摘要
目的 :探讨利拉鲁肽治疗血糖控制不佳的2型糖尿病患者的临床疗效及安全性研究。方法 :选择2015年5月~2017年5月我院接诊的90例血糖控制不佳的2型糖尿病患者为研究对象。按照随机数表法将患者分为观察组(n=45)和对照组(n=45)。观察组使用利拉鲁肽治疗,对照组给予甘精胰岛素治疗。比较两组患者治疗前后血糖、血脂和72h动态血糖监测结果的变化。结果 :治疗后,两组患者血清空腹血糖(FPG)、餐后2h血糖(2hPG)、糖化血红蛋白(HbAlc)水平均低于治疗前,观察组患者血清FPG、2hPG、HbAlc水平明显比对照组低。治疗后,两组患者血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平较治疗前均显著降低,高密度脂蛋白胆固醇(HDL-C)水平显著升高,观察组患者血清TC、TG、LDL-C水平明显低于对照组,HDL-C水平明显高于对照组。在动态血糖参数结果中,两组患者治疗后最大血糖波动幅度(LAGE)、血糖波动系数(SDBG)、平均血糖波动幅度(MAGE)、24h平均血糖水平(24hMBG)较治疗前均显著降低,日平均达标率明显升高。观察组LAGS、SDBG、MAGE、24hMBG水平明显低于对照组,日平均达标率明显比对照组高。结论 :血糖控制不佳的2型糖尿病患者使用利拉鲁肽的降糖效果显著,且无低血糖发生,胃肠道反应少,值得应用推广。
Objective To investigate the clinical efficacy and safety of liraglutide in the treatment of type 2 diabetes mellitus with poor glycemic control. Methods Ninety patients with type 2 diabetes with poor glycemic control who were admitted to our hospital from May 2015 to May 2017 were selected as subjects. According to the random number table method, the patients were divided into observation group(n=45) and control group(n=45). The observation group was treated with liraglutide and the control group was treated with insulin glargine. The changes of blood glucose, blood lipids and 72 h dynamic blood glucose monitoring before and after treatment were compared between the two groups. Results After treatment, the levels of fasting blood glucose(FPG), postprandial blood glucose(2 h PG), glycosylated hemoglobin(HbAlc) in the two groups were lower than those before treatment, while the levels of FPG, 2 h PG and HbAlc in the observation group were significantly lower than those in the control group. After treatment, the levels of serum total cholesterol(TC), triglyceride(TG), low density lipoprotein cholesterol(LDL-C) and high density lipoprotein cholesterol(HDL-C) in the two groups were significantly lower than those before treatment. The levels of serum TC, TG and LDL-C in the observation group were significantly lower than those in the control group,and HDL-C water was significantly higher than that in the control group. The LAGE, SDBG, MAGE and 24 h MBG of the two groups after treatment were significantly lower than those before treatment, and the daily average rate of reaching the standard was significantly higher. The levels of LAGE, SDBG, MAGE and 24 h MBG in the observation group were significantly lower than those in the control group, and the daily average rate of reaching the standard was significantly higher than that in the control group. Conclusion Liraglutide has significant hypoglycemic effect in type 2 diabetes mellitus patients with poor glycemic control, and there is no hypoglycemia and less gastrointestinal reaction, which is worthy of application and promotion.
引文
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