艾司唑仑片联合右佐匹克隆片治疗56例原发性失眠的短期疗效观察
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摘要
目的观察艾司唑仑联合右佐匹克隆片治疗原发性失眠的短期效果。方法 106例原发性失眠患者,根据就诊顺序随机分为对照组(50例)和观察组(56例)。对照组患者采用艾司唑仑片进行治疗,观察组患者采用艾司唑仑片联合右佐匹克隆片进行治疗。治疗30 d后,观察比较两组患者的临床疗效及治疗前后睡眠状况自评量表(SRSS)评分。结果治疗30 d后,观察组患者的临床总有效率为89.29%(50/56),明显高于对照组的62.00%(31/50),差异有统计学意义(X~2=10.912, P=0.001<0.05)。两组患者治疗前的SRSS评分比较差异无统计学意义(P>0.05)。观察组和对照组患者治疗后的SRSS评分分别为(12.13±2.03)、(17.84±4.42)分,均明显低于治疗前的(28.46±3.28)、(28.06±4.01)分,差异均有统计学意义(t=31.680、12.109, P<0.05);观察组治疗后SRSS评分明显低于对照组,差异有统计学意义(t=8.698,P<0.05)。结论艾司唑仑片联合右佐匹克隆片治疗原发性失眠短期效果显著,能够改善患者失眠症状,值得临床推广。
Objective To observe the short-term efficacy of eszolam tablets combined with dexzopiclone tablets in the treatment of 56 cases of primary insomnia. Methods A total of 106 patients with primary insomnia were divided by visiting order into control group(50 cases) and observation group(56 cases). The control group was treated with eszolam tablets and the observation group was treated with eszolam tablets and dexzopiclone tablets. After 30 d of treatment, observation and comparison were made on clinical efficacy and self-rating scale of sleep(SRSS) before and after treatment in two groups. Results After 30 d of treatment, the observation group had obviously higher clinical total effective rate as 89.29%(50/56) than 62.00%(31/50) in the control group, and the difference was statistically significant(X~2=10.912, P=0.001<0.05). Both groups had no statistically significant in SRSS score before treatment(P>0.05). After treatment, the observation group and control group had obviously lower SRSS score as(12.13±2.03) and(17.84±4.42) points than(28.46±3.28) and(28.06±4.01) points before treatment, and their difference was statistically significant(t=31.680, 12.109, P<0.05). After treatment, the observation group had obviously lower SRSS score than the control group, and the difference was statistically significant(t=8.698, P<0.05). Conclusion Combination of eszolam tablets and dexzopiclone tablets shows remarkable short-term effect in treating primary insomnia, and it can improve the insomnia symptom of patients. It is worthy of clinical promotion.
Objective To observe the short-term efficacy of eszolam tablets combined with dexzopiclone tablets in the treatment of 56 cases of primary insomnia. Methods A total of 106 patients with primary insomnia were divided by visiting order into control group(50 cases) and observation group(56 cases). The control group was treated with eszolam tablets and the observation group was treated with eszolam tablets and dexzopiclone tablets. After 30 d of treatment, observation and comparison were made on clinical efficacy and self-rating scale of sleep(SRSS) before and after treatment in two groups. Results After 30 d of treatment, the observation group had obviously higher clinical total effective rate as 89.29%(50/56) than 62.00%(31/50) in the control group, and the difference was statistically significant(X~2=10.912, P=0.001<0.05). Both groups had no statistically significant in SRSS score before treatment(P>0.05). After treatment, the observation group and control group had obviously lower SRSS score as(12.13±2.03) and(17.84±4.42) points than(28.46±3.28) and(28.06±4.01) points before treatment, and their difference was statistically significant(t=31.680, 12.109, P<0.05). After treatment, the observation group had obviously lower SRSS score than the control group, and the difference was statistically significant(t=8.698, P<0.05). Conclusion Combination of eszolam tablets and dexzopiclone tablets shows remarkable short-term effect in treating primary insomnia, and it can improve the insomnia symptom of patients. It is worthy of clinical promotion.
引文
[1]张蕾,和申,余一旻,等.原发性失眠人群特征、睡眠质量及危险因素的研究.上海交通大学学报(医学版), 2016, 36(5):689-694.
[2]中华医学会精神病学分会.中国失眠防治指南.北京:人民卫生出版社, 2012:137-138.
[3]李建明.睡眠状况自评量表(SRSS)简介.中国健康心理学杂志,2012, 20(12):1851.
[4]中华医学会神经病学分会睡眠障碍学组.中国成人失眠诊断与治疗指南.中华神经科杂志, 2012, 45(7):534-540.
[5]沙中玮,徐建.失眠患者睡眠状况的临床调查分析.新疆医学,2016, 46(1):81-83.
[6]王晓彤,林海雄,金远林.艾司唑仑治疗失眠症临床疗效及安全性的网状Meta分析.中国现代应用药学, 2018, 35(5):735-740.
[7]杜彪,谢星星,张杰,等.右旋佐匹克隆与佐匹克隆治疗失眠症的系统评价.药物评价研究, 2016, 39(1):112-115.
[8]田芳,张瑞,江岚.右佐匹克隆片联合艾司唑仑治疗慢性原发性失眠的临床疗效.现代实用医学, 2017, 29(10):93-94.
[2]中华医学会精神病学分会.中国失眠防治指南.北京:人民卫生出版社, 2012:137-138.
[3]李建明.睡眠状况自评量表(SRSS)简介.中国健康心理学杂志,2012, 20(12):1851.
[4]中华医学会神经病学分会睡眠障碍学组.中国成人失眠诊断与治疗指南.中华神经科杂志, 2012, 45(7):534-540.
[5]沙中玮,徐建.失眠患者睡眠状况的临床调查分析.新疆医学,2016, 46(1):81-83.
[6]王晓彤,林海雄,金远林.艾司唑仑治疗失眠症临床疗效及安全性的网状Meta分析.中国现代应用药学, 2018, 35(5):735-740.
[7]杜彪,谢星星,张杰,等.右旋佐匹克隆与佐匹克隆治疗失眠症的系统评价.药物评价研究, 2016, 39(1):112-115.
[8]田芳,张瑞,江岚.右佐匹克隆片联合艾司唑仑治疗慢性原发性失眠的临床疗效.现代实用医学, 2017, 29(10):93-94.