消癖散结汤配合中医情志疗法治疗乳腺增生临床研究
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摘要
目的:观察消癖散结汤配合中医情志治疗乳腺增生的临床疗效。方法:将104例乳腺增生患者采用随机数字法分为对照组和观察组各52例。对照组给予消癖散结汤内服,1剂·d-1。观察组在对照组的基础上给予中医情志护理。疗程均为3个月。治疗后比较主要症状、体征评分;采用高频彩色多谱勒检测治疗前后肿块大小;检测治疗前后雌二醇(estradiol,E2)、泌乳素(prolaction,PRL)、孕酮(progesterone,P)、睾酮(testosterone,T)水平;记录治疗期间的不良反应。结果:观察组临床疗效有效率为96.15%,高于对照组的82.69%(χ~2=4.981,P<0.05);观察组超声疗效有效率为92.31%,优于对照组的76.92%(χ~2=4.727,P<0.05);治疗后观察组乳房疼痛、乳房触痛、肿块硬度、肿块分布范围及肿块大小评分均较治疗前显著下降,并低于对照组(P<0.01);治疗后观察组E2和PRL水平低于对照组(P<0.01);两组治疗期间均无明显不良反应发生。结论:消癖散结汤内服配合情志护理干预乳腺增生能减轻患者疼痛,软化缩小肿块,并能调节内分泌,临床疗效显著。
Objective: To observe the clinical curative effect of Xiaopi Sanjie decoction combined with TCM emotional therapy in treatment of breast hyperplasia. Methods: 104 cases of breast hyperplasia were randomly divided into control group and observation group with 52 cases in each group. The control group was given Xiaopi Sanjie decoction,1 dose a day. The observation group was given TCM mental nursing based on the control group. The treatment lasted for 3 months. After treatment,the main symptoms of comparison signs,score; using high frequency color Doppler detection before and after treatment of tumor size and estradiol( E_2),prolactin( PRL),progesterone( P),testosterone( T) level were detected before and after treatment; and adverse reactions during the treatment were recorded. Results: The clinical curative effect of observation group was 96. 15%,higher than 82. 69% in the control group( χ~2= 4. 981,P < 0. 05); ultrasound effective rate in the observation group was 92. 31%,better than the control group76. 92%( χ2= 4. 727,P < 0. 05); after treatment,breast pain,breast tenderness,swelling hardness,mass distribution and tumor size grading of observation group were significantly lower than before treatment,and lower than that of the control group( P <0. 01); after treatment,E_2 and PRL of the observation group was lower than control group( P < 0. 01); the two groups during treatment had no obvious adverse reaction. Conclusion: Xiaopi Sanjie decoction combined with psychological nursing intervention for breast hyperplasia can reduce the pain of patients,reduce the mass softening,regulate endocrine,and clinical curative effect is remarkable.
Objective: To observe the clinical curative effect of Xiaopi Sanjie decoction combined with TCM emotional therapy in treatment of breast hyperplasia. Methods: 104 cases of breast hyperplasia were randomly divided into control group and observation group with 52 cases in each group. The control group was given Xiaopi Sanjie decoction,1 dose a day. The observation group was given TCM mental nursing based on the control group. The treatment lasted for 3 months. After treatment,the main symptoms of comparison signs,score; using high frequency color Doppler detection before and after treatment of tumor size and estradiol( E_2),prolactin( PRL),progesterone( P),testosterone( T) level were detected before and after treatment; and adverse reactions during the treatment were recorded. Results: The clinical curative effect of observation group was 96. 15%,higher than 82. 69% in the control group( χ~2= 4. 981,P < 0. 05); ultrasound effective rate in the observation group was 92. 31%,better than the control group76. 92%( χ2= 4. 727,P < 0. 05); after treatment,breast pain,breast tenderness,swelling hardness,mass distribution and tumor size grading of observation group were significantly lower than before treatment,and lower than that of the control group( P <0. 01); after treatment,E_2 and PRL of the observation group was lower than control group( P < 0. 01); the two groups during treatment had no obvious adverse reaction. Conclusion: Xiaopi Sanjie decoction combined with psychological nursing intervention for breast hyperplasia can reduce the pain of patients,reduce the mass softening,regulate endocrine,and clinical curative effect is remarkable.
引文
[1]孙巧云.调冲消癥方治疗乳腺增生病63例[J].中国实验方剂学杂志,2015,21(4):197-201.
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[4]王宝玉.洪素兰教授运用“治未病”理论防治乳腺增生病的经验[J].中医学报,2011,26(2):161-162.
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[6]孙小慧,李志远,刘胜.散结止痛膏外敷治疗乳腺增生病(冲任失调证)的大样本、多中心、随机对照临床研究[J].辽宁中医杂志,2015,42(3):449-452.
[7]张敬然,解东莉,李佳,等.中医药干预治疗气郁质乳腺增生病160例[J].河南中医,2014,34(12):2453-2454.
[8]张华军,徐海东.疏肝化瘀散结汤治疗乳腺增生症30例[J].河南中医,2014,34(11):2217-2218.
[9]张素燚,李德辉,廖锐,等.从情志方面探讨乳腺增生病因病机[J].时珍国医国药,2013,24(1):175-176.
[10]杨新伟,吕祥,李萍,等.逍遥蒌贝散加减对乳腺增生病患者抑郁、焦虑水平的影响[J].中国中医药科技,2012,19(3):256-257.
[11]陈显春,蒋成刚,陈庆秋,等.675例乳腺增生女性患者的焦虑、抑郁情绪及其与生活事件和人格的关系研究[J].第三军医大学学报,2014,36(2):174-176.
[12]陈怡君,赵君逵,陈文豪.乳腺增生病中医辨证分型与内分泌的相关性研究[J].湖北中医药大学学报,2014,16(3):35-37.
[13]刘玉斌,李德辉,廖锐,等.肝郁型乳腺增生病发生与雌激素灭活的关系[J].中国老年学杂志,2012,32(22):5076-5078.
[14]朱华宇,李玉洁,司徒红林.林毅运用加减二仙汤结合基础体温监测治疗乳腺增生病经验[J].新中医,2014,46(7):21-23.
[2]苏柏栓.针灸联合消癖汤治疗乳腺增生临床研究[J].中医学报,2012,27(8):1073-1074.
[3]李良.林毅教授论治乳腺增生病经验拾萃[J].时珍国医国药,2015,26(4):980-982.
[4]王宝玉.洪素兰教授运用“治未病”理论防治乳腺增生病的经验[J].中医学报,2011,26(2):161-162.
[5]林毅,唐汉钧.现代中医乳房病学[M].北京:人民卫生出版社,2003:102-105.
[6]孙小慧,李志远,刘胜.散结止痛膏外敷治疗乳腺增生病(冲任失调证)的大样本、多中心、随机对照临床研究[J].辽宁中医杂志,2015,42(3):449-452.
[7]张敬然,解东莉,李佳,等.中医药干预治疗气郁质乳腺增生病160例[J].河南中医,2014,34(12):2453-2454.
[8]张华军,徐海东.疏肝化瘀散结汤治疗乳腺增生症30例[J].河南中医,2014,34(11):2217-2218.
[9]张素燚,李德辉,廖锐,等.从情志方面探讨乳腺增生病因病机[J].时珍国医国药,2013,24(1):175-176.
[10]杨新伟,吕祥,李萍,等.逍遥蒌贝散加减对乳腺增生病患者抑郁、焦虑水平的影响[J].中国中医药科技,2012,19(3):256-257.
[11]陈显春,蒋成刚,陈庆秋,等.675例乳腺增生女性患者的焦虑、抑郁情绪及其与生活事件和人格的关系研究[J].第三军医大学学报,2014,36(2):174-176.
[12]陈怡君,赵君逵,陈文豪.乳腺增生病中医辨证分型与内分泌的相关性研究[J].湖北中医药大学学报,2014,16(3):35-37.
[13]刘玉斌,李德辉,廖锐,等.肝郁型乳腺增生病发生与雌激素灭活的关系[J].中国老年学杂志,2012,32(22):5076-5078.
[14]朱华宇,李玉洁,司徒红林.林毅运用加减二仙汤结合基础体温监测治疗乳腺增生病经验[J].新中医,2014,46(7):21-23.