become one of the major diseases that endanger human health. The early lesions of knee osteoarthritis are articular cartilage, so the diagnosis of early cartilage lesions is of great significance for the clinical delay of osteoarthritis. Magnetic resonance imaging is currently the method of choice for examining articular cartilage injuries. In recent years, the development of magnetic resonance technology, especially the development of physiological imaging technology, can not only show the changes in the morphology of articular cartilage, but also detect changes in the biochemical composition, histological characteristics and biomechanics of cartilage, and is more conducive to Diagnosis of early lesions of knee osteoarthritis.
引文
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[22]R?s?nen L P,Tanska P,Zbyň?,et al.The effect of fixed charge density and cartilage swelling on mechanics of knee joint cartilage during simulated gait[J].Journal of Biomechanics,2017,61.
[23]Choi JA,Gold GE.MR imaging of articular cartilage physiology[J].Magn Reson Imaging Clin N Am,2011,19:249-282.
[24]Brinkhof S,Nizak R,Khlebnikov V,et al.Detection of early cartilage damage:feasibility and potential of gagCEST imaging at 7T[J].European Radiology,2018:1-8.
[25]Lee J,Parasoglou P,Xia D,et al.ERRATUM:Uniform magnetization transfer in chemical exchange saturation transfer magnetic resonance imaging[J].Scientific Reports,2013,3(4):1707.
[2]Arnscheidt C,Meder A,Rolauffs B.Early Diagnosis of Osteoarthritis Clinical Reality and Promising Experimental Techniques[J].Z Orthop Unfall2016,154(3):254-268.
[3]Sandro Kohl,Simon Meier,Sufian S,et al.Accuracy of cartilage-specific 3T3D-DESS magnetic resonance imaging in the diagnosis of chondral lesions comparison with knee arthroscopy[J].Orthopaedic Surgery and Research2015,10(1):191.
[4]Bo Wei,Xiaotao Du,Jun Liu,et al.Associations between the properties of the cartilage matrix and findings from quantitative MRI in human osteoarthritic cartilage of the knee[J].Int J Clin Exp Pathol,2015,8(4):3928-3936.
[5]Tajika Y,Moue T,Ishikawa S,et al.Influence of Periostin on Synoviocytes in Knee Osteoarthritis[J].Vivo,2017,31(1):69-77.
[6]寇博.核磁共振T2-star-mapping成像软骨定量分析在膝关节骨性关节炎诊断中的临床应用研究[D].宁夏医科大学,2015.
[7]赵钊.MR T_2 mapping在曲棍球运动员膝关节早期软骨损伤中的应用[D].暨南大学,2015.
[8]樊子健,吴丽萍,任有忠,等.3.0T磁共振T2-Mapping、3D-FSE-Cube与常规序列对膝关节软骨损伤分级对比分析[J].磁共振成像,20178(9):675-680.
[9]Soellner S,Goldmann A,Muelheims D,et al.Intraoperative validation of quantitative T2 mapping in patients with articular cartilage lesions of the knee[J].Osteoarthritis Cartilage,2017.
[10]Bittersohl B,Miese F R,Hosalkar H S,et al.T2*mapping of acetabular and femoral hip joint cartilage at 3 T:a prospective controlled study[J]Investigative Radiology,2012,47(7):392.
[11]Lee S Y,Park H J,Kwon H J,et al.T2 relaxation times of the glenohumera joint at 3.0 T MRI in patients with and without primary and secondary osteoarthritis[J].Acta Radiologica,2015,56(11):1388.
[12]赵丹丹,李红,秦灏,等.DTI在正常成人髌骨软骨的初步应用及临床意义[J].磁共振成像,2016(2):131-135.
[13]李敏,邓德茂.磁共振扩散张量成像在骨骼肌肉系统的应用进展[J]临床放射学杂志,2015,34(11):1862-1865.
[14]Raya J G,Horng A,Dietrich O,et al.Articular cartilage:in vivo diffusiontensor imaging[J].Radiology,2012,262(2):550-9.
[15]魏沛然.早期髌骨软化症MR T1 mapping和T2 mapping成像的对比研究[D].河北医科大学,2016.
[16]宗敏.基于磁共振多模态影像监测关节软骨变化的定性及定量研究[D].南京医科大学,2017.
[17]Kester B S,Carpenter P M,Yu H J,et al.T1ρ/T2 mapping and histopathology of degenerative cartilage in advanced knee osteoarthritis[J]World Journal of Orthopedics,2017,8(4):350-356.
[18]曹明明.应用dGEMRIC和T2-mapping评价正常犬膝关节软骨[D]中国医科大学,2012
[19]Hatcher C C,Collins A T,Kim S Y,et al.Relationship between T1rho magnetic resonance imaging,synovial fluid biomarkers,and the biochemica and biomechanical properties of cartilage[J].Journal of Biomechanics,201755:18-26.
[20]Wei W,Lambach B,Jia G,et al.A Phase I clinical trial of the knee to assess the correlation of gagCEST MRI,delayed gadolinium-enhanced MRI of cartilage and T2 mapping[J].European Journal of Radiology,2017,90:220.
[21]Engen C N,L?ken S,?r?en A,et al.No degeneration found in foca cartilage defects evaluated with dGEMRIC at 12-year follow-up[J].Acta Orthopaedica,2017,88(1):82.
[22]R?s?nen L P,Tanska P,Zbyň?,et al.The effect of fixed charge density and cartilage swelling on mechanics of knee joint cartilage during simulated gait[J].Journal of Biomechanics,2017,61.
[23]Choi JA,Gold GE.MR imaging of articular cartilage physiology[J].Magn Reson Imaging Clin N Am,2011,19:249-282.
[24]Brinkhof S,Nizak R,Khlebnikov V,et al.Detection of early cartilage damage:feasibility and potential of gagCEST imaging at 7T[J].European Radiology,2018:1-8.
[25]Lee J,Parasoglou P,Xia D,et al.ERRATUM:Uniform magnetization transfer in chemical exchange saturation transfer magnetic resonance imaging[J].Scientific Reports,2013,3(4):1707.