转化生长因子β1/Smad信号通路与早发性卵巢功能不全相关性研究
摘要
早发性卵巢功能不全是妇科临床疑难病,发病机制不明,治疗效果差,治愈率低,以降低育龄期妇女生育功能,影响女性生活质量为特点危害女性群体。防治早发性卵巢功能不足,研究其发病机制是关键。转化生长因子β1和Smad蛋白在信号通路中直接或间接对颗粒细胞的生长发育,以及相关激素分泌产生影响,以达到调控卵巢功能的目的。
引文
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16 纪艺珍,张佳荣,张瑞晴,等.TGF-β1对不孕症患者颗粒细胞卵丘扩展相关基因PTX3、TNFAIP6表达的影响.山东医药,2017,57:84-86.
17 吕时铭,吕红,陈援越.转化生长因子参与调节颗粒细胞雌孕激素的分泌.中华检验医学杂志,2001,24:278-281.
18 卫晓红,祁丽花,迟晓春,等.Smad2/Smad3蛋白在大鼠卵巢颗粒细胞中的表达及FSH对其活化的影响.解剖学报,2007,38:205-208.
19 Zheng X,Price CA,Tremblay Y,et al.Role of transforming growth factor-beta1 in gene expression and activity of estradiol and progesterone-generating enzymes in FSH-stimulated bovine granulosa cells.Reproduction,2008,136:447-457.
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21 Tomic D,Miller KP,Kenny HA.et al.Ovarian follicle development requires Smad3.Mol Endocrinol,2004,18:2224-2240.
22 Li Q,Pangas SA,Jorgez CJ,et al.Redundant roles of SMAD2 and SMAD3 in ovarian granulosa cells in vivo.Mol Cell Biol,2008,28:7001-7011.
23 方兰兰.EGF相关因子和TGF-β1对人颗粒细胞排卵相关基因表达及相关信号通路的调控作用研究.郑州大学,2015:1-121.
24 Yu C,Zhang YL,Fan HY.Selective Smad4 knockout in ovarian preovulatory follicles results in multiple defects in ovulation.Mol Endocrinol,2013,27:966-978.
25 Pangas SA,Li X,Robertson EJ,et al.Premature luteinization and cumulus cell defects in ovarian-specific Smad4 knockout mice.Mol Endocrinol,2006,20:1406-1422.
2 Baber RJ,Panay N,Fenton A,et al.2016 IMS Recommendations on women′s midlife health and menopause hormone therapy.Climacteric,2016,19:109-150.
3 Wang H,Chen H,Qin Y,et al.Risks associated with premature ovarian failure in Han Chinese women.Reprod Biomed Online,2015,30:401-407.
4 Silva CA,Yamakami LY,Aikawa NE,et al.Autoimmune primary ovarian insfficiency.Autoimmun Rev,2014,13:427-430.
5 Siddique S,Sadeu JC,Foster WG,et al,In vitro exposure to cigarette smoke induces oxidative stress in follicular cells of F1 hybrid mice.J Appl Toxicol,2014,34:224-226.
6 Kaivo-oja N,Jeffery LA,Ritvos O,et al.Smad signalling in the ovary.Reprod Biol Endocrin,2006,12:4-21.
7 Kajdaniuk D,Marek B,Borgiel-Marek H,et al.Transforming growth factorβ1 (TGFβ1) in physiology and pathology.Endokrynol Pol,2013,64:384-396.
8 Li Q.Inhibitory SMADs:potential regulators of ovarian function.Biol Reprod,2015,92:50.
9 Ingman WV,Robertson SA.The essential roles of TGFB1 in reproduction.cytokine Growth F R,2009,20:233-239.
10 周敏,冯强,黄丽波,等.转化生长因子β1/Smads信号传导通路在哺乳动物卵巢发育中的调控作用及其作用机制.动物营养学报,2017,29:2283-2288.
11 王莉,霍艳英,张开泰,等.Smad7对Smad2、Smad3、Smad4核转位的抑制作用.生物技术讯,2005,02:128-130.
12 路帅.雷公藤致排卵障碍大鼠卵巢TGFβ1及TGFβR1的变化.中华中医药学会妇科分会第十次全国中医妇科学术大会论文集.2010:279-281.
13 李爱冬,羊惠君,王凡,等.大鼠卵巢颗粒细胞IGF-Ⅰ、TGFβ、Fas-L表达与卵泡闭锁发生的研究.华西医科大学学报,1999,30:158-161.
14 刘慧萍,曾柳庭,胡立娟,等.补肾活血方对卵巢早衰小鼠颗粒细胞TGF-β1、TGF-βRⅡ、Smad2/3表达的影响.中成药,2017,39:1782-1788.
15 胡兴文,王维鹏,秦柳.7种细胞因子在卵泡液和血清中浓度水平的对比分析.中国实验诊断学,2016,20:729-732.
16 纪艺珍,张佳荣,张瑞晴,等.TGF-β1对不孕症患者颗粒细胞卵丘扩展相关基因PTX3、TNFAIP6表达的影响.山东医药,2017,57:84-86.
17 吕时铭,吕红,陈援越.转化生长因子参与调节颗粒细胞雌孕激素的分泌.中华检验医学杂志,2001,24:278-281.
18 卫晓红,祁丽花,迟晓春,等.Smad2/Smad3蛋白在大鼠卵巢颗粒细胞中的表达及FSH对其活化的影响.解剖学报,2007,38:205-208.
19 Zheng X,Price CA,Tremblay Y,et al.Role of transforming growth factor-beta1 in gene expression and activity of estradiol and progesterone-generating enzymes in FSH-stimulated bovine granulosa cells.Reproduction,2008,136:447-457.
20 Sasseville M,Ritter LJ,Nguyen TM.et al.Growth differentiation factor 9 signaling requires ERK1/2 activity in mouse granulosa and cumulus cells.Cell Sci,2010,15:3166-3176.
21 Tomic D,Miller KP,Kenny HA.et al.Ovarian follicle development requires Smad3.Mol Endocrinol,2004,18:2224-2240.
22 Li Q,Pangas SA,Jorgez CJ,et al.Redundant roles of SMAD2 and SMAD3 in ovarian granulosa cells in vivo.Mol Cell Biol,2008,28:7001-7011.
23 方兰兰.EGF相关因子和TGF-β1对人颗粒细胞排卵相关基因表达及相关信号通路的调控作用研究.郑州大学,2015:1-121.
24 Yu C,Zhang YL,Fan HY.Selective Smad4 knockout in ovarian preovulatory follicles results in multiple defects in ovulation.Mol Endocrinol,2013,27:966-978.
25 Pangas SA,Li X,Robertson EJ,et al.Premature luteinization and cumulus cell defects in ovarian-specific Smad4 knockout mice.Mol Endocrinol,2006,20:1406-1422.