抗衰老在慢性阻塞性肺疾病中的应用
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摘要
慢性阻塞性肺病简称慢阻肺,是一组以不完全可逆的持续性气流受限为特征的慢性呼吸系统疾病,其确切的发病机制未明。近十几年来国内外许多相关文献报道,慢阻肺的发病与肺衰老关系密切,被称为"加速的肺老化疾病",研究热点多集中在氧化应激失衡、炎症加重、内分泌紊乱、免疫功能低下、端粒假说、抗衰老蛋白表达异常等层面上,二者相互影响,互为因果。中医学在养生保健方面颇有建树,如何把抗衰老的细想运用到中医治疗慢阻肺等慢性病上,将为今后中医治疗慢阻肺等慢性病提供更丰富的手段和依据。
Chronic obstructive pulmonary disease(COPD) is a chronic respiratory disease, which characterized by incomplete reversible persistent airflow limitation, and pathogenesis is unclear, closely related to the pathogenesis of copd and lung aging found in nearly a decade of many literature reports, known as "accelerated aging lung disease". COPD and lung aging were influence each other each. Research hotspot are mostly concentrated in imbalance oxidative stress, inflammation aggravating, endocrine disorders,immune system weakened, telomere hypothesis, anti-aging abnormal protein expression level. Traditional Chinese medicine in health care is quite effective. It will be a new way to apply the anti-aging in TCM treatment on COPD and other chronic disease.
Chronic obstructive pulmonary disease(COPD) is a chronic respiratory disease, which characterized by incomplete reversible persistent airflow limitation, and pathogenesis is unclear, closely related to the pathogenesis of copd and lung aging found in nearly a decade of many literature reports, known as "accelerated aging lung disease". COPD and lung aging were influence each other each. Research hotspot are mostly concentrated in imbalance oxidative stress, inflammation aggravating, endocrine disorders,immune system weakened, telomere hypothesis, anti-aging abnormal protein expression level. Traditional Chinese medicine in health care is quite effective. It will be a new way to apply the anti-aging in TCM treatment on COPD and other chronic disease.
引文
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[23]朱汉平,张志敏,武如通,等.全真一气汤治疗慢性阻塞性肺疾病急性加重期36例[J].中国中医急症,2011,20(1):124-125.
[2] Ito K,Barnes P J. COPD as a disease of accelerated lung aging[J]. Chest,2009,135:173-180.
[3] Janssens J P,Pache J C,Nicod L P. Physiological changes in respiratory functi on associated with ageing[J]. Eur Respir J,1999,13(1):197-205.
[4] Filaire E,Dupuis C,Galvaing G,et al. Lung cancer:what are the links with oxidative stress,physical activity and nutrition[J]. Lung Cancer,2013,82(3):383-389.
[5]孙涛,夏世金,郑松柏.肺衰老[J].老年医学与保健,2013,19(5):322-325.
[6] Passos J F,Nelson G,Wang C,et al. Feedback between p21 and reactive oxygen production is necessary for cell senescence[J]. Mol Syst Biol,2010,6:347.
[7]李彦霖,王思一,刘持.肺衰老与呼吸系统疾病发病关系的研究进展[J].广东医学,2016,37(6):925-928.
[8] CHEN Hua,ZHOU You sheng,ZHU Lin,et al. Study on the function of sex hormone in acute lung injury[J]. Chinese Journal of Emergency Medicine,2004,13(1):34-36.
[9] Minneci P C,Deans K J,Natanson C. Corticosteroid therapy for severe sepsis and septic shock[J]. JAMA,2009,302(15):1643.
[10] Wertheimer A M,Bennett M S,Byung P,et al. Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T cell subsets in humans[J]. J Immunol,2014,192(5):2143-2155.
[11] Freeman C M,Martinez F J,Han MK,et al. Lung CD8+T cells in COPD have increased expression of bacterial TLRs[J].Respir Res,2013,14:13.
[12] Abdelmagid S M,Barbe M F,Safadi F F. Role of inflammation in the aging bones[J]. Life Sci,2015,123:25-34.
[13] Houben J M,Mercken E M,Ketelslegers H B,et al. Telomere shortening in chronic obstructive pulmonary disease[J]. Respir Med,2009,103:230-236.
[14] Amsellem V,Gary-Bobo G,Marcos E,et al. Telomere dysfunction causes sustained inflammation in chronic obstructive pulmonary disease[J].Am J Respir Crit Care Med,2011(184):1358-66.
[15] Kim H S,Xiao C,Wang R H,et al. Hepatic-specififc disruption of SIRT6in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis[J]. Cell Metab,2010,12(3):224-236.
[16]陈洋,平键,沈自尹,等.淫羊藿苷提高SIRT6酶活性及抑制小鼠NF-κB炎症信号通路的实验研究[J].老年医学与保健,2012,18(6):338-341,346.
[17]沈自尹,张新民,林伟,等.基于基因表达谱数据建立肾虚证量化数学模型[J].中国中西医结合杂志,2008,28(2):131-134.
[18]潘露茜,顾耘,许若玢,等.益肾口服液延缓肾精亏虚型生理性衰老的试验研究[J].老年医学与保健,2015,21(2):90-92,100.
[19]蔡定芳,沈自尹,张玲娟,等.右归饮对大鼠下丘脑-垂体-肾上腺-胸腺轴抑制模型的影响[J].中国免疫学杂志,1994,10(4):236-239.
[20] Buffie C G,Pamer E G. Microbiota-mediated colonization resistance against intestinal pathogens[J]. Nature Reviews Immunology,2013.
[21]蔡瑞元.肺与衰老相关的理论及实验研究[D].武汉:湖北中医学院,2005.
[22]李静,陈超畅.黄芪抗衰老作用分子机制的研究进展[J].中国现代药物应用,2008,2(2):92-93.
[23]朱汉平,张志敏,武如通,等.全真一气汤治疗慢性阻塞性肺疾病急性加重期36例[J].中国中医急症,2011,20(1):124-125.