罗汉果药用功能研究与进展
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摘要
罗汉果为葫芦科多年生宿根性藤本植物罗汉果的果实,也是中国特有的地道药材和甜味植物。被列入国家发展重点项目后,对其研究日渐增多,在各种医疗领域的应用功能也渐渐被开发出来,在镇咳祛痰、糖尿病治疗、免疫调节作用、抗肿瘤作用、抗菌抗疲劳等的研究逐渐深入。罗汉果作为广西特色经济作物,在医疗方面具有很大的潜力,特别是在肿瘤和糖尿病的治疗中,能提供一定的治疗作用。
The fruit of a perennial vine of the Cucurbitaceae family, Momordica Grosvenori, which is also a unique Chinese herbal medicine and sweet plant. After being included in the national development key project, the research on it is increasing day by day, and the application function in various medical fields has been gradually developed. The research gradually deepening on function of it's antitussive and eliminating phlegm, diabetes treatment, immunomodulation, anti-tumor, antibacterial and anti-fatigue, etc. As a special cash crop in Guangxi, Luohanguo has great potential in medical treatment, especially in the treatment of cancer and diabetes, can provide a certain therapeutic effect.
The fruit of a perennial vine of the Cucurbitaceae family, Momordica Grosvenori, which is also a unique Chinese herbal medicine and sweet plant. After being included in the national development key project, the research on it is increasing day by day, and the application function in various medical fields has been gradually developed. The research gradually deepening on function of it's antitussive and eliminating phlegm, diabetes treatment, immunomodulation, anti-tumor, antibacterial and anti-fatigue, etc. As a special cash crop in Guangxi, Luohanguo has great potential in medical treatment, especially in the treatment of cancer and diabetes, can provide a certain therapeutic effect.
引文
[1]刘金磊,卢凤来,周玉恒,等.不同生长日龄罗汉果中糖基转苷蛋白凝胶电泳分析[J].生物技术通报,2008(z1):213-215.
[2]唐其,马小军,莫长明,等.罗汉果全基因组Survey分析[J].广西植物,2015,35(6):786-791.
[3]李典鹏,黄永林,刘金磊,等.HPLC法测定罗汉果中罗汉果苷ⅡE、苷Ⅲ的含量[J].天然产物研究与开发,2006(5):850-853.
[4]杨秀伟,张建业,钱忠明.罗汉果中新的天然皂苷[J].中草药,2008(6):810-814.
[5]陈兵,羊学荣,卢凤来,徐风,李典鹏.罗汉果醇的制备及大鼠体内代谢研究[J].广西植物,2014,34(2):198-202.
[6]刘婷,王旭华,李春,张毅,等.罗汉果皂苷V的镇咳、祛痰及解痉作用研究[J].中国药学杂志,2007,42(20):1534-1536.
[7]Zou Cuili,Zhang Qiaoqin,Zhang Shenghong.Mogroside IIIEattenuates gestational diabetes mellitus through activating of AMPKsignaling pathway in mice[J].J Pharmacol Sci,2018,138(3):161-166.
[8]孟凡燕,肖颖梅,王亚军,等.不同生长期罗汉果皂苷对α-葡萄糖苷酶的体外抑制作用研究[J].右江民族医学院学报,2016,38(4):359-363.
[9]何超文,姚美村,夏星,等.鲜罗汉果皂苷对小鼠血糖的调节作用研究[J].现代食品科技,2012,28(4):382-386.
[10]陈玉容.罗汉果提取物配合运动对血压血脂水平的改善[J].食品研究与开发,2017,38(7):178-181.
[11]李俊,黄艳,廖日权,等.罗汉果多糖对小鼠免疫功能的影响[J].中国药理学通报,2008,24(9):1237-1240.
[12]余佩华,邓跃敏,钟牧源.一种新型罗汉果醇衍生物单体及其组合物的用途.中国广东,44:CN201610520359.0[P],2016-12-07.
[13]Pana MH,Yanga JR,Tsaia ML,et al.Anti-inflammatory effect of Momordica grosvenori Swingle extract through suppressed LPS-in-duced upregulation of i-NOS and COX-2 in murine macrophages[J].Func.Foods,2009,1(1):145-152.
[14]Tao L,Yang J,Cao F,et al.Mogroside IIIE,a Novel AntiFibrotic Compound,Reduces Pulmonary Fibrosis through TollLike Receptor 4 Pathways[J].The Journal of pharmacology and experimental therapeutics,2017,361(2):268-279.
[15]Liu C,Dai LH,Dou DQ,et al.A natural food sweetener with anti-pancreatic cancer properties[J].Oncogenesis,2016,5:217.
[16]符毓夏,王磊,李典鹏.罗汉果醇抗肿瘤活性及其作用机制研究[J].广西植物,2016,36(11):1369-1375.
[17]Liu C,Dai Longhai,Liu Yueping,et al.Antiproliferative Activity of Triterpene Glycoside Nutrient from Monk Fruit in Colorectal Cancer and Throat Cancer[J].Nutrients,2016,8(6):360.
[18]Liu C,Zeng Y,Dai LH,et al.Mogrol represents a novel leukemia therapeutic,via ERK and STAT3 inhibition[J].American journal of cancer research,2015,5(4):1308-1318.
[19]刘灿,蔡天宇,赵晓萌,等.罗汉果提取物诱导肺癌细胞A549凋亡的研究[J].中国药理学通报,2015,31(9):1310-1314.
[20]周治德,张连香,杨裴庆,等.罗汉果口香糖工艺研究[J].广东化工,2016,43(5):23-24,27.
[21]喻聪,王洁.罗汉果提取物对负重游泳训练大鼠物质代谢及抗运动疲劳能力的影响[J].中国老年学杂志,2016,36(1):12-13.
[22]范建华,梁敏,刘布鸣.基于双聚类的近10年罗汉果研究热点可视化分析[J].中国中医药信息杂志,2017,24(11):91-95.
[23]卢凤来,黄振聪,颜小捷,等.罗汉果皂苷V在人工胃液中的稳定性和体外代谢研究[J].广西植物,2015,35(6):792-795.
[24]羊学荣,卢凤来,王磊,等.酶水解百分之五十罗汉果皂苷V方法学研究[J].广西植物,2015,35(6):812-816,898.
[2]唐其,马小军,莫长明,等.罗汉果全基因组Survey分析[J].广西植物,2015,35(6):786-791.
[3]李典鹏,黄永林,刘金磊,等.HPLC法测定罗汉果中罗汉果苷ⅡE、苷Ⅲ的含量[J].天然产物研究与开发,2006(5):850-853.
[4]杨秀伟,张建业,钱忠明.罗汉果中新的天然皂苷[J].中草药,2008(6):810-814.
[5]陈兵,羊学荣,卢凤来,徐风,李典鹏.罗汉果醇的制备及大鼠体内代谢研究[J].广西植物,2014,34(2):198-202.
[6]刘婷,王旭华,李春,张毅,等.罗汉果皂苷V的镇咳、祛痰及解痉作用研究[J].中国药学杂志,2007,42(20):1534-1536.
[7]Zou Cuili,Zhang Qiaoqin,Zhang Shenghong.Mogroside IIIEattenuates gestational diabetes mellitus through activating of AMPKsignaling pathway in mice[J].J Pharmacol Sci,2018,138(3):161-166.
[8]孟凡燕,肖颖梅,王亚军,等.不同生长期罗汉果皂苷对α-葡萄糖苷酶的体外抑制作用研究[J].右江民族医学院学报,2016,38(4):359-363.
[9]何超文,姚美村,夏星,等.鲜罗汉果皂苷对小鼠血糖的调节作用研究[J].现代食品科技,2012,28(4):382-386.
[10]陈玉容.罗汉果提取物配合运动对血压血脂水平的改善[J].食品研究与开发,2017,38(7):178-181.
[11]李俊,黄艳,廖日权,等.罗汉果多糖对小鼠免疫功能的影响[J].中国药理学通报,2008,24(9):1237-1240.
[12]余佩华,邓跃敏,钟牧源.一种新型罗汉果醇衍生物单体及其组合物的用途.中国广东,44:CN201610520359.0[P],2016-12-07.
[13]Pana MH,Yanga JR,Tsaia ML,et al.Anti-inflammatory effect of Momordica grosvenori Swingle extract through suppressed LPS-in-duced upregulation of i-NOS and COX-2 in murine macrophages[J].Func.Foods,2009,1(1):145-152.
[14]Tao L,Yang J,Cao F,et al.Mogroside IIIE,a Novel AntiFibrotic Compound,Reduces Pulmonary Fibrosis through TollLike Receptor 4 Pathways[J].The Journal of pharmacology and experimental therapeutics,2017,361(2):268-279.
[15]Liu C,Dai LH,Dou DQ,et al.A natural food sweetener with anti-pancreatic cancer properties[J].Oncogenesis,2016,5:217.
[16]符毓夏,王磊,李典鹏.罗汉果醇抗肿瘤活性及其作用机制研究[J].广西植物,2016,36(11):1369-1375.
[17]Liu C,Dai Longhai,Liu Yueping,et al.Antiproliferative Activity of Triterpene Glycoside Nutrient from Monk Fruit in Colorectal Cancer and Throat Cancer[J].Nutrients,2016,8(6):360.
[18]Liu C,Zeng Y,Dai LH,et al.Mogrol represents a novel leukemia therapeutic,via ERK and STAT3 inhibition[J].American journal of cancer research,2015,5(4):1308-1318.
[19]刘灿,蔡天宇,赵晓萌,等.罗汉果提取物诱导肺癌细胞A549凋亡的研究[J].中国药理学通报,2015,31(9):1310-1314.
[20]周治德,张连香,杨裴庆,等.罗汉果口香糖工艺研究[J].广东化工,2016,43(5):23-24,27.
[21]喻聪,王洁.罗汉果提取物对负重游泳训练大鼠物质代谢及抗运动疲劳能力的影响[J].中国老年学杂志,2016,36(1):12-13.
[22]范建华,梁敏,刘布鸣.基于双聚类的近10年罗汉果研究热点可视化分析[J].中国中医药信息杂志,2017,24(11):91-95.
[23]卢凤来,黄振聪,颜小捷,等.罗汉果皂苷V在人工胃液中的稳定性和体外代谢研究[J].广西植物,2015,35(6):792-795.
[24]羊学荣,卢凤来,王磊,等.酶水解百分之五十罗汉果皂苷V方法学研究[J].广西植物,2015,35(6):812-816,898.