试论辐射旁效应损伤的中医学病因:辐射毒
|
摘要
辐射旁效应作为近现代临床肿瘤放疗中的不良反应,目前中医药对其缺乏明确、规范的认识,研究认为辐射损伤属于中医学"毒邪致病"的范畴,但因其有不同于传统毒邪的独特致病特点,笔者将辐射旁效应损伤的中医病因命名为辐射毒。辐射毒邪致病猛烈,耗伤机体气血阴津,且具有传舍性。文章深入认识辐射毒的传舍性,探讨辐射毒的概念、致病特点,为更好地应用中医药对其进行防护奠定理论基础。
Radiation induced bystander effect is the toxic and adverse effects of tumor radiotherapy in clinic in modern times. At present, traditional Chinese medicine has no clear and normative understanding of it. This study suggested that radiation injury was a disease induced by poisonous pathogenic factors in Chinese medicine. Because of its unique pathogenic character different from traditional poisonous pathogenic factors, its Chinese medicine pathogenesis is named poisonous pathogenic factor of radiation. The poisonous pathogenic factor of radiation is a violent pathogenic factor. It can damage qi and blood of the body and it has the transfer property. Understanding the transmission of radiation poison deeply, and discussion on the concept and pathogenicity of radiation toxicity, which lay a theoretical foundation for better application of Chinese medicine to protect them.
Radiation induced bystander effect is the toxic and adverse effects of tumor radiotherapy in clinic in modern times. At present, traditional Chinese medicine has no clear and normative understanding of it. This study suggested that radiation injury was a disease induced by poisonous pathogenic factors in Chinese medicine. Because of its unique pathogenic character different from traditional poisonous pathogenic factors, its Chinese medicine pathogenesis is named poisonous pathogenic factor of radiation. The poisonous pathogenic factor of radiation is a violent pathogenic factor. It can damage qi and blood of the body and it has the transfer property. Understanding the transmission of radiation poison deeply, and discussion on the concept and pathogenicity of radiation toxicity, which lay a theoretical foundation for better application of Chinese medicine to protect them.
引文
[1]Fernandez-Palomo C,Seymour C,Mothersill C.Inter-relationship between low-dose hyper-radiosensitivity and radiation-induced bystander effects in the human T98G glioma and the epithelial Ha Ca T cell line.Radiat Res,2016,185(2):124-133
[2]Prise K M,Folkard M,Kuosaite V,et al.What role for DNA damage and repair in the bystander response?.Mutat Res,2006,597(1-2):1-4
[3]Lara P C,López-Pe?alver J J,deAraújo Farias V,et al.Direct and bystander radiation effects:A biophysical model and clinical perspectives.Cancer Letters,2015,356(1):5-16
[4]杨利丹,杨云霜,杜磊,等.补肾解毒方对辐射损伤小鼠胸腺、脾脏的影响.中医杂志,2016,57(1):67-71
[5]谢颖桢,高颖,邹忆怀.试论毒邪致病及证候特征.北京中医药大学学报,2001,24(1):11-14
[6]骆丰,周庆博.毒邪辨析.江苏中医,1999,20(11):7-10
[7]第五永长,李妮矫.论中医“毒”概念的演变及其阴阳属性.中华中医药杂志,2010,25(5):654-658
[8]崔文成.毒邪病因论.中医药通报,2008,7(5):24-28
[9]杨仓良.从“毒邪致病”角度论治痛风.辽宁中医药大学学报,2009,3(3):6-9
[10]敖海清,朱艳芳.“毒邪”的内涵及其致病特点.山东中医杂志,2008,27(1):5-6
[11]王忠,王安民,鞠大宏.“毒邪致络病”与证候及基因组关系的探讨.中医杂志,2000,41(8):500-501
[12]孙广仁,郑洪欣.中医基础理论.9版.北京:中国中医药出版社,2012:230-231
[13]苏凤哲.毒邪论.中国中医基础医学杂志,2007,13(9):649-650
[14]考希良.从毒邪角度探讨痛风性关节炎中医病因病机.环球中医药,2011,4(6):460-461
[15]马学玉.“毒邪”致病浅见.陕西中医学院学报,1993,16(4):3-4
[16]王玉玺,王松岩.毒邪理论与治疗方法.中国中西医结合皮肤性病学杂志,2010,9(2):127-130
[17]李运伦.毒邪的源流及其分类诠释.中医药学刊,2001,18(1):44-45
[18]张蕾,刘更生.毒邪概念辨析.中国中医基础医学杂志,2003,9(7):487-488
[19]常富业,王永炎.中风病毒邪论.北京中医药大学学报,2004,27(1):4-7
[20]赵智强.略论毒邪的致病特点、界定与治疗.南京中医药大学学报,2003,19(2):73-76
[21]Faqihi F,Neshastehriz A,Soleymanifard S,et al.Radiation-induced bystander effect in non-irradiated glioblastoma spheroid cells.J Radiat Res,2015,56(5):777-783
[22]张蓉,骆斌,李峰.从毒邪致病论电离辐射损伤的中医病机.北京中医药大学学报,2007,30(9):595-596
[23]石鹏展,张蓉.关于核辐射与中医火邪致病的理论探讨.陕西中医,2013,34(9):1196-1197
[24]高明泽,徐文慧,王天琪.急性辐射损伤的中医病因学探讨.中医杂志,2016,57(6):454-458
[25]张积.汉代旅舍探析(下).北京联合大学学报(人文社会科学版),2008,6(20):59-66
[26]汪春泓.读《史》、《汉》“传舍”札记.中国典籍与文化,2012,80(1):144-153
[27]朱慈恩.汉代传舍考述.南都学坛(人文社会科学学报),2008,28(3):6-10
[28]陈鸿彝.汉代干线上传舍与邮亭.文化·史话交通,2017,2(31):116-117
[29]袁培尧.中国古代旅游名词考.商丘职业技术学院学报,2014,3(13):72-75
[30]张俊民.悬泉汉简所见传舍及传舍制度.鲁东大学学报(哲学社会科学版),2010,27(6):83-89
[31]张健,张淑贤.中医传舍理论与肿瘤转移.中国中医基础医学杂志,1999,5(6):4-7
[2]Prise K M,Folkard M,Kuosaite V,et al.What role for DNA damage and repair in the bystander response?.Mutat Res,2006,597(1-2):1-4
[3]Lara P C,López-Pe?alver J J,deAraújo Farias V,et al.Direct and bystander radiation effects:A biophysical model and clinical perspectives.Cancer Letters,2015,356(1):5-16
[4]杨利丹,杨云霜,杜磊,等.补肾解毒方对辐射损伤小鼠胸腺、脾脏的影响.中医杂志,2016,57(1):67-71
[5]谢颖桢,高颖,邹忆怀.试论毒邪致病及证候特征.北京中医药大学学报,2001,24(1):11-14
[6]骆丰,周庆博.毒邪辨析.江苏中医,1999,20(11):7-10
[7]第五永长,李妮矫.论中医“毒”概念的演变及其阴阳属性.中华中医药杂志,2010,25(5):654-658
[8]崔文成.毒邪病因论.中医药通报,2008,7(5):24-28
[9]杨仓良.从“毒邪致病”角度论治痛风.辽宁中医药大学学报,2009,3(3):6-9
[10]敖海清,朱艳芳.“毒邪”的内涵及其致病特点.山东中医杂志,2008,27(1):5-6
[11]王忠,王安民,鞠大宏.“毒邪致络病”与证候及基因组关系的探讨.中医杂志,2000,41(8):500-501
[12]孙广仁,郑洪欣.中医基础理论.9版.北京:中国中医药出版社,2012:230-231
[13]苏凤哲.毒邪论.中国中医基础医学杂志,2007,13(9):649-650
[14]考希良.从毒邪角度探讨痛风性关节炎中医病因病机.环球中医药,2011,4(6):460-461
[15]马学玉.“毒邪”致病浅见.陕西中医学院学报,1993,16(4):3-4
[16]王玉玺,王松岩.毒邪理论与治疗方法.中国中西医结合皮肤性病学杂志,2010,9(2):127-130
[17]李运伦.毒邪的源流及其分类诠释.中医药学刊,2001,18(1):44-45
[18]张蕾,刘更生.毒邪概念辨析.中国中医基础医学杂志,2003,9(7):487-488
[19]常富业,王永炎.中风病毒邪论.北京中医药大学学报,2004,27(1):4-7
[20]赵智强.略论毒邪的致病特点、界定与治疗.南京中医药大学学报,2003,19(2):73-76
[21]Faqihi F,Neshastehriz A,Soleymanifard S,et al.Radiation-induced bystander effect in non-irradiated glioblastoma spheroid cells.J Radiat Res,2015,56(5):777-783
[22]张蓉,骆斌,李峰.从毒邪致病论电离辐射损伤的中医病机.北京中医药大学学报,2007,30(9):595-596
[23]石鹏展,张蓉.关于核辐射与中医火邪致病的理论探讨.陕西中医,2013,34(9):1196-1197
[24]高明泽,徐文慧,王天琪.急性辐射损伤的中医病因学探讨.中医杂志,2016,57(6):454-458
[25]张积.汉代旅舍探析(下).北京联合大学学报(人文社会科学版),2008,6(20):59-66
[26]汪春泓.读《史》、《汉》“传舍”札记.中国典籍与文化,2012,80(1):144-153
[27]朱慈恩.汉代传舍考述.南都学坛(人文社会科学学报),2008,28(3):6-10
[28]陈鸿彝.汉代干线上传舍与邮亭.文化·史话交通,2017,2(31):116-117
[29]袁培尧.中国古代旅游名词考.商丘职业技术学院学报,2014,3(13):72-75
[30]张俊民.悬泉汉简所见传舍及传舍制度.鲁东大学学报(哲学社会科学版),2010,27(6):83-89
[31]张健,张淑贤.中医传舍理论与肿瘤转移.中国中医基础医学杂志,1999,5(6):4-7