中医药结合放疗治疗食管癌及机制的研究进展
|
摘要
近年来,食管癌精确放疗技术能有效提高治疗增益比,最大限度减少肿瘤周围正常组织的受照量,放疗反应及并发症却不可避免,同时由于肿瘤生物学特性和患者个体差异,放射敏感度亟待提高。中医重视整体,调节机体平衡,在抗癌、减少放射性损伤和提高放疗疗效等方面具有优势。中医药结合放疗治疗食管癌是中国特色肿瘤诊治模式。本文就中医药结合放疗增敏减毒作用及机制研究做一综述。
In recent years, accurate radiotherapy of esophageal cancer has effectively improved the therapeutic gain ratio and minimized the exposure of healthy tissues around the tumor. Nonetheless, the adverse effects and complications of radiotherapy are unavoidable. At the same time, because of the different biological characteristics and individual specificity, altering therapy for improving radiosensitivity is urgently needed. Traditional Chinese medicine(TCM) attaches great importance to the whole body and regulates the balance of the body. It has great advantages in anti-cancer treatment, reducing radiation damage, and improving the efficacy of radiotherapy. Radiotherapy combined with TCM in the treatment of esophageal cancer is a special form of cancer prevention and treatment in China. In this review, the effect and mechanism of radiosensitization and decreasing toxicity function of Chinese medicine are summarized.
In recent years, accurate radiotherapy of esophageal cancer has effectively improved the therapeutic gain ratio and minimized the exposure of healthy tissues around the tumor. Nonetheless, the adverse effects and complications of radiotherapy are unavoidable. At the same time, because of the different biological characteristics and individual specificity, altering therapy for improving radiosensitivity is urgently needed. Traditional Chinese medicine(TCM) attaches great importance to the whole body and regulates the balance of the body. It has great advantages in anti-cancer treatment, reducing radiation damage, and improving the efficacy of radiotherapy. Radiotherapy combined with TCM in the treatment of esophageal cancer is a special form of cancer prevention and treatment in China. In this review, the effect and mechanism of radiosensitization and decreasing toxicity function of Chinese medicine are summarized.
引文
[1]张巧丽,黄金昶.中药放疗增敏剂的研究进展[J].中国临床医生杂志,2014,42(11):23-25.
[2]王雪华,秦海涛,刘树民.中医药对恶性肿瘤放疗减毒增敏作用的研究[J].中医药信息,1993,(4):33-35.
[3]孙尧,刘希军,于甬华.食管癌精确放疗的研究进展[J].中华肿瘤防治杂志,2012,19(9):712-716.
[4]郑凯,邓甜甜,刘志成,等.针药并用配合放疗治疗中晚期食管癌临床观察[J].辽宁中医药大学学报,2014,16(10):9-11.
[5]徐海帆,谭风波,陈华兵.自拟方剂配合放疗治疗中晚期食管癌的疗效观察[J].中国药房,2012,23(23):2185-2187.
[6]薛婷,王运波,耿惠,等.中药联合放疗治疗中晚期食管癌近期和远期效果观察[J].中国药物与临床,2017,17(7):1004-1006.
[7]李玉海.益气养阴方加味联合放疗治疗食管癌疗效分析[J].中医临床研究,2017,9(3):108-110.
[8]崔珍,柳雯,殷红梅,等.清肺祛瘀汤预防食管癌同步放化疗致放射性肺炎的疗效观察[J].中国中西医结合杂志,2016,36(3):317-321.
[9]马纯政,王蓉,张明智,等.化痰散瘀法对中晚期食管癌放疗增效的研究[J].北京中医药大学学报,2014,37(12):830-833.
[10]黄泽桦.清热复液汤在食管癌放疗反应及并发症中的临床作用[J].中国实用医药,2014,9(14):37-38.
[11]莫凯岚,彭苗,陈晓兰等.调强放疗对中晚期食管癌患者短期生活质量的影响及其影响因素分析[J].中国当代医药,2016,23(14):47-49+53.
[12]Chen H,Zhou L,Yang Y,et al.Clinical Effect of Radiotherapy Combined with Chemotherapy for Non-Surgical Treatment of the Esophageal Squamous Cell Carcinoma[J].Med Sci Monit,2018,24:4183-4191.
[13]冯献明,王月峰,陈小兵,等.复方苦参注射液联合放化疗对老年食管癌患者生存质量的影响[J].医药论坛杂志,2015,36(10):165-166.
[14]吴冬梅,刘冠军.养正消积胶囊对食管癌放疗患者生存质量的影响[J].河南科技大学学报(医学版),2014,32(2):109-111.
[15]姜付显,方文岩,陈军,等.中药治疗对食管癌放疗患者的疗效及生存质量的影响[J].中医药导报,2014,20(1):33-35.
[16]胥芸芸,洪梅,李桂香.放疗对机体抗肿瘤免疫效应机制的影响[J].现代肿瘤医学,2016,24(24):4023-4025.
[17]张宁,王剑锋,程光惠,等.西黄胶囊辅助放化疗治疗中晚期食管癌患者的疗效评价[J].吉林大学学报(医学版),2017,43(04):812-817.
[18]张莹,王蕾,杜梦楠.注射用黄芪多糖治疗肿瘤的临床研究进展[J].药物评价研究,2016,39(6):1092-1094.
[19]吕翠田,董志斌,陈玉龙.六君子汤对4-硝基喹啉-1-氧化物诱导食管癌小鼠免疫调节的影响[J].中华中医药杂志,2016,31(7):2831-2834.
[20]林琳,曹鹏.放化疗结合中医药治疗食管癌的临床研究进展[J].世界华人消化杂志,2012,20(35):3505-3509.
[21]顾曦,戴安伟.中药配合肿瘤放射治疗及增敏的现状与发展[J].辽宁中医药大学学报,2013,15(7):262-264.
[22]许冠华,金柏军,雷俊华.丹参及丹参提取物增敏放疗的研究进展[J].浙江中西医结合杂志,2016,26(8):770-772.
[23]黄炜平,王洪琦,郭婷婷,等.姜黄素对恶性肿瘤放射增敏作用研究进展[J].中华中医药学刊,2017,35(11):2855-2857.
[24]刘连花,杨晓峰.放疗加马蔺子素增敏治疗食管癌112例疗效分析[J].华夏医学,2000,(4):467-468.
[25]邱淑敏,陈涛,刘美玲,等.中药诱导肿瘤细胞凋亡机制研究进展[J].动物医学进展,2015,36(1):83-86.
[26]杨玖,葛小林,曹远东,等.人参皂苷Rg3对食管癌细胞放射增敏作用的初步研究[J].临床肿瘤学杂志,2014,19(10):886-890.
[27]景绍武,王雅棣,吴凤鹏,等.三氧化二砷对食管癌细胞株Eca109的放射增敏作用及机制[J].肿瘤防治研究,2011,38(6):620-623.
[28]胡格,朱宇,周月鹏,等.白藜芦醇联合放疗对食管癌细胞株凋亡的影响[J].江苏大学学报(医学版),2017,27(3):194-199.
[29]任凌燕,徐磊,赵青,等.β-榄香烯对人食管癌细胞EC9706增殖、凋亡及caspase-3的影响[J].实用癌症杂志,2016,31(2):202-204.
[30]王祥麒,郑玉玲,王俊涛,等.地黄管食通颗粒对放射治疗后食管癌模型大鼠c-myc,TERT表达的影响[J].中国实验方剂学杂志,2011,17(18):240-243.
[31]Barker HE,Paget JT,Khan AA,et al.The tumour microenvironment after radiotherapy:mechanisms of resistance and recurrence[J].Nat Rev Can,2015,15(7):409-25.
[32]张慧.六神丸联合放疗治疗食管癌的临床观察及对食管癌炎性微环境与血管生成的作用机制研究[D].湖南中医药大学,2015:38-39.
[33]徐冬磊.黄芪扶正颗粒防治食管癌放疗诱发放射性食管炎的有效性研究[D].甘肃中医药大学,2016:24.
[34]韩钦芮,符秀琼,禹志领,等.肿瘤微环境的脾虚本质探讨[J].中医杂志,2014,55(04):292-294+298.
[35]王原来,卞卡,章丹丹.肿瘤中巨噬细胞表型极化的调控机制及中药干预的研究进展[J].中国中药杂志,2015,40(02):180-184.
[2]王雪华,秦海涛,刘树民.中医药对恶性肿瘤放疗减毒增敏作用的研究[J].中医药信息,1993,(4):33-35.
[3]孙尧,刘希军,于甬华.食管癌精确放疗的研究进展[J].中华肿瘤防治杂志,2012,19(9):712-716.
[4]郑凯,邓甜甜,刘志成,等.针药并用配合放疗治疗中晚期食管癌临床观察[J].辽宁中医药大学学报,2014,16(10):9-11.
[5]徐海帆,谭风波,陈华兵.自拟方剂配合放疗治疗中晚期食管癌的疗效观察[J].中国药房,2012,23(23):2185-2187.
[6]薛婷,王运波,耿惠,等.中药联合放疗治疗中晚期食管癌近期和远期效果观察[J].中国药物与临床,2017,17(7):1004-1006.
[7]李玉海.益气养阴方加味联合放疗治疗食管癌疗效分析[J].中医临床研究,2017,9(3):108-110.
[8]崔珍,柳雯,殷红梅,等.清肺祛瘀汤预防食管癌同步放化疗致放射性肺炎的疗效观察[J].中国中西医结合杂志,2016,36(3):317-321.
[9]马纯政,王蓉,张明智,等.化痰散瘀法对中晚期食管癌放疗增效的研究[J].北京中医药大学学报,2014,37(12):830-833.
[10]黄泽桦.清热复液汤在食管癌放疗反应及并发症中的临床作用[J].中国实用医药,2014,9(14):37-38.
[11]莫凯岚,彭苗,陈晓兰等.调强放疗对中晚期食管癌患者短期生活质量的影响及其影响因素分析[J].中国当代医药,2016,23(14):47-49+53.
[12]Chen H,Zhou L,Yang Y,et al.Clinical Effect of Radiotherapy Combined with Chemotherapy for Non-Surgical Treatment of the Esophageal Squamous Cell Carcinoma[J].Med Sci Monit,2018,24:4183-4191.
[13]冯献明,王月峰,陈小兵,等.复方苦参注射液联合放化疗对老年食管癌患者生存质量的影响[J].医药论坛杂志,2015,36(10):165-166.
[14]吴冬梅,刘冠军.养正消积胶囊对食管癌放疗患者生存质量的影响[J].河南科技大学学报(医学版),2014,32(2):109-111.
[15]姜付显,方文岩,陈军,等.中药治疗对食管癌放疗患者的疗效及生存质量的影响[J].中医药导报,2014,20(1):33-35.
[16]胥芸芸,洪梅,李桂香.放疗对机体抗肿瘤免疫效应机制的影响[J].现代肿瘤医学,2016,24(24):4023-4025.
[17]张宁,王剑锋,程光惠,等.西黄胶囊辅助放化疗治疗中晚期食管癌患者的疗效评价[J].吉林大学学报(医学版),2017,43(04):812-817.
[18]张莹,王蕾,杜梦楠.注射用黄芪多糖治疗肿瘤的临床研究进展[J].药物评价研究,2016,39(6):1092-1094.
[19]吕翠田,董志斌,陈玉龙.六君子汤对4-硝基喹啉-1-氧化物诱导食管癌小鼠免疫调节的影响[J].中华中医药杂志,2016,31(7):2831-2834.
[20]林琳,曹鹏.放化疗结合中医药治疗食管癌的临床研究进展[J].世界华人消化杂志,2012,20(35):3505-3509.
[21]顾曦,戴安伟.中药配合肿瘤放射治疗及增敏的现状与发展[J].辽宁中医药大学学报,2013,15(7):262-264.
[22]许冠华,金柏军,雷俊华.丹参及丹参提取物增敏放疗的研究进展[J].浙江中西医结合杂志,2016,26(8):770-772.
[23]黄炜平,王洪琦,郭婷婷,等.姜黄素对恶性肿瘤放射增敏作用研究进展[J].中华中医药学刊,2017,35(11):2855-2857.
[24]刘连花,杨晓峰.放疗加马蔺子素增敏治疗食管癌112例疗效分析[J].华夏医学,2000,(4):467-468.
[25]邱淑敏,陈涛,刘美玲,等.中药诱导肿瘤细胞凋亡机制研究进展[J].动物医学进展,2015,36(1):83-86.
[26]杨玖,葛小林,曹远东,等.人参皂苷Rg3对食管癌细胞放射增敏作用的初步研究[J].临床肿瘤学杂志,2014,19(10):886-890.
[27]景绍武,王雅棣,吴凤鹏,等.三氧化二砷对食管癌细胞株Eca109的放射增敏作用及机制[J].肿瘤防治研究,2011,38(6):620-623.
[28]胡格,朱宇,周月鹏,等.白藜芦醇联合放疗对食管癌细胞株凋亡的影响[J].江苏大学学报(医学版),2017,27(3):194-199.
[29]任凌燕,徐磊,赵青,等.β-榄香烯对人食管癌细胞EC9706增殖、凋亡及caspase-3的影响[J].实用癌症杂志,2016,31(2):202-204.
[30]王祥麒,郑玉玲,王俊涛,等.地黄管食通颗粒对放射治疗后食管癌模型大鼠c-myc,TERT表达的影响[J].中国实验方剂学杂志,2011,17(18):240-243.
[31]Barker HE,Paget JT,Khan AA,et al.The tumour microenvironment after radiotherapy:mechanisms of resistance and recurrence[J].Nat Rev Can,2015,15(7):409-25.
[32]张慧.六神丸联合放疗治疗食管癌的临床观察及对食管癌炎性微环境与血管生成的作用机制研究[D].湖南中医药大学,2015:38-39.
[33]徐冬磊.黄芪扶正颗粒防治食管癌放疗诱发放射性食管炎的有效性研究[D].甘肃中医药大学,2016:24.
[34]韩钦芮,符秀琼,禹志领,等.肿瘤微环境的脾虚本质探讨[J].中医杂志,2014,55(04):292-294+298.
[35]王原来,卞卡,章丹丹.肿瘤中巨噬细胞表型极化的调控机制及中药干预的研究进展[J].中国中药杂志,2015,40(02):180-184.