中国精神卫生学科发展的回顾与展望
摘要
<正>近年来,我国精神卫生事业取得了快速发展,然而精神卫生学科的发展仍面临诸多困境。随着美国、欧洲等多个国家的"脑计划"相继推出及我国"中国脑计划"的即将启动,必将为精神障碍的预防、早诊和优治带来发展契机。本文将简要回望精神卫生事业发展历程,总结精神障碍的诊疗现状和最新研究进展,并在现
引文
[1]陈一鸣.我国精神专科医院发展和改革中的若干问题[J].临床精神医学杂志,2009,19(1):68-69.
[2]《中国卫生年鉴》编辑委员会.中国卫生年鉴[M].北京:人民卫生出版社,2000.
[3]郑灵巧.中国精神卫生服务现状调查[J].医院管理论坛,2008,25(1):28-30.
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[5]张维熙,李淑然,陈昌惠,等.中国七个地区精神疾病流行病学调查[J].中华精神科杂志,1998,31(2):69-71.
[6]杨德森.中国精神疾病分类方案与诊断标准制定工作的历史与现状[J].上海精神医学,1989(1):10-12.
[7] Huang Y,Wang Y,Wang H,et al. Prevalence of mental disorders in China:a cross-sectional epidemiological study[J]. Lancet Psychiatry,2019,6(3):211-224.
[8] Charlson FJ,Baxter AJ,Cheng HG,et al. The burden of mental,neurological,and substance use disorders in China and India:a systematic analysis of community representative epidemiological studies[J]. Lancet,2016,388(10042):376-389.
[9]马弘,刘津,何燕玲,等.中国精神卫生服务模式改革的重要方向:686模式[J].中国心理卫生杂志,2011,25(10):725-728.
[10]阙建宇,师乐,刘佳佳,等. 2002-2016年我国精神专科医院发展状况分析[J].中华精神科杂志,2019,52(2):139-144.
[11] WHO. World mental health atlas 2017[EB/OL].(2018-05-09)[2018-11-14]https://www. who. int/mental_health/evidence/atlas/mental_health_atlas_2017/en/.
[12] CONVERGE consortium. Sparse whole-genome sequencing identifies two loci for major depressive disorder[J]. Nature,2015,523(7562):588-591.
[13] Zhou X,Hetrick SE,Cuijpers P,et al. Comparative efficacy and acceptability of psychotherapies for depression in children and adolescents:A systematic review and network meta-analysis[J]. World Psychiatry,2015,14(2):207-222.
[14] Cipriani A,Zhou X,Del Giovane C,et al. Comparative efficacy and tolerability of antidepressants for major depressive disorder in children and adolescents:a network meta-analysis[J]. Lancet,2016,388(10047):881-890.
[15] Yang Y,Cui Y,Sang K,et al. Ketamine blocks bursting in the lateral habenula to rapidly relieve depression[J]. Nature,2018,554(7692):317-322.
[16] Cui Y,Yang Y,Ni Z,et al. Astroglial Kir4. 1 in the lateral habenula drives neuronal bursts in depression[J]. Nature,2018,554(7692):323-327.
[17] Li SX,Han Y,Xu LZ,et al. Uncoupling DAPK1 from NMDA receptor GluN2B subunit exerts rapid antidepressant-like effects[J]. Mol Psychiatry,2018,23(3):597-608.
[18] Yan W,Liu JF,Han Y,et al. Protein kinase Mzeta in medial prefrontal cortex mediates depressive-like behavior and antidepressant response[J].Mol Psychiatry,2018,23(9):1878-1891.
[19] Yu H,Yan H,Li J,et al. Common variants on 2p16. 1,6p22. 1 and 10q24. 32 are associated with schizophrenia in Han Chinese population[J].Mol Psychiatry,2017,22(7):954-960.
[20] Yu H,Yan H,Wang L,et al. Five novel loci associated with antipsychotic treatment response in patients with schizophrenia:a genome-wide association study[J]. Lancet Psychiatry,2018,5(4):327-338.
[21] Wang Q,Man Wu H,Yue W,et al. Effect of damaging rare mutations in synapse-related gene sets on response to short-term antipsychotic medication in Chinese patients with schizophrenia:A randomized clinical trial[J]. JAMA Psychiatry,2018,75(12):1261-1269.
[22] Goff DC,Zeng B,Ardekani BA,et al. Association of hippocampal atrophy with duration of untreated psychosis and molecular biomarkers during initial antipsychotic treatment of first-episode psychosis[J]. JAMA Psychiatry,2018,75(4):370-378.
[23] Jin WS,Shen LL,Bu XL,et al. Peritoneal dialysis reduces amyloid-beta plasma levels in humans and attenuates Alzheimer-associated phenotypes in an APP/PS1 mouse model[J]. Acta Neuropathol,2017,134(2):207-220.
[24] Bu XL,Xiang Y,Jin WS,et al. Blood-derived amyloid-beta protein induces Alzheimer’s disease pathologies[J]. Mol Psychiatry,2018,23(9):1-9.
[25] Shi L,Chen SJ,Ma MY,et al. Sleep disturbances increase the risk of dementia:A systematic review and meta-analysis[J]. Sleep Med Rev,2018,40:4-16.
[26] Xie L,Kang H,Xu Q,et al. Sleep drives metabolite clearance from the adult brain[J]. Science,2013,342(6156):373-377.
[27] Ren S,Wang Y,Yue F,et al. The paraventricular thalamus is a critical thalamic area for wakefulness[J]. Science,2018,362(6413):429-434.
[28] Bao YP,Han Y,Ma J,et al. Cooccurrence and bidirectional prediction of sleep disturbances and depression in older adults:meta-analysis and systematic review[J]. Neurosci Biobehav Rev,2017,75:257-273.
[29] Cheng W,Rolls ET,Ruan H,et al. Functional connectivities in the brain that mediate the association between depressive problems and sleep quality[J]. JAMA Psychiatry,2018,75(10):1052-1061.
[30]刘彩萍,陈立今,谢斌,等.中国精神卫生机构中的专业人员数量和特征[J].上海精神医学,2013,5(5):277-285.
[31] National Institute of Mental Health. The national institute of mental health strategic plan[EB/OL].(2015-03-26)[2018-07-19]. https://www.nimh. nih. gov/about/strategic-planning-reports/index. shtml.
[2]《中国卫生年鉴》编辑委员会.中国卫生年鉴[M].北京:人民卫生出版社,2000.
[3]郑灵巧.中国精神卫生服务现状调查[J].医院管理论坛,2008,25(1):28-30.
[4]陆林.沈渔邨精神病学[M].北京:人民卫生出版社,2018:127.
[5]张维熙,李淑然,陈昌惠,等.中国七个地区精神疾病流行病学调查[J].中华精神科杂志,1998,31(2):69-71.
[6]杨德森.中国精神疾病分类方案与诊断标准制定工作的历史与现状[J].上海精神医学,1989(1):10-12.
[7] Huang Y,Wang Y,Wang H,et al. Prevalence of mental disorders in China:a cross-sectional epidemiological study[J]. Lancet Psychiatry,2019,6(3):211-224.
[8] Charlson FJ,Baxter AJ,Cheng HG,et al. The burden of mental,neurological,and substance use disorders in China and India:a systematic analysis of community representative epidemiological studies[J]. Lancet,2016,388(10042):376-389.
[9]马弘,刘津,何燕玲,等.中国精神卫生服务模式改革的重要方向:686模式[J].中国心理卫生杂志,2011,25(10):725-728.
[10]阙建宇,师乐,刘佳佳,等. 2002-2016年我国精神专科医院发展状况分析[J].中华精神科杂志,2019,52(2):139-144.
[11] WHO. World mental health atlas 2017[EB/OL].(2018-05-09)[2018-11-14]https://www. who. int/mental_health/evidence/atlas/mental_health_atlas_2017/en/.
[12] CONVERGE consortium. Sparse whole-genome sequencing identifies two loci for major depressive disorder[J]. Nature,2015,523(7562):588-591.
[13] Zhou X,Hetrick SE,Cuijpers P,et al. Comparative efficacy and acceptability of psychotherapies for depression in children and adolescents:A systematic review and network meta-analysis[J]. World Psychiatry,2015,14(2):207-222.
[14] Cipriani A,Zhou X,Del Giovane C,et al. Comparative efficacy and tolerability of antidepressants for major depressive disorder in children and adolescents:a network meta-analysis[J]. Lancet,2016,388(10047):881-890.
[15] Yang Y,Cui Y,Sang K,et al. Ketamine blocks bursting in the lateral habenula to rapidly relieve depression[J]. Nature,2018,554(7692):317-322.
[16] Cui Y,Yang Y,Ni Z,et al. Astroglial Kir4. 1 in the lateral habenula drives neuronal bursts in depression[J]. Nature,2018,554(7692):323-327.
[17] Li SX,Han Y,Xu LZ,et al. Uncoupling DAPK1 from NMDA receptor GluN2B subunit exerts rapid antidepressant-like effects[J]. Mol Psychiatry,2018,23(3):597-608.
[18] Yan W,Liu JF,Han Y,et al. Protein kinase Mzeta in medial prefrontal cortex mediates depressive-like behavior and antidepressant response[J].Mol Psychiatry,2018,23(9):1878-1891.
[19] Yu H,Yan H,Li J,et al. Common variants on 2p16. 1,6p22. 1 and 10q24. 32 are associated with schizophrenia in Han Chinese population[J].Mol Psychiatry,2017,22(7):954-960.
[20] Yu H,Yan H,Wang L,et al. Five novel loci associated with antipsychotic treatment response in patients with schizophrenia:a genome-wide association study[J]. Lancet Psychiatry,2018,5(4):327-338.
[21] Wang Q,Man Wu H,Yue W,et al. Effect of damaging rare mutations in synapse-related gene sets on response to short-term antipsychotic medication in Chinese patients with schizophrenia:A randomized clinical trial[J]. JAMA Psychiatry,2018,75(12):1261-1269.
[22] Goff DC,Zeng B,Ardekani BA,et al. Association of hippocampal atrophy with duration of untreated psychosis and molecular biomarkers during initial antipsychotic treatment of first-episode psychosis[J]. JAMA Psychiatry,2018,75(4):370-378.
[23] Jin WS,Shen LL,Bu XL,et al. Peritoneal dialysis reduces amyloid-beta plasma levels in humans and attenuates Alzheimer-associated phenotypes in an APP/PS1 mouse model[J]. Acta Neuropathol,2017,134(2):207-220.
[24] Bu XL,Xiang Y,Jin WS,et al. Blood-derived amyloid-beta protein induces Alzheimer’s disease pathologies[J]. Mol Psychiatry,2018,23(9):1-9.
[25] Shi L,Chen SJ,Ma MY,et al. Sleep disturbances increase the risk of dementia:A systematic review and meta-analysis[J]. Sleep Med Rev,2018,40:4-16.
[26] Xie L,Kang H,Xu Q,et al. Sleep drives metabolite clearance from the adult brain[J]. Science,2013,342(6156):373-377.
[27] Ren S,Wang Y,Yue F,et al. The paraventricular thalamus is a critical thalamic area for wakefulness[J]. Science,2018,362(6413):429-434.
[28] Bao YP,Han Y,Ma J,et al. Cooccurrence and bidirectional prediction of sleep disturbances and depression in older adults:meta-analysis and systematic review[J]. Neurosci Biobehav Rev,2017,75:257-273.
[29] Cheng W,Rolls ET,Ruan H,et al. Functional connectivities in the brain that mediate the association between depressive problems and sleep quality[J]. JAMA Psychiatry,2018,75(10):1052-1061.
[30]刘彩萍,陈立今,谢斌,等.中国精神卫生机构中的专业人员数量和特征[J].上海精神医学,2013,5(5):277-285.
[31] National Institute of Mental Health. The national institute of mental health strategic plan[EB/OL].(2015-03-26)[2018-07-19]. https://www.nimh. nih. gov/about/strategic-planning-reports/index. shtml.