胞磷胆碱联合普罗布考治疗急性脑梗死的疗效观察
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摘要
目的研究胞磷胆碱钠胶囊联合普罗布考片治疗急性脑梗死的临床疗效。方法选取2015年12月—2017年12月十堰市人民医院收治的急性脑梗死患者100例为研究对象,所有患者随机分为对照组和治疗组,每组各50例。对照组患者每日早晚餐时口服普罗布考片,1片/次,2次/d。治疗组患者在对照组治疗的基础上口服胞磷胆碱钠胶囊,2粒/次,3次/d。两组患者持续治疗6个月。观察两组的临床疗效,比较两组的美国国立卫生研究院卒中量表(NIHSS)评分、日常生活活动量表(ADL)评分、血脂水平。结果治疗后,对照组和治疗组的总有效率分别为82.00%、96.00%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者的NIHSS评分显著下降,ADL评分显著升高,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组NIHSS评分和ADL评分明显优于对照组,同组治疗前后比较差异有统计学意义(P<0.05)。治疗后,两组患者总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)水平明显下降,低密度脂蛋白胆固醇(LDL-C)水平显著升高,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组血脂水平明显优于对照组,同组治疗前后比较差异有统计学意义(P<0.05)。结论胞磷胆碱钠胶囊联合普罗布考片治疗急性脑梗死具有较好的临床疗效,可改善患者神经功能损伤和生活质量,降低患者血脂水平,安全性较好,具有一定的临床推广应用价值。
Objective To study the clinical effect of Citicoline Sodium Capsules combined with Probucol Tablets in treatment of acute cerebral infarction. Methods Patients(100 cases) with acute cerebral infarction in Shiyan People's Hospital from December 2015 to December 2017 were randomly divided into control and treatment groups, and each group had 50 cases. Patients in the control group were po administered with Probucol Tablets, 1 tablet/time, twice daily. Patients in the treatment group were po administered with Citicoline Sodium Capsules on the basis of the control group, 2 grains/time, three times daily. Patients in two groups were treated for 6 months. After treatment, the clinical efficacies were evaluated, and NIHSS scores, ADL scores, and blood lipid levels in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 82.00% and 96.00%, respectively, and there was difference between two groups(P < 0.05). After treatment, NIHSS scores in two groups were significantly decreased, but ADL scores in two groups were significantly increased, and the difference was statistically significant in the same group(P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups(P < 0.05). After treatment, the levels of TC, TG, and HDL-C in two groups were significantly decreased, but the levels of LDL-C in two groups were significantly increased, and the difference was statistically significant in the same group(P < 0.05). And the blood lipid indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups(P < 0.05). Conclusion Citicoline Sodium Capsules combined with Probucol Tablets has clinical curative effect in treatment of acute cerebral infarction, can improve neurological impairment and quality of life, reduce blood lipid level, with good safety, which has a certain clinical application value.
Objective To study the clinical effect of Citicoline Sodium Capsules combined with Probucol Tablets in treatment of acute cerebral infarction. Methods Patients(100 cases) with acute cerebral infarction in Shiyan People's Hospital from December 2015 to December 2017 were randomly divided into control and treatment groups, and each group had 50 cases. Patients in the control group were po administered with Probucol Tablets, 1 tablet/time, twice daily. Patients in the treatment group were po administered with Citicoline Sodium Capsules on the basis of the control group, 2 grains/time, three times daily. Patients in two groups were treated for 6 months. After treatment, the clinical efficacies were evaluated, and NIHSS scores, ADL scores, and blood lipid levels in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 82.00% and 96.00%, respectively, and there was difference between two groups(P < 0.05). After treatment, NIHSS scores in two groups were significantly decreased, but ADL scores in two groups were significantly increased, and the difference was statistically significant in the same group(P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups(P < 0.05). After treatment, the levels of TC, TG, and HDL-C in two groups were significantly decreased, but the levels of LDL-C in two groups were significantly increased, and the difference was statistically significant in the same group(P < 0.05). And the blood lipid indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups(P < 0.05). Conclusion Citicoline Sodium Capsules combined with Probucol Tablets has clinical curative effect in treatment of acute cerebral infarction, can improve neurological impairment and quality of life, reduce blood lipid level, with good safety, which has a certain clinical application value.
引文
[1]周坤.急性脑梗死治疗的研究进展[J].实用心脑肺血管病杂志, 2010, 18(11):1726-1728.
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[7]陈清棠.脑卒中患者临床神经功能缺损程度评分标准(1995)[J].中华神经科杂志, 1996, 29(6):381-383.
[8]闵瑜,吴媛媛,燕铁斌.改良Barthel指数(简体中文版)量表评定脑卒中患者日常生活活动能力的效度和信度研究[J].中华物理医学与康复杂志,2008,30(3):185-188.
[9]魏巍.浅议脑梗死患者血液黏度及血脂改变[J].中国伤残医学, 2010, 18(4):102-103.
[10]邓丽,刘晓冬,张拥波,等.急性脑梗死的治疗进展[J].中国全科医学, 2011, 14(8):825-829.
[11]王跃龙,谢莉,钱林学.普罗布考联合阿托伐他汀治疗急性脑梗死的临床研究[J].现代药物与临床,2014,29(12):1372-1375.
[12]侯静,王凌云,张勇.胞二磷胆碱联合阿替普酶治疗急性脑梗死的疗效观察[J].现代药物与临床,2018,33(2):256-259.
[2]陈洪汉,黎红华,林琅,等.高血压、糖尿病和高脂血症对脑梗死患者血管内皮功能损伤的相关研究[J].脑与神经疾病杂志, 2013, 21(3):196-198.
[3]张梦云.普罗布考对动脉粥样硬化兔外周血CD4+CD25+T细胞水平及功能的影响[D].合肥:安徽医科大学, 2016.
[4]侯荣华.胞磷胆碱的临床应用[J].医药导报,2003,22(S1):67-68.
[5]饶明俐.中国脑血管病防治指南[M].北京:人民卫生出版社, 2007:30.
[6]郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社, 2002:102.
[7]陈清棠.脑卒中患者临床神经功能缺损程度评分标准(1995)[J].中华神经科杂志, 1996, 29(6):381-383.
[8]闵瑜,吴媛媛,燕铁斌.改良Barthel指数(简体中文版)量表评定脑卒中患者日常生活活动能力的效度和信度研究[J].中华物理医学与康复杂志,2008,30(3):185-188.
[9]魏巍.浅议脑梗死患者血液黏度及血脂改变[J].中国伤残医学, 2010, 18(4):102-103.
[10]邓丽,刘晓冬,张拥波,等.急性脑梗死的治疗进展[J].中国全科医学, 2011, 14(8):825-829.
[11]王跃龙,谢莉,钱林学.普罗布考联合阿托伐他汀治疗急性脑梗死的临床研究[J].现代药物与临床,2014,29(12):1372-1375.
[12]侯静,王凌云,张勇.胞二磷胆碱联合阿替普酶治疗急性脑梗死的疗效观察[J].现代药物与临床,2018,33(2):256-259.