健脾益肾粥用于脾肾阳虚型慢性疲劳综合征患者减轻症状研究
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摘要
目的探讨健脾益肾粥干预改善脾肾阳虚型慢性疲劳综合征(CFS)患者疲劳严重程度及生活质量的效果。方法将86例脾肾阳虚型CFS患者随机分成两组各43例。对照组采用个体指导和集体指导的方式进行疾病相关知识、饮食等健康教育;观察组在此基础上食用健脾益肾粥,每2天1次。两组均干预至8周末评价效果。结果干预后观察组疲劳严重程度评分显著低于对照组、简明健康调查问卷7个维度(除外健康变化维度)及总体健康得分显著高于对照组(均P<0.01)。结论脾肾阳虚型CFS患者食用健脾益肾粥有利于减轻疲劳程度和提高生活质量。
Objective To evaluate the effect of Jian Pi Yi Shen(spleen-kidney nourishing) porridge on relief of fatigue and improvement of quality of life in patients with chronic fatigue syndrome(CFS) of spleen and kidney Yang deficiency.Methods Eighty-six CFS patients with spleen and kidney Yang deficiency were randomized into two groups,with 43 cases in each group.The control group was given both one-to-one and group-based disease-related knowledge and dietary education,while the observation group additionally received spleen-kidney nourishing porridge once every two days.Effect was measured after 8 weeks of intervention.Results The fatigue severity score was significantly lower,whereas the total 36-item short-form health survey(SF-36) score and 7 dimension scores(except general health perceptions) were significantly higher in the observation group compared with the control group after the intervention(P<0.01 for all).Conclusions Jian Pi Yi Shen porridge can alleviate fatigue and improve quality of life of patients with CFS of spleen and kidney Yang deficiency.
Objective To evaluate the effect of Jian Pi Yi Shen(spleen-kidney nourishing) porridge on relief of fatigue and improvement of quality of life in patients with chronic fatigue syndrome(CFS) of spleen and kidney Yang deficiency.Methods Eighty-six CFS patients with spleen and kidney Yang deficiency were randomized into two groups,with 43 cases in each group.The control group was given both one-to-one and group-based disease-related knowledge and dietary education,while the observation group additionally received spleen-kidney nourishing porridge once every two days.Effect was measured after 8 weeks of intervention.Results The fatigue severity score was significantly lower,whereas the total 36-item short-form health survey(SF-36) score and 7 dimension scores(except general health perceptions) were significantly higher in the observation group compared with the control group after the intervention(P<0.01 for all).Conclusions Jian Pi Yi Shen porridge can alleviate fatigue and improve quality of life of patients with CFS of spleen and kidney Yang deficiency.
引文
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[19]刘琳,刘洋洋,占颖,等.芡实的化学成分、药理作用及临床应用研究进展[J].中华中医药杂志,2015,30(2):477-479.
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[23]蒋方程,李傲然,何静仁,等.不同品种山药的营养成分分析及其水提物的体外抗氧化能力研究[J].食品工业科技,2018,39(4):12-17.
[24]王娜,包一枫,蔡金巧,等.芡实的营养价值分析及开发利用现状[J].中国食物与营养,2016,22(2):76-78.
[25]李欢,张梦飞,苗明三.韭菜籽的现代研究与思考[J].中医学报,2017,32(3):430-432.
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[27]黄小波,李宗信,陈文强,等.慢性疲劳综合征患者疲劳程度与生活质量的相关性研究[J].中华行为医学与脑科学杂志,2006,15(8):687-688.
[28]De B P,De M K,Joos E,et al.Dehydroepiandrosterone(DHEA)response to i.v.ACTH in patients with chronic fatigue syndrome[J].Horm Metab Res,1999,31(1):18-21.
[29]陈兆蓉,刘太容.益神安眠贴联合耳穴贴压治疗慢性疲劳综合征护士睡眠障碍[J].护理学杂志,2014,29(13):13-15.()
[2]Samantha J,Brenu E W,Donald S,et al.The prevalence of chronic fatigue syndrome/myalgic encephalomyelitis:a meta-analysis[J].Clin Epidemiol,2013,5:105-110.
[3]袁萍,梁伯衡.慢性疲劳综合征的流行病学特征[J].国外医学卫生学分册,2003,30(2):70-74.
[4]张智君.慢性疲劳综合征的流行特征与临床诊断[J].中华流行病学杂志,2001,22(3):229-232.
[5]左谦,单广良.慢性疲劳综合征常见病因及干预措施[J].中国慢性病预防与控制,2010,18(2):212-215.
[6]Kirchgessner A.Chapter 21-The role of the microbiota and potential for dietary intervention in chronic fatigue syndrome[EB/OL].[2018-07-20].http://www.science Direct.com/science/article/pii/B978012802304400219.
[7]Hobday R A,Thomas S,O'donovan A,et al.Dietary intervention in chronic fatigue syndrome[J].J Hum Nutr Diet,2010,21(2):141-149.
[8]官杰,邹丽妍,朱丽萍,等.老年糖尿病病人药膳临床应用与思考[J].中西医结合心脑血管病杂志,2018,16(3):376-377.
[9]李红芸,李建华.药膳粥辅助治疗老年高血压和高血脂[J].护理学杂志,2007,22(7):51.
[10]陈汝文,林丽华,冯碧英.辨证施膳对糖尿病肾病患者生化指标的影响[J].护理学杂志,2010,25(1):48-49.
[11]何慧颖.中医辨体施膳对于亚健康疲劳综合征痰湿体质的干预研究[D].北京:北京中医药大学,2012.
[12]李应存,李鑫浩.敦煌道家《呼吸静功妙诀》与神仙粥的今用[C].中华中医药学会养生康复分会第十二次学术年会暨服务老年产业研讨会论文集,2014:37-39.
[13]郑筱萸.中药新药临床研究指导原则[M].中国医药科技出版社,2002:362-367.
[14]Krupp L B,Larocca N G,Muirnash J,et al.The fatigue severity scale.Application to patients with multiple sclerosis and systemic lupus erythematosus[J].Arch Neurol,1989,46(10):1121-1123.
[15]吴春薇,王得新.疲劳严重度量表中译本应用于脑梗死患者的临床与评价[J].中华物理医学与康复杂志,2007,29(9):608-611.
[16]李鲁,王红妹,沈毅.SF-36健康调查量表中文版的研制及其性能测试[J].中华预防医学杂志,2002,36(2):109-113.
[17]诸毅晖,成词松,刘美琳,等.调补脾肾治疗慢性疲劳综合征思路探讨[J].中医杂志,2011,52(9):737-739.
[18]王邈,李德远,李玮,等.山药的药理作用分析及其开发利用[J].中国食物与营养,2010(4):72-75.
[19]刘琳,刘洋洋,占颖,等.芡实的化学成分、药理作用及临床应用研究进展[J].中华中医药杂志,2015,30(2):477-479.
[20]余丹平.粳米的营养价值及机插高产高效栽培技术[J].魅力中国,2014(9):111.
[21]Klimas N G,Koneru A O B.Chronic fatigue syndrome:inflammation,immune function,and neuroendocrine interactions[J].Curr Rheumatol Rep,2007,9(6):482-487.
[22]Behan P O,Behan W M,Horrobin D.Effect of high doses of essential fatty acids on the postviral fatigue syndrome[J].Acta Neurol Scand,2010,82(3):209-216.
[23]蒋方程,李傲然,何静仁,等.不同品种山药的营养成分分析及其水提物的体外抗氧化能力研究[J].食品工业科技,2018,39(4):12-17.
[24]王娜,包一枫,蔡金巧,等.芡实的营养价值分析及开发利用现状[J].中国食物与营养,2016,22(2):76-78.
[25]李欢,张梦飞,苗明三.韭菜籽的现代研究与思考[J].中医学报,2017,32(3):430-432.
[26]Dotsenko V A,Mosichuk L V,Paramonov A E.Biologically active food additives for correction of the chronic fatigue syndrome[J].Vopr Pitan,2004,73(2):17-21.
[27]黄小波,李宗信,陈文强,等.慢性疲劳综合征患者疲劳程度与生活质量的相关性研究[J].中华行为医学与脑科学杂志,2006,15(8):687-688.
[28]De B P,De M K,Joos E,et al.Dehydroepiandrosterone(DHEA)response to i.v.ACTH in patients with chronic fatigue syndrome[J].Horm Metab Res,1999,31(1):18-21.
[29]陈兆蓉,刘太容.益神安眠贴联合耳穴贴压治疗慢性疲劳综合征护士睡眠障碍[J].护理学杂志,2014,29(13):13-15.()