摘要
为了解国产绿‘奇楠’沉香的化学成分,采用色谱和波谱方法从其乙醚和乙醇提取物中分离鉴定了7个化合物,分别鉴定为顺式-7-羟基菖蒲烯(1),(5R,6R,7S,8R)-2-(苯乙基)-6,7,8-三羟基-5,6,7,8-四氢-5-[2-(2-苯乙基)色酮基-6-氧代]色酮(2), 1-羟基-1,5-二苯基戊-3-酮(3),丁香树脂酚葡萄糖苷(4),(3β)-齐墩果-12-烯-3,23-二醇(5),β-谷甾醇(6)和棕榈酸-α-单甘油酯(7)。化合物1、3~5和7均为首次从沉香中分离得到,其中化合物1表现出非常甜的芳香气味。乙酰胆碱酯酶体外抑制活性测试结果表明,50μmol L~(–1)的化合物1对乙酰胆碱酯酶抑制率为(49.9±1.4)%。
To understand the chemical constituents of Chinese agarwood "Qi-Nan", seven compounds were isolated by various column chromatographic methods. On the basis of spectral data, they were identified as cis-7-hydroxycalamenene(1),(5 R,6 R,7 S,8 R)-2-(phenylethyl)-6,7,8-trihydroxy-5,6,7,8-tetrahydro-5-[2-(2-phenylethyl)chromonyl-6-oxy]chromone(2), 1-hydroxy-1,5-diphenylpentan-3-one(3), syringaresinol-glycoside(4),(3β)-olean-12-ene-3,23-diol(5), β-sitosterol(6) and hexadecanoic acid, 2,3-dihydroxypropyl ester(7). Compounds 1,3-5, and 7 were isolated from agarwood for the first time, and compound 1 showed a very sweet aromatic odor.Compound 1 showed acetylcholinesterase(AChE) inhibitory activity with the inhibition rate of(49.9 ±1.4)% at the concentration of 50 μmol L~(–1).
引文
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