210例抗菌药物不良反应报告分析
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摘要
目的:了解我院抗菌药物致药品不良反应(ADR)发生的特点和规律,为临床安全合理使用抗菌药物提供参考依据。方法:收集我院2015年1月–2017年12月上报国家ADR监测中心的抗菌药物致药品不良反应210例,对患者年龄及性别、给药途径、抗菌药物种类分布、累及系统/器官及临床表现、ADR分布情况等进行回顾性分析。结果:210例由抗菌药物所致ADR中,30～59岁患者比例最高(62.86%);静脉滴注引起ADR最多(98.10%);青霉素类药物引起ADR最多(27.62%);皮肤及其附件损害最常见(54.40%);严重ADR主要以皮疹为主,新的ADR主要以头孢菌素类药物为主。结论:医疗机构应加强医务人员对ADR监测敏感性,规范抗菌药物使用,促进抗菌药物安全、合理用药。
Objective: To investigate the characteristics and patterns of adverse drug reactions(ADR) of antibacterials in our hospital, and provide data references for clinical safety and reasonable use of antibacterials. Methods: A total of 210 cases of ADRs caused by antibacterials, which were reported to the national ADR surveillance, from January 2015 to December 2017 in our hospital were collected for retrospective analysis based on patients' age, sex, route of administration, categories of antibacterials, system/organ involvement, clinical manifestations and ADR distribution. Results: ADR mainly occurred in patients aged 30 – 59 years old, which had the highest rate as 62.86%. About 98.10% of ADR was occurred with the administration route of intravenous infusion. Most ADR(27.62%) was caused by penicillin drugs. Skin and its appendants were the most common, accounting for 54.40%. Severe ADRs mainly consist of rash. New ADRs were mainly caused by cephalosporins. Conclusion: Medical institution should enhance the ADR monitoring and standardize the use of antibacterials in order to promote drug safety and rational use of antibacterials.
Objective: To investigate the characteristics and patterns of adverse drug reactions(ADR) of antibacterials in our hospital, and provide data references for clinical safety and reasonable use of antibacterials. Methods: A total of 210 cases of ADRs caused by antibacterials, which were reported to the national ADR surveillance, from January 2015 to December 2017 in our hospital were collected for retrospective analysis based on patients' age, sex, route of administration, categories of antibacterials, system/organ involvement, clinical manifestations and ADR distribution. Results: ADR mainly occurred in patients aged 30 – 59 years old, which had the highest rate as 62.86%. About 98.10% of ADR was occurred with the administration route of intravenous infusion. Most ADR(27.62%) was caused by penicillin drugs. Skin and its appendants were the most common, accounting for 54.40%. Severe ADRs mainly consist of rash. New ADRs were mainly caused by cephalosporins. Conclusion: Medical institution should enhance the ADR monitoring and standardize the use of antibacterials in order to promote drug safety and rational use of antibacterials.
引文
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[13]葛云.临床药师对莫西沙星注射液致精神异常患者的药学监护[J].中国医院用药评价与分析,2016,16(12):1715-1717.
[2]汪复,张婴元.实用抗感染治疗学[M].2版.北京:人民卫生出版社,2013:10-15.
[3]沈正泽,傅川,金梅.我院抗菌药物致不良反应111例分析[J].中国药房,2015,26(26):3667-3669.
[4]梁河,韦凤华,钟丽球.我院抗菌药物致不良反应233例[J].中国药房,2016,27(5):632-634.
[5]乐可佳,钟晗,施芳红.112例抗菌药物不良反应分析[J].医药导报,2016,35(Suppl):169-171.
[6]张笑颖,叶银梅.432例药品不良反应报告分析[J].中国药物应用与监测,2016,13(5):287-289.
[7]董莫然,徐丹,万里燕,等.我院718例药品不良反应报告分析[J].中国药物应用与监测,2017,14(6):350-353.
[8]段晓玲,李明.270例抗菌药物致药品不良反应报告[J].中国医院用药评价与分析,2017,17(10):1413-1415.
[9]陈新谦,金有豫.新编药物学[M].17版.北京:人民卫生出版社,2011:14-16.
[10]谢彦军,田月洁,刘翠丽,等.346例克林霉素注射剂致过敏性休克报告分析[J].中国药物警戒,2014,11(12):749-752.
[11]曹艳萍.56例克林霉素致过敏性休克文献分析[J].临床荟萃,2010,25(11):996-997.
[12]计紫超,赵环宇.66例静脉滴注莫西沙星不良反应报告分析[J].中国药物应用与监测,2017,14(6):353-356.
[13]葛云.临床药师对莫西沙星注射液致精神异常患者的药学监护[J].中国医院用药评价与分析,2016,16(12):1715-1717.