清心化瘤汤治疗子宫肌瘤61例
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摘要
目的:观察自拟清心化瘤汤治疗子宫肌瘤的临床疗效。方法:将122例子宫肌瘤患者按照随机数字表法分为对照组和观察组,每组各61例。对照组患者口服米非司酮片,观察组在对照组的基础上加用自拟清心化瘤汤进行治疗。观察两组患者的临床疗效,比较两组患者治疗前后子宫肌瘤体积、子宫体积、症状积分及激素水平[黄体生成素(luteinizing hormone,LH)、孕酮(progesterone,P)、促卵泡生成素(follicle stimulating hormone,FSH)、雌二醇(estradiol,E_2)]水平。结果:观察组有效率为91.80%,对照组有效率为81.97%,两组患者临床疗效比较,差异具有统计学意义(P<0.05)。两组患者治疗后子宫肌瘤体积与子宫体积均小于本组治疗前,且观察组小于对照组,差异具有统计学意义(P<0.05)。两组患者治疗后症状积分低于本组治疗前,且观察组低于对照组,差异具有统计学意义(P<0.05)。两组患者治疗后E_2、P、FSH以及LH水平低于本组治疗前,且观察组低于对照组,差异具有统计学意义(P<0.05)。观察组不良反应发生率为9.83%,对照组不良反应发生率为22.95%,差异具有统计学意义(P<0.05)。结论:清心化瘤汤治疗子宫肌瘤可有效缩小肌瘤体积,改善临床症状及激素水平。
Objective:To observe the clinical curative effect of Self-Made Heart-Clearing and Tumor-Removing Decoction on uterine leiomyoma.Methods:A total of 122 cases of uterine leiomyoma were divided into the control group and the observation group according to random number table method,with 61 cases in each group.The control group was treated with mifepristone tablets for oral administration,while the observation group was treated with Self-Made Heart-Clearing and Tumor-Removing Decoction on the basis of the control group.The clinical efficacies of the two groups were observed.The volume of uterine leiomyoma,uterine volume,symptom score and hormone levels,such as luteinizing hormone(LH),progesterone(P),follicle-stimulating hormone(FSH),estradiol(E_2),were compared between the two groups before and after the treatment.Results:The effective rate was 91.80% in the observation group and 81.97% in the control group.There was a significant difference between the two groups(P<0.05).The uterine leiomyoma volume and uterine volume of the two groups after the treatment were smaller than those before the treatment,and the observation group was smaller than the control group,the differences were statistically significant(P<0.05).After the treatment,the symptom score of each group was lower than that of the control group,and the observation group was lower than the control group,the difference was statistically significant(P<0.05).After the treatment,the levels of E_2,P,FSH and LH in each group were lower than those before the treatment,and the observation group were lower than the control group,and all the differences were statistically significant(P<0.05).The incidence of adverse reactions was 9.83% in the observation group and 22.95% in the control group.The difference was statistically significant(P<0.05).Conclusion:Heart-Clearing and Tumor-Removing Decoction has a remarkable efficacy on uterine leiomyoma,can effectively reduce the volume of uterine leiomyoma,improve clinical symptoms and hormone levels.
Objective:To observe the clinical curative effect of Self-Made Heart-Clearing and Tumor-Removing Decoction on uterine leiomyoma.Methods:A total of 122 cases of uterine leiomyoma were divided into the control group and the observation group according to random number table method,with 61 cases in each group.The control group was treated with mifepristone tablets for oral administration,while the observation group was treated with Self-Made Heart-Clearing and Tumor-Removing Decoction on the basis of the control group.The clinical efficacies of the two groups were observed.The volume of uterine leiomyoma,uterine volume,symptom score and hormone levels,such as luteinizing hormone(LH),progesterone(P),follicle-stimulating hormone(FSH),estradiol(E_2),were compared between the two groups before and after the treatment.Results:The effective rate was 91.80% in the observation group and 81.97% in the control group.There was a significant difference between the two groups(P<0.05).The uterine leiomyoma volume and uterine volume of the two groups after the treatment were smaller than those before the treatment,and the observation group was smaller than the control group,the differences were statistically significant(P<0.05).After the treatment,the symptom score of each group was lower than that of the control group,and the observation group was lower than the control group,the difference was statistically significant(P<0.05).After the treatment,the levels of E_2,P,FSH and LH in each group were lower than those before the treatment,and the observation group were lower than the control group,and all the differences were statistically significant(P<0.05).The incidence of adverse reactions was 9.83% in the observation group and 22.95% in the control group.The difference was statistically significant(P<0.05).Conclusion:Heart-Clearing and Tumor-Removing Decoction has a remarkable efficacy on uterine leiomyoma,can effectively reduce the volume of uterine leiomyoma,improve clinical symptoms and hormone levels.
引文
[1] 王慧珍,张大伟.中西医结合治疗子宫肌瘤65例[J].河南中医,2016,36(6):1066-1068.
[2] 李巨奇,李卫青,马全庆,等.从六经辨证探讨肺肾阳虚相关子宫肌瘤与月经性肺系疾病的临证思路[J].中医学报,2016,31(2):217-220.
[3] 王晓莉,曾静,王珏,等.雌激素代谢酶CYP1A1及COMT基因多态性与子宫肌瘤相关性研究[J].实用妇产科杂志,2015,31(2):120-123.
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[12] 朱杰华,陈喜悦,黄健,等.自拟消癥经验方内服联合米非司酮对子宫肌瘤患者子宫肌瘤体积和血清E2变化的影响[J].海南医学,2017,28(2):224-226.
[13] 陈璐,李盛,李伊莎,等.自拟清瘤方联合米非司酮对子宫肌瘤患者的临床疗效研究[J].河北中医药学报,2017,32(3):27-29.
[14] 余成浩,孙涛,冯业琼,等.三棱-莪术关联子宫肌瘤的研究进展[J].时珍国医国药,2012,23(6):1493-1494.
[15] 梁学清,李丹丹,黄忠威.茯苓药理作用研究进展[J].河南科技大学学报(医学版),2012,30(2):154-156.
[2] 李巨奇,李卫青,马全庆,等.从六经辨证探讨肺肾阳虚相关子宫肌瘤与月经性肺系疾病的临证思路[J].中医学报,2016,31(2):217-220.
[3] 王晓莉,曾静,王珏,等.雌激素代谢酶CYP1A1及COMT基因多态性与子宫肌瘤相关性研究[J].实用妇产科杂志,2015,31(2):120-123.
[4] 王泽琴,钟媛媛.孕激素辅助治疗妊娠合并子宫肌瘤对母婴结局影响分析[J].中国计划生育学杂志,2017,25(11):772-775.
[5] 李丽.不同剂量米非司酮治疗子宫肌瘤效果比较[J].山东医药,2015,55(29):94-95.
[6] 方海娅,张海燕,寿华锋,等.米非司酮治疗围绝经期子宫肌瘤的临床研究[J].中国临床药理学杂志,2016,32(11):987-989.
[7] 张凌焱,杨建华.子宫肌瘤的诊治进展和争议问题[J].实用肿瘤杂志,2016,31(6):505-507.
[8] 胡艳萍,李璐,李馨,等.植物性雌激素对子宫肌瘤合并缺铁性贫血患者血清激素水平、NOS及氧化应激产物影响[J].中国生化药物杂志,2015,35(7):113-115.
[9] 赵菁,肖霞.子宫肌瘤发病的危险因素分析[J].山东医药,2017,57(14):94-95.
[10] 宋芳.中药消瘤汤配伍米非司酮对子宫肌瘤患者子宫及肌瘤体积及激素指标水平的影响[J].现代中西医结合杂志,2016,25(14):1558-1560.
[11] 宋海鹏.自拟消瘤汤联合小剂量米非司酮治疗子宫肌瘤临床效果观察[J].中医临床研究,2015,5(25):54-55.
[12] 朱杰华,陈喜悦,黄健,等.自拟消癥经验方内服联合米非司酮对子宫肌瘤患者子宫肌瘤体积和血清E2变化的影响[J].海南医学,2017,28(2):224-226.
[13] 陈璐,李盛,李伊莎,等.自拟清瘤方联合米非司酮对子宫肌瘤患者的临床疗效研究[J].河北中医药学报,2017,32(3):27-29.
[14] 余成浩,孙涛,冯业琼,等.三棱-莪术关联子宫肌瘤的研究进展[J].时珍国医国药,2012,23(6):1493-1494.
[15] 梁学清,李丹丹,黄忠威.茯苓药理作用研究进展[J].河南科技大学学报(医学版),2012,30(2):154-156.