牛樟芝的研究现状·问题与展望
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摘要
近年来,牛樟芝以其稀有的资源和独特的功效为人们所关注。从分类学地位、寄生范围及分布、生活史及有性生殖类型、药理学作用及化学成分、人工栽培等方面对牛樟芝的研究现状进行总结,指出研究中存在的一些问题,并对前景进行展望。
Because of the scarcest resource and unique efficacy,Taiwanofungus camphorates has aroused people's wide concern.We reviewed recent research progresses of Taiwanofungus camphorates on taxonomy,host range and distribution,life cycle and mode of sexual reproduction,pharmacology effect and chemical constituents and artificial cultivation.We also discussed the major issues remaining in the current research for this fungal organism and suggested the approaches for future studies.
Because of the scarcest resource and unique efficacy,Taiwanofungus camphorates has aroused people's wide concern.We reviewed recent research progresses of Taiwanofungus camphorates on taxonomy,host range and distribution,life cycle and mode of sexual reproduction,pharmacology effect and chemical constituents and artificial cultivation.We also discussed the major issues remaining in the current research for this fungal organism and suggested the approaches for future studies.
引文
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[4]GEETHANGILI M,TZENG Y.Review of pharmacological effects of Antrodia camphorate and its bioactive compounds[J].Evidence-based complementary and alternative medicine,2011,2011:1-17.
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[6]HO C L,WANG J L,LEE C C,et al.Antroquinonol blocks Ras and Rho signaling via the inhibition of protein isoprenyltransferase activity in cancer cells[J].Biomedicine&pharmacotherapy,2014,68(8):1007-1014.
[7]汪雯翰,孙太萍,杨海芮,等.樟芝子实体和菌丝体萃取物的抑菌及抗氧化活性[J].食用菌学报,2016,23(2):79-83.
[8]刘燕隔.牛樟芝菌株培养条件优化、抗疲劳及保肝作用研究[D].长春:吉林大学,2016.
[9]臧穆,苏庆华.我国台湾产灵芝属一新种---樟芝[J].云南植物研究,1990,12(4):395-396.
[10]陈体强,方忠玉.台湾珍稀药用菌樟芝及其寄(腐)生树种牛樟[J].福建农业科技,2003(1):41-42.
[11]CHANG T T,CHOU W N.Antrodia cinnamomea sp.nov.on Cinnamomum kanehirai in Taiwan[J].Mycological research,1995,99(6):756-758.
[12]WU S H,RYVARDEN L,CHANG T T.Antrodia camphorata(“niu-chang-chih”),new combination of a medicinal fungus in Taiwan[J].Bot Bull Acad Sin,1997,38:273-275.
[13]CHANG T T,CHOU W N.Antrodia cinnamomea reconsidered and A.salmonea sp.nov.on Cunninghamia konishii in Taiwan[J].Bot Bull Acad Sinica,2004,45:347-352.
[14]徐唯哲.借由分析18S r DNA序列探讨牛樟芝在多孔菌的亲缘关系[D].台中:东海大学,1997.
[15]WU S H,YU Z H,DAI Y C,et al.Taiwanofungus,a polypore new genus[J].Fung Sci,2004,19(3/4):109-116.
[16]张东柱.台湾特有珍贵药用真菌牛樟芝[J].食药用菌,2011,19(1):33-34.
[17]黄大斌,杨菁,黄进华,等.樟芝生物学特性研究[J].食用菌学报,2001,8(2):24-28.
[18]杨远波,刘和义,吕胜由.台湾维管束植物简志Ⅱ.种子植物门[M].台北:台湾省行政院农业委员会,1999:131-133.
[19]理筱龙.牛樟芝之简介[C]//中国菌物学会.首届药用真菌产业发展暨学术研讨会论文集.北京:中国菌物学会,2005:79-80.
[20]杨亚道.牛樟芝培养与观察研究[D].台中:朝阳科技大学,2011.
[21]周德庆.微生物学教程[M].2版.北京:高等教育出版社,2002:58.
[22]浦跃武,熊冬生.樟芝的研究及其应用现状[J].中国医院药学杂志,2005,25(2):171-173.
[23]刘华,周堃,贾薇,等.药用真菌樟芝菌丝体多糖提取工艺及活性的研究[J].食品科学,2007,28(6):243-245.
[24]陈柏玮.牛樟芝子实体酒精萃取物之基因毒理评估及对大鼠短期致肝癌性之影响[D].台中:中兴大学,2017.
[25]陈启桢,苏庆华,蓝明煌.樟芝固体栽培及其生物活性之研究[J].中华真菌学会会刊,2001,16(2):65-72.
[26]刘晓凤,王召初,高昊峰,等.牛樟芝发酵碎红茶及其特性研究[J].工业微生物,2018(1):14-21.
[27]CHENG J J,YANG C J,CHENG C H,et al.Characterization and functional study of Antrodia camphorata lipopolysaccharide[J].J Agric Food Chem,2005,53(2):469-474.
[28]李晶,林雄杰,何静敏,等.牛樟芝菌丝体和子实体三萜含量测定及Se和Mvd基因表达分析[J].西南农业学报,2016,29(9):2206-2211.
[29]林信亿.高效液相层析紫外光侦测器飞行式质谱仪于牛樟芝子实体乙醇萃取物之分析[J].台湾:虎尾科技大学,2015.
[30]CHEN L Y,SHEU M T,LIU D Z,et al.Pretreatment with an ethanolic extract of Taiwanofungus camphoratus(Antrodia camphorata)enhances the cytotoxic effects of amphotericin B[J].J Agric Food Chem,2011,59(20):11255-11263.
[31]NAKAMURA N,HIRAKAWA A,GAO J J,et al.Five new maleic and succinic acid derivatives from the mycelium of Antrodia camphorata and their cytotoxic effects on LLC tumor cell line[J].J Nat Prod,2004,67(1):46-48.
[32]ZAKARIJA A,SOFF G.Update on angiogenesis inhibitors[J].Curr Opin Oncol,2005,17(6):578-583.
[33]YANG H L,KUO Y H,TSAI C T,et al.Anti-metastatic activities of Antrodia camphorata against human breast cancer cells mediated through suppression of the MAPK signaling pathway[J].Food and chemical toxicology,2011,49(1):290-298.
[34]SONG T Y,YEN G C.Antioxidant properties of Antrodia camphorata in submerged culture[J].J Agric Food Chem,2002,50(11):3322-3327.
[35]SONG T Y,YEN G C.Protective effects of fermented filtrate from Antrodia camphorata in submerged culture against CCl4-induced hepatic toxicity in rats[J].J Agric Food Chem,2003,51(6):1571-1577.
[36]WU M T,TZANG B S,CHANG Y Y,et al.Effects of Antrodia camphorata on alcohol clearance and antifibrosis in livers of rats continuously fed alcohol[J].J Agric Food Chem,2011,59(8):4248-4254.
[37]HUANG G J,DENG J S,HUANG S S,et al.Protective effect of antrosterol from Antrodia camphorata submerged whole broth against carbon tetrachloride-induced acute liver injury in mice[J].Food chemistry,2012,132(2):709-716.
[38]HSIEH Y H,CHU F H,WANG Y S,et al.Antrocamphin A,an anti-inflammatory principal from the fruiting body of Taiwanofungus camphoratus,and its mechanisms[J].J Agric Food Chem,2010,58(5):3153-3158.
[39]LI S L,HUANG Z N,HSIEH H H,et al.The augmented anti-tumor effects of Antrodia camphorata co-fermented with Chinese medicinal herb in human hepatoma cells[J].Am J Chin Med,2009,37(4):771-783.
[40]HUANG G J,HUANG S S,LIN S L,et al.Analgesic effects and the mechanisms of anti-inflammation of ergostatrien-3β-ol from Antrodia camphorata submerged whole broth in mice[J].J Agric Food Chem,2010,58(12):7445-7452.
[41]陆震鸣.樟芝深层液态发酵及其三萜类化合物的研究[D].无锡:江南大学,2009.
[42]CHEN C H,YANG S W.New steroid acids from Antrodia cinnamomea,a fungal parasite of Cinnamomum micranthum[J].J Nat Prod,1995,58(11):1655-1661.
[43]CHIANG H C,WU D P,CHERNG I W,et al.Asequiterpene lactone,phenyl and biphenyl compounds from Antrodia camphorate[J].Phytochemistry,1995,39(3):613-616.
[44]CHERNG H C,WU D P,CHERNG I W,et al.Triterpenoids from Antrodia cinnamomea[J].Phytochemistry,1996,41(1):263-267.
[45]陈体强,方忠玉.珍稀药用菌樟芝研究现状与进展[J].食用菌学报,2003,10(4):55-60.
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