心可舒片联合尼可地尔治疗微血管性心绞痛的临床疗效及其对炎症因子的影响
摘要
目的观察心可舒片联合尼可地尔治疗微血管性心绞痛的临床疗效及其对超敏C反应蛋白(hs-CRP)、血管内皮生长因子(VEGF)、一氧化氮(NO)及不良情绪的影响。方法将符合入选标准的60例病人随机分为两组,每组30例。对照组采用西医常规疗法,观察组在对照组治疗基础上加用心可舒片及尼可地尔治疗。随访3个月,比较两组临床疗效及其hs-CRP、VEGF、NO、抑郁自评量表(Self-rating Depression Scale,SDS)及焦虑自评量表(Self-rating Anxiety Scale,SAS)等指标的影响。结果观察组治疗后临床有效率明显高于对照组(90%与67%,P<0.05),hs-CRP、SDS评分、SAS评分明显下降,NO明显升高(P<0.05)。结论心可舒片联合尼可地尔可以改善微血管性心绞痛病人临床症状,还可以保护血管内皮功能,改善不良情绪。
引文
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[2] GULATI M,COOPER-DEHOFF R M,MCCLURE C,et al.Adverse cardiovascular outcomes in women with nonobstructive coronary artery disease:a report from the women′s ischemia syndrome evaluation study and the st james women take heart project[J].Arch Intern Med,2009,169(9):843-850.
[3] SHAW L J,BAIREY M C,PEPINE C J,et al.Insights from the NHLBI-Sponsored women′s ischemia syndrome evaluation(WISE) study:part Ⅰ:gender differences in traditional and novel risk factors,symptom evaluation,and gender-optimized diagnostic strategies[J].J Am Coll Cardiol,2006,47(3 suppl):s4-s20.
[4] 钱菊英,陈傲,陈章炜.心脏X综合征研究进展[J].内科理论与实践,2017,12(1):4-8.
[5] 雷斌,邹东华,何世安,等.尼可地尔对内皮细胞氧化应激损伤的保护作用[J].中国临床药理学杂志,2013,29(7):527-529.
[6] 贺学魁,董静,赵运,等.尼可地尔对心脏X综合征的疗效及对血管内皮功能的影响[J].中国循环杂志,2017,32(7):676-679.
[7] 靳刚强.尼可地尔治疗微血管性心绞痛的疗效及其对血管内皮功能的影响[J].当代医学,2016,22(23):131-132.
[8] CHEOK F,SCHRADER G,BANHAM D,et al.Identification,course,and treatment of depression after admission for a cardiac condition:rationale and patient characteristics for the Identifying Depression As a Comorbid Condition(IDACC) project[J].Am Heart J,2003,146(6):978-984.
[9] JOVANOVICD,JAKOVLJEVICB,PAUNOVIC K,et al.Importance of personality traits and psychosocial factors for the development of coronary heart disease[J].Vojnosanit Pregl,2006,63(2):153-158.
[10] 陈梅贤,罗助荣,曹小织.心可舒对冠心病伴焦虑状态病人血浆神经肽Y的影响[J].中西医结合心脑血管病杂志,2016,14(14):1636-1638.
[11] 张晓蕾,任岩春,赵永峰,等.心可舒治疗冠心病各分型患者焦虑、抑郁情绪的疗效观察[J].中国急救医学,2015,35(Z2):207-208.
[12] DOLLARD J,KEARNEY P,DINAN T G.Cardiac syndrome X in Ireland:incidence and phenotype[J].Ir J Med Sci,2016,185(4):857-863.
[13] REIS S E,HOLUBKOV R,CONRAD S A,et al.Coronary microvascular dysfunction is highly prevalent in women with chest pain in the absence of coronary artery disease:results from the NHLBI WISE study[J].Am Heart J,2001,141(5):735-741.