细菌脂肪酸合成多样性的研究进展
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摘要
与哺乳动物、真菌采用I型脂肪酸合成系统不同,细菌采用II型脂肪酸合成系统,每步反应都由独立的酶催化,因此细菌脂肪酸合成酶是研究抗菌药物的优良靶标。研究表明,在不同细菌中参与脂肪酸合成的酶都具有较高的多样性,而脂肪酸种类不同,合成方式也不尽相同,本文对此进行了总结。
Differ from mammalian and fungal system(FAS I) adopting type I fatty acid synthetic system,bacteria adopt type II fatty acid synthetic system,each step of the reactions is catalyzed by independent enzymes,therefore,the synthetic enzyme of bacterial fatty acid is a fine target to study antibiotic medicine.The studies have showed that fatty acid synthetic enzymes take part in different bacteria all have relatively high diversity,and different kinds of fatty acid,the synthetic forms are not fully the same.These respects were summarized in this paper.
Differ from mammalian and fungal system(FAS I) adopting type I fatty acid synthetic system,bacteria adopt type II fatty acid synthetic system,each step of the reactions is catalyzed by independent enzymes,therefore,the synthetic enzyme of bacterial fatty acid is a fine target to study antibiotic medicine.The studies have showed that fatty acid synthetic enzymes take part in different bacteria all have relatively high diversity,and different kinds of fatty acid,the synthetic forms are not fully the same.These respects were summarized in this paper.
引文
[1]Parsons J B,Rock C O.Bacterial lipids:metabolism and membrane homeostasis[J].Prog Lipid Res,2013,52(3):249-276.
[2]Song H,Ao G-Z,Li H-Q.Novel Fab H inhibitors:an updated article literature review(July 2012 to June 2013)[J].Expert opinion on therapeutic patents,2014,24(1):19-27.
[3]Cheng J,Ma J,Lin J,et al.Only One of the Five Ralstonia solanacearum Long-Chain 3-Ketoacyl-Acyl Carrier Protein Synthase Homologues Functions in Fatty Acid Synthesis[J].Appl Environ Microb,2012,78(5):1563-1573.
[4]Zhang Y M,Rock C O.Membrane lipid homeostasis in bacteria[J].Nat Rev Microbiol,2008,6(3):222-233.
[5]Wang X,Quinn P J.Lipopolysaccharide:Biosynthetic pathway and structure modification[J].Prog Lipid Res,2010,49(2):97-107.
[6]Geske G D,O'Neill J C,Miller D M,et al.Comparative analyses of N-acylated homoserine lactones reveal unique structural features that dictate their ability to activate or inhibit quorum sensing[J].Chembiochem,2008,9(3):389-400.
[7]Bi H,Christensen Q H,Feng Y,et al.The Burkholderia cenocepacia BDSF quorum sensing fatty acid is synthesized by a bifunctional crotonase homologue having both dehydratase and thioesterase activities[J].Mol Microbiol,2012,83(4):840-855.
[8]Zhou L,Yu Y,Chen X,et al.The Multiple DSF-family QS Signals are Synthesized from Carbohydrate and Branched-chain Amino Acids via the FAS Elongation Cycle[J].Scientific reports,2015,5:13294.
[9]Lin S,Cronan J E.Closing in on complete pathways of biotin biosynthesis[J].Mol Biosyst,2011,7(6):1811-1821.
[10]Zhu K,Rock C O.Rhl A converts beta-hydroxyacyl-acyl carrier protein intermediates in fatty acid synthesis to the beta-hydroxydecanoyl-beta-hydroxydecanoate component of rhamnolipids in Pseudomonas aeruginosa[J].J Bacteriol,2008,190(9):3147-3154.
[11]Joseph J.Fattening by deprivation:methyl balance and perinatal cardiomyopathy[J].J Pathology,2011,225(3):315-317.
[12]董会娟,余永红,王海洪,等.野油菜黄单胞菌中长链3-酮脂酰ACP合成酶的鉴定[J].华南农业大学学报,2015,36(2):49-54.
[13]Zhu L,Cheng J,Luo B,et al.Functions of the Clostridium acetobutylicium Fab F and Fab Z proteins in unsaturated fatty acid biosynthesis[J].BMC Microbiol,2009,9:119-130.
[14]马金成,邓丽婷,童文华,等.五个3-酮脂酰ACP合成酶同源蛋白的功能鉴定[J].生物化学与生物物理进展,2014,41(9):887-895.
[15]Yuan Y,Sachdeva M,Leeds J A,et al.Fatty acid biosynthesis in Pseudomonas aeruginosa is initiated by the Fab Y class of beta-ketoacyl acyl carrier protein synthases[J].J Bacteriol,2012,194(19):5171-5184.
[16]Yuan Y,Leeds J A,Meredith T C.Pseudomonas aeruginosa directly shunts beta-oxidation degradation intermediates into de novo fatty acid biosynthesis[J].J Bacteriol,2012,194(19):5185-5196.
[17]Ya-Hui Mao J-C M,Feng Li,et al.Ralstonia solanacearum RSp0194 Encodes a Novel 3-Keto-Acyl Carrier Protein Synthase III[J].Plos One,2015,10(8):e0136261.
[18]雷鸣,马金成,王海洪.流产布氏杆菌烯脂酰ACP还原酶的鉴定[J].生物化学与生物物理进展,2012,39(5):464-471.
[19]Zhu L,Bi H,Ma J,et al.The Two Functional Enoyl-Acyl Carrier Protein Reductases of Enterococcus faecalis Do Not Mediate Triclosan Resistance[J].m Bio,2013,4(5):e00613-13.
[20]Kim K H,Ha B H,Kim S J,et al.Crystal structures of EnoylACP reductases I(Fab I)and III(Fab L)from B.subtilis[J].J Mol Biol,2011,406(3):403-415.
[21]Massengo-Tiasse R P,Cronan J E.Vibrio cholerae Fab V defines a new class of enoyl-acyl carrier protein reductase[J].J Biol Chem,2008,283(3):1308-1316.
[22]Li H,Zhang X,Bi L,et al.Determination of the crystal structure and active residues of Fab V,the enoyl-ACP reductase from Xanthomonas oryzae[J].PLo S One,2011,6(10):e26743.
[23]Zhu L,Lin J,Ma J,et al.Triclosan resistance of Pseudomonas aeruginosa PAO1 is due to Fab V,a triclosan-resistant enoyl-acyl carrier protein reductase[J].Antimicrob Agents Chemother,2010,54(2):689-698.
[24]Mou R,Bai F,Duan Q,et al.Mutation of pfm affects the adherence of Pseudomonas aeruginosa to host cells and the quorum sensing system[J].FEMS microbiol lett,2011,324(2):173-180.
[25]Bushby K,Finkel R,Wong B,et al.Ataluren treatment of patients with nonsense mutation dystrophinopathy[J].Muscle&nerve,2014,50(4):477-487.
[26]Bi H,Wang H,Cronan J E.Fab Q,a dual-function dehydratase/isomerase,circumvents the last step of the classical fatty acid synthesis cycle[J].Chem Biol,2013,20(9):1157-1167.
[27]Zhu K,Choi K H,Schweizer H P,et al.Two aerobic pathways for the formation of unsaturated fatty acids in Pseudomonas aeruginosa[J].Mol Microbiol,2006,60(2):260-273.
[28]Chazarreta Cifre L,Alemany M,de Mendoza D,et al.Exploring the biosynthesis of unsaturated fatty acids in Bacillus cereus ATCC 14579 and functional characterization of novel acyl-lipid desaturases[J].Appl Environ Microbiol,2013,79(20):6271-6279.
[29]马金成,周俊超,吴楚云,等.苜蓿中华根瘤菌des A基因功能的鉴定[J].生物化学与生物物理进展,2015,42(8):740-749.
[30]Singh A K,Zhang Y M,Zhu K,et al.Fab H selectivity for anteiso branched-chain fatty acid precursors in low-temperature adaptation in Listeria monocytogenes[J].FEMS Microbiol Lett,2009,301(2):188-192.
[31]Santiago B,Marek M,Faustoferri R C,et al.The Streptococcus mutans aminotransferase encoded by ilv E is regulated by Cod Y and Ccp A[J].J Bacteriol,2013,195(16):3552-3562.
[32]Feng Y,Cronan J E.The Vibrio cholerae fatty acid regulatory protein,FadR,represses transcription of pls B,the gene encoding the first enzyme of membrane phospholipid biosynthesis[J].Mol Microbiol,2011,81(4):1020-1033.
[33]Parsons J B,Rock C O.Is bacterial fatty acid synthesis a valid target for antibacterial drug discovery[J].Curr Opin Microbiol,2011,14:1-6.
[34]Helge Jans Janen,Steinbüchel A.Fatty acid synthesis in Escherichia coli and its applications towards the production of fatty acid based biofuels[J].Biotechnol for Biofuels,2014,7(7):1-26.
[2]Song H,Ao G-Z,Li H-Q.Novel Fab H inhibitors:an updated article literature review(July 2012 to June 2013)[J].Expert opinion on therapeutic patents,2014,24(1):19-27.
[3]Cheng J,Ma J,Lin J,et al.Only One of the Five Ralstonia solanacearum Long-Chain 3-Ketoacyl-Acyl Carrier Protein Synthase Homologues Functions in Fatty Acid Synthesis[J].Appl Environ Microb,2012,78(5):1563-1573.
[4]Zhang Y M,Rock C O.Membrane lipid homeostasis in bacteria[J].Nat Rev Microbiol,2008,6(3):222-233.
[5]Wang X,Quinn P J.Lipopolysaccharide:Biosynthetic pathway and structure modification[J].Prog Lipid Res,2010,49(2):97-107.
[6]Geske G D,O'Neill J C,Miller D M,et al.Comparative analyses of N-acylated homoserine lactones reveal unique structural features that dictate their ability to activate or inhibit quorum sensing[J].Chembiochem,2008,9(3):389-400.
[7]Bi H,Christensen Q H,Feng Y,et al.The Burkholderia cenocepacia BDSF quorum sensing fatty acid is synthesized by a bifunctional crotonase homologue having both dehydratase and thioesterase activities[J].Mol Microbiol,2012,83(4):840-855.
[8]Zhou L,Yu Y,Chen X,et al.The Multiple DSF-family QS Signals are Synthesized from Carbohydrate and Branched-chain Amino Acids via the FAS Elongation Cycle[J].Scientific reports,2015,5:13294.
[9]Lin S,Cronan J E.Closing in on complete pathways of biotin biosynthesis[J].Mol Biosyst,2011,7(6):1811-1821.
[10]Zhu K,Rock C O.Rhl A converts beta-hydroxyacyl-acyl carrier protein intermediates in fatty acid synthesis to the beta-hydroxydecanoyl-beta-hydroxydecanoate component of rhamnolipids in Pseudomonas aeruginosa[J].J Bacteriol,2008,190(9):3147-3154.
[11]Joseph J.Fattening by deprivation:methyl balance and perinatal cardiomyopathy[J].J Pathology,2011,225(3):315-317.
[12]董会娟,余永红,王海洪,等.野油菜黄单胞菌中长链3-酮脂酰ACP合成酶的鉴定[J].华南农业大学学报,2015,36(2):49-54.
[13]Zhu L,Cheng J,Luo B,et al.Functions of the Clostridium acetobutylicium Fab F and Fab Z proteins in unsaturated fatty acid biosynthesis[J].BMC Microbiol,2009,9:119-130.
[14]马金成,邓丽婷,童文华,等.五个3-酮脂酰ACP合成酶同源蛋白的功能鉴定[J].生物化学与生物物理进展,2014,41(9):887-895.
[15]Yuan Y,Sachdeva M,Leeds J A,et al.Fatty acid biosynthesis in Pseudomonas aeruginosa is initiated by the Fab Y class of beta-ketoacyl acyl carrier protein synthases[J].J Bacteriol,2012,194(19):5171-5184.
[16]Yuan Y,Leeds J A,Meredith T C.Pseudomonas aeruginosa directly shunts beta-oxidation degradation intermediates into de novo fatty acid biosynthesis[J].J Bacteriol,2012,194(19):5185-5196.
[17]Ya-Hui Mao J-C M,Feng Li,et al.Ralstonia solanacearum RSp0194 Encodes a Novel 3-Keto-Acyl Carrier Protein Synthase III[J].Plos One,2015,10(8):e0136261.
[18]雷鸣,马金成,王海洪.流产布氏杆菌烯脂酰ACP还原酶的鉴定[J].生物化学与生物物理进展,2012,39(5):464-471.
[19]Zhu L,Bi H,Ma J,et al.The Two Functional Enoyl-Acyl Carrier Protein Reductases of Enterococcus faecalis Do Not Mediate Triclosan Resistance[J].m Bio,2013,4(5):e00613-13.
[20]Kim K H,Ha B H,Kim S J,et al.Crystal structures of EnoylACP reductases I(Fab I)and III(Fab L)from B.subtilis[J].J Mol Biol,2011,406(3):403-415.
[21]Massengo-Tiasse R P,Cronan J E.Vibrio cholerae Fab V defines a new class of enoyl-acyl carrier protein reductase[J].J Biol Chem,2008,283(3):1308-1316.
[22]Li H,Zhang X,Bi L,et al.Determination of the crystal structure and active residues of Fab V,the enoyl-ACP reductase from Xanthomonas oryzae[J].PLo S One,2011,6(10):e26743.
[23]Zhu L,Lin J,Ma J,et al.Triclosan resistance of Pseudomonas aeruginosa PAO1 is due to Fab V,a triclosan-resistant enoyl-acyl carrier protein reductase[J].Antimicrob Agents Chemother,2010,54(2):689-698.
[24]Mou R,Bai F,Duan Q,et al.Mutation of pfm affects the adherence of Pseudomonas aeruginosa to host cells and the quorum sensing system[J].FEMS microbiol lett,2011,324(2):173-180.
[25]Bushby K,Finkel R,Wong B,et al.Ataluren treatment of patients with nonsense mutation dystrophinopathy[J].Muscle&nerve,2014,50(4):477-487.
[26]Bi H,Wang H,Cronan J E.Fab Q,a dual-function dehydratase/isomerase,circumvents the last step of the classical fatty acid synthesis cycle[J].Chem Biol,2013,20(9):1157-1167.
[27]Zhu K,Choi K H,Schweizer H P,et al.Two aerobic pathways for the formation of unsaturated fatty acids in Pseudomonas aeruginosa[J].Mol Microbiol,2006,60(2):260-273.
[28]Chazarreta Cifre L,Alemany M,de Mendoza D,et al.Exploring the biosynthesis of unsaturated fatty acids in Bacillus cereus ATCC 14579 and functional characterization of novel acyl-lipid desaturases[J].Appl Environ Microbiol,2013,79(20):6271-6279.
[29]马金成,周俊超,吴楚云,等.苜蓿中华根瘤菌des A基因功能的鉴定[J].生物化学与生物物理进展,2015,42(8):740-749.
[30]Singh A K,Zhang Y M,Zhu K,et al.Fab H selectivity for anteiso branched-chain fatty acid precursors in low-temperature adaptation in Listeria monocytogenes[J].FEMS Microbiol Lett,2009,301(2):188-192.
[31]Santiago B,Marek M,Faustoferri R C,et al.The Streptococcus mutans aminotransferase encoded by ilv E is regulated by Cod Y and Ccp A[J].J Bacteriol,2013,195(16):3552-3562.
[32]Feng Y,Cronan J E.The Vibrio cholerae fatty acid regulatory protein,FadR,represses transcription of pls B,the gene encoding the first enzyme of membrane phospholipid biosynthesis[J].Mol Microbiol,2011,81(4):1020-1033.
[33]Parsons J B,Rock C O.Is bacterial fatty acid synthesis a valid target for antibacterial drug discovery[J].Curr Opin Microbiol,2011,14:1-6.
[34]Helge Jans Janen,Steinbüchel A.Fatty acid synthesis in Escherichia coli and its applications towards the production of fatty acid based biofuels[J].Biotechnol for Biofuels,2014,7(7):1-26.