肺癌患者中医体质及中医辨证分型与临床TNM分期及病理类型之间的关系分析
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摘要
目的:研究分析肺癌患者中医体质及中医辨证分型与临床TNM分期及病理类型之间的关系,为临床诊疗提供依据。方法:选取肺癌患者200例,根据患者的中医体质及中医辨证分型对患者进行统计整理,同时收集整理全部患者的临床TNM分期及病理类型,并分析总结中医体质及中医辨证分型与临床TNM分期及病理类型之间的关系。结果:肺癌患者中医体质与TNM分期的研究中,Ⅰ期患者量少,以平和质、气虚质、痰湿质为主,Ⅱ期患者以痰湿质、湿热质为主,Ⅲ期患者以阳虚质为主,其次为气虚质、阴虚质,Ⅳ期患者主要为阴虚质、气虚质和气郁质,通过应用Fisher确切概率法检验,中医体质与TNM分期之间具有一定的统计学意义(P<0.05);肺癌患者中医辨证分型与TNM分期的研究中,Ⅰ期、Ⅱ期患者均以气虚痰湿证为主,Ⅱ期患者其次为阴虚热毒证,Ⅲ期、Ⅳ期患者均以气阴两虚证为主,其次为阴虚热毒证、气血瘀滞证。通过应用Fisher确切概率法检验,中医辨证分型与TNM分期之间具有一定的统计学意义(P<0.05),中医体质与病理类型之间、中医辨证分型与病理类型之间无统计学意义(P>0.05)。结论:肺癌患者的中医体质及中医辨证分型与临床TNM分期之间具有一定的相关性,但是中医体质及中医辨证分型与其病理类型之间无明确的相关性。
Objective: To study the relationship between TCM constitution and TCM syndrome differentiation and clinical TNM staging and pathological types in patients with lung cancer and provide the evidence for clinical diagnosis and treatment. Methods: A total of 200 patients were randomly divided into two groups according to the TCM constitution and syndrome differentiation of TCM. The clinical TNM staging and pathological type were collected and analyzed. To summarize the relationship between TCM constitution and TCM syndrome differentiation and clinical TNM staging and pathological type. Results: In the study of TCM constitution and TNM staging in patients with lung cancer,the number of patients with stage I was less than that of plain,qi deficiency,phlegm and dampness,and phlegm and dampness were mainly in stage II( P<0. 05). There were some statistically significant differences between TCM constitution and TNM staging( P<0. 05). According to the study on lung cancer patients with TCM syndrome differentiation and TNM staging,patients at stage I and II were mainly phlegm-dampness syndrome and patients at stage II were followed by Yin deficiency syndrome.Patients at stage III and Ⅳ were qi and yin deficiency,followed by Yin deficiency and heat syndrome and blood stasis syndrome( P<0. 05). There was no significant difference between TCM constitution and pathologic type. TCM syndrome differentiation and pathologic type between TCM syndrome type and pathologic type had significant difference( P< 0. 05)and there was no significant difference between TCM syndrome type and pathologic type( P>0. 05). There was a certain correlation between TCM constitution and TCM syndrome differentiation and clinical TNM staging in patients with lung cancer,but there was no clear correlation between TCM constitution and syndrome differentiation of TCM and its pathological type.
Objective: To study the relationship between TCM constitution and TCM syndrome differentiation and clinical TNM staging and pathological types in patients with lung cancer and provide the evidence for clinical diagnosis and treatment. Methods: A total of 200 patients were randomly divided into two groups according to the TCM constitution and syndrome differentiation of TCM. The clinical TNM staging and pathological type were collected and analyzed. To summarize the relationship between TCM constitution and TCM syndrome differentiation and clinical TNM staging and pathological type. Results: In the study of TCM constitution and TNM staging in patients with lung cancer,the number of patients with stage I was less than that of plain,qi deficiency,phlegm and dampness,and phlegm and dampness were mainly in stage II( P<0. 05). There were some statistically significant differences between TCM constitution and TNM staging( P<0. 05). According to the study on lung cancer patients with TCM syndrome differentiation and TNM staging,patients at stage I and II were mainly phlegm-dampness syndrome and patients at stage II were followed by Yin deficiency syndrome.Patients at stage III and Ⅳ were qi and yin deficiency,followed by Yin deficiency and heat syndrome and blood stasis syndrome( P<0. 05). There was no significant difference between TCM constitution and pathologic type. TCM syndrome differentiation and pathologic type between TCM syndrome type and pathologic type had significant difference( P< 0. 05)and there was no significant difference between TCM syndrome type and pathologic type( P>0. 05). There was a certain correlation between TCM constitution and TCM syndrome differentiation and clinical TNM staging in patients with lung cancer,but there was no clear correlation between TCM constitution and syndrome differentiation of TCM and its pathological type.
引文
[1]董静波,卢晓峰,翁国爱,等.肺癌患者中医体质及辨证分型与临床TNM分期及病理类型的相关性研究[J].中国中医药科技,2016,23(5):506-509.
[2]郑同宝,张征,蔚敏,等.肺癌中医体质辨证探讨[J].新中医,2005,37(4):13-14.
[3]崔芳囡,贾立群,刘猛,等.老年肺癌患者中医体质的相关探讨[J].中国中医急症,2012,21(11):1786-1788.
[4]黄婉.肺癌的中医证型分布与体质类型的相关性研究[D].咸阳:陕西中医药大学,2015,12(9):116-118.
[5]陈世贤,袁立霞,邱钰芹,等.肺癌与中医体质的关系[J].长春中医药大学学报,2014,30(1):62-63.
[6]王帅,钱彦方,杨雪春,等.中医体质学说在肺癌临床论治中的研究进展[J].环球中医药,2016,9(12):1560-1564.
[7]申龙树,朱长乐,谢玲,等.表皮生长因子受体基因突变与肺癌病理类型的关系[J].临床与实验病理学杂志,2015,25(2):197-200.
[8]赵静,戴随,李会强,等.肿瘤标志物联检与肺癌诊断及肺癌与中医辨证分型关系探讨[J].陕西中医,2014,7(2):184-186.
[9]晏雪生,李瀚旻,彭亚琴,等.肺癌肿瘤标志物与中医辨证分型的相关性研究[J].湖北中医杂志,2007,29(9):11-12.
[10]杜建飞,崔立春,耿会生,等.慢性阻塞性肺疾病合并肺癌与单纯肺癌临床特征差异的分析[J].中华肺部疾病杂志(电子版),2016,9(3):275-277.
[11]王蕾,宁小晓,李和根,等.肺癌患者中医证型与其组织类型、临床分期及肿瘤标志物的相关性分析[J].检验医学,2013,28(5):387-390.
[12]徐永强.原发性支气管肺癌中医证型与国际TNM分期、病理类型及相关肿瘤标志物的相关性研究[D].济南:山东中医药大学,2010,9(10):76-78.
[13]周建龙,梁静,邓青南,等.非小细胞肺癌的中西医分型分期相关性研究[J].吉林中医药,2015,35(4):358-360.
[14]楼洋,陈献国,施亚明,等.周围型小肺癌198例TNM分期及临床意义[J].中国老年学杂志,2014,19(24):7094-7095.
[15]谢长生,王东建,潘磊,等.561例肺癌中医证型与TNM分期及病理类型的相关性探索[J].浙江中医杂志,2014,45(6):398-399.
[16]王生海,吴鹏,陈海海,等.肺癌脑转移合并出血的影像特征及其与病理类型的相关性[J].中国临床医学影像杂志,2015,26(9):609-611,615.
[2]郑同宝,张征,蔚敏,等.肺癌中医体质辨证探讨[J].新中医,2005,37(4):13-14.
[3]崔芳囡,贾立群,刘猛,等.老年肺癌患者中医体质的相关探讨[J].中国中医急症,2012,21(11):1786-1788.
[4]黄婉.肺癌的中医证型分布与体质类型的相关性研究[D].咸阳:陕西中医药大学,2015,12(9):116-118.
[5]陈世贤,袁立霞,邱钰芹,等.肺癌与中医体质的关系[J].长春中医药大学学报,2014,30(1):62-63.
[6]王帅,钱彦方,杨雪春,等.中医体质学说在肺癌临床论治中的研究进展[J].环球中医药,2016,9(12):1560-1564.
[7]申龙树,朱长乐,谢玲,等.表皮生长因子受体基因突变与肺癌病理类型的关系[J].临床与实验病理学杂志,2015,25(2):197-200.
[8]赵静,戴随,李会强,等.肿瘤标志物联检与肺癌诊断及肺癌与中医辨证分型关系探讨[J].陕西中医,2014,7(2):184-186.
[9]晏雪生,李瀚旻,彭亚琴,等.肺癌肿瘤标志物与中医辨证分型的相关性研究[J].湖北中医杂志,2007,29(9):11-12.
[10]杜建飞,崔立春,耿会生,等.慢性阻塞性肺疾病合并肺癌与单纯肺癌临床特征差异的分析[J].中华肺部疾病杂志(电子版),2016,9(3):275-277.
[11]王蕾,宁小晓,李和根,等.肺癌患者中医证型与其组织类型、临床分期及肿瘤标志物的相关性分析[J].检验医学,2013,28(5):387-390.
[12]徐永强.原发性支气管肺癌中医证型与国际TNM分期、病理类型及相关肿瘤标志物的相关性研究[D].济南:山东中医药大学,2010,9(10):76-78.
[13]周建龙,梁静,邓青南,等.非小细胞肺癌的中西医分型分期相关性研究[J].吉林中医药,2015,35(4):358-360.
[14]楼洋,陈献国,施亚明,等.周围型小肺癌198例TNM分期及临床意义[J].中国老年学杂志,2014,19(24):7094-7095.
[15]谢长生,王东建,潘磊,等.561例肺癌中医证型与TNM分期及病理类型的相关性探索[J].浙江中医杂志,2014,45(6):398-399.
[16]王生海,吴鹏,陈海海,等.肺癌脑转移合并出血的影像特征及其与病理类型的相关性[J].中国临床医学影像杂志,2015,26(9):609-611,615.