摘要
目的探讨丙种球蛋白辅助治疗新生儿呼吸道合胞病毒(RSV)肺炎的疗效及对免疫功能的影响。方法 50例新生儿RSV肺炎患儿,随机分为对照组和观察组,每组25例。对照组采用常规治疗方法 ,观察组在对照组治疗基础上使用丙种球蛋白辅助治疗。观察比较两组患儿治疗后咳嗽、气促、喘息、发热、肺部湿啰音及喘鸣音、肺部阴影等症状消失时间;治疗后免疫球蛋白(Ig)G、IgA、IgM、白细胞介素-2(IL-2)等免疫因子水平;临床疗效。结果观察组患儿治疗总有效率为96.00%,明显高于对照组的72.00%,差异具有统计学意义(P<0.05)。观察组患儿的咳嗽、气促、喘息、发热、肺部湿啰音及喘鸣音、肺部阴影等症状消失时间均明显短于对照组,差异具有统计学意义(P<0.05)。观察组患儿治疗后IgG、IgA、IgM水平均明显高于对照组, IL-2水平明显低于对照组,差异具有统计学意义(P<0.05)。结论丙种球蛋白辅助治疗新生儿RSV肺炎的疗效显著,能加快症状消退,促进免疫功能的提高,提升治愈率,具有积极的临床意义。
Objective To discuss the efficacy of gamma globulin in adjuvant treatment of neonatal respiratory syncytial virus(RSV) pneumonia and its effect on immune function. Methods A total of 50 neonatal RSV pneumonia children were randomly divided into control group and observation group, with 25 cases in each group. The control group received conventional therapy, and the observation group received gamma globulin for adjuvant treatment on the basis of the control group. Observation and comparison were made on cough, shortness of breath, wheezing, fever, pulmonary rales, wheezing and lung shadows disappearance time, immunoglobulin(Ig) G, IgA, IgM, interleukin-2(IL-2) after treatment and clinical efficacy between the two groups. Results The observation group had total treatment effective rate as 96.00% than 72.00% in the control group, and the difference was statistically significant(P<0.05). The observation group had obviously shorter cough, shortness of breath, wheezing, fever, pulmonary rales, wheezing rales and lung shadows disappearance time than the control group, and the difference was statistically significant(P<0.05). After treatment, the observation group had obviously higher IgG, IgA and IgM than the control group, and obviously lower IL-2 than the control group. Their difference was statistically significant(P<0.05). Conclusion The efficacy of gamma globulin in the treatment of neonatal RSV pneumonia is significant. It can accelerate the symptoms subsidence, promote the improvement of immune function and improve the cure rate. This method has a positive clinical significance.
引文
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