TNF-α基因238位点多态性与乳腺癌易感性关系Meta分析
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摘要
目的目前关于TNF-α基因238位点多态性与女性乳腺癌易感性的报道不一致。本研究通过Meta分析的方法探讨TNF-α基因238位点多态性与乳腺癌易感性的关系。方法通过检索万方、维普、PubMed和Medline数据库,检索时间为1996-01—2016-12,获取相关文献及研究结果,以乳腺癌组与对照组人群TNF-α基因SNP-238位点基因型分布的OR值为效应指标,采用Stata 11软件进行荟萃分析。结果 Meta分析共纳入9篇文献,累计共77 181例,包括37 429例病例和39 752例对照。等位基因G与A比,OR值为0.980,95%CI:0.960~1.000,P<0.001。亚组分析中亚洲人G等位基因相对于A等位基因OR值为0.982,95%CI:0.782~1.233(P<0.001),而欧美洲人对应的结果 OR值为0.979,95%CI:0.958~1.002,P=0.202。结论总体上,TNF-α基因238位点多态性与乳腺癌易感性无关,不推荐作为筛选乳腺癌基因的候选指标。
OBJECTIVE At present,there is no consistent report on the polymorphisms of the TNF-α-238 and the susceptibility of female breast cancer.This study was to study the relation of genetic polymorphism of TNF-α-238 and breast cancer risk.METHODS All the published studies about TNF-α-238 and breast cancer for the last 20 years were reviewed and standard techniques of meta-analysis to combined with the results of these studies were used to produce a more precise estimate of the significant expression of TNF-α-238.Meta-analysis odds ratios(ORs)were estimated using a fixed effects model or random effects model.RESULTS Nine eligible reports were identified,concerning about 37 429 cancer cases and 39 752 controls.The pooled OR of G allele compared with that of A allele was 0.980(95%CI:0.960-1.000,P<0.001).The pooled OR of G allele compared with that of A allele for Caucasian was 0.979(95%CI:0.958-1.002,P=0.202),for Asian was 0.982(95%CI:0.782-1.233,P<0.001).CONCLUSIONS This meta-analysis suggests that the TNF-a-238 Gallele may not be significantly associated with breast cancer.TNF-a-238 gene is not recommended as a candidate for screening breast cancer genes.Further studies are needed to explore gene-gene and gene-environment interactions.
OBJECTIVE At present,there is no consistent report on the polymorphisms of the TNF-α-238 and the susceptibility of female breast cancer.This study was to study the relation of genetic polymorphism of TNF-α-238 and breast cancer risk.METHODS All the published studies about TNF-α-238 and breast cancer for the last 20 years were reviewed and standard techniques of meta-analysis to combined with the results of these studies were used to produce a more precise estimate of the significant expression of TNF-α-238.Meta-analysis odds ratios(ORs)were estimated using a fixed effects model or random effects model.RESULTS Nine eligible reports were identified,concerning about 37 429 cancer cases and 39 752 controls.The pooled OR of G allele compared with that of A allele was 0.980(95%CI:0.960-1.000,P<0.001).The pooled OR of G allele compared with that of A allele for Caucasian was 0.979(95%CI:0.958-1.002,P=0.202),for Asian was 0.982(95%CI:0.782-1.233,P<0.001).CONCLUSIONS This meta-analysis suggests that the TNF-a-238 Gallele may not be significantly associated with breast cancer.TNF-a-238 gene is not recommended as a candidate for screening breast cancer genes.Further studies are needed to explore gene-gene and gene-environment interactions.
引文
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[10]Sirotkovic-Skerlev M,Cacev T,Krizanac S,et al.TNF alpha promoter polymorphisms analysis in benign and malignant breast lesions[J].Exp Mol Pathol,2007,83(1):54-58.
[11]Gaudet MM,Milne RL,Cox A,et al.Polymorphisms in the BRCA1and ABCB1genes modulate menopausal hormone therapy associated breast cancer risk in postmenopausal women[J].Breast Cancer Res Treat,2010,120(3):727-736.
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[14]Kohaar I,Tiwari P,Kumar R,et al.Association of single nucleotide polymorphisms(SNPs)in TNF-LTA locus with breast cancer risk in Indian population[J].Breast Cancer Res Treat,2009,114(2):347-355.
[15]Pooja S,Francis A,Bid HK,et al.Role of ethnic variations in TNF-alpha and TNFbeta polymorphisms and risk of breast cancer in India[J].Breast Cancer Res Treat,2011,126(3):739-747.
[16]Richardson A,Joof FS,Ackerman H,et a1.Nucleotide diversity of the TNF gene region in all African village[J].Genes Immun,2001,2(6):343-348.
[17]Xu XW,Lu MH,Tan DM.Association between tumor necrosis factor gene polymorphisms and the clinical types of patients with chronic hepatitis B virus infection[J].Clin Micrubiol Infect,2005,11(1):52-56.
[18]Jiang L,He B,Zhao MW,et al.Association of gene polymorphisms of tumor necrosis factor-a and interleukin-13with chronic obstmctive pulmonary disease in Han nationality in Beijing[J].CMJ,2005,118(7):541-547.
[19]Fernandez AM,Arroyo R,Rubio A,et al.Primary association of a TNF gene polymorphism with susceptibility to multiple sclerosis[J].Neurology,1999,53(6):1361-1363.
[20]胡金华,张耀晴,朱斌.乳腺癌患者血清VEGF、TNF-α和IL-6的表达与预后的相关分析[J].现代肿瘤医学,2015,23(5):639-642.
[21]殷咏梅,束永前,陈晓锋,等.TNF-α通过JNK和AP-1途径调节乳腺癌MCF-7细胞VEGF的表达[J].中国肿瘤生物治疗杂志,2009,16(1):12-17.
[22]Gamia-Tunon I,Ricote MV,Ruiz A,et a1.Role of tumor necrosis factor-alpha and its receptors in human benign breast lesions and tumors(in situ and infiltrative)[J].Cancer Sci,2006,97(10):1044-1049.
[23]Cui LF,Guo XJ,wei J,et al.Overexpression of TNF-alpha and TNFRⅡin invasive micropillary carcinoma of the breast:cIiniropaIhological correlaIions[J].Histopalhology,2008,53(4):381-388.
[24]Warren MA,Shoemaker SF,Shealy DJ,et al.Tumor necrosis factor deficiency inhibit s mammary tumo rigenesis and a tumor necrosis factor neutr alizing antibody decreases mammar y tumor growth in neu/erbB2transgenic mice[J].Mol Cancer Ther,2009,8(9):2655-2663.
[25]Yin Y,Chen X,Shu Y.Gene expression of the invasive phenotype of TNF-alpha treated MCF-7cells[J].Biomed Pharmacother,2009,63(6):421-428.
[2]Smyth MJ,Cretney E,Kershaw MH,et al.Cytokines in cancer immunity and immunotherapy[J].Immunol Rev,2004,202(1):275-293.
[3]Takeda K,Smyth MJ,Cretney E,et al.Critical role for tumor necrosis factor-related apoptosis-inducing ligand in immune surveillance against tumor development[J].J Exp Med,2002,195(2):161-169.
[4]Gorelik L,Flavell RA.Transforming growth factor-beta in T-cell biology[J].Nat Rev Immunol,2002,2(1):46-53.
[5]Raabe T,Bukrinsky M,Currie RA.Relative contribution of transcription and translation to the induction of tumor necrosis factor-alpha by lipopolysaccharide[J].J Biol Chem,1998,273(2):974-980.
[6]Louis E,Franchimont D,Piron A,et al.Tumour necrosis factor(TNF)gene polymorphism influences TNF-alpha production in lipopolysaccharide(LPS)-stimulated whole blood cell culture in healthy humans[J].Clin Exp Immunol,1998,113(3):401-406.
[7]陈紫萱,陈德波,林毅胜,等.肿瘤坏死因子α启动子-238/-308基因多态性与乳腺癌的相关性分析[J].中国卫生检验杂志,2016,26(22):3283-3286.
[8]Xu FY,Zhou GQ,Han SL,et al.Association of TNF-a,TNFRSF1A and TNFRSF1Bgene polymorphisms with the risk of sporadic breast cancer in northeast Chinese Han women[EB/OL].PLoS One,2014,9(7):e101138[2017-01-10].https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091942/.
[9]Azmy IA,Balasubramanian SP,Wilson AG,et al.Role of tumor necrosis factor gene polymorphisms(308and 238)in breast cancer susceptibility and severity[J].Breast Cancer Res,2004,6(4):395-400.
[10]Sirotkovic-Skerlev M,Cacev T,Krizanac S,et al.TNF alpha promoter polymorphisms analysis in benign and malignant breast lesions[J].Exp Mol Pathol,2007,83(1):54-58.
[11]Gaudet MM,Milne RL,Cox A,et al.Polymorphisms in the BRCA1and ABCB1genes modulate menopausal hormone therapy associated breast cancer risk in postmenopausal women[J].Breast Cancer Res Treat,2010,120(3):727-736.
[12]Erdei E,Kang H,Meisner A,et al.Polymorphisms in cytokine genes and serum cytokine levels among New Mexican women with and without breast cancer[J].Cytokine,2010,51(1):18-24.
[13]Gaudet MM,Egan KM,Lissowska J,et al.Genetic variation in tumor necrosis factor and lymphotoxin-alpha(TNF-LTA)and breast cancer risk[J].Hum Genet,2007,121(3-4):483-490.
[14]Kohaar I,Tiwari P,Kumar R,et al.Association of single nucleotide polymorphisms(SNPs)in TNF-LTA locus with breast cancer risk in Indian population[J].Breast Cancer Res Treat,2009,114(2):347-355.
[15]Pooja S,Francis A,Bid HK,et al.Role of ethnic variations in TNF-alpha and TNFbeta polymorphisms and risk of breast cancer in India[J].Breast Cancer Res Treat,2011,126(3):739-747.
[16]Richardson A,Joof FS,Ackerman H,et a1.Nucleotide diversity of the TNF gene region in all African village[J].Genes Immun,2001,2(6):343-348.
[17]Xu XW,Lu MH,Tan DM.Association between tumor necrosis factor gene polymorphisms and the clinical types of patients with chronic hepatitis B virus infection[J].Clin Micrubiol Infect,2005,11(1):52-56.
[18]Jiang L,He B,Zhao MW,et al.Association of gene polymorphisms of tumor necrosis factor-a and interleukin-13with chronic obstmctive pulmonary disease in Han nationality in Beijing[J].CMJ,2005,118(7):541-547.
[19]Fernandez AM,Arroyo R,Rubio A,et al.Primary association of a TNF gene polymorphism with susceptibility to multiple sclerosis[J].Neurology,1999,53(6):1361-1363.
[20]胡金华,张耀晴,朱斌.乳腺癌患者血清VEGF、TNF-α和IL-6的表达与预后的相关分析[J].现代肿瘤医学,2015,23(5):639-642.
[21]殷咏梅,束永前,陈晓锋,等.TNF-α通过JNK和AP-1途径调节乳腺癌MCF-7细胞VEGF的表达[J].中国肿瘤生物治疗杂志,2009,16(1):12-17.
[22]Gamia-Tunon I,Ricote MV,Ruiz A,et a1.Role of tumor necrosis factor-alpha and its receptors in human benign breast lesions and tumors(in situ and infiltrative)[J].Cancer Sci,2006,97(10):1044-1049.
[23]Cui LF,Guo XJ,wei J,et al.Overexpression of TNF-alpha and TNFRⅡin invasive micropillary carcinoma of the breast:cIiniropaIhological correlaIions[J].Histopalhology,2008,53(4):381-388.
[24]Warren MA,Shoemaker SF,Shealy DJ,et al.Tumor necrosis factor deficiency inhibit s mammary tumo rigenesis and a tumor necrosis factor neutr alizing antibody decreases mammar y tumor growth in neu/erbB2transgenic mice[J].Mol Cancer Ther,2009,8(9):2655-2663.
[25]Yin Y,Chen X,Shu Y.Gene expression of the invasive phenotype of TNF-alpha treated MCF-7cells[J].Biomed Pharmacother,2009,63(6):421-428.