中西医结合疗法改善艾滋病患者免疫状况的meta分析
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摘要
目的对当前国内中西医结合疗法治疗艾滋病的治疗效果,应用meta分析的方法进行初步评价。方法通过计算机检索国内2005年1月1日—2017年12月31日发表的应用中西医结合治疗艾滋病的相关文献,同时采用Cochrane中心的Jadad评分法(5分法)对文献质量进行初步评价,用Revman 5.3软件对所选文献研究进行分析。结果满足标准可以纳入研究的随机对照试验研究文献共有9篇(病例共732例),Meta分析结果显示:两组治疗前后的CD4~+变化合并效应量标准组均数差(MD)=28.55(个/mm~3),95%CI:8.06～74.63(Z=2.97,P<0.01);两组治疗前后的CD8~+变化合并效应量MD=-10.33(个/mm~3),95%CI:-59.36～38.71(Z=0.41,P>0.05)。结论同单纯应用中医药治疗或西医治疗相比,在改善艾滋病患者CD4~+水平以及临床症状方面,中西医结合疗法有着明显的优势。
[Objective] To preliminarily evaluate the efficacy of integrated traditional Chinese and western medicine in the treatment of AIDS in China by meta-analysis.[Methods]The literatures on the treatment of AIDS with integrated traditional Chinese and western medicine,which published from 1 January,2005 to 31 December,2017,were searched by computer.The quality of the literature was evaluated by Jadad score(5 points)of Cochrane Center.The selected literature was analyzed with Revman5.3 software.[Results]A total of nine randomized controlled trial studies(732 cases)were included in the study.Meta analysis showed that the merger effect of CD4~+ change in two groups before and after treatment was as follows:MD=28.55 cells/mm~3,95%CI:9.72-47.37(Z=2.97,P<0.01),while merger effect of CD8~+ was as follows:MD=-10.33 cells/mm~3,95%CI:-59.36-38.71(Z=0.41,P>0.05).[Conclusion]Compared with traditional Chinese medicine or western medicine treatment,the combination of Chinese and western medicine has obvious advantages in improving the CD4~+ level and clinical symptoms of AIDS patients.
[Objective] To preliminarily evaluate the efficacy of integrated traditional Chinese and western medicine in the treatment of AIDS in China by meta-analysis.[Methods]The literatures on the treatment of AIDS with integrated traditional Chinese and western medicine,which published from 1 January,2005 to 31 December,2017,were searched by computer.The quality of the literature was evaluated by Jadad score(5 points)of Cochrane Center.The selected literature was analyzed with Revman5.3 software.[Results]A total of nine randomized controlled trial studies(732 cases)were included in the study.Meta analysis showed that the merger effect of CD4~+ change in two groups before and after treatment was as follows:MD=28.55 cells/mm~3,95%CI:9.72-47.37(Z=2.97,P<0.01),while merger effect of CD8~+ was as follows:MD=-10.33 cells/mm~3,95%CI:-59.36-38.71(Z=0.41,P>0.05).[Conclusion]Compared with traditional Chinese medicine or western medicine treatment,the combination of Chinese and western medicine has obvious advantages in improving the CD4~+ level and clinical symptoms of AIDS patients.
引文
[1]张爱民,谭行华,岑玉文,等.中医辨证联合HAART疗法治疗艾滋病63例临床观察[C].中华中医药学会防治艾滋病国际学术研讨会论文集,河南:郑州,2007:274-277.
[2]李秀惠,胡建华,刘翠娥,等.中西医结合治疗85例艾滋病患者临床疗效观察[J].北京中医药,2007,26(1):11-12.
[3]吴亚梅,张毅.中西医结合治疗HIV/AIDS的临床疗效观察[J].河南中医,2009,29(3):282-284.
[4]江涛,何鹏.中西医结合治疗艾滋病68例临床观察[J].云南中医中药杂志,2011,32(10):51-52.
[5]李静茹,马建萍,马秀兰,等.平艾合剂I号方治疗HIV/AIDS患者107例临床研究[J].世界科学技术-中医药现代化,2013,15(5):877-880.
[6]卢杰.高效抗逆转录病毒联合中药疗法治疗艾滋病效果分析[J].河北医药,2012,34(12):1884-1885.
[7]李钦,王莉,马兰.扶正抗毒丸联合HAART疗法对HIV感染IIB期患者氧化应激反应的影响[J].中国实验方剂学杂志,2016,22(18):144-148.
[8]任小华,肖科,郭夕源,等.扶正清肺汤对艾滋病合并肺部感染86例疗效观察[J].重庆医学,2017,46(35):4932-4934.
[9]金燕.艾灵颗粒对HAART增效作用的临床研究[D].北京:中国中医科学院,2007:16-30.
[10]李淑梅,王梅枝.中西医结合治疗艾滋病患者50例临床观察[J].医药论坛杂志,2009,30(24):97-98.
[11]邓鑫,苏齐鉴,韦斌,等.中西医结合治疗促进AIDS病人免疫功能重建的研究[J].中国艾滋病性病,2010,16(6):599-600.
[12]杨新勇,冀爱英,郭长河.益艾康胶囊治疗HIV/AIDS50例临床分析[J].中医学报,2007,22(4):6-7.
[13]唐宁新,黄绍标,刘燕芬,等.中医辨证施治与ART协同治疗艾滋病的临床研究[J].广西中医药,2010,33(4):5-8.
[14]马英莲.中药抗艾胶囊联合抗逆转录病毒药物治疗艾滋病临床分析[J].辽宁中医药大学学报,2010,12(8):151-152.
[15]张进宝,刘成丽,方路.应用Meta分析法分析中西医结合治疗艾滋病的疗效[J].云南中医中药杂志,2012,33(1):16-19.
[16]丘纯,蔡凯.中西医结合疗法在改善艾滋病患者生活质量方面的观察与研究[J].中国实用医药,2011,6(31):123-124.
[17]周韶梅.中研II号联合抗病毒疗法(HARRT)治疗HIV/AIDS的理论探讨和临床研究[D].北京:中国中医科学院,2007:36-42.
[18]董继鹏,王健,徐立然,等.中药加HARRT降低HIV/AIDS病人HIV耐药发生的临床研究[J].中国艾滋病性病,2016,22(10):768-771.
[19]苏齐鉴,李益忠,吴卫群,等.参灵扶正胶囊和清毒胶囊治疗艾滋病的临床疗效分析[J].中国中西医结合杂志,2013,33(11):1476-1480.
[20]李娜,陈均,吴薇,等.中医药配合HARRT对HIV/AIDS患者CD4+T细胞及病毒载量影响的研究[J].成都中医药大学学报,2016,39(3):70-73.
[21]彭勃,王丹妮.无症状HIV感染期是中医药治疗艾滋病的关键切入点[J].浙江中医杂志,2006,41(10):571-572.
[22]吴新娟,许文芳,吴勇.芪灵汤联合高效抗逆转录病毒治疗艾滋病的临床观察[J].浙江临床医学,2014(10):1578-1579.
[23]王小平,闫琴,刘颖,等.艾乃吉I号颗粒治疗HIV/AIDS临床研究[J].山东中医药大学学报,2006,30(4):295-296.
[24]徐向田.中药安体维康胶囊药学和临床研究近况[J].山东医学高等专科学校学报,2007,29(6):471-472.
[25]李江红,刘宝录,全福才,等.扶正逐毒丸治疗25例HIV/AIDS病人效果分析[J].中国艾滋病性病,2014,20(7):532-533.
[2]李秀惠,胡建华,刘翠娥,等.中西医结合治疗85例艾滋病患者临床疗效观察[J].北京中医药,2007,26(1):11-12.
[3]吴亚梅,张毅.中西医结合治疗HIV/AIDS的临床疗效观察[J].河南中医,2009,29(3):282-284.
[4]江涛,何鹏.中西医结合治疗艾滋病68例临床观察[J].云南中医中药杂志,2011,32(10):51-52.
[5]李静茹,马建萍,马秀兰,等.平艾合剂I号方治疗HIV/AIDS患者107例临床研究[J].世界科学技术-中医药现代化,2013,15(5):877-880.
[6]卢杰.高效抗逆转录病毒联合中药疗法治疗艾滋病效果分析[J].河北医药,2012,34(12):1884-1885.
[7]李钦,王莉,马兰.扶正抗毒丸联合HAART疗法对HIV感染IIB期患者氧化应激反应的影响[J].中国实验方剂学杂志,2016,22(18):144-148.
[8]任小华,肖科,郭夕源,等.扶正清肺汤对艾滋病合并肺部感染86例疗效观察[J].重庆医学,2017,46(35):4932-4934.
[9]金燕.艾灵颗粒对HAART增效作用的临床研究[D].北京:中国中医科学院,2007:16-30.
[10]李淑梅,王梅枝.中西医结合治疗艾滋病患者50例临床观察[J].医药论坛杂志,2009,30(24):97-98.
[11]邓鑫,苏齐鉴,韦斌,等.中西医结合治疗促进AIDS病人免疫功能重建的研究[J].中国艾滋病性病,2010,16(6):599-600.
[12]杨新勇,冀爱英,郭长河.益艾康胶囊治疗HIV/AIDS50例临床分析[J].中医学报,2007,22(4):6-7.
[13]唐宁新,黄绍标,刘燕芬,等.中医辨证施治与ART协同治疗艾滋病的临床研究[J].广西中医药,2010,33(4):5-8.
[14]马英莲.中药抗艾胶囊联合抗逆转录病毒药物治疗艾滋病临床分析[J].辽宁中医药大学学报,2010,12(8):151-152.
[15]张进宝,刘成丽,方路.应用Meta分析法分析中西医结合治疗艾滋病的疗效[J].云南中医中药杂志,2012,33(1):16-19.
[16]丘纯,蔡凯.中西医结合疗法在改善艾滋病患者生活质量方面的观察与研究[J].中国实用医药,2011,6(31):123-124.
[17]周韶梅.中研II号联合抗病毒疗法(HARRT)治疗HIV/AIDS的理论探讨和临床研究[D].北京:中国中医科学院,2007:36-42.
[18]董继鹏,王健,徐立然,等.中药加HARRT降低HIV/AIDS病人HIV耐药发生的临床研究[J].中国艾滋病性病,2016,22(10):768-771.
[19]苏齐鉴,李益忠,吴卫群,等.参灵扶正胶囊和清毒胶囊治疗艾滋病的临床疗效分析[J].中国中西医结合杂志,2013,33(11):1476-1480.
[20]李娜,陈均,吴薇,等.中医药配合HARRT对HIV/AIDS患者CD4+T细胞及病毒载量影响的研究[J].成都中医药大学学报,2016,39(3):70-73.
[21]彭勃,王丹妮.无症状HIV感染期是中医药治疗艾滋病的关键切入点[J].浙江中医杂志,2006,41(10):571-572.
[22]吴新娟,许文芳,吴勇.芪灵汤联合高效抗逆转录病毒治疗艾滋病的临床观察[J].浙江临床医学,2014(10):1578-1579.
[23]王小平,闫琴,刘颖,等.艾乃吉I号颗粒治疗HIV/AIDS临床研究[J].山东中医药大学学报,2006,30(4):295-296.
[24]徐向田.中药安体维康胶囊药学和临床研究近况[J].山东医学高等专科学校学报,2007,29(6):471-472.
[25]李江红,刘宝录,全福才,等.扶正逐毒丸治疗25例HIV/AIDS病人效果分析[J].中国艾滋病性病,2014,20(7):532-533.