短暂性脑缺血发作患者血清LP(a)、ApoB/ApoA1水平与颈动脉粥样硬化的关系
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摘要
目的探讨短暂性脑缺血发作患者血清LP(a)、ApoB/ApoA1水平与颈动脉粥样硬化的关系。方法选择80例健康体检者(对照组)和80例短暂性脑缺血发作患者(观察组)为研究对象,两组均进行颈动脉超声检查和血清LP(a)、ApoB/ApoA1检测。结果观察组患者的血清LP(a)水平为(345.25±24.69)mg/L,ApoB/ApoA1为1.59±0.45,LDL为(3.58±0.74)mmol/L,Hs-CRP水平为(5.36±1.36)mg/L,均显著高于对照组,差异有统计学意义(P<0.05)。观察组患者中,有斑块患者的血清LP(a)水平、ApoB/ApoA1水平均显著高于无斑块患者,差异有统计学意义(P<0.05)。结论短暂性脑缺血发作患者的颈动脉粥样硬化发生与血清LP(a)、ApoB/ApoA1水平密切相关。
Objective To investigate the relationship between carotid atherosclerosis and serumLP(a),ApoB/ApoA1 levels in patients with transient ischemic attack.Methods 80 healthy subjects(control group) and 80 cases of patients with transient ischemic attack(observation group) were selected as research objects.All cases received carotid artery ultrasound examination and detection of serumLP(a)and ApoB/ApoA1.Results The levels of serumLP(a),ApoB/ApoA1,LDL and Hs-CRP of observation group were(345.25±24.69) mg/L,1.59±0.45,(3.58±0.74) mmol/L and(5.36±1.36) mg/L respectively,significantly higher than those of control group(P<0.05).In the observation group,patients with plaque had significantly higher levels of serumLP(a) and ApoB/ApoA1 than patients without plaque(P<0.05).Conclusions Carotid atherosclerosis in patients with transient ischemic attack is closely related to serum levels of LP(a) and ApoB/ApoA1.
Objective To investigate the relationship between carotid atherosclerosis and serumLP(a),ApoB/ApoA1 levels in patients with transient ischemic attack.Methods 80 healthy subjects(control group) and 80 cases of patients with transient ischemic attack(observation group) were selected as research objects.All cases received carotid artery ultrasound examination and detection of serumLP(a)and ApoB/ApoA1.Results The levels of serumLP(a),ApoB/ApoA1,LDL and Hs-CRP of observation group were(345.25±24.69) mg/L,1.59±0.45,(3.58±0.74) mmol/L and(5.36±1.36) mg/L respectively,significantly higher than those of control group(P<0.05).In the observation group,patients with plaque had significantly higher levels of serumLP(a) and ApoB/ApoA1 than patients without plaque(P<0.05).Conclusions Carotid atherosclerosis in patients with transient ischemic attack is closely related to serum levels of LP(a) and ApoB/ApoA1.
引文
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[2]华键,周其达.短暂性脑缺血发作后脑梗死与纤维蛋白原水平和颈动脉粥样硬化的关系研究[J].实用心脑肺血管病杂志,2012,20(9):1448-1449.
[3]费娜,刘勇.短暂性脑缺血发作患者血清LP(a)、Apo B/Apo A1水平与颈动脉粥样硬化的关系[J].中国老年学杂志,2015,35(3):792-794.
[4]刘素梅.短暂性脑缺血发作患者微量白蛋白尿水平和颈动脉粥样硬化的相关性分析[J].中国卫生标准管理,2016,7(11):46-47.
[5]Geeganage CM,Diener HC,Algra A,et al.Dual or mono antiplatelet therapy for patients with acute ischemic stroke or transient ischemic attack[J].Stroke,2012,43(4):1058-1066.
[6]刘书来,董瑞国.颈动脉系统粥样斑块与短暂性脑缺血关系研究[J].中国医学创新,2013,10(17):157-159.
[7]王淼霞,陈钢,周文胜,等.短暂性脑缺血发作患者血脂水平与ABCD2评分的相关性研究[J].现代生物医学进展,2011,11(11):2138-2140.
[8]唐振旺,徐晓东.血清脂联素,载脂蛋白B/A1比值与颈总动脉内-中膜厚度和冠脉病变的相关性研究[J].现代生物医学进展,2010,10(14):2674-2676.