阿司匹林联合丹红注射液治疗老年冠心病不稳定型心绞痛的疗效及对患者血管内皮功能的影响
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摘要
目的:探讨阿司匹林联合丹红注射液治疗老年冠心病不稳定型心绞痛的疗效及对患者血管内皮功能的影响。方法:选取120例老年冠心病不稳定型心绞痛患者作为研究对象。采用随机数字表法将其分为观察组与对照组,对照组60例患者接受包含阿司匹林的常规基础药物治疗方案,观察组60例在对照组治疗方案基础上联合应用丹红注射液治疗,比较两组冠心病心绞痛治疗效果及治疗前后患者血管内皮功能相关指标变化情况。结果:治疗前两组心绞痛发作次数、心绞痛持续时间、硝酸甘油应用剂量比较差异无统计学意义(P>0.05),治疗后观察组心绞痛发作次数、心绞痛持续时间、硝酸甘油用量明显低于对照组(P<0.05);并且治疗后观察组患者心功能相关指标(射血分数、心输出量)改善效果明显优于对照组(P<0.05);观察组治疗总有效率明显高于对照组(P<0.05);治疗前两组血管内皮素(ET)、血栓素B2(TXB2)、6-酮-前列腺素F1α水平比较差异无统计学意义(P>0.05),治疗后观察组ET、TXB2水平明显低于对照组,而6-酮-前列腺素F1α水平明显高于对照组(P<0.05);两组患者治疗期间及治疗后均未发生任何严重药物不良反应或并发症。结论:采用阿司匹林联合丹红注射液治疗老年冠心病不稳定型心绞痛疗效显著,较传统药物治疗方案能够显著提升患者治疗总有效率,改善患者心功能及血管内皮功能,具有临床应用价值。
Objective:Investigate the effect of aspirin combined with Danhong red injection on unstable angina pectoris in elderly patients with coronary heart disease(CHD)and its effect on vascular endothelial function.Methods:from January 2016 to June 2017,120 elderly patients with unstable angina pectoris of coronary heart disease were selected as the research subjects.It was divided into the observation group and the control group by the random digital table,60 patients in the control group accepted the routine basic medicine treatment plan containing aspirin,and the observation group 60 cases were combined with Danhong injection on the basis of the control group,compared the treatment effect of the two groups of coronary heart disease and the intravascular injection of the patients before and after the treatment.The changes of skin function related indexes.Results:there was no significant difference in the number of angina pectoris episodes,the duration of angina pectoris and the dosage of nitroglycerin before treatment(P>0.05).After treatment,the frequency of angina pectoris,the duration of angina pectoris and the dosage of nitroglycerin were significantly lower than that in the control group(P<0.05),and the cardiac function related indexes of the observation group after treatment(shooting).The improvement effect of blood fraction and cardiac output was significantly better than that in the control group(P<0.05),and the total effective rate in the observation group was significantly higher than that in the control group(P<0.05),and the level of ET and TXB2 in the observation group was significantly lower than that in the control group.The level of 6-prostaglandin F1-alpha was significantly higher than that in the control group(P<0.05),and no serious adverse drug reactions or complications occurred during and after treatment in the two groups.Conclusion:The effect of aspirin combined with Danhong injection in the treatment of unstable angina pectoris in elderly patients is significant.Compared with the traditional drug therapy,it can significantly improve the total effective rate of treatment.
Objective:Investigate the effect of aspirin combined with Danhong red injection on unstable angina pectoris in elderly patients with coronary heart disease(CHD)and its effect on vascular endothelial function.Methods:from January 2016 to June 2017,120 elderly patients with unstable angina pectoris of coronary heart disease were selected as the research subjects.It was divided into the observation group and the control group by the random digital table,60 patients in the control group accepted the routine basic medicine treatment plan containing aspirin,and the observation group 60 cases were combined with Danhong injection on the basis of the control group,compared the treatment effect of the two groups of coronary heart disease and the intravascular injection of the patients before and after the treatment.The changes of skin function related indexes.Results:there was no significant difference in the number of angina pectoris episodes,the duration of angina pectoris and the dosage of nitroglycerin before treatment(P>0.05).After treatment,the frequency of angina pectoris,the duration of angina pectoris and the dosage of nitroglycerin were significantly lower than that in the control group(P<0.05),and the cardiac function related indexes of the observation group after treatment(shooting).The improvement effect of blood fraction and cardiac output was significantly better than that in the control group(P<0.05),and the total effective rate in the observation group was significantly higher than that in the control group(P<0.05),and the level of ET and TXB2 in the observation group was significantly lower than that in the control group.The level of 6-prostaglandin F1-alpha was significantly higher than that in the control group(P<0.05),and no serious adverse drug reactions or complications occurred during and after treatment in the two groups.Conclusion:The effect of aspirin combined with Danhong injection in the treatment of unstable angina pectoris in elderly patients is significant.Compared with the traditional drug therapy,it can significantly improve the total effective rate of treatment.
引文
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[9]陈靖,王志明,刘杰敏.稳心颗粒联合丹红注射液治疗冠心病心绞痛疗效观察及其对患者CRP和血液流变学的影响[J].中国中医药科技,2016,23(3):321-322.
[10]薛晨,王军,贺金亮,等.采用CONSORT标准评价丹红注射液对比丹参类注射液治疗冠心病心绞痛随机对照试验文献质量[J].山西中医学院学报,2016,17(1):1-3.
[11]赵芳,吴连拼.阿托伐他汀联合丹红注射液治疗冠心病心绞痛的临床疗效观察[J].中国现代医生,2015,53(27):24-26.
[12]王玉.丹红注射液对冠心病心绞痛患者的临床症状、血脂及心电图的改善作用[J].医疗装备,2016,29(10):134-135.
[2]马书红,陈冬梅.硫酸氢氯吡格雷联合阿司匹林治疗不稳定型心绞痛的临床疗效[J].临床合理用药杂志,2016,9(9):3-5.
[3]叶兴,卞辰,田一鸣,等.替格瑞洛联合阿司匹林治疗不稳定性心绞痛的疗效及安全性[J].徐州医学院学报,2016,36(11):747-749.
[4]葛均波,徐永健.内科学[M].8版.北京:人民卫生出版社,2013:549.
[5]邱霞.丹红注射液联合脑心通胶囊治疗冠心病不稳定型心绞痛的临床疗效观察[J].世界中医药,2012,7(6):517-519.
[6]缪玲,胡咏华.阿托伐他汀联合丹红注射液治疗不稳定型心绞痛疗效观察[J].中国医药导报,2013,10(1):78-80.
[7]颜程光,曾俊权.丹红注射液对不稳定性心绞痛患者血管内皮功能的影响[J].山东医药,2009,49(8):78-79.
[8]孙雪慧.丹红注射液治疗冠心病心绞痛的疗效观察[J].中西医结合心血管病电子杂志,2016,4(4):58-59.
[9]陈靖,王志明,刘杰敏.稳心颗粒联合丹红注射液治疗冠心病心绞痛疗效观察及其对患者CRP和血液流变学的影响[J].中国中医药科技,2016,23(3):321-322.
[10]薛晨,王军,贺金亮,等.采用CONSORT标准评价丹红注射液对比丹参类注射液治疗冠心病心绞痛随机对照试验文献质量[J].山西中医学院学报,2016,17(1):1-3.
[11]赵芳,吴连拼.阿托伐他汀联合丹红注射液治疗冠心病心绞痛的临床疗效观察[J].中国现代医生,2015,53(27):24-26.
[12]王玉.丹红注射液对冠心病心绞痛患者的临床症状、血脂及心电图的改善作用[J].医疗装备,2016,29(10):134-135.