百令胶囊联合二甲双胍对糖尿病肾病患者的临床疗效
|
摘要
目的探讨百令胶囊联合二甲双胍对糖尿病肾病患者的临床疗效。方法 94例患者随机分为观察组与对照组,每组47例,对照组给予二甲双胍,观察组在对照组基础上加用百令胶囊,疗程12周。然后,检测总有效率、24 h尿蛋白定量、UAER、HOMA-IR及Cr、BUN、FPG、Hb A1c、脂联素、血清炎性因子(IL-6、MCP-1、TNF-α)水平。结果观察组总有效率显著高于对照组(P<0. 05)。治疗后,2组24 h尿蛋白定量、UAER、HOMA-IR及Cr、BUN、FPG、Hb A1c水平显著降低(P<0. 05),以观察组更显著(P<0. 05);观察组脂联素、IL-6、MCP-1、TNF-α水平显著降低(P<0. 05),也显著低于对照组(P<0. 05)。结论百令胶囊联合二甲双胍可改善糖尿病肾病患者胰岛素抵抗和炎性反应,降低脂联素水平,具有重要临床意义。
AIM To explore the clinical effects of Bailing Capsules combined with metformin on diabetic nephropathy patients. METHODS Ninety-four patients randomly assigned into observation group and control group,47 cases in each group,went on 12-week intervention either of metformin( control group),or metformin+Bailing Capsules( observation group). Subsequently,total effective rate,24 h urine protein quantity,UAER,HOMA-IR and Cr,BUN,FPG,HbA1 c,adiponectin,serum inflammatory factors( IL-6,MCP-1,TNF-α) levels were detected. RESULTS The observation group demonstrated significantly higher total effective rate than the control group( P<0. 05). Both groups shared markedly decreased 24 h urinary protein quantity,UAER,HOMA-IR and Cr,BUN,FPG,HbA1 c levels after the treatment( P<0. 05),especially for the observation group( P<0. 05),which was observed with obviously decreased adiponectin,IL-6,MCP-1,TNF-α levels( P<0. 05),significantly lower in contrast to the control group( P < 0. 05). CONCLUSION Bailing Capsules combined with metformin highlights the clinical management of diabetic nephropathy patients through improving insulin resistance and inflammatory reaction,and reducing the level of adiponectin.
AIM To explore the clinical effects of Bailing Capsules combined with metformin on diabetic nephropathy patients. METHODS Ninety-four patients randomly assigned into observation group and control group,47 cases in each group,went on 12-week intervention either of metformin( control group),or metformin+Bailing Capsules( observation group). Subsequently,total effective rate,24 h urine protein quantity,UAER,HOMA-IR and Cr,BUN,FPG,HbA1 c,adiponectin,serum inflammatory factors( IL-6,MCP-1,TNF-α) levels were detected. RESULTS The observation group demonstrated significantly higher total effective rate than the control group( P<0. 05). Both groups shared markedly decreased 24 h urinary protein quantity,UAER,HOMA-IR and Cr,BUN,FPG,HbA1 c levels after the treatment( P<0. 05),especially for the observation group( P<0. 05),which was observed with obviously decreased adiponectin,IL-6,MCP-1,TNF-α levels( P<0. 05),significantly lower in contrast to the control group( P < 0. 05). CONCLUSION Bailing Capsules combined with metformin highlights the clinical management of diabetic nephropathy patients through improving insulin resistance and inflammatory reaction,and reducing the level of adiponectin.
引文
[1] Zhao L,Wang X L,Sun L N,et al. Critical role of serum response factor in podocyte epithelial-mesenchymal transition of diabetic nephropathy[J]. Diab Vasc Dis Res,2016,13(1):81-92.
[2] Hadjadj S,Cariou B,Fumeron F,et al. Death,end-stage renal disease and renal function decline in patients with diabetic nephropathy in French cohorts of type 1 and type 2 diabetes[J].Diabetologia,2016,59(1):208-216.
[3] Rahimi Z. The role of renin angiotensin aldosterone system genes in diabetic nephropathy[J]. Can J Diabetes,2016,40(2):178-183.
[4] Betz B B,Jenks S J,Cronshaw A D,et al. Urinary peptidomics in a rodent model of diabetic nephropathy highlights epidermal growth factor as a biomarker for renal deterioration in patients with type 2 diabetes[J]. Kidney Int, 2016, 89(5):1125-1135.
[5]杨敬伟.中西医结合治疗糖尿病肾病30例临床研究[J].江苏中医药,2016,48(4):39-40.
[6]朱风琴,赵晓光.中西医结合治疗糖尿病肾病52例疗效观察[J].中国继续医学教育,2016,8(22):197-198.
[7]赵春艳,刘亚玮.中西医结合治疗糖尿病肾病临床疗效观察[J].四川中医,2016,34(4):65-67.
[8]中华中医药学会肾病分会.糖尿病肾病诊断、辨证分型及疗效评定标准(试行方案)[J].上海中医药杂志,2007,41(7):7-8.
[9]杨广.百令胶囊辅助治疗早期糖尿病肾病的可行性分析[J].中医临床研究,2016,8(16):15-16.
[10]李骏,梁金玲,麦高阳.百令胶囊联合利拉鲁肽治疗早期糖尿病肾病的疗效观察[J].现代药物与临床,2016,31(2):174-177.
[11]刘莉,魏莱,侯君,等.维格列汀联合二甲双胍治疗2型糖尿病肾病患者疗效及其对血清炎性因子的影响[J].疑难病杂志,2016,15(11):1124-1126,1130.
[12]侯翠荣.天芪降糖胶囊联合二甲双胍治疗糖尿病肾病的疗效观察[J].内蒙古中医药,2017,36(8):81-82.
[13]潘金英,黄波,成蔚,等.糖尿病肾病患者血清脂联素、尿微量白蛋白的相关性分析[J].热带医学杂志,2015,15(3):303-306.
[14]邵小群,陈捷,王世俊,等.老年2型糖尿病肾病与FGF-21、脂联素及胰岛β细胞功能的相关性分析[J].检验医学,2016,31(6):462-466.
[15]李斌,张跃,郭兵.肾炎舒颗粒联合氯沙坦治疗早期糖尿病肾病的疗效及对血清炎症因子的影响[J].重庆医学,2015,44(34):4835-4837.
[16]宋光明,柴可夫,杜月光. LOX-1和炎症因子在糖尿病肾病中的作用及糖肾颗粒早期干预研究[J].内蒙古中医药,2016,35(1):137-139.
[17]李雪英,杨丽霞,姜良恩,等.炎症因子在糖尿病肾病发病机制中的中西医研究述评[J].世界中西医结合杂志,2016,11(4):572-575.
[2] Hadjadj S,Cariou B,Fumeron F,et al. Death,end-stage renal disease and renal function decline in patients with diabetic nephropathy in French cohorts of type 1 and type 2 diabetes[J].Diabetologia,2016,59(1):208-216.
[3] Rahimi Z. The role of renin angiotensin aldosterone system genes in diabetic nephropathy[J]. Can J Diabetes,2016,40(2):178-183.
[4] Betz B B,Jenks S J,Cronshaw A D,et al. Urinary peptidomics in a rodent model of diabetic nephropathy highlights epidermal growth factor as a biomarker for renal deterioration in patients with type 2 diabetes[J]. Kidney Int, 2016, 89(5):1125-1135.
[5]杨敬伟.中西医结合治疗糖尿病肾病30例临床研究[J].江苏中医药,2016,48(4):39-40.
[6]朱风琴,赵晓光.中西医结合治疗糖尿病肾病52例疗效观察[J].中国继续医学教育,2016,8(22):197-198.
[7]赵春艳,刘亚玮.中西医结合治疗糖尿病肾病临床疗效观察[J].四川中医,2016,34(4):65-67.
[8]中华中医药学会肾病分会.糖尿病肾病诊断、辨证分型及疗效评定标准(试行方案)[J].上海中医药杂志,2007,41(7):7-8.
[9]杨广.百令胶囊辅助治疗早期糖尿病肾病的可行性分析[J].中医临床研究,2016,8(16):15-16.
[10]李骏,梁金玲,麦高阳.百令胶囊联合利拉鲁肽治疗早期糖尿病肾病的疗效观察[J].现代药物与临床,2016,31(2):174-177.
[11]刘莉,魏莱,侯君,等.维格列汀联合二甲双胍治疗2型糖尿病肾病患者疗效及其对血清炎性因子的影响[J].疑难病杂志,2016,15(11):1124-1126,1130.
[12]侯翠荣.天芪降糖胶囊联合二甲双胍治疗糖尿病肾病的疗效观察[J].内蒙古中医药,2017,36(8):81-82.
[13]潘金英,黄波,成蔚,等.糖尿病肾病患者血清脂联素、尿微量白蛋白的相关性分析[J].热带医学杂志,2015,15(3):303-306.
[14]邵小群,陈捷,王世俊,等.老年2型糖尿病肾病与FGF-21、脂联素及胰岛β细胞功能的相关性分析[J].检验医学,2016,31(6):462-466.
[15]李斌,张跃,郭兵.肾炎舒颗粒联合氯沙坦治疗早期糖尿病肾病的疗效及对血清炎症因子的影响[J].重庆医学,2015,44(34):4835-4837.
[16]宋光明,柴可夫,杜月光. LOX-1和炎症因子在糖尿病肾病中的作用及糖肾颗粒早期干预研究[J].内蒙古中医药,2016,35(1):137-139.
[17]李雪英,杨丽霞,姜良恩,等.炎症因子在糖尿病肾病发病机制中的中西医研究述评[J].世界中西医结合杂志,2016,11(4):572-575.