活血化瘀法治疗先兆流产文献的Meta分析
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摘要
目的:评价活血化瘀法治疗先兆流产的临床疗效。方法:检索中国知网、重庆维普全文数据库、万方数据库及PUBMED数据库关于活血化瘀法治疗先兆流产的对照试验文献,筛选文献并提取数据,运用Revman 5. 3统计软件进行Meta分析。结果:符合纳入标准的文献共14篇累计1365例患者,试验组739例,对照组626例;合并效应量OR=3. 26,其95%的可信区间为(2. 40,4. 43),检验结果 Z=7. 57,P<0. 00001。结论:当前文献数据表明,活血化瘀法治疗先兆流产临床疗效高于对照组,其选用活血药物大多为比较温和的养血活血或活血止血类的药物,但因所纳入研究的文献质量较低且存在发表偏倚,缺乏大数据、大样本、高质量的临床研究,未能得出全面肯定的结论,仍需高质量研究的进一步验证。
Objective: To evaluate the efficacy of promoting the blood circulation for removing the blood stasis in treating threatened abortion.Methods: To retrieve the documents about the promoting the blood circulation for removing the blood stasis in treating threatened abortion from CNKI,VIP,WANGFANG and PUBMED databases,extract the data by screening the documents and using Revman 5. 3 software to proceed the meta-analysis.Result: There are 14 documents that meet with the inclusive criteria,including 1365 patients,739 cases of experimental group and 626 cases of controlled group.The combined effect side OR = 3. 26,95% confidence interval is( 2. 40,4. 43),the testing result Z = 7. 57,P < 0. 00001.Conclusion: The current data shows that promoting the blood circulation for removing the blood stasis in treating threatened abortion gets better efficacy than the controlled group.Most of the drugs used for blood circulation are mild blood circulation or blood hemostasis.However,because of the inferior quality and publication bias from the inclusive documents,lack of big data,large sample and high-quality clinical trials,the fully affirmed conclusion have not been drawn,which need highquality trials to be validated.
Objective: To evaluate the efficacy of promoting the blood circulation for removing the blood stasis in treating threatened abortion.Methods: To retrieve the documents about the promoting the blood circulation for removing the blood stasis in treating threatened abortion from CNKI,VIP,WANGFANG and PUBMED databases,extract the data by screening the documents and using Revman 5. 3 software to proceed the meta-analysis.Result: There are 14 documents that meet with the inclusive criteria,including 1365 patients,739 cases of experimental group and 626 cases of controlled group.The combined effect side OR = 3. 26,95% confidence interval is( 2. 40,4. 43),the testing result Z = 7. 57,P < 0. 00001.Conclusion: The current data shows that promoting the blood circulation for removing the blood stasis in treating threatened abortion gets better efficacy than the controlled group.Most of the drugs used for blood circulation are mild blood circulation or blood hemostasis.However,because of the inferior quality and publication bias from the inclusive documents,lack of big data,large sample and high-quality clinical trials,the fully affirmed conclusion have not been drawn,which need highquality trials to be validated.
引文
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[13]崔晓萍,杨鉴冰,邰迎春.胎儿安冲剂治疗胎漏胎动不安50例[J].陕西中医,2002,23(5):387-388.
[14]罗献英,王炎秋,林洁.化瘀止血法在早期先兆流产中治疗作用的临床观察[J].湖南中医药导报,2000,6(6):26-27.
[15]谢幸,苟文丽.妇产科学[M].8版.北京:人民卫生出版社,2015:47-51.
[2]骆春,谢正华,徐慧婷.益君化瘀补肾安胎汤治疗先兆流产的临床观察[J].世界临床药物,2016,37(5):328-331.
[3]陈茶荣,王水明.自拟暖宫化瘀汤联合西药治疗血瘀型先兆流产68例[J].江西中医药大学学报,2016,28(2):48-50.
[4]贺爱华.补肾健脾活血法治疗早期先兆流产合并绒毛膜下血肿临床观察[J].黑龙江中医药,2015,47(4):26-27.
[5]邓娟,陆金霞,马瑞芬.中西医结合治疗高子宫动脉血流阻力指数早期先兆流产15例[J].浙江中医杂志,2015,50(12):915.
[6]时思毛,邹红,杨新鸣.补肾活血法合地屈孕酮治疗早期先兆流产合并绒毛膜下出血的临床研究[J].医学信息,2014,27(7):31-32.
[7]倪娇芳,王鹭霞,吴涢婷.定痛止血安胎方治疗血瘀肾虚型先兆流产临床研究[J].中医药通报,2014,13(3):37-40.
[8]张雪,须义贞,王采文.两种中医治则治疗先兆流产401例回顾分析[J].辽宁中医杂志,2013,40(8):1599-1600.
[9]张莉莉,侯莉莉.补肾活血中药治疗胚胎移植术后先兆流产[J].中外医疗,2013,32(28):139-141.
[10]甘小利.活血化瘀法在先兆流产中的运用[J].光明中医,2013,28(12):2656-2659.
[11]王晨晔,丁彩飞.中西结合治疗胚胎移植后早期先兆流产30例[J].环球中医药,2012,5(6):463-464.
[12]侯莉莉,沈玮玮.健脾补肾活血法治疗先兆流产合并宫腔血肿51例[J].四川中医,2010,28(11):96-97.
[13]崔晓萍,杨鉴冰,邰迎春.胎儿安冲剂治疗胎漏胎动不安50例[J].陕西中医,2002,23(5):387-388.
[14]罗献英,王炎秋,林洁.化瘀止血法在早期先兆流产中治疗作用的临床观察[J].湖南中医药导报,2000,6(6):26-27.
[15]谢幸,苟文丽.妇产科学[M].8版.北京:人民卫生出版社,2015:47-51.