Nrf2天然抑制剂对抗肿瘤药物的增敏作用
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摘要
核转录因子2(Nrf2)被认为是重要的细胞保护因子之一,肿瘤细胞Nrf2的异常激活,与癌症的药物治疗抗性有关。近年来,从中草药中分离的几种天然产物对Nrf2具有显著的抑制作用,称其为"Nrf2天然抑制剂"。本文综述了三种Nrf2天然抑制剂在抗肿瘤以及抗肿瘤药物的增敏作用中的研究进展,有助于更好地预测它们在抗肿瘤领域的应用潜力,发掘最新的肿瘤治疗策略。
引文
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[9]刘思园,蔡萌,李春建,等.鸦胆子苦醇抑制结直肠癌细胞增殖与Nrf2通路相关性研究[J].中华肿瘤防治杂志,2018,2,25(4):243-257.
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[24]Chian S,Li YY,Wang XJ,et al.Luteolin sensitizes two oxaliplatin-resistant colorectal cancer cell lines to chemotherapeutic drugs via inhibition of the Nrf2 pathway[J].Asian Pac J Cancer Prev,2014,15(6):2911-2916.
[25]陈思翰,朱德东,付丽云.木犀草素对顺铂诱导肝癌HepG2细胞凋亡的增敏作用及机制[J].中国临床药理学杂志,2018,34(14):1637-1640.
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[27]Xu H,Yang T,Liu X,et al.Luteolin synergizes the antitumor effects of5-fluorouracil against human hepatocellular carcinoma cells through apoptosisinductionandmetabolism[J].LifeSci,2016,1(144):138-147.
[28]Yang L,Zhang HW,Hu R,et al.Wogonin induces G1 phase arrest through inhibiting Cdk4 and cyclin D1 concomitant with an elevation in p21Cip1 in human cervical carcinoma He La cells[J].Biochem Cell Biol,2009,87(6):933-942.
[29]Khan NM,Haseeb A,Ansari MY,et al.Wogonin,a plant derived small molecule,exerts potent anti-inflammatory and chondroprotective effects through the activation of ROS/ERK/Nrf2 signaling pathways in human Osteoarthritis chondrocytes[J].Free Radic Biol Med,2017(106):288-301.
[30]Li SJ,Sun SJ,Gao J,et al.Wogonin induces Beclin-1/PI3K and reactive oxygen species-mediated autophagyin human pancreatic cancer cells[J].Oncol Lett,2016,12(6):5059-5067.
[31]Xu X,Zhang X,Zhang Y,et al.Wogonin reversed resistant human myelogenous leukemia cells via inhibiting Nrf2 signaling by Stat3/NF-κBinactivation[J].Sci Rep,2017(7):39950.
[32]Yao J,Zhao L,Zhao Q,et al.NF-κB and Nrf2 signaling pathways contribute to wogonin-mediated inhibition of inflammation-associated colorectal carcinogenesis[J].Cell Death Dis,2014,5(6):e1283.
[33]Rong LW,Wang RX,Zheng XL,et al.Combination of wogonin and sorafenib effectively kills human hepatocellular carcinoma cells through apoptosis potentiation and autophagy inhibition[J].Oncol Lett,2017,13(6):5028-5034.
[34]张娜,周琦,陆松梅,等.汉黄芩素逆转卵巢癌SKOV3细胞对顺铂的耐药性[J].肿瘤,2016,2(36):166-172.
[35]陈维中,蔡靖斌,陈晓兰,等.汉黄芩素与氟尿嘧啶联用抗人肝癌细胞HepG2作用的拮抗效应研究[J].药学实践杂志,2015,33(5):411-414.
[36]Qian C,Wang Y,Zhong Y,et al.Wogonin-enhanced reactive oxygen species-induced apoptosis and potentiated cytotoxic effects of chemotherapeutic agents by suppression Nrf2-mediated signaling in Hep G2 cells[J].Free Radic Res,2014,48(5):607-621.
[2]Rocha CR,Kajitani A GS,Quinet A,et al.NRF2 and glutathione are key resistance mediators to temozolomide in glioma and melanoma cells[J].Oncotarget,2016,7(30):48081-48092.
[3]Vollenuve NF,Lau A,Zhang DD,et al.Regulation of the Nrf2-Keap1Antioxidant Response by the Ubiquitin Proteasome System:An Insight into Cullin-Ring Ubiquitin Ligases[J].Antioxid Redox Signal,2010,13(11):1699-1712.
[4]Sun Z,Zhang S,Chan JY,et al.Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2[J].Mol Cell Biol,2007(27)6334-6349.
[5]Kitanmura H,Motohashi H.NRF2 addiction in cancer cells[J].Cancer Sci,2018,109(4):900-911.
[6]Ren D,Villeneuve NF,Jiang T,et al.Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism[J].Proc Natl Acad Sci USA,2011(108):1433-1438.
[7]Ahgulo P,Kaushik G,Subramania D.Natural compounds targetingmajor cell signaling pathways:a novel paradigm for osteosarcoma therapy[J].JHematol Oncol,2017,10(1):10.
[8]丁洁,程小耕,胡祥宇.鸦胆子苦醇抑制黑色素瘤生长和增殖的作用机理研究[J].贵州医药,2018,42(8):899-903.
[9]刘思园,蔡萌,李春建,等.鸦胆子苦醇抑制结直肠癌细胞增殖与Nrf2通路相关性研究[J].中华肿瘤防治杂志,2018,2,25(4):243-257.
[10]Hu SZ,Jin L,Yu T,et al.Brusatol[J].Acta Cryst.2012,68(Pt6):o1592-o1593.
[11]Vartanian S,Ma TP,Lee J,et al.Application of Mass Spectrometry Profiling to Establish Brusatol as an Inhibitor of Global Protein Synthesis[J].Mol Cell Proteomics,2016(15):1220-1231.
[12]OlayanjuA,Copple IM,Bryan HK,et al.Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes ma mmalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2[J].Free Radic Biol Med,2015(78):202-212.
[13]Sun X,Wang Q,Wang Y.Brusatol Enhances the Radiosensitivity of A549CellsbyPromotingROSProductionandEnhancingDNADamage[J].Int J Mol Sci,2016,17(7):997.
[14]Wu T,HharaderR BG,Wong PK,et al.Oxidative stress,mammospheres and Nrf2-newimplication for breast cancer therapy[J].Mol Carcinog,2015(54):1494-1502.
[15]Tao S,Wang S,Mogjaddam SJ,et al.Oncogenic KRAS confers chemoresistance by upregulating NRF2[J].Cancer Res,2014(74):7430-7441.
[16]谢娜,钱云峰,许卫国,等.木犀草素对食管癌TE-1细胞增殖和迁移的影响[J].中国肿瘤临床与康复,2018,25(8):938-941.
[17]Tang X,Wang H,Fan L,et al.Luteolin inhibits Nrf2 leading to negative regulation of the Nrf2/ARE pathway and sensitization of human lung carcinoma A549 cells to therapeutic drugs[J].Free Radic Biol Med,2011,50(11):1599-1609.
[18]Yang D,Tan X,Lv Z,et al.Regulation of Sirt1/Nrf2/TNF-α signaling pathway by luteolin is critical to attenuate acute mercuric chloride exposure induced hepatotoxicity[J].Sci Rep,2016,17(6):37157.
[19]Chain S,Thap R,Chi Z,et al.Luteolin inhibits the Nrf2 signaling pathway and tumor growth in vivo[J].Biochem Biophys Res Commun,2014,47(4):602-608.
[20]Son YO,Pratheeshkumar P,Wang Y,et al.Protection from Cr(VI)-induced malignant cell transformation and tumorigenesis of Cr(VI)-transformed cells byluteolin through Nrf2 signaling[J].Toxicol Appl Pharmacol,2017(331):24-32.
[21]Kittiratphatthana N,Kukongviriyapan V,Prawan A,et al.Luteolin induces cholangiocarcinoma cell apoptosis through the mitochondrial-dependent pathway mediated by reactive oxygen species[J].J Pharm Pharmacol,2016,8(9):1184-1192.
[22]Kang KA,Piao MJ,Ryu YS,et al.Luteolin induces apoptotic cell death via antioxidant activity in human colon cancer cells[J].Int J Oncol,2017,51(4):1169-1178.
[23]Wang Q,Wang H,Jia Y,et al.Luteolin reduces migration of human glioblastoma cell lines via inhibition of the p-IGF-1R/PI3K/AKT/mTORsignaling pathway[J].Oncol Lett,2017,14(3):3545-3551.
[24]Chian S,Li YY,Wang XJ,et al.Luteolin sensitizes two oxaliplatin-resistant colorectal cancer cell lines to chemotherapeutic drugs via inhibition of the Nrf2 pathway[J].Asian Pac J Cancer Prev,2014,15(6):2911-2916.
[25]陈思翰,朱德东,付丽云.木犀草素对顺铂诱导肝癌HepG2细胞凋亡的增敏作用及机制[J].中国临床药理学杂志,2018,34(14):1637-1640.
[26]史晓欣,全文婕,汤芊.木犀草素抗乳腺癌作用机制的研究进展[J].肿瘤药学[J].肿瘤药学,2018,8(2):135-138.
[27]Xu H,Yang T,Liu X,et al.Luteolin synergizes the antitumor effects of5-fluorouracil against human hepatocellular carcinoma cells through apoptosisinductionandmetabolism[J].LifeSci,2016,1(144):138-147.
[28]Yang L,Zhang HW,Hu R,et al.Wogonin induces G1 phase arrest through inhibiting Cdk4 and cyclin D1 concomitant with an elevation in p21Cip1 in human cervical carcinoma He La cells[J].Biochem Cell Biol,2009,87(6):933-942.
[29]Khan NM,Haseeb A,Ansari MY,et al.Wogonin,a plant derived small molecule,exerts potent anti-inflammatory and chondroprotective effects through the activation of ROS/ERK/Nrf2 signaling pathways in human Osteoarthritis chondrocytes[J].Free Radic Biol Med,2017(106):288-301.
[30]Li SJ,Sun SJ,Gao J,et al.Wogonin induces Beclin-1/PI3K and reactive oxygen species-mediated autophagyin human pancreatic cancer cells[J].Oncol Lett,2016,12(6):5059-5067.
[31]Xu X,Zhang X,Zhang Y,et al.Wogonin reversed resistant human myelogenous leukemia cells via inhibiting Nrf2 signaling by Stat3/NF-κBinactivation[J].Sci Rep,2017(7):39950.
[32]Yao J,Zhao L,Zhao Q,et al.NF-κB and Nrf2 signaling pathways contribute to wogonin-mediated inhibition of inflammation-associated colorectal carcinogenesis[J].Cell Death Dis,2014,5(6):e1283.
[33]Rong LW,Wang RX,Zheng XL,et al.Combination of wogonin and sorafenib effectively kills human hepatocellular carcinoma cells through apoptosis potentiation and autophagy inhibition[J].Oncol Lett,2017,13(6):5028-5034.
[34]张娜,周琦,陆松梅,等.汉黄芩素逆转卵巢癌SKOV3细胞对顺铂的耐药性[J].肿瘤,2016,2(36):166-172.
[35]陈维中,蔡靖斌,陈晓兰,等.汉黄芩素与氟尿嘧啶联用抗人肝癌细胞HepG2作用的拮抗效应研究[J].药学实践杂志,2015,33(5):411-414.
[36]Qian C,Wang Y,Zhong Y,et al.Wogonin-enhanced reactive oxygen species-induced apoptosis and potentiated cytotoxic effects of chemotherapeutic agents by suppression Nrf2-mediated signaling in Hep G2 cells[J].Free Radic Res,2014,48(5):607-621.