母细胞性浆细胞样树突细胞肿瘤临床病理分析
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摘要
目的探讨母细胞性浆细胞样树突细胞肿瘤的临床病理学特征。方法应用光镜及免疫组化法观察母细胞性浆细胞样树突细胞肿瘤的组织学特点及免疫表型,并复习相关文献。结果母细胞性浆细胞样树突细胞肿瘤好发于老年患者,多以皮肤病变为首发症状,形态学表现为肿瘤细胞呈弥漫、密集、单一性浸润真皮及皮下组织,细胞中等大小,细胞浆量少,核卵圆形或不规则,染色质细,核分裂易见。免疫组化肿瘤细胞阳性表达CD4、CD56、CD123;而CD2、CD3、CD5、CD8、GranB、TIA-1、CD20、CD79a、PAX-5、MPO阴性。结论 BPDCN是一种罕见的淋巴造血系统恶性肿瘤,临床侵袭性强,易复发,预后差,应注意与其他淋巴造血系统肿瘤相鉴别。
Objective To investigate the clinicopathological characteristics of blast plasmacytoid dendritic cell neoplasm. Methods The histological features and immunophenotype of blast plasmacytoid dendritic cell neoplasm were observed by light microscopy and immunohistochemistry. The related literature was reviewed. Results Blast plasmacytoid dendritic cell neoplasm was usually seen in the elderly patients, mostly with the skin lesions as the first symptom.Morphological manifestations were diffuse and dense tumor cells, and single infiltration of dermis and subcutaneous tissues. Cells were medium size, with less cytoplasm. The nucleolus was oval or irregular, the chromatin was fine, and the nuclear fission was easy to be observed. Immunohistochemistry showed that the tumor cells positively expressed CD4,CD56, CD123; CD2, CD3, CD5, CD8, GranB, TIA-1, CD20, CD79 a, PAX-5, MPO were negative. Conclusion BPDCN is a rare lymphoid hematopoietic malignancy. The clinical invasiveness is high, and it is easy to relapse, with poor prognosis, which should be differentiated with other lymphoid hematopoietic tumors.
Objective To investigate the clinicopathological characteristics of blast plasmacytoid dendritic cell neoplasm. Methods The histological features and immunophenotype of blast plasmacytoid dendritic cell neoplasm were observed by light microscopy and immunohistochemistry. The related literature was reviewed. Results Blast plasmacytoid dendritic cell neoplasm was usually seen in the elderly patients, mostly with the skin lesions as the first symptom.Morphological manifestations were diffuse and dense tumor cells, and single infiltration of dermis and subcutaneous tissues. Cells were medium size, with less cytoplasm. The nucleolus was oval or irregular, the chromatin was fine, and the nuclear fission was easy to be observed. Immunohistochemistry showed that the tumor cells positively expressed CD4,CD56, CD123; CD2, CD3, CD5, CD8, GranB, TIA-1, CD20, CD79 a, PAX-5, MPO were negative. Conclusion BPDCN is a rare lymphoid hematopoietic malignancy. The clinical invasiveness is high, and it is easy to relapse, with poor prognosis, which should be differentiated with other lymphoid hematopoietic tumors.
引文
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[8]Xiong Jingshu,Chen Hao,Aman Chang,et al.Clinical analysis of seven cases of maternal plasmacytoid dendritic cell tumor[J].Chinese Medical Journal,2014,94(8):599-602.
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[14]Hauswirth AW,Florian S,Printz D,et al.Expression of the target receptor CD33 in CD34+/CD38-/CD123+AML stem cells[J].Eur J Clin Invest,2007,37:73-82.
[15]Du X,Ho M,Pastan I.New immunotoxins targeting CD123.astem cell antigen on acute myeloid leukemia cells[J].J Immunother,2007,30:607-613.
[16]Jordan CT,Upchurch D,Szilvassy SJ,et al.The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells[J].Leukemia,2000,14:1777-1784.
[17]Zong-min li,Jiang Ping,Guan Xiao Jun,et al.Mother cell plasma cells,dendritic cell tumor case of clinical pathology analysis[J].Leukemia,Lymphoma,2015,24(5):287-289.
[18]Sun jian,luo yufeng,Cao Jinling,et al.Mother cell plasma cells,dendritic cell tumor in 5 cases of clinical pathology analysis[J].Journal of Clinical and Experimental Pathology,2016,32(6):635-638.
[19]Cui-ling zheng,Xian-yong jiang.Mother cell plasma cells,dendritic cell tumor patients with bone marrow bone marrow after infringement phase analysis[J].China tumor,2011,20(10):780-783.
[20]Xiang-shan fan,Sa A Wang.Mother cell plasma cells,dendritic cell tumor is reviewed[J].Chinese Journal of Pathology,2013,42(2):131-134.
[21]Yong-feng Chen,Xue Ruzeng,Jennie,et al.Mother cell plasma cells,dendritic cell tumor[J].Chinese Journal of Dermatology,2010,43(8):555-557.
[22]Lucioni M,Novara F,Fiandrino G,et al.Twenty-one cases of blastic plasmacytoid dendritic cell neoplasm:Focus on biallelic locus 9p21.3 deletion[J].Blood,2011,118(17):4591-4594.
[23]Chen Jing,Li Jian,Zou Nong,et al.Mother cell plasmacytoid dendritic cell tumor:A report of 1 cases and review of the literature[J].Journal of Clinical Hematology,2011,24(4):408-410.
[24]Yang Xufang,Wang Xiaoyan.Primary cutaneous plasmacytoid dendritic cell tumor:A report of two cases[J].International Journal of Dermatology and Venereology,2015,41(4):209-212.
[2]Lucio P,Parreira A,Orfao.CD123hi dentritic cell lymphoma:an unusal case of non-Hodgkin lymphoma[J].Ann intern med 1999,131:549-550.
[3]Dimopoulos MA,Hamilos G.Solitary bone plasmacytoma and extramedudlary plasmacytoma[J].Curr Treat Options Oncol,2002,3(3):255-259.
[4]Dimopoulos MA.Solitary plasmacytoma of bone and asymptomatic multiple myeloma[J].Blood,2000,96(6):2037-2044.
[5]Vardiman JW,Thiele J,Arber DA,et al.The 2008 revision of the World Health Organizatian(WHO)classification of myeloid neoplasms and acute leukemia:rationale and important changes[J].Blood,2009,114(5):937-951.
[6]Vardiman JW.The World Health Organization(WHO)classification of tumors of the hematopoietic and lymphoid tissues:An overview with emphasis on the myeloid neoneoplasms[J].Chem Biol Interact,2010,184(1-2):16-20.
[7]Fan Xiangshan,Wu Jinrong,Shi Qunli,et al.Clinical analysis of 4 cases of maternal plasmacytoid dendritic cell tumor[J].Journal of Diagnostic Pathology,2013,20(3):131-136.
[8]Xiong Jingshu,Chen Hao,Aman Chang,et al.Clinical analysis of seven cases of maternal plasmacytoid dendritic cell tumor[J].Chinese Medical Journal,2014,94(8):599-602.
[9]Ma Lei,Li Yang,Liu Ling,et al.Children's mother cell plasma cells,dendritic cell tumor 1 case analysis[J].Chinese Journal of Experimental Hematology,2013,21(1):140-145.
[10]Wang Yan.Mother cell plasma cells,dendritic cell tumor clinical pathological observation[J].Diagnostic Pathology Journal,2010,17(5):346-348.
[11]Pagano L,Valentini CG,Pulsoni A,et al.Blastic plasmacytoid dendritic cell neoplasm with leukemic presentation:An Italian multicenter study[J].Hematologica,2013,98(2):239-246.
[12]Rao Jin,Yin Li,Lin Zhimei,et al.Clinical analysis of 41cases of maternal plasmacytoid dendritic cell tumor[J].Clinical Misdiagnosis&Mistherapy,2014,(12):25-28.
[13]Garnache-Ottou F,Feuillard J,Ferrand C,et al.Extended diagnostic criteria for plasmacytoid dendritic cell leukaemia[J].Br J Haematol,2009,145(5):624-636.
[14]Hauswirth AW,Florian S,Printz D,et al.Expression of the target receptor CD33 in CD34+/CD38-/CD123+AML stem cells[J].Eur J Clin Invest,2007,37:73-82.
[15]Du X,Ho M,Pastan I.New immunotoxins targeting CD123.astem cell antigen on acute myeloid leukemia cells[J].J Immunother,2007,30:607-613.
[16]Jordan CT,Upchurch D,Szilvassy SJ,et al.The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells[J].Leukemia,2000,14:1777-1784.
[17]Zong-min li,Jiang Ping,Guan Xiao Jun,et al.Mother cell plasma cells,dendritic cell tumor case of clinical pathology analysis[J].Leukemia,Lymphoma,2015,24(5):287-289.
[18]Sun jian,luo yufeng,Cao Jinling,et al.Mother cell plasma cells,dendritic cell tumor in 5 cases of clinical pathology analysis[J].Journal of Clinical and Experimental Pathology,2016,32(6):635-638.
[19]Cui-ling zheng,Xian-yong jiang.Mother cell plasma cells,dendritic cell tumor patients with bone marrow bone marrow after infringement phase analysis[J].China tumor,2011,20(10):780-783.
[20]Xiang-shan fan,Sa A Wang.Mother cell plasma cells,dendritic cell tumor is reviewed[J].Chinese Journal of Pathology,2013,42(2):131-134.
[21]Yong-feng Chen,Xue Ruzeng,Jennie,et al.Mother cell plasma cells,dendritic cell tumor[J].Chinese Journal of Dermatology,2010,43(8):555-557.
[22]Lucioni M,Novara F,Fiandrino G,et al.Twenty-one cases of blastic plasmacytoid dendritic cell neoplasm:Focus on biallelic locus 9p21.3 deletion[J].Blood,2011,118(17):4591-4594.
[23]Chen Jing,Li Jian,Zou Nong,et al.Mother cell plasmacytoid dendritic cell tumor:A report of 1 cases and review of the literature[J].Journal of Clinical Hematology,2011,24(4):408-410.
[24]Yang Xufang,Wang Xiaoyan.Primary cutaneous plasmacytoid dendritic cell tumor:A report of two cases[J].International Journal of Dermatology and Venereology,2015,41(4):209-212.