力学刺激对膝骨关节炎软骨细胞作用的分子生物学机制进展
摘要
<正>膝骨关节炎(Knee Osteoarthritis,KOA)是一种常见的慢性疾病,并随着年龄的增加发病率不断上升。关于KOA的发病的确切机制尚未明确,而力学刺激引起软骨细胞、细胞外基质以及软骨下骨三者降解与合成失衡是当前研究的热点。本文就从力学刺激对膝骨关节炎软骨细胞、细胞外基质以及细胞骨架作用的分子学机制方面进行综述。1力学刺激对软骨细胞增殖和分化的影响软骨细胞作为维持人体运动系统完整性的重要结构,其形态、功能以及增殖、分化和修复等均受各种力
引文
[1]莫骏,陈颖,仲冬艳,等.适量循环压应力影响细胞骨架促进关节软骨细胞的合成代谢[J].中国组织工程研究,2016,20(37):5511~5517.
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[3]李灿锋,陈卓,杨静,等.miR-140在不同阶段骨关节炎软骨细胞中的表达规律及功能[J].实用骨科杂志,2017,23(11):995~999.
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[5]段王平,苑伟,孙振伟,等.力学刺激对体外立体培养软骨细胞基质代谢的影响[J].实用骨科杂志,2015,21(5):428~431.
[6]M Tatsumura,M Sakane,N Ochiai,et al.Off-loading of cyclic hydrostatic pressure promotes production of extracellular matrix by chondrocytes[J].Cells Tissues Organs,2014,198(6):405~413.
[7]徐守宇,张丽梅,姚新苗,等.低强度脉冲超声对兔膝骨关节炎软骨细胞外基质的影响及机制[J].中国骨伤,2014,27(9):766~771.
[8]杜登悝,陈世荣,易刚,等.低强度脉冲超声促进人骨性关节炎软骨细胞合成细胞外基质[J].细胞与分子免疫学杂志,2016,32(11):1536~1540.
[9]P Xia,S Ren,Q Lin,et al.Low-intensity pulsed ultrasound affects chondrocyte extracellular matrix production via an integrin-mediated p38 MAPK signaling pathway[J].Ultrasound in Medicine&Biology,2015,41(6):1690~1700.
[10]Gronau T,Krüger K,Prein C,et al.Forced exercise-induced osteoarthritis is attenuated in mice lacking the small leucine-rich proteoglycan decorin[J].Ann Rheum Dis,2017,76(2):442~449.
[11]黄术,杨君君,吴江怡,等.细胞骨架结构改变对软骨细胞表型的影响[J].中国医学物理学杂志,2017,14(12):1287~1292.
[12]Chen C,Yin L,Song X,et al.Effects of vimentin disruption on the mechanoresponses of articular chondrocyte[J].Biochem Biophys Res Commun,2016,469(1):132~137.
[13]宋雄波,吴江怡,黄术,等.调节软骨细胞骨架蛋白对成软骨表型的影响[J].第三军医大学学报,2015,37(21):2137~2141.
[14]王雪冰,宋玉娟,邓雪峰,等.软骨细胞在机械力刺激下细胞骨架及细胞形态改变的体外研究[J].中国医药科学,2017,7(1):36~40.
[15]Jalilian I,Heu C,Cheng H,et al.Cell elasticity is regulated by the tropomyosin isoform composition of the actin cytoskeleton[J].PLoS One,2015,10(5):e0126214.
[2]黄正,杨松滨,刘益杰,等.不同频率的周期性压力对兔软骨细胞影响的生物学研究[J].河北医学,2014,20(12):1941~1944.
[3]李灿锋,陈卓,杨静,等.miR-140在不同阶段骨关节炎软骨细胞中的表达规律及功能[J].实用骨科杂志,2017,23(11):995~999.
[4]Cheleschi S,De Palma A,Pecorelli A,et al.Hydrostatic pressure regulates microRNA expression levels in osteoarthritic chondrocyte cultures via the Wnt/β-catenin pathway[J].International Journal of Molecular Sciences,2017,18(1):133.
[5]段王平,苑伟,孙振伟,等.力学刺激对体外立体培养软骨细胞基质代谢的影响[J].实用骨科杂志,2015,21(5):428~431.
[6]M Tatsumura,M Sakane,N Ochiai,et al.Off-loading of cyclic hydrostatic pressure promotes production of extracellular matrix by chondrocytes[J].Cells Tissues Organs,2014,198(6):405~413.
[7]徐守宇,张丽梅,姚新苗,等.低强度脉冲超声对兔膝骨关节炎软骨细胞外基质的影响及机制[J].中国骨伤,2014,27(9):766~771.
[8]杜登悝,陈世荣,易刚,等.低强度脉冲超声促进人骨性关节炎软骨细胞合成细胞外基质[J].细胞与分子免疫学杂志,2016,32(11):1536~1540.
[9]P Xia,S Ren,Q Lin,et al.Low-intensity pulsed ultrasound affects chondrocyte extracellular matrix production via an integrin-mediated p38 MAPK signaling pathway[J].Ultrasound in Medicine&Biology,2015,41(6):1690~1700.
[10]Gronau T,Krüger K,Prein C,et al.Forced exercise-induced osteoarthritis is attenuated in mice lacking the small leucine-rich proteoglycan decorin[J].Ann Rheum Dis,2017,76(2):442~449.
[11]黄术,杨君君,吴江怡,等.细胞骨架结构改变对软骨细胞表型的影响[J].中国医学物理学杂志,2017,14(12):1287~1292.
[12]Chen C,Yin L,Song X,et al.Effects of vimentin disruption on the mechanoresponses of articular chondrocyte[J].Biochem Biophys Res Commun,2016,469(1):132~137.
[13]宋雄波,吴江怡,黄术,等.调节软骨细胞骨架蛋白对成软骨表型的影响[J].第三军医大学学报,2015,37(21):2137~2141.
[14]王雪冰,宋玉娟,邓雪峰,等.软骨细胞在机械力刺激下细胞骨架及细胞形态改变的体外研究[J].中国医药科学,2017,7(1):36~40.
[15]Jalilian I,Heu C,Cheng H,et al.Cell elasticity is regulated by the tropomyosin isoform composition of the actin cytoskeleton[J].PLoS One,2015,10(5):e0126214.