深圳市成人25-(OH)VD水平及其与血糖的相关性研究
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摘要
目的了解深圳市企事业单位职工25-(OH)维生素D[25-(OH)VD]的营养状况,并分析其与血糖及糖化血红蛋白的相关性。方法选取2013年7~12月在深圳市某体检中心体检的深圳市机关和企事业单位员工作为研究对象,采集空腹外周静脉血,采用酶联免疫法对血浆25-(OH)VD的含量进行检测,并对血糖及糖化血红蛋白进行检测。分析检测指标的异常情况。结果深圳企事业单位人群中25-(OH)VD的平均水平为(60.98±15.92)nmol/L,25-(OH)VD缺乏或不足率为83.37%,且性别之间25-(OH)VD的营养水平及不足与缺乏率差异有统计学意义;血糖及糖化血红蛋白的平均水平分别为(5.45±0.88)mmol/L及(5.69±0.59)%;扣除年龄、性别及BMI的影响,血清25-(OH)VD水平与血糖呈负相关(r=-0.062,P<0.01),与糖化血红蛋白有一定的相关性(r=-0.051,P<0.01)。结论正常人群中25-(OH)VD水平与血糖及糖化血红蛋白有一定的相关性,维持人体正常25-(OH)VD水平可能对预防糖尿病的发生、降低糖尿病的患病率起到一定作用。
Objective To understand the serum level of 25-hydroxyvitamin D [25-(OH)VD]among enterprise workers and government employees,and to explore the correlation between serum vitamin D level and fasting blood glucose(FBG)as well as glycosylated hemoglobin. Methods Blood samples were collected from 3 392 enterprise workers and government employees who did physical check up in a medical center in Shenzhen from July 2013 to January 2014,serum levels of 25-(OH)VD,FBG and glycosylated hemoglobin were measured and analyzed based on gender and age. Results The mean level of serum 25(OH)VD was(60.98±15.92)nmol/L and the overall insufficiency/deficiency rate was 83.37% which was higher in women.The mean levels of FBG and glycosylated hemoglobin were(5.45±0.88)mmol/L and(5.69±0.59)%.Excluding the influence of age and gender as well as body mass index(BMI),there was negative correlation between serum level of 25-(OH)VD and FBG as well as glycosylated hemoglobin. ConclusionsThe serum level of 25(OH)VD is closely related to the FBG and glycosylated hemoglobin among enterprise workers and government employees in Shenzhen.Maintaining normal level of 25-(OH)VD may help to prevent or reduce the incidence of diabetes.
Objective To understand the serum level of 25-hydroxyvitamin D [25-(OH)VD]among enterprise workers and government employees,and to explore the correlation between serum vitamin D level and fasting blood glucose(FBG)as well as glycosylated hemoglobin. Methods Blood samples were collected from 3 392 enterprise workers and government employees who did physical check up in a medical center in Shenzhen from July 2013 to January 2014,serum levels of 25-(OH)VD,FBG and glycosylated hemoglobin were measured and analyzed based on gender and age. Results The mean level of serum 25(OH)VD was(60.98±15.92)nmol/L and the overall insufficiency/deficiency rate was 83.37% which was higher in women.The mean levels of FBG and glycosylated hemoglobin were(5.45±0.88)mmol/L and(5.69±0.59)%.Excluding the influence of age and gender as well as body mass index(BMI),there was negative correlation between serum level of 25-(OH)VD and FBG as well as glycosylated hemoglobin. ConclusionsThe serum level of 25(OH)VD is closely related to the FBG and glycosylated hemoglobin among enterprise workers and government employees in Shenzhen.Maintaining normal level of 25-(OH)VD may help to prevent or reduce the incidence of diabetes.
引文
[1]陈柳,陈文晓,赵肖丽.血清维生素D检测对2型糖尿病患者的临床意义[J].检验医学与临床,2013,10(3):261-262,264.
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[6]汪月娟,鲁衍强,李慧娟,等.深圳地区汉族儿童维生素D受体基因BsmⅠ和FokⅠ位点多态性调查[J].中国儿童保健杂志,2016,24(1):19-21.
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[14]Bentes CM,Costa PB,Resende M,et al.Association between muscle function and body composition,vitamin D status,and blood glucose in postmenopausal women with type2diabetes[J].Diabetes Metab Syndr,2017,S1871-4021(17):30132-30137.
[15]崔丽娟,常向云,冯罡,等.25-羟维生素D与糖尿病慢性肾脏疾病患者血糖控制的相关性研究[J].中国糖尿病杂志,2015,23(11):970-972.
[16]Eisenberg Y,Mohiuddin H,Cherukupally K,et al.Similarities and differences between patients included and excluded from a randomized clinical trial of vitamin d supplementation for improving glucose tolerance in prediabetes:interpreting broader applicability[J].Trials,2015,16(1):306.
[17]谷丽娟.2型糖尿病及糖尿病肾病患者血清1,25-二羟维生素D3水平的观察[D].南昌:南昌大学,2011.
[2]Holick MF,Binkley NC,Bischoff-Ferrari HA,et al.Evaluation,treatment,and prevention of vitamin D deficiency:an Endocrine Society clinical practice guideline[J].J Clin Endocrinol Metab,2011,96(7):1911-1930.
[3]于正清,李礼,胡娟玉,等.2型糖尿病患者血清CA199与HbA1c的相关性研究[J].现代检验医学杂志,2013,28(3):114-116.
[4]Rosen CJ.Clinical practice.Vitamin D insufficiency[J].N Engl J Med,2011,364(3):248-254.
[5]冷敏.聊城市东阿县成人维生素D营养状况调查研究[J].医学检验与临床,2014,25(5):74-75.
[6]汪月娟,鲁衍强,李慧娟,等.深圳地区汉族儿童维生素D受体基因BsmⅠ和FokⅠ位点多态性调查[J].中国儿童保健杂志,2016,24(1):19-21.
[7]王莹,刘俊丽,司少艳,等.男性非糖尿病人群维生素D与血糖关系研究[J].临床军医杂志,2016,44(4):414-416.
[8]Yin X,Sun Q,Zhang X,et al.Serum 25-(OH)D is inversely associated with metabolic syndrome risk profile among urban middle-aged Chinese population[J].Nutr J,2012,11:68.
[9]Wranicz J,Szostak-Wegierek D.Health outcomes of vitamin D.Part II.Role in prevention of diseases[J].Rocz Panstw Zakl Hig,2014,65(4):273-279.
[10]Hurskainen AR,Virtanen JK,Tuomainen TP,et al.Association of serum 25-hydroxyvitamin D with type 2diabetes and markers of insulin resistance in a general older population in Finland[J].Diabetes Metab Res Rev,2012,28(5):418-423.
[11]陈锦,黄存敏,冯广贵,等.糖尿病三项检测的临床应用[J].实验与检验医学,2013,31(3):264-266,283.
[12]Xu Y,Wang L,He J,et al.Prevalence and control of diabetes in Chinese adults[J].JAMA,2013,310(9):948-959.
[13]张艳玲,张栩,张雯雯,等.济南地区成人血清25(OH)D水平与空腹血糖的相关性[J].山东大学学报(医学版),2014,52(3):59-63.
[14]Bentes CM,Costa PB,Resende M,et al.Association between muscle function and body composition,vitamin D status,and blood glucose in postmenopausal women with type2diabetes[J].Diabetes Metab Syndr,2017,S1871-4021(17):30132-30137.
[15]崔丽娟,常向云,冯罡,等.25-羟维生素D与糖尿病慢性肾脏疾病患者血糖控制的相关性研究[J].中国糖尿病杂志,2015,23(11):970-972.
[16]Eisenberg Y,Mohiuddin H,Cherukupally K,et al.Similarities and differences between patients included and excluded from a randomized clinical trial of vitamin d supplementation for improving glucose tolerance in prediabetes:interpreting broader applicability[J].Trials,2015,16(1):306.
[17]谷丽娟.2型糖尿病及糖尿病肾病患者血清1,25-二羟维生素D3水平的观察[D].南昌:南昌大学,2011.