丙种球蛋白辅助治疗新生儿RSV肺炎的疗效及对免疫功能的影响观察
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摘要
目的探讨丙种球蛋白辅助治疗新生儿呼吸道合胞病毒(RSV)肺炎的疗效及对免疫功能的影响。方法 50例新生儿RSV肺炎患儿,随机分为对照组和观察组,每组25例。对照组采用常规治疗方法 ,观察组在对照组治疗基础上使用丙种球蛋白辅助治疗。观察比较两组患儿治疗后咳嗽、气促、喘息、发热、肺部湿啰音及喘鸣音、肺部阴影等症状消失时间;治疗后免疫球蛋白(Ig)G、IgA、IgM、白细胞介素-2(IL-2)等免疫因子水平;临床疗效。结果观察组患儿治疗总有效率为96.00%,明显高于对照组的72.00%,差异具有统计学意义(P<0.05)。观察组患儿的咳嗽、气促、喘息、发热、肺部湿啰音及喘鸣音、肺部阴影等症状消失时间均明显短于对照组,差异具有统计学意义(P<0.05)。观察组患儿治疗后IgG、IgA、IgM水平均明显高于对照组, IL-2水平明显低于对照组,差异具有统计学意义(P<0.05)。结论丙种球蛋白辅助治疗新生儿RSV肺炎的疗效显著,能加快症状消退,促进免疫功能的提高,提升治愈率,具有积极的临床意义。
Objective To discuss the efficacy of gamma globulin in adjuvant treatment of neonatal respiratory syncytial virus(RSV) pneumonia and its effect on immune function. Methods A total of 50 neonatal RSV pneumonia children were randomly divided into control group and observation group, with 25 cases in each group. The control group received conventional therapy, and the observation group received gamma globulin for adjuvant treatment on the basis of the control group. Observation and comparison were made on cough, shortness of breath, wheezing, fever, pulmonary rales, wheezing and lung shadows disappearance time, immunoglobulin(Ig) G, IgA, IgM, interleukin-2(IL-2) after treatment and clinical efficacy between the two groups. Results The observation group had total treatment effective rate as 96.00% than 72.00% in the control group, and the difference was statistically significant(P<0.05). The observation group had obviously shorter cough, shortness of breath, wheezing, fever, pulmonary rales, wheezing rales and lung shadows disappearance time than the control group, and the difference was statistically significant(P<0.05). After treatment, the observation group had obviously higher IgG, IgA and IgM than the control group, and obviously lower IL-2 than the control group. Their difference was statistically significant(P<0.05). Conclusion The efficacy of gamma globulin in the treatment of neonatal RSV pneumonia is significant. It can accelerate the symptoms subsidence, promote the improvement of immune function and improve the cure rate. This method has a positive clinical significance.
Objective To discuss the efficacy of gamma globulin in adjuvant treatment of neonatal respiratory syncytial virus(RSV) pneumonia and its effect on immune function. Methods A total of 50 neonatal RSV pneumonia children were randomly divided into control group and observation group, with 25 cases in each group. The control group received conventional therapy, and the observation group received gamma globulin for adjuvant treatment on the basis of the control group. Observation and comparison were made on cough, shortness of breath, wheezing, fever, pulmonary rales, wheezing and lung shadows disappearance time, immunoglobulin(Ig) G, IgA, IgM, interleukin-2(IL-2) after treatment and clinical efficacy between the two groups. Results The observation group had total treatment effective rate as 96.00% than 72.00% in the control group, and the difference was statistically significant(P<0.05). The observation group had obviously shorter cough, shortness of breath, wheezing, fever, pulmonary rales, wheezing rales and lung shadows disappearance time than the control group, and the difference was statistically significant(P<0.05). After treatment, the observation group had obviously higher IgG, IgA and IgM than the control group, and obviously lower IL-2 than the control group. Their difference was statistically significant(P<0.05). Conclusion The efficacy of gamma globulin in the treatment of neonatal RSV pneumonia is significant. It can accelerate the symptoms subsidence, promote the improvement of immune function and improve the cure rate. This method has a positive clinical significance.
引文
[1]徐利,杨征,何挺,等.静脉注射丙种球蛋白辅治婴幼儿重症肺炎的临床疗效及免疫功能观察.实用心脑肺血管病杂志,2012,20(2):253-254.
[2]吴风栋,胡勇,陈坚强.丙种球蛋白对婴幼儿重症肺炎的辅助治疗作用.现代中西医结合杂志,2012,21(14):1527-1528.
[3]高杰.丙种球蛋白辅助治疗新生儿肺炎的疗效及对免疫功能的影响.中国妇幼保健,2016,31(7):1451-1453.
[4]张颖辉,冯国仙,孙小莉.静脉滴注丙种球蛋白治疗新生儿肺炎的效果及对免疫功能的影响.中国医药科学,2017,7(5):52-55.
[5]王珍妮,龚唯鸣,肖晓东.丙种球蛋白治疗新生儿肺炎的疗效及其对免疫功能的影响.现代医院,2018,18(3):423-425.
[6]谢意茹.静脉注射丙种球蛋白对新生儿肺炎的临床疗效以及对免疫功能的影响.北方药学,2017(5):29.
[7]张玉荣,杨文东.静脉注射丙种球蛋白辅助治疗婴幼儿重症肺炎的疗效观察.实用心脑肺血管病杂志,2012,20(8):1334.
[8]刘相英.静脉丙种球蛋白辅治婴幼儿重症肺炎疗效观察.现代中西医结合杂志,2010,19(26):3310-3311.
[9]陈柱荣,林天云.静注丙种球蛋白辅治婴幼儿肺炎的临床疗效及免疫功能观察.中国农村卫生,2012(z2):399-400.
[10]曹静,李春燕.丙种球蛋白辅助治疗新生儿肺炎的疗效及对免疫功能的影响.医药论坛杂志,2016(4):23-26.
[11]邵志英,朱敏蓉,陆俊,等.中西医治疗联合丙种球蛋白对新生儿肺炎的疗效观察.世界中医药,2017(11):2630-2633.
[12]胡孝成,刘宁.丙种球蛋白辅助治疗新生儿肺炎疗效分析.当代医学,2018(9):45-48.
[2]吴风栋,胡勇,陈坚强.丙种球蛋白对婴幼儿重症肺炎的辅助治疗作用.现代中西医结合杂志,2012,21(14):1527-1528.
[3]高杰.丙种球蛋白辅助治疗新生儿肺炎的疗效及对免疫功能的影响.中国妇幼保健,2016,31(7):1451-1453.
[4]张颖辉,冯国仙,孙小莉.静脉滴注丙种球蛋白治疗新生儿肺炎的效果及对免疫功能的影响.中国医药科学,2017,7(5):52-55.
[5]王珍妮,龚唯鸣,肖晓东.丙种球蛋白治疗新生儿肺炎的疗效及其对免疫功能的影响.现代医院,2018,18(3):423-425.
[6]谢意茹.静脉注射丙种球蛋白对新生儿肺炎的临床疗效以及对免疫功能的影响.北方药学,2017(5):29.
[7]张玉荣,杨文东.静脉注射丙种球蛋白辅助治疗婴幼儿重症肺炎的疗效观察.实用心脑肺血管病杂志,2012,20(8):1334.
[8]刘相英.静脉丙种球蛋白辅治婴幼儿重症肺炎疗效观察.现代中西医结合杂志,2010,19(26):3310-3311.
[9]陈柱荣,林天云.静注丙种球蛋白辅治婴幼儿肺炎的临床疗效及免疫功能观察.中国农村卫生,2012(z2):399-400.
[10]曹静,李春燕.丙种球蛋白辅助治疗新生儿肺炎的疗效及对免疫功能的影响.医药论坛杂志,2016(4):23-26.
[11]邵志英,朱敏蓉,陆俊,等.中西医治疗联合丙种球蛋白对新生儿肺炎的疗效观察.世界中医药,2017(11):2630-2633.
[12]胡孝成,刘宁.丙种球蛋白辅助治疗新生儿肺炎疗效分析.当代医学,2018(9):45-48.