植物雌激素抗氧化应激损伤的实验研究进展
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摘要
氧化应激被认为是衰老和疾病的重要原因,因此对抗氧化应激损伤的研究广泛而深入。植物雌激素种类繁多、不良反应较小,具有合成雌激素不可替代的优点。本文按照植物雌激素的化学结构进行分类,阐述了其在抗氧化应激损伤方面的实验研究进展,为深入研究植物雌激素的作用机制和分子路径提供依据,为临床治疗提供理论基础。
Oxidative stress is considered to be an important cause of aging and multiple diseases,studies associated with antioxidative stress have drawn extensive and intensive attention. Phytoestrogens have high varieties and few side effects compared with synthetic estrogens. This paper reviewed phytoestrogens according to the chemical structure and the experimental research progress in antioxidative stress injury,providing a basis for further research on the mechanisms and molecular pathways of them and expounding a theoretical basis for clinical treatment.
Oxidative stress is considered to be an important cause of aging and multiple diseases,studies associated with antioxidative stress have drawn extensive and intensive attention. Phytoestrogens have high varieties and few side effects compared with synthetic estrogens. This paper reviewed phytoestrogens according to the chemical structure and the experimental research progress in antioxidative stress injury,providing a basis for further research on the mechanisms and molecular pathways of them and expounding a theoretical basis for clinical treatment.
引文
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[17] Shakya G,Manjini S,Hoda M,et al. Hepatoprotective role of kaempferol during alcohol-andΔPUFA-induced oxidative stress[J].J Basic Clin Physiol Pharmacol,2014,25(1):73-79. DOI:10. 1515/jbcpp-2013-0051.
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[19]王颖,鲁雅琴,蒋珍秀,等.羟基红花黄色素A对淀粉样蛋白诱导的氧化应激和学习记忆功能损伤的影响[J].中国临床药理学与治疗学,2016,21(1):60-63.Wang Y,Lu YQ,Jiang ZX,et al. Effects of hydroxysafflor yellow A onβ-amyloid-induced oxidative stress and dysfunction of learning and memory in rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics,2016,21(1):60-63.
[20] Han B,Zhao H. Effects of hydroxysafflor yellow A in the attenuation of MPTP neurotoxicity in mice[J]. Neurochem Res,2010,35(1):107-113. DOI:10. 1007/s11064-009-0035-4.
[21]任欢欢,韩吉春,卢宁,等.异甘草素对心肌缺血再灌注损伤的保护作用[J].石河子大学学报:自然科学版,2016,34(3):343-348. DOI:10. 13880/j. cnki. 65-1174/n. 2016. 03. 014.Ren HH, Han JC, Lu N, et al. Cardioprotection effect of isoliquiritigenin against ischemia/reperfusion injury in isolated rat hearts[J]. Journal of Shihezi University(Natural Science),2016,34(3):343-348. DOI:10. 13880/j. cnki. 65-1174/n. 2016.03. 014.
[22]龙锐,杜俊蓉,陈淑杰,等.当归内酯清除自由基及抗氧化活性的研究[J].华西药学杂志,2010,25(4):420-422.Long R,Du JR,Chen SJ,et al. Free radical scavenging and antioxidant activities of Angelica sinensis(Oliv.)Diels lactones[J].West China Journal of Pharmaceutical Sciences,2010,25(4):420-422.
[23] Puukila S,Fernandes RO,Türck P,et al. Secoisolariciresinol diglucoside attenuates cardiac hypertrophy and oxidative stress in monocrotaline-induced right heart dysfunction[J]. Mol Cell Biochem,2017,432(1-2):33-39. DOI:10. 1007/s11010-017-2995-z.
[24] Leonard SS,Xia C,Jiang BH,et al. Resveratrol scavenges reactive oxygen species and effects radical-induced cellular responses[J].Biochem Biophys Res Commun,2003,309(4):1017-1026.
[25]徐碧林,俞秀华,申甜,等.白藜芦醇对胰岛β细胞凋亡的影响及机制探讨[J].山东医药,2015,55(46):1-3. DOI:10. 3969/j. issn. 1002-266X. 2015. 46. 001.Xu BL,Yu XH,Shen T,et al. Effect of resveratrol on apoptosis of pancreaticβcells and the mechanism[J]. Shandong Medical Journal,2015,55(46):1-3. DOI:10. 3969/j. issn. 1002-266X. 2015. 46. 001.
[26] Oh SJ,Kim K,Lim CJ. Protective properties of ginsenoside Rb1against UV-B radiation-induced oxidative stress in human dermal keratinocytes[J]. Pharmazie,2015,70(6):381-387.
[27]边立功,钟莲梅,艾青龙,等.人参皂苷Rg1调控Nrf2在SD大鼠脑缺血再灌注损伤后的抗氧化作用[J].昆明医科大学学报,2018,39(6):35-38. DOI:10. 3969/j. issn. 1003-4706. 2018.06. 008.Bian LG,Zhong LM,Ai QL,et al. The anti-antioxidant role of ginsenoside rg1 regulating Nrf2 on focal cerebral ischemia reperfusion SD rats[J]. Journal of Kunming Medical University,2018,39(6):35-38. DOI:10. 3969/j. issn. 1003-4706. 2018. 06. 008.
[28] Sun HY,Lee JH,Han YS,et al. Pivotal roles of ginsenoside rg3 in tumor apoptosis through regulation of reactive oxygen species[J].Anticancer Res,2016,36(9):4647-4654. DOI:10. 21873/anticanres. 11015.
[29]孙雯怡,罗旺辉,周铖,等.三七总皂苷预处理对大鼠肾缺血再灌注损伤的保护作用及机制研究[J].湖南中医药大学学报,2018,38(1):21-26. DOI:10. 3969/j. issn. 1674-070X. 2018.01. 006.Sun WY,Luo WH,Zhou C,et al. Protective effect and mechanism research of panax notoginseng saponins pretreatment on renal ischemia reperfusion injury of rats[J]. Journal of Traditional Chinese Medicine University of Hunan,2018,38(1):21-26.DOI:10. 3969/j. issn. 1674-070X. 2018. 01. 006.
[30] Xia KP,Ca HM,Shao CZ. Protective effect of notoginsenoside R1in a rat model of myocardial ischemia reperfusion injury by regulation of Vitamin D3 upregulated protein 1/NF-κB pathway[J].Pharmazie,2015,70(11):740-744.
[31]肖志彬,刘小雷,成日青,等.β-谷甾醇对阿司匹林致胃黏膜损伤副作用及其药理作用的影响[J].中国实验方剂学杂志,2016,22(1):148-152. DOI:10. 13422/j. cnki. syfjx. 2016010148.Xiao ZB,Liu XL,Cheng RQ,et al. Effects of beta-sitosterol on side effects and pharmacological effects of aspirin-induced gastric mucosal injury[J]. Chinese Journal of Experimental Traditional Medical Formulae,2016,22(1):148-152. DOI:10. 13422/j.cnki. syfjx. 2016010148.
[32] Yang GL,Jia LQ,Wu J,et al. Effect of tanshinoneⅡA on oxidative stress and apoptosis in a rat model of fatty liver[J]. Exp Ther Med,2017,14(5):4639-4646. DOI:10. 3892/etm. 2017. 5162.
[33] Dai C,Liu Y,Dong Z. TanshinoneⅠalleviates motor and cognitive impairments via suppressing oxidative stress in the neonatal rats after hypoxic-ischemic brain damage[J]. Mol Brain,2017,10(1):52. DOI:10. 1186/s13041-017-0332-9.
[2] Niki E. Oxidative stress and antioxidants:Distress or eustress?[J].Arch Biochem Biophys,2016,595:19-24. DOI:10. 1016/j. abb.2015. 11. 017.
[3] Song X,Bao M,Li D,et al. Advanced glycation in D-galactose induced mouse aging model[J]. Mech Ageing Dev,1999,108(3):239-251.
[4] Niki E. Oxidant-specific biomarkers of oxidative stress. Association with atherosclerosis and implication for antioxidant effects[J]. Free Radic Biol Med,2018,120:425-440. DOI:10. 1016/j. freeradbiomed. 2018. 04. 001.
[5] Yuhai GU,Zhen Z. Significance of the changes occurring in the levels of interleukins,SOD and MDA in rat pulmonary tissue following exposure to different altitudes and exposure times[J]. Exp Ther Med,2015,10(3):915-920. DOI:10. 3892/etm. 2015. 2604.
[6] Seyhan N,Canseven AG. In vivo effects of ELF MFs on collagen synthesis, free radical processes, natural antioxidant system,respiratory burst system,immune system activities,and electrolytes in the skin,plasma,spleen,lung,kidney,and brain tissues[J].Electromagn Biol Med, 2006,25(4):291-305. DOI:10.1080/15368370601054787.
[7] Park MH,Ju JW,Kim M,et al. The protective effect of daidzein on high glucose-induced oxidative stress in human umbilical vein endothelial cells[J]. Z Naturforsch C,2016,71(1-2):21-28.DOI:10. 1515/znc-2015-0141.
[8]刘社星.大豆异黄酮对糖尿病大鼠心肌损伤的保护作用[J].中医学报,2017,32(10):1939-1942. DOI:10. 16368/j. issn.1674-8999. 2017. 10. 509.Liu SX. The protective effect of soybean isoflavone on heart injury in diabetic rats[J]. China Journal of Chinese Medicine,2017,32(10):1939-1942. DOI:10. 16368/j. issn. 1674-8999. 2017.10. 509.
[9] Mansour DF,Saleh DO,Mostafa RE. Genistein ameliorates cyclophosphamide-induced hepatotoxicity by modulation of oxidative stress and inflammatory mediators[J]. Open Access Maced J Med Sci,2017,5(7):836-843. DOI:10. 3889/oamjms. 2017. 093.
[10] Wang G,Li W,Lu X,et al. Luteolin ameliorates cardiac failure in type I diabetic cardiomyopathy[J]. J Diabetes Complications,2012,26(4):259-265. DOI:10. 1016/j. jdiacomp. 2012.04. 007.
[11]王雷,孙书红,付爱萍,等.木犀草素减轻糖尿病小鼠心肌损伤及其机制[J].心脏杂志,2018,30(1):30-34,39. DOI:10.13191/j. chj. 2018. 0008.Wang L,Sun SH,Fu AP,et al. Luteolin alleviates myocardial injury in diabetic mice and its mechanism[J]. Chinese Heart Journal,2018,30(1):30-34,39. DOI:10. 13191/j. chj. 2018. 0008.
[12] Chang J,Xie M,Shah VR,et al. Activation of Rho-associated coiled-coil protein kinase 1(ROCK-1)by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis[J]. Proc Natl Acad Sci U S A,2006,103(39):14495-14500. DOI:10. 1073/pnas. 0601911103.
[13] Yu D,Li M,Tian Y,et al. Luteolin inhibits ROS-activated MAPK pathway in myocardial ischemia/reperfusion injury[J]. Life Sci,2015,122:15-25. DOI:10. 1016/j. lfs. 2014. 11. 014.
[14]刘慧,张薇,卢少平,等.槲皮素在大鼠心肌损伤中的抗氧化作用[J].陕西医学杂志,2017,46(8):995-996. DOI:10. 3969/j.issn. 1000-7377. 2017. 08. 004.Liu H,Zhang W,Lu SP,et al. Antioxidant effect of quercetin on myocardial injury in rats[J]. Shaanxi Medical Journal,2017,46(8):995-996. DOI:10. 3969/j. issn. 1000-7377. 2017. 08. 004.
[15] Tang Y,Li Y,Yu H,et al. Quercetin attenuates chronic ethanol hepatotoxicity:implication of"free"iron uptake and release[J].Food Chem Toxicol,2014,67:131-138. DOI:10. 1016/j. fct.2014. 02. 022.
[16]王海燕,杨金龙,谷山林,等.桑叶槲皮素提取物抗氧化活性研究[J].丝绸,2018,55(3):15-20. DOI:10. 3969/j. issn. 1001-7003. 2018. 03. 003.Wang HY,Yang JL,Gu SL,et al. Study on antioxidant activity of quercetin extract from mulberry leaves[J]. Silk,2018,55(3):15-20. DOI:10. 3969/j. issn. 1001-7003. 2018. 03. 003.
[17] Shakya G,Manjini S,Hoda M,et al. Hepatoprotective role of kaempferol during alcohol-andΔPUFA-induced oxidative stress[J].J Basic Clin Physiol Pharmacol,2014,25(1):73-79. DOI:10. 1515/jbcpp-2013-0051.
[18] Bentes AL,Borges RS,Monteiro WR,et al. Structure of dihydrochalcones and related derivatives and their scavenging and antioxidant activity against oxygen and nitrogen radical species[J]. Molecules,2011,16(2):1749-1760. DOI:10. 3390/molecules16021749.
[19]王颖,鲁雅琴,蒋珍秀,等.羟基红花黄色素A对淀粉样蛋白诱导的氧化应激和学习记忆功能损伤的影响[J].中国临床药理学与治疗学,2016,21(1):60-63.Wang Y,Lu YQ,Jiang ZX,et al. Effects of hydroxysafflor yellow A onβ-amyloid-induced oxidative stress and dysfunction of learning and memory in rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics,2016,21(1):60-63.
[20] Han B,Zhao H. Effects of hydroxysafflor yellow A in the attenuation of MPTP neurotoxicity in mice[J]. Neurochem Res,2010,35(1):107-113. DOI:10. 1007/s11064-009-0035-4.
[21]任欢欢,韩吉春,卢宁,等.异甘草素对心肌缺血再灌注损伤的保护作用[J].石河子大学学报:自然科学版,2016,34(3):343-348. DOI:10. 13880/j. cnki. 65-1174/n. 2016. 03. 014.Ren HH, Han JC, Lu N, et al. Cardioprotection effect of isoliquiritigenin against ischemia/reperfusion injury in isolated rat hearts[J]. Journal of Shihezi University(Natural Science),2016,34(3):343-348. DOI:10. 13880/j. cnki. 65-1174/n. 2016.03. 014.
[22]龙锐,杜俊蓉,陈淑杰,等.当归内酯清除自由基及抗氧化活性的研究[J].华西药学杂志,2010,25(4):420-422.Long R,Du JR,Chen SJ,et al. Free radical scavenging and antioxidant activities of Angelica sinensis(Oliv.)Diels lactones[J].West China Journal of Pharmaceutical Sciences,2010,25(4):420-422.
[23] Puukila S,Fernandes RO,Türck P,et al. Secoisolariciresinol diglucoside attenuates cardiac hypertrophy and oxidative stress in monocrotaline-induced right heart dysfunction[J]. Mol Cell Biochem,2017,432(1-2):33-39. DOI:10. 1007/s11010-017-2995-z.
[24] Leonard SS,Xia C,Jiang BH,et al. Resveratrol scavenges reactive oxygen species and effects radical-induced cellular responses[J].Biochem Biophys Res Commun,2003,309(4):1017-1026.
[25]徐碧林,俞秀华,申甜,等.白藜芦醇对胰岛β细胞凋亡的影响及机制探讨[J].山东医药,2015,55(46):1-3. DOI:10. 3969/j. issn. 1002-266X. 2015. 46. 001.Xu BL,Yu XH,Shen T,et al. Effect of resveratrol on apoptosis of pancreaticβcells and the mechanism[J]. Shandong Medical Journal,2015,55(46):1-3. DOI:10. 3969/j. issn. 1002-266X. 2015. 46. 001.
[26] Oh SJ,Kim K,Lim CJ. Protective properties of ginsenoside Rb1against UV-B radiation-induced oxidative stress in human dermal keratinocytes[J]. Pharmazie,2015,70(6):381-387.
[27]边立功,钟莲梅,艾青龙,等.人参皂苷Rg1调控Nrf2在SD大鼠脑缺血再灌注损伤后的抗氧化作用[J].昆明医科大学学报,2018,39(6):35-38. DOI:10. 3969/j. issn. 1003-4706. 2018.06. 008.Bian LG,Zhong LM,Ai QL,et al. The anti-antioxidant role of ginsenoside rg1 regulating Nrf2 on focal cerebral ischemia reperfusion SD rats[J]. Journal of Kunming Medical University,2018,39(6):35-38. DOI:10. 3969/j. issn. 1003-4706. 2018. 06. 008.
[28] Sun HY,Lee JH,Han YS,et al. Pivotal roles of ginsenoside rg3 in tumor apoptosis through regulation of reactive oxygen species[J].Anticancer Res,2016,36(9):4647-4654. DOI:10. 21873/anticanres. 11015.
[29]孙雯怡,罗旺辉,周铖,等.三七总皂苷预处理对大鼠肾缺血再灌注损伤的保护作用及机制研究[J].湖南中医药大学学报,2018,38(1):21-26. DOI:10. 3969/j. issn. 1674-070X. 2018.01. 006.Sun WY,Luo WH,Zhou C,et al. Protective effect and mechanism research of panax notoginseng saponins pretreatment on renal ischemia reperfusion injury of rats[J]. Journal of Traditional Chinese Medicine University of Hunan,2018,38(1):21-26.DOI:10. 3969/j. issn. 1674-070X. 2018. 01. 006.
[30] Xia KP,Ca HM,Shao CZ. Protective effect of notoginsenoside R1in a rat model of myocardial ischemia reperfusion injury by regulation of Vitamin D3 upregulated protein 1/NF-κB pathway[J].Pharmazie,2015,70(11):740-744.
[31]肖志彬,刘小雷,成日青,等.β-谷甾醇对阿司匹林致胃黏膜损伤副作用及其药理作用的影响[J].中国实验方剂学杂志,2016,22(1):148-152. DOI:10. 13422/j. cnki. syfjx. 2016010148.Xiao ZB,Liu XL,Cheng RQ,et al. Effects of beta-sitosterol on side effects and pharmacological effects of aspirin-induced gastric mucosal injury[J]. Chinese Journal of Experimental Traditional Medical Formulae,2016,22(1):148-152. DOI:10. 13422/j.cnki. syfjx. 2016010148.
[32] Yang GL,Jia LQ,Wu J,et al. Effect of tanshinoneⅡA on oxidative stress and apoptosis in a rat model of fatty liver[J]. Exp Ther Med,2017,14(5):4639-4646. DOI:10. 3892/etm. 2017. 5162.
[33] Dai C,Liu Y,Dong Z. TanshinoneⅠalleviates motor and cognitive impairments via suppressing oxidative stress in the neonatal rats after hypoxic-ischemic brain damage[J]. Mol Brain,2017,10(1):52. DOI:10. 1186/s13041-017-0332-9.