GDF-15在急性心肌梗死患者中的表达情况及临床价值
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摘要
目的研究生长分化因子-15(GDF-15)在急性心肌梗死(AMI)患者外周血中的表达情况及其临床价值。方法选取我院心内科2016年3月至2017年8月收治的AMI患者184例为观察组,其中ST段抬高型心肌梗死(STEMI)患者116例记为STEMI组,非ST段抬高型心肌梗死(NSTEMI)患者68例记为NSTEMI组;另外选择63名健康体检者作为对照组。采用双抗体夹心ELISA法测定受试者血清GDF-15表达水平。结果观察组血清GDF-15水平明显高于对照组,且在观察组中,STEMI组血清GDF-15水平明显高于NSTEMI组(P<0.05)。观察组GDF-15阳性表达率、预后不良率均明显高于对照组,且在观察组中,STEMI组GDF-15阳性表达率、预后不良率均明显高于NSTEMI组(P<0.05)。结论 GDF-15阳性表达率与AMI患者的病情及预后情况均存在一定的联系,其可作为心肌梗死的标志物,具有较高的临床价值。
Objective To study the expression and clinical value of growth differentiation factor-15(GDF-15) in patients with acute myocardial infarction(AMI). Methods A total of 184 patients with AMI admitted in our hospital from March 2016 to August 2017 were selected as observation group, in which 116 patients with ST-segment elevation myocardial infarction(STEMI) recorded as STEMI group and 68 patients with non-ST-segment elevation myocardial infarction(NSTEMI) recorded as NSTEMI group. Another 63 health examinees were selected as control group. The expression levels of serum GDF-15 were measured by double antibody sandwich ELISA. Results The level of serum GDF-15 in the observation group was significantly higher than that in the control group, and in the observation group, the level of serum GDF-15 in the STEMI group was significantly higher than that in the NSTEMI group(P<0.05). The rates of positive expression of GDF-15 and poor prognosis in the observation group were significantly higher than those in the control group, and in the observation group, the rates of positive expression of GDF-15 and poor prognosis in the STEMI group were significantly higher than those in the NSTEMI group(P<0.05). Conclusion The positive expression rate of GDF-15 is related to the condition and prognosis of AMI patients.The GDF-15 can be used as a marker of myocardial infarction and has high clinical value.
Objective To study the expression and clinical value of growth differentiation factor-15(GDF-15) in patients with acute myocardial infarction(AMI). Methods A total of 184 patients with AMI admitted in our hospital from March 2016 to August 2017 were selected as observation group, in which 116 patients with ST-segment elevation myocardial infarction(STEMI) recorded as STEMI group and 68 patients with non-ST-segment elevation myocardial infarction(NSTEMI) recorded as NSTEMI group. Another 63 health examinees were selected as control group. The expression levels of serum GDF-15 were measured by double antibody sandwich ELISA. Results The level of serum GDF-15 in the observation group was significantly higher than that in the control group, and in the observation group, the level of serum GDF-15 in the STEMI group was significantly higher than that in the NSTEMI group(P<0.05). The rates of positive expression of GDF-15 and poor prognosis in the observation group were significantly higher than those in the control group, and in the observation group, the rates of positive expression of GDF-15 and poor prognosis in the STEMI group were significantly higher than those in the NSTEMI group(P<0.05). Conclusion The positive expression rate of GDF-15 is related to the condition and prognosis of AMI patients.The GDF-15 can be used as a marker of myocardial infarction and has high clinical value.
引文
[1]赵定学,苗云凤,龚必锋.急性心肌梗死患者血清GDF-15的水平变化及其临床意义[J].中国循证心血管医学杂志,2016,8(2):232-235.
[2]张玉英,陶志刚.大剂量瑞舒伐他汀治疗急性心肌梗死患者血清GDF-15、hs-CRP水平变化及临床意义[J].山东医药,2017,57(17):75-77.
[3]孙铃,臧璇,张良峰,等.急性心肌梗死患者介入治疗术中无复流现象与生长分化因子15的相关性[J].中国动脉硬化杂志,2017,25(6):599-603.
[4]邓诗武.GDF-15、cTnI、BNP在急性心肌梗死病人中的关系及对其近期预后的预测价值[J].中西医结合心脑血管病杂志,2017,15(18):2294-2296.
[5]郑晓青.阿托伐他汀对急性心肌梗死患者血清生长分化因子15和C反应蛋白水平的影响[J].中华老年心脑血管病杂志,2016,18(4):421-422.
[6]刘哲,王晶.生长分化因子-15表达水平与心肌梗死致心力衰竭程度的相关性研究[J].检验医学与临床,2016,13(7):959-960.
[7]武岳,郭靖涛.急性心肌梗死患者生长分化因子-15与梗死面积及相关梗死标志物水平相关性研究[J].临床和实验医学杂志,2016,15(5):430-433.
[2]张玉英,陶志刚.大剂量瑞舒伐他汀治疗急性心肌梗死患者血清GDF-15、hs-CRP水平变化及临床意义[J].山东医药,2017,57(17):75-77.
[3]孙铃,臧璇,张良峰,等.急性心肌梗死患者介入治疗术中无复流现象与生长分化因子15的相关性[J].中国动脉硬化杂志,2017,25(6):599-603.
[4]邓诗武.GDF-15、cTnI、BNP在急性心肌梗死病人中的关系及对其近期预后的预测价值[J].中西医结合心脑血管病杂志,2017,15(18):2294-2296.
[5]郑晓青.阿托伐他汀对急性心肌梗死患者血清生长分化因子15和C反应蛋白水平的影响[J].中华老年心脑血管病杂志,2016,18(4):421-422.
[6]刘哲,王晶.生长分化因子-15表达水平与心肌梗死致心力衰竭程度的相关性研究[J].检验医学与临床,2016,13(7):959-960.
[7]武岳,郭靖涛.急性心肌梗死患者生长分化因子-15与梗死面积及相关梗死标志物水平相关性研究[J].临床和实验医学杂志,2016,15(5):430-433.