子宫内膜容受性分子标记物的研究进展
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摘要
研究显示,白血病抑制因子(leukemia inhibitory factor, LIF)、白介素-1(interleukin-1, IL-1)、胰岛素样生长因子(insulin-like growth factors, IGF)、前列腺素(prostaglandin, PG)、基质金属蛋白酶(matrix metalloproteinases, MMPs)和组织金属蛋白酶抑制剂(tissue inhibitor of matrix metalloproteinases, TIMPs)等可作为子宫内膜容受性的分子标志物。本文主要对评估子宫内膜容受性的分子标志物进行综述,以期更好地评估子宫内膜的容受性,进一步提高临床妊娠率。
This paper mainly reviewed some biomarkers of endometrial receptivity, including leukemia inhibitory factor(LIF), interleukin-1(IL-1), insulin-like growth factors(IGF), prostaglandin(PG), calctionin, matrix metalloproteinases(MMPs) and tissue inhibitor of matrix metalloproteinases(TIMPs) in the endometrium. Through summarizing the progress in these biomarkers, the paper discussed the practical value for endometrial receptivity, in order to improve the clinicalpregnancy rate.
This paper mainly reviewed some biomarkers of endometrial receptivity, including leukemia inhibitory factor(LIF), interleukin-1(IL-1), insulin-like growth factors(IGF), prostaglandin(PG), calctionin, matrix metalloproteinases(MMPs) and tissue inhibitor of matrix metalloproteinases(TIMPs) in the endometrium. Through summarizing the progress in these biomarkers, the paper discussed the practical value for endometrial receptivity, in order to improve the clinicalpregnancy rate.
引文
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[2] Malina A,Pooley JA.Psychological consequences of IVF fertilization-Review of research[J].Ann Agric Environ Med,2017,24(4):554-558.
[3] Kim S M,Kim JS.A Review of mechanisms of implantation[J].Dev Reprod,2017,21(4):351-359.
[4] Cao H,You D,Yuan M,et al.Hysteroscopy after repeated implantation failure of assisted reproductive technology:A meta-analysis[J].J Obstet Gynaecol Res,2018.44(3):365-373.
[5] Miyamoto T,Minase G,Shin T,et al.Human male infertility and its genetic causes[J].Reprod Med Biol,2017,16(2):81-88.
[6] Fawzy M,AbdelRahman MY,Zidan MH,et al.,Humid versus dry incubator:A prospective,randomized,controlled trial[J].Fertil Steril,2017,108(2):277-283.
[7] Coates A,Kung A,Mounts E,et al.Optimal euploid embryo transfer strategy,fresh versus frozen,after preimplantation genetic screening with next generation sequencing:A randomized controlled trial[J].Fertil Steril,2017,107(3):723-730.
[8] Fawzy M,Sabry M,Nour M,et al.Integrating insulin into single-step culture medium regulates human embryo development in vitro[J].Fertil Steril,2017,107(2):405-412.
[9] Kleijkers SH,Mantikou E,Slappendel E,et al.,Influence of embryo culture medium (G5 and HTF) on pregnancy and perinatal outcome after IVF:A multicenter RCT[J].Hum Reprod,2016,31(10):2219-2230.
[10] Zhao H,Sui L,Miao K,et al.Comparative analysis between endometrial proteomes of pregnant and non-pregnant ewes during the peri-implantation period[J]. J Anim Sci Biotechnol,2015(6):18-32.
[11] Benkhalifa M,Madkour A,Louanjli N, et al.From global proteome profiling to single targeted molecules of follicular fluid and oocyte:Contribution to embryo development and IVF outcome[J]. Expert Rev Proteomics,2015,12(4):407-423.
[12] Fernandez GE,Spiessens C,D′Hooghe T,et al.Effect of embryo morphology and morphometrics on implantation of vitrified day 3 embryos after warming:A retrospective cohort study[J].Reprod Biol Endocrinol,2016(14):40-51.
[13] Patel BG,Lessey BA.Clinical assessment and management of the endometrium in recurrent early pregnancy loss[J]. Semin Reprod Med,2011,29(6):491-506.
[14] Warning JC,McCracken SA,Morris JM.A balancing act:mechanisms by which the fetus avoids rejection by the maternal immune system[J]. Reproduction,2011,141(6):715-724.
[15] Li B,Kohler JJ.Glycosylation of the nuclear pore[J]. Traffic,2014,15(4):347-61.
[16] Virant-Klun I,Krijgsveld J,Proteomes of animal oocytes:What can we learn for human oocytes in the in vitro fertilization programme?[J].Biomed Res Int,2014(1):856907.
[17] Egea RR,Puchalt NG,Escriva MM, et al.OMICS:Current and future perspectives in reproductive medicine and technology[J]. J Hum Reprod Sci,2014,7(2):73-92.
[18] Altmae S,Esteban FJ,Stavreus-Evers A, et al. Guidelines for the design,analysis and interpretation of ′omics′ data:focus on human endometrium[J]. Hum Reprod Update,2014,20(1):12-28.
[19] Becnel LB,McKenna NJ.Minireview:Progress and challenges in proteomics data management,sharing,and integration[J]. Mol Endocrinol,2012,26(10):1660-1674.
[20] Cappadona S,Baker PR,Cutillas PR,et al.Current challenges in software solutions for mass spectrometry-based quantitative proteomics[J]. Amino Acids,2012,43(3):1087-1088.