孟鲁司特钠联合盐酸氮卓斯汀治疗过敏性鼻炎的疗效及对血清炎性因子、微量元素水平的影响
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摘要
目的:探讨孟鲁司特钠联合盐酸氮卓斯汀治疗过敏性鼻炎的疗效及对血清炎性因子、微量元素水平的影响。方法:选取2017年2月至2018年9月海南省人民医院耳鼻咽喉头颈外科收治的过敏性鼻炎患者128例,按照随机数字表法分为对照组和观察组,每组64例。对照组患者给予孟鲁司特钠治疗,观察组患者在对照组的基础上加用盐酸氮卓斯汀鼻喷雾剂治疗。观察两组患者的临床疗效,治疗前后临床症状积分和血清白细胞介素6(IL-6)、白细胞介素8(IL-8)、白细胞介素-10(IL-10)、锌(Zn)、铜(Cu)、铁(Fe)、锰(Mn)水平及不良反应发生情况。结果:观察组患者的总有效率为89.06%(57/64),明显高于对照组的71.88%(46/64),差异有统计学意义(P<0.05);治疗后,观察组患者鼻痒、鼻塞、喷嚏、擤鼻积分及总评分明显低于对照组,差异均有统计学意义(P<0.05);治疗后,观察组患者血清IL-6、IL-8及IL-10水平明显优于对照组,差异均有统计学意义(P<0.05);治疗后,观察组患者血清Zn、Cu、Fe及Mn水平明显优于对照组,差异均有统计学意义(P<0.05);两组患者未发生明显不良反应。结论:孟鲁司特钠联合盐酸氮卓斯汀治疗过敏性鼻炎的疗效确切,安全性高,其作用机制可能与改善患者机体微量元素水平、抑制炎症反应有关。
OBJECTIVE: To investigate the efficacy of montelukast combined with azosteine hydrochloride in treatment of allergic rhinitis and its effects on serum inflammatory factors and trace element levels. METHODS: Totally 128 patients with allergic rhinitis admitted into otolaryngology head and neck surgery of Hainan People's Hospital from Feb. 2017 to Sept. 2018 were extracted to be divided into the observation group and the control group via the random number table, with 64 cases in each group. The control group was treated with montelukast, while the observation group received azoxetine hydrochloride on the basis of the control group. The clinical efficacy, clinical symptom scores, serum interleukin-6(IL-6), interleukin-8(IL-8), interleukin-10(IL-10), zinc(Zn), copper(Cu), ferritin(Fe), manganese(Mn) levels before and after treatment and adverse drug reactions of two groups were observed. RESULTS: The total effective rate of the observation group was 89.06%(57/64), significantly higher than that of the control group [71.88%(46/64)], the difference was statistically significant(P<0.05). After treatment, the scores of nasal itching, nasal congestion, sneezing and blowing and total scores in the observation group were significantly lower than those in the control group, with statistically significant differences(P<0.05). After treatment, the serum levels of IL-6, IL-8 and IL-10 in the observation group were significantly better than those in the control group(P<0.05). After treatment, the serum levels of Zn, Cu, Fe and Mn in the observation group were significantly better than those in the control group, and the differences were statistically significant(P<0.05). There were no significant adverse drug reactions in both groups. CONCLUSIONS: The efficacy of montelukast combined with azosteine hydrochloride in treatment of allergic rhinitis is significant with higher safety, its mechanism of action may be related to improving the trace element levels in patients and inhibiting inflammatory response.
OBJECTIVE: To investigate the efficacy of montelukast combined with azosteine hydrochloride in treatment of allergic rhinitis and its effects on serum inflammatory factors and trace element levels. METHODS: Totally 128 patients with allergic rhinitis admitted into otolaryngology head and neck surgery of Hainan People's Hospital from Feb. 2017 to Sept. 2018 were extracted to be divided into the observation group and the control group via the random number table, with 64 cases in each group. The control group was treated with montelukast, while the observation group received azoxetine hydrochloride on the basis of the control group. The clinical efficacy, clinical symptom scores, serum interleukin-6(IL-6), interleukin-8(IL-8), interleukin-10(IL-10), zinc(Zn), copper(Cu), ferritin(Fe), manganese(Mn) levels before and after treatment and adverse drug reactions of two groups were observed. RESULTS: The total effective rate of the observation group was 89.06%(57/64), significantly higher than that of the control group [71.88%(46/64)], the difference was statistically significant(P<0.05). After treatment, the scores of nasal itching, nasal congestion, sneezing and blowing and total scores in the observation group were significantly lower than those in the control group, with statistically significant differences(P<0.05). After treatment, the serum levels of IL-6, IL-8 and IL-10 in the observation group were significantly better than those in the control group(P<0.05). After treatment, the serum levels of Zn, Cu, Fe and Mn in the observation group were significantly better than those in the control group, and the differences were statistically significant(P<0.05). There were no significant adverse drug reactions in both groups. CONCLUSIONS: The efficacy of montelukast combined with azosteine hydrochloride in treatment of allergic rhinitis is significant with higher safety, its mechanism of action may be related to improving the trace element levels in patients and inhibiting inflammatory response.
引文
[1] Mims JW.Allergic rhinitis[J].Facial Plast Surg Clin North Am,2012,20(1):11-20.
[2] 王明婧.盐酸氮卓斯汀鼻喷剂联合地氯雷他定治疗过敏性鼻炎40例[J].中国药业,2015,24(17):88-90.
[3] 陈玉卿,穆会君,张桢,等.孟鲁司特钠辅助治疗老年变应性鼻炎的疗效及对IL-6、IL-8、IL-10的影响[J].中国老年学杂志,2016,36(13):3263-3265.
[4] Ridolo E,Montagni M,Melli V,et al.A role for the intranasal formulation of azelastine hydrochloride/fluticasone propionate in the treatment of allergic rhinitis[J].Ther Deliv,2015,6(6):653-659.
[5] 中华耳鼻咽喉头颈外科杂志编辑委员会鼻科组,中华医学会耳鼻咽喉头颈外科学分会鼻科学组.变应性鼻炎诊断和治疗指南(2015年,天津)[J].中华耳鼻咽喉头颈外科杂志,2016,51(1):6-24.
[6] 徐艳,马梅,张宗强.通窍鼻炎颗粒联合针刺治疗过敏性鼻炎及对患者血清IL-4,IL-6及IL-10的影响[J].中国实验方剂学杂志,2015,21(14):169-172.
[7] 闫燕,李鹏,刘丹丹.孟鲁司特钠、布地奈德鼻喷剂、枸地氯雷他定联合治疗变应性鼻炎的疗效及对炎性因子的影响[J].中国药师,2016,19(10):1900-1901.
[8] 张静,孟令民.孟鲁司特钠联合布地奈德鼻喷剂治疗变应性鼻炎的疗效及对患者血清炎性因子的影响[J].重庆医学,2014,43(23):3065-3067.
[9] 王咏丽,佟欣,袁建军,等.盐酸氮卓斯汀与曲安奈德治疗变应性鼻炎的临床观察[J].中国药房,2014,25(24):2256-2258.
[10] 王虹,杨淑玲,关向群,等.氮卓斯汀鼻喷剂联用吸入激素对控制不良的中重度哮喘的治疗作用[J].安徽医科大学学报,2012,47(12):1439-1422.
[11] Elazab SZ,Hessam WF.Effect of Allergen Specific Immunotherapy on Serum levels of IL-17 and IL-35 in Allergic Rhinitis Patients[J].Egypt J Immunol,2017,24(2):101-107.
[12] Brickey WJ,Alexis NE,Hernandez ML,et al.Sputum inflammatory cells from patients with allergic rhinitis and asthma have decreased inflammasome gene expression[J].J Allergy Clin Immunol,2011,128(4):900-903.
[13] Youssef MA,El-khodery SA,Ibrahim HM.Effect of selenium and vitamin C on clinical outcomes,trace element status,and antioxi-dant enzyme activity in horses with acute and chronic lower airway disease.A randomized clinical trial[J]Biol Trace Elem Res,2013,152(3):333-342.
[14] 郦海能,黄佳,郦航波,等.血清微量元素及T淋巴细胞亚群与变应性鼻炎的关系研究[J].实用预防医学,2017,24(2):234-235.
[15] 刘懿初,侯丽,王武臣,等.宁夏地区回汉人群变应性鼻炎患者血清中IL-4浓度与微量元素水平的相关性研究[J].临床耳鼻咽喉头颈外科杂志,2016,30(9):715-717.
[2] 王明婧.盐酸氮卓斯汀鼻喷剂联合地氯雷他定治疗过敏性鼻炎40例[J].中国药业,2015,24(17):88-90.
[3] 陈玉卿,穆会君,张桢,等.孟鲁司特钠辅助治疗老年变应性鼻炎的疗效及对IL-6、IL-8、IL-10的影响[J].中国老年学杂志,2016,36(13):3263-3265.
[4] Ridolo E,Montagni M,Melli V,et al.A role for the intranasal formulation of azelastine hydrochloride/fluticasone propionate in the treatment of allergic rhinitis[J].Ther Deliv,2015,6(6):653-659.
[5] 中华耳鼻咽喉头颈外科杂志编辑委员会鼻科组,中华医学会耳鼻咽喉头颈外科学分会鼻科学组.变应性鼻炎诊断和治疗指南(2015年,天津)[J].中华耳鼻咽喉头颈外科杂志,2016,51(1):6-24.
[6] 徐艳,马梅,张宗强.通窍鼻炎颗粒联合针刺治疗过敏性鼻炎及对患者血清IL-4,IL-6及IL-10的影响[J].中国实验方剂学杂志,2015,21(14):169-172.
[7] 闫燕,李鹏,刘丹丹.孟鲁司特钠、布地奈德鼻喷剂、枸地氯雷他定联合治疗变应性鼻炎的疗效及对炎性因子的影响[J].中国药师,2016,19(10):1900-1901.
[8] 张静,孟令民.孟鲁司特钠联合布地奈德鼻喷剂治疗变应性鼻炎的疗效及对患者血清炎性因子的影响[J].重庆医学,2014,43(23):3065-3067.
[9] 王咏丽,佟欣,袁建军,等.盐酸氮卓斯汀与曲安奈德治疗变应性鼻炎的临床观察[J].中国药房,2014,25(24):2256-2258.
[10] 王虹,杨淑玲,关向群,等.氮卓斯汀鼻喷剂联用吸入激素对控制不良的中重度哮喘的治疗作用[J].安徽医科大学学报,2012,47(12):1439-1422.
[11] Elazab SZ,Hessam WF.Effect of Allergen Specific Immunotherapy on Serum levels of IL-17 and IL-35 in Allergic Rhinitis Patients[J].Egypt J Immunol,2017,24(2):101-107.
[12] Brickey WJ,Alexis NE,Hernandez ML,et al.Sputum inflammatory cells from patients with allergic rhinitis and asthma have decreased inflammasome gene expression[J].J Allergy Clin Immunol,2011,128(4):900-903.
[13] Youssef MA,El-khodery SA,Ibrahim HM.Effect of selenium and vitamin C on clinical outcomes,trace element status,and antioxi-dant enzyme activity in horses with acute and chronic lower airway disease.A randomized clinical trial[J]Biol Trace Elem Res,2013,152(3):333-342.
[14] 郦海能,黄佳,郦航波,等.血清微量元素及T淋巴细胞亚群与变应性鼻炎的关系研究[J].实用预防医学,2017,24(2):234-235.
[15] 刘懿初,侯丽,王武臣,等.宁夏地区回汉人群变应性鼻炎患者血清中IL-4浓度与微量元素水平的相关性研究[J].临床耳鼻咽喉头颈外科杂志,2016,30(9):715-717.