IL-17的生物学功能和相关疾病研究
摘要
白细胞介素17(Interleukin 17, IL-17)是免疫反应的中枢蛋白,既是免疫反应关键的炎性细胞因子,也是调控细胞凋亡的关键细胞因子。本文从白介素17生物学功能及相关疾病来阐明其在动物体内发挥的作用,为IL-17的研究提供简明扼要的参考资料。
引文
[1]Ouyang W, Kolls J K, Zheng Y. The biological functions of t helper 17 cell effector cytokines in inflammation[J]. Immunity, 2008, 28(4):454-467.
[2]Milner J D. IL-17 producing cells in host defense and atopy[J]. Current Opinion in Immunology, 2011,23(6):784-788.
[3]Besnard A G, Sabat R, Dumoutier L, et al. Dual role of IL-22 in allergic airway inflammation and its cross-talk with IL-17 A[J]. American Journal of Respiratory and Critical Care Medicine, 2011, 183(9):1153-1163.
[4]Yoichiro I, Susumu N, Shinobu S, et al. The roles of IL-17 A in inflammatory immune responses and host defense against pathogens[J]. Immunological Reviews, 2008, 226:57-79.
[5]Hot A, Miossec P. Effects of interleukin(IL)-17 A and IL-17 F in human rheumatoid arthritis synoviocytes[J]. Annals of the Rheumatic Diseases, 2011, 70(5):727-732.
[6]Andrew B, Andrea C. The Immunologic role of IL-17 in psoriasis and psoriatic arthritis pathogenesis[J].Clinical Reviews in Allergy&Immunology, 2018, 55(3):379-390.
[7]Fu Z W, Zhang Z Y, Ge H Y. Mesenteric injection of adipose-derived mesenchymal stem cells relieves experimentally-induced colitis in rats by regulating Th17/Treg cell balance[J]. Am J Transl Res, 2018,10(1):54-66.
[8]Koenders M I, Kolls J, Opperswalgreen B, et al. Interleukin-17 receptor deficiency results in impaired synovial expression of interleukin-1 and matrix metalloproteinases 3, 9, and 13 and prevents cartilage destruction during chronic reactivated streptococcal cell wall-induced arthritis[J]. Arthritis&Rheumatism,2014, 52(10):3239-3247.
[9]Abdel-Moneim A, Bakery H H, Allam G. The potential pathogenic role of IL-17/Th17 cells in both type1 and type 2 diabetes mellitus[J]. Biomedicine&Pharmacotherapy, 2018, 101:287-292.
[10]Bloodworth M H, Newcomb D C, Dulek D E, et al. STAT6 signaling attenuates IL-17-producingγδT cells during acute Klebsiella pneumoniae infection[J]. Infection and Immunity, 2016,84(5):1548-1555.
[11]Willerslev-olsen A, Krejsgaard T, Lindahl L M, et al. Staphylococcus aureus enterotoxin A(SEA)stimulates STAT3 activation and IL-17 expression in cutaneous T-cell lymphoma[J]. Blood, 2016,127(10):1287-1296.
[12]LorèN I, Cigana C, Riva C, et al. IL-17 A impairs host tolerance during airway chronic infection by Pseudomonas aeruginosa[J].Scientific Reports, 2016, 6(1):25937.
[13]Stoppelenburg A J, Salimi V, Hennus M, et al. Local IL-17 a potentiates early neutrophil recruitment to the respiratory tract during severe RSV infection[J]. Plos One, 2013, 8(10):78461.
[14]Kolls J K, Kanaly S T, Ramsay A J. Interleukin-17:an emerging role in lung inflammation[J]. American Journal of Respiratory Cell&Molecular Biology, 2003, 28(1):9-11.
[15]Fossiez F.T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines[J].Journal of Experimental Medicine, 1996, 183(6):2593-2603.
[16]Wang L, Li Q, Wang L, et al. The role of Th 17/IL-17 in the pathogenesis of primary nephrotic syndrome in children[J]. Kidney&Blood Pressure Research, 2013, 37(4-5):332-345.
[17]Vazqueztello A, Halwani R, Hamid Q, et al. Glucocorticoid receptor-beta up-regulation and steroid resistance induction by IL-17 and IL-23 cytokine stimulation in peripheral mononuclear cells[J]. Journal of Clinical Immunology, 2013, 33(2):466-478.
[2]Milner J D. IL-17 producing cells in host defense and atopy[J]. Current Opinion in Immunology, 2011,23(6):784-788.
[3]Besnard A G, Sabat R, Dumoutier L, et al. Dual role of IL-22 in allergic airway inflammation and its cross-talk with IL-17 A[J]. American Journal of Respiratory and Critical Care Medicine, 2011, 183(9):1153-1163.
[4]Yoichiro I, Susumu N, Shinobu S, et al. The roles of IL-17 A in inflammatory immune responses and host defense against pathogens[J]. Immunological Reviews, 2008, 226:57-79.
[5]Hot A, Miossec P. Effects of interleukin(IL)-17 A and IL-17 F in human rheumatoid arthritis synoviocytes[J]. Annals of the Rheumatic Diseases, 2011, 70(5):727-732.
[6]Andrew B, Andrea C. The Immunologic role of IL-17 in psoriasis and psoriatic arthritis pathogenesis[J].Clinical Reviews in Allergy&Immunology, 2018, 55(3):379-390.
[7]Fu Z W, Zhang Z Y, Ge H Y. Mesenteric injection of adipose-derived mesenchymal stem cells relieves experimentally-induced colitis in rats by regulating Th17/Treg cell balance[J]. Am J Transl Res, 2018,10(1):54-66.
[8]Koenders M I, Kolls J, Opperswalgreen B, et al. Interleukin-17 receptor deficiency results in impaired synovial expression of interleukin-1 and matrix metalloproteinases 3, 9, and 13 and prevents cartilage destruction during chronic reactivated streptococcal cell wall-induced arthritis[J]. Arthritis&Rheumatism,2014, 52(10):3239-3247.
[9]Abdel-Moneim A, Bakery H H, Allam G. The potential pathogenic role of IL-17/Th17 cells in both type1 and type 2 diabetes mellitus[J]. Biomedicine&Pharmacotherapy, 2018, 101:287-292.
[10]Bloodworth M H, Newcomb D C, Dulek D E, et al. STAT6 signaling attenuates IL-17-producingγδT cells during acute Klebsiella pneumoniae infection[J]. Infection and Immunity, 2016,84(5):1548-1555.
[11]Willerslev-olsen A, Krejsgaard T, Lindahl L M, et al. Staphylococcus aureus enterotoxin A(SEA)stimulates STAT3 activation and IL-17 expression in cutaneous T-cell lymphoma[J]. Blood, 2016,127(10):1287-1296.
[12]LorèN I, Cigana C, Riva C, et al. IL-17 A impairs host tolerance during airway chronic infection by Pseudomonas aeruginosa[J].Scientific Reports, 2016, 6(1):25937.
[13]Stoppelenburg A J, Salimi V, Hennus M, et al. Local IL-17 a potentiates early neutrophil recruitment to the respiratory tract during severe RSV infection[J]. Plos One, 2013, 8(10):78461.
[14]Kolls J K, Kanaly S T, Ramsay A J. Interleukin-17:an emerging role in lung inflammation[J]. American Journal of Respiratory Cell&Molecular Biology, 2003, 28(1):9-11.
[15]Fossiez F.T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines[J].Journal of Experimental Medicine, 1996, 183(6):2593-2603.
[16]Wang L, Li Q, Wang L, et al. The role of Th 17/IL-17 in the pathogenesis of primary nephrotic syndrome in children[J]. Kidney&Blood Pressure Research, 2013, 37(4-5):332-345.
[17]Vazqueztello A, Halwani R, Hamid Q, et al. Glucocorticoid receptor-beta up-regulation and steroid resistance induction by IL-17 and IL-23 cytokine stimulation in peripheral mononuclear cells[J]. Journal of Clinical Immunology, 2013, 33(2):466-478.