系统性红斑狼疮自身抗体的研究进展
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摘要
系统性红斑狼疮是一种病因不明的自身免疫性疾病,其特点是产生一系列针对核抗原和细胞质抗原的自身抗体。自身抗体是一种针对自身组织、器官、细胞和细胞成分的抗体,在正常人体血液中可有较低水平的自身抗体,超过一定水平的自身抗体会对身体产生损害,从而引起疾病。自身抗体可见于系统性红斑狼疮、系统性硬化症等多种自身免疫性疾病,研究自身抗体与相应疾病的关系可提高疾病确诊率,降低误诊率及漏诊率,有利于疾病治疗及预后。
Systemic lupus erythematosus is a typical chronic autoimmune disease involving multiple systemic and organ damages,which is characterized by product of a large number of autoantibodies of the nuclear antigens and cytoplasmic antigens. Autoantibody is a kind of antibody mainly against own tissue,organ,cell and cellular components. There is a low degree of autoantibodies in the blood of normal humans,excessive levels of autoantibodies can damage the body and cause diseases. Autoantibody can be found in various autoimmune diseases such as systemic lupus erythematosus and systemic sclerosis. Studying the relationship between autoantibodies and the corresponding diseases can improve the diagnosis of the condition,reduce misdiagnosis and missed diagnosis rate,which is conductive to the treatment and prognosis.
Systemic lupus erythematosus is a typical chronic autoimmune disease involving multiple systemic and organ damages,which is characterized by product of a large number of autoantibodies of the nuclear antigens and cytoplasmic antigens. Autoantibody is a kind of antibody mainly against own tissue,organ,cell and cellular components. There is a low degree of autoantibodies in the blood of normal humans,excessive levels of autoantibodies can damage the body and cause diseases. Autoantibody can be found in various autoimmune diseases such as systemic lupus erythematosus and systemic sclerosis. Studying the relationship between autoantibodies and the corresponding diseases can improve the diagnosis of the condition,reduce misdiagnosis and missed diagnosis rate,which is conductive to the treatment and prognosis.
引文
[1] Tian XP,Zhang X. Gastrointestinal involvement in systemic lupus erythematosus:Insight into pathogenesis,diagnosis and treatment[J].World J Gastroenterol,2010,16(24):2971-2977.
[2] Li M,Zhang W,Leng X,et al. Chinese SLE Treatment and Research group(CSTAR)registry:I. Major clinical characteristics of Chinese patients with systemic lupus erythematosus[J].Lupus,2013,22(11):1192-1199.
[3]谷联清,陈文莉.系统性红斑狼疮靶向治疗进展[J].武汉大学学报(医学版),2014,35(1):160-164.
[4]周厚清,梁静文,董敏. ANA谱和ds-DNA检测在系统性红斑狼疮诊断中的临床意义[J].中国卫生检验杂志,2013,23(5):1228-1230.
[5]王柳,吕昭萍.自身抗体在狼疮性肾炎中的作用机制[J].医学综述,2013,19(14):2533-2536.
[6] van der Vlag J,Berden JH. Lupus nephritis:Role of antinucleosome autoantibodies[J]. Semin Nephrol,2011,31(4):376-389.
[7] Chen A,Chen HT,Hwang YH,et al. Severity of dry eye syndrome is related to anti-dsDNA autoantibody in systemic lupus erythematosus patients without secondary Sjogren syndrome:A cross-sectional analysis[J]. Medicine(Baltimore),2016,95(28):e4218.
[8] Muller S,Bonnier D,Thiry M,et al. Reactivity of autoantibodies in systemic lupus erythematosus with synthetic core histone peptides[J]. Int Arch Allergy Appl Immunol,1989,89(2/3):288-296.
[9] Sun XY,Shi J,Han L,et al. Anti-histones antibodies in systemic lupus erythematosus:Prevalence and frequency in neuropsychiatric lupus[J]. J Clin Lab Anal,2008,22(4):271-277.
[10]彭赛蛟,陶锡东,王敏.不同自身抗体联合检测在系统性红斑狼疮中的诊断价值[J].中国免疫学杂志,2014,30(6):831-833,837.
[11]李峥,毕胜,杨曦,等.抗核抗体谱检测对系统性红斑狼疮的诊断价值[J].云南医药,2005,26(5):400-402.
[12]代荣琴,陈洋,刘玉枝,等.抗U1RNP抗体检测在系统性红斑狼疮中的应用价值[J].热带医学杂志,2016,16(10):1242-1244.
[13] Chindalore V,Neas B,Reichlin M. The association between antiribosomal P antibodies and active nephritis in systemic lupus erythematosus[J]. Clin Immunol Immunopathol,1998,87(3):292-296.
[14] Chandran V,Upadhyaya SK,Haroon N,et al. Lack of clinical association with antibodies to ribosomal P proteins in Indian patients with systemic lupus erythematosus[J]. J Rheumatol,2006,33(10):1987-1989.
[15] Dima A,Jurcut C. The impact of anti-U1-RNP positivity:Systemic lupus erythematosus versus mixed connective tissue disease[J]. Rheumatol Int,2018,38(7):1169-1178.
[16] Williams RC Jr,Malone CC,Meyers C,et al. Detection of nucleosome particles in serum and plasma from patients with systemic lupus erythematosus using monoclonal antibody 4H7[J]. J Rheumatol,2001,28(1):81-94.
[17] Mjelle JE,Rekvig OP,Fenton KA. Nueleasomes possess a high affinity for glomerular laminin and collagenⅣand bind nephritogenic antibodies in murine lupus-like nephritis[J]. Ann Rheum Dis,2007,66(12):1661-1668.
[18] Garrett-Sinha LA,John S,Gaffen SL. IL-17 and Th17 lineage in systemic lupus erythematosus[J]. Curr Opin Rheumatol,2008,20(5):519-525.
[19] Abraham Simón J,Rojas-Serrano J,Cabiedes J,et al. Antinucleosome antibodies may help predict development of systemic lupus erythematosus in patients with primary antiphospholipid syndrome[J].Lupus,2004,13(3):177-181.
[20] Goulvestre C. Antinuclear antibodies[J]. Presse Med,2006,35(2Pt 2):287-295.
[21] Sarfaraz S,Anis S,Ahmed E,et al. Clinical Significance of AntiRibosomal P Protein Antibodies in Patients with Lupus Nephritis[J].Rev Recent Clin Trials,2018,13(4):281-286.
[22] Reichlin M,Broyles TF,Hubscher O,et al. Prevalence of autoantibodies to ribosomal P proteins in juvenile-onset systemic lupus erythematosus compared with the adult disease[J]. Arthritis Rheum,1999,42(1):69-75.
[23] do Nascimento AP,Viana Vdos S,Testagrossa Lde A,et al. Antibodies to ribosomal P proteins:A potential serologic marker for lupus membranous glomerulonephritis[J]. Arthritis Rheum,2006,54(5):1568-1572.
[24] Ghirardello A,Briani C,Lucchetta M,et al. Anti-ribosomal P protein antibodies and neuropsychiatric systemic lupus erythematosus:Cross-sectional vs. prospective studies[J]. Lupus,2010,19(6):771-773.
[25] Yoshio T,Hirata D,Onda K,et al. Antiribosomal P protein antibodies in cerebrospinal fluid are associated with neuropsychiatric systemic lupus erythematosus[J]. J Rheumatol,2005,32(1):34-39.
[26] Haddouk S,Marzouk S,Jallouli M,et al. Clinical and diagnostic value of ribosomal P autoantibodies in systemic lupus erythematosus[J]. Rheumatology(Oxford),2009,48(8):953-957.
[27] Fukuda MV,Lo SC,de Almeida CS,et al. Anti-Ro antibody and cutaneous vasculitis in systemic lupus erythematosus[J]. Clin Rheumatol,2009,28(3):301-304.
[28] Cozzani E,Drosera M,Gasparini G,et al. Serology of Lupus Erythematosus:Correlation between Immunopathological Features and Clinical Aspects[J]. Autoimmune Dis,2014,2014:321359.
[29] Tarr T,Dérfalvi B,Gy9ri N,et al. Similarities and differences between pediatric and adult patients with systemic lupus erythematosus[J]. Lupus,2015,24(8):796-803.
[30]孙瓅贤,李春华.系统性红斑狼疮心脏受累的诊治进展[J].心血管病学进展,2011,32(5):636-639.
[31] Brito-Zerón P,Izmirly PM,Ramos-Casals M,et al. The clinical spectrum of autoimmune congenital heart block[J]. Nat Rev Rheumatol,2015,11(5):301-312.
[32] Logar D,Kveder T,Rozman B,et al. Possible association between anti-Ro antibodies and myocarditis or cardiac conduction defects in adults with systemic lupus erythematosus[J]. Ann Rheum Dis,1990,49(8):627-629.
[33]李炎梅,谭毅.抗核抗体的研究进展[J].中国临床新医学,2013,6(8):814-817.
[34] Novak GV,Marques M,Balbi V,et al. Anti-RO/SSA and anti-La/SSB antibodies:Association with mild lupus manifestations in 645childhood-onset systemic lupus erythematosus[J]. Autoimmun Rev,2017,16(2):132-135.
[35] Respaldiza N,Wichmann I,Oca1a C,et al. Anti-centromere antibodies in patients with systemic lupus erythematosus[J].Scand J Rheumatol,2006,35(4):290-294.
[36] Miyawaki S,Asanuma H,Nishiyama S,et al. Clinical and serological heterogeneity in patients with anticentromere antibodies[J].J Rheumatol,2005,32(8):1488-1494.
[37] Takada K,Suzuki K,Matsumoto M,et al. Clinical characteristics of patients with both anti-U1RNP and anti-centromere antibodies[J].Scand J Rheumatol,2008,37(5):360-364.
[38] Nalli C,Iodice A,Andreoli L,et al. The effects of lupus and antiphospholipid antibody syndrome on foetal outcomes[J].Lupus,2014,23(6):507-517.
[39]黄建萍.抗磷脂抗体和狼疮性肾炎[J].临床儿科杂志,2007,25(4):315-317.
[40] Duarte-García A,Romero-Díaz J,Juárez S,et al. Disease activity,autoantibodies,and inflammatory molecules in serum and cerebrospinal fluid of patients with systemic lupus erythematosus and cognitive dysfunction[J]. PLo S One,2018,13(5):e0196487.
[41] Zandman-Goddard G,Chapman J,Shoenfeld Y. Autoantibodies involved in neuropsychiatric SLE and antiphospholipid syndrome[J].Semin Arthritis Rheum,2007,36(5):297-315.
[2] Li M,Zhang W,Leng X,et al. Chinese SLE Treatment and Research group(CSTAR)registry:I. Major clinical characteristics of Chinese patients with systemic lupus erythematosus[J].Lupus,2013,22(11):1192-1199.
[3]谷联清,陈文莉.系统性红斑狼疮靶向治疗进展[J].武汉大学学报(医学版),2014,35(1):160-164.
[4]周厚清,梁静文,董敏. ANA谱和ds-DNA检测在系统性红斑狼疮诊断中的临床意义[J].中国卫生检验杂志,2013,23(5):1228-1230.
[5]王柳,吕昭萍.自身抗体在狼疮性肾炎中的作用机制[J].医学综述,2013,19(14):2533-2536.
[6] van der Vlag J,Berden JH. Lupus nephritis:Role of antinucleosome autoantibodies[J]. Semin Nephrol,2011,31(4):376-389.
[7] Chen A,Chen HT,Hwang YH,et al. Severity of dry eye syndrome is related to anti-dsDNA autoantibody in systemic lupus erythematosus patients without secondary Sjogren syndrome:A cross-sectional analysis[J]. Medicine(Baltimore),2016,95(28):e4218.
[8] Muller S,Bonnier D,Thiry M,et al. Reactivity of autoantibodies in systemic lupus erythematosus with synthetic core histone peptides[J]. Int Arch Allergy Appl Immunol,1989,89(2/3):288-296.
[9] Sun XY,Shi J,Han L,et al. Anti-histones antibodies in systemic lupus erythematosus:Prevalence and frequency in neuropsychiatric lupus[J]. J Clin Lab Anal,2008,22(4):271-277.
[10]彭赛蛟,陶锡东,王敏.不同自身抗体联合检测在系统性红斑狼疮中的诊断价值[J].中国免疫学杂志,2014,30(6):831-833,837.
[11]李峥,毕胜,杨曦,等.抗核抗体谱检测对系统性红斑狼疮的诊断价值[J].云南医药,2005,26(5):400-402.
[12]代荣琴,陈洋,刘玉枝,等.抗U1RNP抗体检测在系统性红斑狼疮中的应用价值[J].热带医学杂志,2016,16(10):1242-1244.
[13] Chindalore V,Neas B,Reichlin M. The association between antiribosomal P antibodies and active nephritis in systemic lupus erythematosus[J]. Clin Immunol Immunopathol,1998,87(3):292-296.
[14] Chandran V,Upadhyaya SK,Haroon N,et al. Lack of clinical association with antibodies to ribosomal P proteins in Indian patients with systemic lupus erythematosus[J]. J Rheumatol,2006,33(10):1987-1989.
[15] Dima A,Jurcut C. The impact of anti-U1-RNP positivity:Systemic lupus erythematosus versus mixed connective tissue disease[J]. Rheumatol Int,2018,38(7):1169-1178.
[16] Williams RC Jr,Malone CC,Meyers C,et al. Detection of nucleosome particles in serum and plasma from patients with systemic lupus erythematosus using monoclonal antibody 4H7[J]. J Rheumatol,2001,28(1):81-94.
[17] Mjelle JE,Rekvig OP,Fenton KA. Nueleasomes possess a high affinity for glomerular laminin and collagenⅣand bind nephritogenic antibodies in murine lupus-like nephritis[J]. Ann Rheum Dis,2007,66(12):1661-1668.
[18] Garrett-Sinha LA,John S,Gaffen SL. IL-17 and Th17 lineage in systemic lupus erythematosus[J]. Curr Opin Rheumatol,2008,20(5):519-525.
[19] Abraham Simón J,Rojas-Serrano J,Cabiedes J,et al. Antinucleosome antibodies may help predict development of systemic lupus erythematosus in patients with primary antiphospholipid syndrome[J].Lupus,2004,13(3):177-181.
[20] Goulvestre C. Antinuclear antibodies[J]. Presse Med,2006,35(2Pt 2):287-295.
[21] Sarfaraz S,Anis S,Ahmed E,et al. Clinical Significance of AntiRibosomal P Protein Antibodies in Patients with Lupus Nephritis[J].Rev Recent Clin Trials,2018,13(4):281-286.
[22] Reichlin M,Broyles TF,Hubscher O,et al. Prevalence of autoantibodies to ribosomal P proteins in juvenile-onset systemic lupus erythematosus compared with the adult disease[J]. Arthritis Rheum,1999,42(1):69-75.
[23] do Nascimento AP,Viana Vdos S,Testagrossa Lde A,et al. Antibodies to ribosomal P proteins:A potential serologic marker for lupus membranous glomerulonephritis[J]. Arthritis Rheum,2006,54(5):1568-1572.
[24] Ghirardello A,Briani C,Lucchetta M,et al. Anti-ribosomal P protein antibodies and neuropsychiatric systemic lupus erythematosus:Cross-sectional vs. prospective studies[J]. Lupus,2010,19(6):771-773.
[25] Yoshio T,Hirata D,Onda K,et al. Antiribosomal P protein antibodies in cerebrospinal fluid are associated with neuropsychiatric systemic lupus erythematosus[J]. J Rheumatol,2005,32(1):34-39.
[26] Haddouk S,Marzouk S,Jallouli M,et al. Clinical and diagnostic value of ribosomal P autoantibodies in systemic lupus erythematosus[J]. Rheumatology(Oxford),2009,48(8):953-957.
[27] Fukuda MV,Lo SC,de Almeida CS,et al. Anti-Ro antibody and cutaneous vasculitis in systemic lupus erythematosus[J]. Clin Rheumatol,2009,28(3):301-304.
[28] Cozzani E,Drosera M,Gasparini G,et al. Serology of Lupus Erythematosus:Correlation between Immunopathological Features and Clinical Aspects[J]. Autoimmune Dis,2014,2014:321359.
[29] Tarr T,Dérfalvi B,Gy9ri N,et al. Similarities and differences between pediatric and adult patients with systemic lupus erythematosus[J]. Lupus,2015,24(8):796-803.
[30]孙瓅贤,李春华.系统性红斑狼疮心脏受累的诊治进展[J].心血管病学进展,2011,32(5):636-639.
[31] Brito-Zerón P,Izmirly PM,Ramos-Casals M,et al. The clinical spectrum of autoimmune congenital heart block[J]. Nat Rev Rheumatol,2015,11(5):301-312.
[32] Logar D,Kveder T,Rozman B,et al. Possible association between anti-Ro antibodies and myocarditis or cardiac conduction defects in adults with systemic lupus erythematosus[J]. Ann Rheum Dis,1990,49(8):627-629.
[33]李炎梅,谭毅.抗核抗体的研究进展[J].中国临床新医学,2013,6(8):814-817.
[34] Novak GV,Marques M,Balbi V,et al. Anti-RO/SSA and anti-La/SSB antibodies:Association with mild lupus manifestations in 645childhood-onset systemic lupus erythematosus[J]. Autoimmun Rev,2017,16(2):132-135.
[35] Respaldiza N,Wichmann I,Oca1a C,et al. Anti-centromere antibodies in patients with systemic lupus erythematosus[J].Scand J Rheumatol,2006,35(4):290-294.
[36] Miyawaki S,Asanuma H,Nishiyama S,et al. Clinical and serological heterogeneity in patients with anticentromere antibodies[J].J Rheumatol,2005,32(8):1488-1494.
[37] Takada K,Suzuki K,Matsumoto M,et al. Clinical characteristics of patients with both anti-U1RNP and anti-centromere antibodies[J].Scand J Rheumatol,2008,37(5):360-364.
[38] Nalli C,Iodice A,Andreoli L,et al. The effects of lupus and antiphospholipid antibody syndrome on foetal outcomes[J].Lupus,2014,23(6):507-517.
[39]黄建萍.抗磷脂抗体和狼疮性肾炎[J].临床儿科杂志,2007,25(4):315-317.
[40] Duarte-García A,Romero-Díaz J,Juárez S,et al. Disease activity,autoantibodies,and inflammatory molecules in serum and cerebrospinal fluid of patients with systemic lupus erythematosus and cognitive dysfunction[J]. PLo S One,2018,13(5):e0196487.
[41] Zandman-Goddard G,Chapman J,Shoenfeld Y. Autoantibodies involved in neuropsychiatric SLE and antiphospholipid syndrome[J].Semin Arthritis Rheum,2007,36(5):297-315.