早发型子痫前期血清胎盘生长因子与子宫动脉血流、分娩孕周及新生儿出生体重的关系
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摘要
目的:探讨早发型子痫前期(EOPE)孕妇血清胎盘生长因子(PLGF)与子宫动脉血流参数、分娩孕周及新生儿出生体重的相关性。方法:选取本院EOPE孕妇作为观察组,同期血压正常的孕妇作为对照组,比较两组孕妇血清PLGF与子宫动脉血流参数的差异,分析观察组孕妇血清PLGF水平与子宫动脉血流及分娩孕周、新生儿出生体重的关系。结果:观察组孕妇分娩孕周、新生儿出生体重及血清PLGF水平低于对照组(P<0.001),子宫动脉血流S/D、RI及PI值均明显高于对照组(P<0.05);观察组血清PLGF水平与子宫动脉血流S/D、RI及PI值均呈负相关(r=-0.832、-0.366、-0.562,P<0.001),与分娩孕周及新生儿出生体重均呈正相关(r=0.327、0.763,P<0.005)。结论:EOPE孕妇血清PLGF水平与EOPE发生发展密切相关,可以作为预测EOPE临床诊断的参考指标。
Objective:To explore the correlation between the placental growth factor(PLGF)level and uterine arterial blood flow,gestational weeks,or newborn weight of pregnant women with early onset preeclampsia(EOPE).Methods:The pregnant women with EOPE were selected into study group,and normal pregnant women were selected into control group during the same time.The differences of serum PLGF level and uterine artery blood flow parameters were compared between the two groups.The relationship between the level of serum PLGF and uterine artery blood flow,the gestational weeks,or the newborn weight of women in study group was also analyzed.Results:The delivery gestational weeks,newborn birth weight and the level of serum PLGF of women in study group were significant lower than those of women in control group(P<0.001),but the S/D,RI and PI of uterine artery blood flow of women in study group were significant higher than that those of women in control group(P<0.05).In the study group,the level of serum PLGF was negatively correlated to the S/D,RI and PI values of uterine artery blood flow(r=-0.832,-0.366,-0.562,P<0.001),but was positively correlated to the gestational weeks and the newborn weight(r=0.327,0.763,P<0.005).Conclusion:The level of serum PLGF of pregnant women is closely related to the occurrence of EOPE,which can be used as a reference indicator for predicting EOPE.
Objective:To explore the correlation between the placental growth factor(PLGF)level and uterine arterial blood flow,gestational weeks,or newborn weight of pregnant women with early onset preeclampsia(EOPE).Methods:The pregnant women with EOPE were selected into study group,and normal pregnant women were selected into control group during the same time.The differences of serum PLGF level and uterine artery blood flow parameters were compared between the two groups.The relationship between the level of serum PLGF and uterine artery blood flow,the gestational weeks,or the newborn weight of women in study group was also analyzed.Results:The delivery gestational weeks,newborn birth weight and the level of serum PLGF of women in study group were significant lower than those of women in control group(P<0.001),but the S/D,RI and PI of uterine artery blood flow of women in study group were significant higher than that those of women in control group(P<0.05).In the study group,the level of serum PLGF was negatively correlated to the S/D,RI and PI values of uterine artery blood flow(r=-0.832,-0.366,-0.562,P<0.001),but was positively correlated to the gestational weeks and the newborn weight(r=0.327,0.763,P<0.005).Conclusion:The level of serum PLGF of pregnant women is closely related to the occurrence of EOPE,which can be used as a reference indicator for predicting EOPE.
引文
[1]乔宠,杨小梅,林其德.子痫前期的流行病学研究进展[J].中国计划生育和妇产科,2013,5(6):5-8.
[2]倪琰琰,程蔚蔚.早发型子痫前期发病机制的研究进展[J].山东医药,2016,56(8):101-104.
[3]韩瑾,张蒙,许遵鹏,等.孕早期血清胎盘生长因子在妊娠期高血压疾病筛查中的应用[J].中国妇幼健康研究,2016,27(6):698-701.
[4]中华医学会妇产科学分会妊娠期高血压疾病学组.妊娠期高血压疾病诊治指南(2015)[J].中华妇产科杂志,2015,50(10):206-213.
[5]史丽,赵喜娃,赵艳玲,等.孕早期血脂联合子宫动脉舒张早期切迹检测对早发型子痫前期的预测价值[J].河北医药,2014(23):3552-3554.
[6]冯亚玲,许倩,项静英.早发型子痫前期病因及其预测的研究进展[J].中华妇幼临床医学杂志:电子版,2013,9(1):113-116.
[7]蒋艳平,王欣,王维春,等.孕11~14周妊娠相关蛋白A联合子宫动脉搏动指数预测早发型子痫前期的研究[J].安徽医药,2016,20(8):1539-1541.
[8]郭芳芳,杨洁霞.胎盘生长因子与妊娠关系的研究进展[J].中国妇幼保健,2014,29(36):6173-6175.
[9]韦敬锡,李妹燕,蒋柳艳.妊娠期高血压疾病脂联素和胎盘生长因子的表达及相关性研究[J].中华全科医学,2013,11(5):738-738.
[10]刘志永,陈静伟,吴香丽,等.胎盘生长因子和可溶性血管内皮生长因子受体-1与子痫前期的关系研究[J].吉林医学,2016,37(9):2159-2161.
[11]高阳,周红辉,魏永琴,等.胎盘生长因子水平与重度子痫前期的相关性研究[J].中国医药,2016,11(7):1059-1062.
[12]华绍芳,李月琴.早发子痫前期患者血浆胎盘生长因子水平与围生结局的研究[J].实用妇产科杂志,2017,33(10):768-771.
[13]黄容弟,王莹,赖放颖,等.孕早期血清胎盘生长因子预测子痫前期发生的价值[J].中国医药科学,2018(14):71-74.
[14]刘浏.子痫前期患者三维能量多普勒超声检测指标和胎盘生长因子及可溶性血管内皮细胞生长因子受体-1表达的相关性[J].中华全科医学,2017,15(8):1398-1401.
[15]韩清,王英华,薛亚丽,等.子宫螺旋动脉血流参数与孕妇血清胎盘生长因子对早发型子痫前期预测[J].中国超声医学杂志,2016,32(2):153-156.
[16]曹伍兰.联合检测可溶性血管内皮生长因子受体-1/胎盘生长因子和子宫动脉血流对早发型子痫前期的预测价值[J].中国妇幼保健,2016,31(21):4386-4387.
[2]倪琰琰,程蔚蔚.早发型子痫前期发病机制的研究进展[J].山东医药,2016,56(8):101-104.
[3]韩瑾,张蒙,许遵鹏,等.孕早期血清胎盘生长因子在妊娠期高血压疾病筛查中的应用[J].中国妇幼健康研究,2016,27(6):698-701.
[4]中华医学会妇产科学分会妊娠期高血压疾病学组.妊娠期高血压疾病诊治指南(2015)[J].中华妇产科杂志,2015,50(10):206-213.
[5]史丽,赵喜娃,赵艳玲,等.孕早期血脂联合子宫动脉舒张早期切迹检测对早发型子痫前期的预测价值[J].河北医药,2014(23):3552-3554.
[6]冯亚玲,许倩,项静英.早发型子痫前期病因及其预测的研究进展[J].中华妇幼临床医学杂志:电子版,2013,9(1):113-116.
[7]蒋艳平,王欣,王维春,等.孕11~14周妊娠相关蛋白A联合子宫动脉搏动指数预测早发型子痫前期的研究[J].安徽医药,2016,20(8):1539-1541.
[8]郭芳芳,杨洁霞.胎盘生长因子与妊娠关系的研究进展[J].中国妇幼保健,2014,29(36):6173-6175.
[9]韦敬锡,李妹燕,蒋柳艳.妊娠期高血压疾病脂联素和胎盘生长因子的表达及相关性研究[J].中华全科医学,2013,11(5):738-738.
[10]刘志永,陈静伟,吴香丽,等.胎盘生长因子和可溶性血管内皮生长因子受体-1与子痫前期的关系研究[J].吉林医学,2016,37(9):2159-2161.
[11]高阳,周红辉,魏永琴,等.胎盘生长因子水平与重度子痫前期的相关性研究[J].中国医药,2016,11(7):1059-1062.
[12]华绍芳,李月琴.早发子痫前期患者血浆胎盘生长因子水平与围生结局的研究[J].实用妇产科杂志,2017,33(10):768-771.
[13]黄容弟,王莹,赖放颖,等.孕早期血清胎盘生长因子预测子痫前期发生的价值[J].中国医药科学,2018(14):71-74.
[14]刘浏.子痫前期患者三维能量多普勒超声检测指标和胎盘生长因子及可溶性血管内皮细胞生长因子受体-1表达的相关性[J].中华全科医学,2017,15(8):1398-1401.
[15]韩清,王英华,薛亚丽,等.子宫螺旋动脉血流参数与孕妇血清胎盘生长因子对早发型子痫前期预测[J].中国超声医学杂志,2016,32(2):153-156.
[16]曹伍兰.联合检测可溶性血管内皮生长因子受体-1/胎盘生长因子和子宫动脉血流对早发型子痫前期的预测价值[J].中国妇幼保健,2016,31(21):4386-4387.