病毒感染与肠道菌群关系的研究进展
|
摘要
人和动物的肠道内定植着数量众多的微生物,它们对宿主正常生理功能至关重要。肠道菌群与宿主不断地进行相互作用,形成互利共生的关系,影响机体健康。病毒感染会通过影响肠道菌群进而影响机体的免疫和代谢功能。肠道菌群或益生菌也会影响病毒的感染和疫苗的免疫效果。了解病毒与肠道菌群或益生菌的相互作用及肠道菌群对疫苗免疫效果的影响,有助于揭示疾病的发病机制,通过调控肠道菌群来治疗疾病。现主要从病毒与肠道菌群的相互作用,益生菌对病毒感染的影响和肠道菌群对疫苗免疫效果的影响三方面进行综述。
Humans and animals harbor large numbers of microbiota in their gut.They are vital to many aspects of normal host physiology.In addition,they interact with the host,form a symbiotic relationship and affect the health of host.Viral infections affect the immune and metabolism of host through interacting with intestinal microbiota.Additionally,intestinal microbiota or probiotics influence the process of the infection and vaccine efficacy.Unravelling the interactions between viruses and intestinal microbiota or probiotics,and the influence of intestinal microbiota on vaccine efficacy will facilitate our understanding of the infection process and produce strategies for manipulating the microbiota against diseases.This review mainly summarized the interactions between virus and intestinal flora,the influence of probiotics on viral infection and influence of intestinal microbiota on vaccine efficacy.
Humans and animals harbor large numbers of microbiota in their gut.They are vital to many aspects of normal host physiology.In addition,they interact with the host,form a symbiotic relationship and affect the health of host.Viral infections affect the immune and metabolism of host through interacting with intestinal microbiota.Additionally,intestinal microbiota or probiotics influence the process of the infection and vaccine efficacy.Unravelling the interactions between viruses and intestinal microbiota or probiotics,and the influence of intestinal microbiota on vaccine efficacy will facilitate our understanding of the infection process and produce strategies for manipulating the microbiota against diseases.This review mainly summarized the interactions between virus and intestinal flora,the influence of probiotics on viral infection and influence of intestinal microbiota on vaccine efficacy.
引文
[1] B?CKHED F,LEY R E,SONNENBURG J L,et al.Host-bacterial mutualism in the human intestine[J].Science,2016,307(5717):1915-1920.
[2] SOMMER F,B?CKHED F.The gut microbiota- masters of host development and physiology[J].Nat Rev Microbiol,2013,11(4):227-238.
[3] CLEMENTE J,URSELL L,PARFREY L W,et al.The impact of the gut microbiota on human health:an integrative view[J].Cell,2012,148(6):1258-1270.
[4] LUCKEY T D.Introduction to intestinal microecology[J].Am J Clin Nutr,1972,25(12):1292-1294.
[5] Human Microbiome Project Consortium.Structure,function and diversity of the healthy human microbiome[J].Nature,2012,486(7402):207-214.
[6] DOMINGUEZ-BELLO M G,BLASER M J,LEY R E,et al.Development of the human gastrointestinal microbiota and insights from high-throughput sequencing[J].Gastroenterology,2011,140(6):1713-1719.
[7] MANARY M J.Human gut microbiome viewed across age and geography[J].Nature,2012,486(7402):222-227.
[8] LIU J,WILLIAMS B,FRANK D,et al.Inside out:HIV,the gut microbiome,and the mucosal immune system[J].J Immunol,2017,198(2):605-614.
[9] CLEMENTE J C,URSELL L K,PARFREY L W,et al.The impact of the gut microbiota on human health:an integrative view[J].Cell,2012,148(6):1258-1270.
[10] QIN J,LI R,RAES J,et al.A human gut microbial gene catalogue established by metagenomic sequencing[J].Nature,2010,464(7285):59-65.
[11] TURNBAUGH P J,LEY R E,HAMADY M,et al.The human microbiome project[J].Nature,2007,449(7164):804-810.
[12] 韩丽丽,贺纪正.病毒生态学研究进展[J].生态学报,2016,36(16):4988-4996.
[13] SAVAGE D C.Gastrointestinal microflora in mammalian nutrition[J].Annu Rev Nutr,1986,6(6):155-178.
[14] HOOPER L V,MIDTVEDT T,GORDON J I.How host-microbial interactions shape the nutrient environment of the mammalian intestine[J].Annu Rev Nutr,2002,22(1):283-307.
[15] BRESTOFF J R,ARTIS D.Commensal bacteria at the interface of host metabolism and the immune system[J].Nat Immunol,2013,14(7):676-684.
[16] PETTA I,FRAUSSEN J,SOMERS V,et al.Interrelation of diet,gut microbiome,and autoantibody production[J].Front Immunol,2018(9):439.
[17] RAKOFF-NAHOUM S,PAGLINO J,ESLAMI-VARZANEH F,et al.Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis[J].Cell,2004,118(2):229-241.
[18] KAMADA N,SEO S,CHEN G Y,et al.Role of the gut microbiota in immunity and inflammatory disease[J].Nat Rev Immunol,2013,13(5):321-335.
[19] TURNBAUGH P J,LEY R E,MAHOWALD M A,et al.An obesity-associated gut microbiome with increased capacity for energy harvest[J].Nature,2006,444(7122):1027-1031.
[20] QIN J,LI Y,CAI Z,et al.A metagenome-wide association study of gut microbiota in type 2 diabetes[J].Nature,2012,490(7418):55-60.
[21] SERINO M,LUCHE E,CHABO C,et al.Intestinal microflora and metabolic diseases[J].Diabetes Metab,2009,35(4):262-272.
[22] SANTOS ROCHA C,HIRAO L A,WEBER M G,et al.Subclinical cytomegalovirus infection is associated with altered host immunity,gut microbiota and vaccine responses[J].J Virol,2018,92(13):e00167-18.
[23] QIN N,ZHENG B,YAO J,et al.Influence of H7N9 virus infection and associated treatment on human gut microbiota[J].Sci Rep,2015(5):14771.
[24] YU B,DAI C,CHEN J,et al.Dysbiosis of gut microbiota induced the disorder of helper T cells in influenza virus-infected mice[J].Hum Vacc Immunother,2015,11(5):1140-1146.
[25] KOH H,KIM M S,LEE J,et al.Changes in the swine gut microbiota in response to porcine epidemic diarrhea infection[J].Microbes Environ,2015,30(3):284-287.
[26] LI L,KUBASOVA T,RYCHLIK I,et al.Infectious bursal disease virus infection leads to changes in the gut associated-lymphoid tissue and the microbiota composition[J].PLoS One,2018,13(2):e192066.
[27] SALK H M,SIMON W L,LAMBERT N D,et al.Taxa of the nasal nicrobiome are associated with influenza-specific IgA response to live attenuated influenza vaccine[J].PLoS One,2016,11(9):e162803.
[28] LEI S,SAMUEL H,TWITCHELL E,et al.Enterobacter cloacae inhibits human norovirus infectivity in gnotobiotic pigs[J].Sci Rep,2016(6):25017.
[29] ICHINOHE T,PANG I K,KUMAMOTO Y,et al.Microbiota regulates immune defense against respiratory tract influenza A virus infection[J].PNAS,2011,108(13):5354-5359.
[30] RAMIREZ J L,SOUZANETO J,COSME R T,et al.Reciprocal tripartite interactions between the Aedes aegypti midgut microbiota,innate immune system and dengue virus influences vector competence[J].PLoS Negl Trop Dis,2012,6(3):e1561.
[31] ROOKS M G,GARRETT W S.Gut microbiota,metabolites and host immunity[J].Nat Rev Immunol,2016,16(6):341-352.
[32] KUSS S K,BEST G T,ETHEREDGE C A,et al.Intestinal mcrobiota promote enteric virus replication and systemic pathogenesis[J].Science,2011,334(6053):249-252.
[33] ROBINSON C M,JESUDHASAN P R,PFEIFFER J K.Bacterial lipopolysaccharide binding enhances virion stability and promotes environmental fitness of an enteric virus[J].Cell Host Microbe,2014,15(1):36-46.
[34] KANE M,CASE L K,KOPASKIE K,et al.Successful transmission of a retrovirus depends on the commensal microbiota[J].Science,2011,334(6053):245-249.
[35] ISAAK D D,BARTIZAL K F,CAULFIELD M J.Decreased pathogenicity of murine leukemia virus-moloney in gnotobiotic mice[J].Leukemia,1988,2(8):540-544.
[36] HILL C,GUARNER F,REID G,et al.Expert consensus document:the international scientific association for probiotics and prebiotics consensus statement on the scope and appropriate use of the term probiotic[J].Nat Rev Gastroenterol Hepatol,2014,11(8):506-514.
[37] LEE D K,KANG J Y,SHIN H S,et al.Antiviral activity of Bifidobacterium adolescentis SPM0212 against Hepatitis B virus[J].Arch Pharm Res,2013,36(12):1525-1532.
[38] OLAYA GALáN N N,ULLOA RUBIANO J C,VELEZ REYES F A,et al.In vitro antiviral activity of Lactobacillus casei and Bifidobacterium adolescentis against rotavirus infection monitored by NSP4 protein production[J].J Appl Microbiol,2016,120(4):1041-1051.
[39] PARK S,KIM J I,BAE J,et al.Effects of heat-killed Lactobacillus plantarum against influenza viruses in mice[J].J Microbiol,2018,56(2):145-149.
[40] ZIMMERMANN P,CURTIS N.The influence of probiotics on vaccine responses-A systematic review[J].Vaccine,2017,36(2):207-213.
[41] LAMOUSé-SMITH E S,ALICE T,STARNBACH M N.The intestinal flora is required to support antibody responses to systemic immunization in infant and germ free mice[J].PLoS One,2011,6(11):e27662.
[42] OH J Z,RAVINDRAN R,CHASSAING B,et al.TLR5-mediated sensing of gut microbiota is necessary for antibody responses to seasonal influenza vaccination[J].Immunity,2014,41(3):478-492.
[43] HUDA M N,LEWIS Z,KALANETRA K M,et al.Stool microbiota and vaccine responses of infants[J].Pediatrics,2014,134(2):e362.
[44] HARRIS V C,ARMAH G,FUENTES S,et al.Significant correlation between the infant gut microbiome and rotavirus vaccine response in rural Ghana[J].J Infect Dis,2017,215(1):34-41.
[45] VATANEN T,KOSTIC A D,HENNEZEL E,et al.Variation in microbiome LPS immunogenicity contributes to autoimmunity in humans[J].Cell,2016,165(4):842-853.
[46] DAVIDSON L E,FIORINO A,SNYDMAN D R,et al.Lactobacillus GG as an immune adjuvant for live-attenuated influenza vaccine in healthy adults:a randomized double-blind placebo-controlled trial[J].Eur J Clin Nutr,2011,65(4):501-507.
[47] GILL H,PRASAD J.Probiotics,immunomodulation,and health benefits[J].Adv Exp Med Biol,2008,606:423-454.
[48] VALDEZ Y,BROWN E M,FINLAY B B.Influence of the microbiota on vaccine effectiveness[J].Trends Immunol,2014,35(11):526-537.
[49] MOAYYEDI P,YUAN Y,BAHARITH H,et al.Faecal microbiota transplantation for Clostridium difficile-associated diarrhoea:a systematic review of randomised controlled trials[J].Med J Aust,2017,207(4):166-172.
[50] MONEDERO V,COLLADO M C,RODRíGUEZ-DíAZ J.Therapeutic opportunities in intestinal microbiota-virus interactions[J].Trends Biotechnol,2018,36(7):645-648.
[2] SOMMER F,B?CKHED F.The gut microbiota- masters of host development and physiology[J].Nat Rev Microbiol,2013,11(4):227-238.
[3] CLEMENTE J,URSELL L,PARFREY L W,et al.The impact of the gut microbiota on human health:an integrative view[J].Cell,2012,148(6):1258-1270.
[4] LUCKEY T D.Introduction to intestinal microecology[J].Am J Clin Nutr,1972,25(12):1292-1294.
[5] Human Microbiome Project Consortium.Structure,function and diversity of the healthy human microbiome[J].Nature,2012,486(7402):207-214.
[6] DOMINGUEZ-BELLO M G,BLASER M J,LEY R E,et al.Development of the human gastrointestinal microbiota and insights from high-throughput sequencing[J].Gastroenterology,2011,140(6):1713-1719.
[7] MANARY M J.Human gut microbiome viewed across age and geography[J].Nature,2012,486(7402):222-227.
[8] LIU J,WILLIAMS B,FRANK D,et al.Inside out:HIV,the gut microbiome,and the mucosal immune system[J].J Immunol,2017,198(2):605-614.
[9] CLEMENTE J C,URSELL L K,PARFREY L W,et al.The impact of the gut microbiota on human health:an integrative view[J].Cell,2012,148(6):1258-1270.
[10] QIN J,LI R,RAES J,et al.A human gut microbial gene catalogue established by metagenomic sequencing[J].Nature,2010,464(7285):59-65.
[11] TURNBAUGH P J,LEY R E,HAMADY M,et al.The human microbiome project[J].Nature,2007,449(7164):804-810.
[12] 韩丽丽,贺纪正.病毒生态学研究进展[J].生态学报,2016,36(16):4988-4996.
[13] SAVAGE D C.Gastrointestinal microflora in mammalian nutrition[J].Annu Rev Nutr,1986,6(6):155-178.
[14] HOOPER L V,MIDTVEDT T,GORDON J I.How host-microbial interactions shape the nutrient environment of the mammalian intestine[J].Annu Rev Nutr,2002,22(1):283-307.
[15] BRESTOFF J R,ARTIS D.Commensal bacteria at the interface of host metabolism and the immune system[J].Nat Immunol,2013,14(7):676-684.
[16] PETTA I,FRAUSSEN J,SOMERS V,et al.Interrelation of diet,gut microbiome,and autoantibody production[J].Front Immunol,2018(9):439.
[17] RAKOFF-NAHOUM S,PAGLINO J,ESLAMI-VARZANEH F,et al.Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis[J].Cell,2004,118(2):229-241.
[18] KAMADA N,SEO S,CHEN G Y,et al.Role of the gut microbiota in immunity and inflammatory disease[J].Nat Rev Immunol,2013,13(5):321-335.
[19] TURNBAUGH P J,LEY R E,MAHOWALD M A,et al.An obesity-associated gut microbiome with increased capacity for energy harvest[J].Nature,2006,444(7122):1027-1031.
[20] QIN J,LI Y,CAI Z,et al.A metagenome-wide association study of gut microbiota in type 2 diabetes[J].Nature,2012,490(7418):55-60.
[21] SERINO M,LUCHE E,CHABO C,et al.Intestinal microflora and metabolic diseases[J].Diabetes Metab,2009,35(4):262-272.
[22] SANTOS ROCHA C,HIRAO L A,WEBER M G,et al.Subclinical cytomegalovirus infection is associated with altered host immunity,gut microbiota and vaccine responses[J].J Virol,2018,92(13):e00167-18.
[23] QIN N,ZHENG B,YAO J,et al.Influence of H7N9 virus infection and associated treatment on human gut microbiota[J].Sci Rep,2015(5):14771.
[24] YU B,DAI C,CHEN J,et al.Dysbiosis of gut microbiota induced the disorder of helper T cells in influenza virus-infected mice[J].Hum Vacc Immunother,2015,11(5):1140-1146.
[25] KOH H,KIM M S,LEE J,et al.Changes in the swine gut microbiota in response to porcine epidemic diarrhea infection[J].Microbes Environ,2015,30(3):284-287.
[26] LI L,KUBASOVA T,RYCHLIK I,et al.Infectious bursal disease virus infection leads to changes in the gut associated-lymphoid tissue and the microbiota composition[J].PLoS One,2018,13(2):e192066.
[27] SALK H M,SIMON W L,LAMBERT N D,et al.Taxa of the nasal nicrobiome are associated with influenza-specific IgA response to live attenuated influenza vaccine[J].PLoS One,2016,11(9):e162803.
[28] LEI S,SAMUEL H,TWITCHELL E,et al.Enterobacter cloacae inhibits human norovirus infectivity in gnotobiotic pigs[J].Sci Rep,2016(6):25017.
[29] ICHINOHE T,PANG I K,KUMAMOTO Y,et al.Microbiota regulates immune defense against respiratory tract influenza A virus infection[J].PNAS,2011,108(13):5354-5359.
[30] RAMIREZ J L,SOUZANETO J,COSME R T,et al.Reciprocal tripartite interactions between the Aedes aegypti midgut microbiota,innate immune system and dengue virus influences vector competence[J].PLoS Negl Trop Dis,2012,6(3):e1561.
[31] ROOKS M G,GARRETT W S.Gut microbiota,metabolites and host immunity[J].Nat Rev Immunol,2016,16(6):341-352.
[32] KUSS S K,BEST G T,ETHEREDGE C A,et al.Intestinal mcrobiota promote enteric virus replication and systemic pathogenesis[J].Science,2011,334(6053):249-252.
[33] ROBINSON C M,JESUDHASAN P R,PFEIFFER J K.Bacterial lipopolysaccharide binding enhances virion stability and promotes environmental fitness of an enteric virus[J].Cell Host Microbe,2014,15(1):36-46.
[34] KANE M,CASE L K,KOPASKIE K,et al.Successful transmission of a retrovirus depends on the commensal microbiota[J].Science,2011,334(6053):245-249.
[35] ISAAK D D,BARTIZAL K F,CAULFIELD M J.Decreased pathogenicity of murine leukemia virus-moloney in gnotobiotic mice[J].Leukemia,1988,2(8):540-544.
[36] HILL C,GUARNER F,REID G,et al.Expert consensus document:the international scientific association for probiotics and prebiotics consensus statement on the scope and appropriate use of the term probiotic[J].Nat Rev Gastroenterol Hepatol,2014,11(8):506-514.
[37] LEE D K,KANG J Y,SHIN H S,et al.Antiviral activity of Bifidobacterium adolescentis SPM0212 against Hepatitis B virus[J].Arch Pharm Res,2013,36(12):1525-1532.
[38] OLAYA GALáN N N,ULLOA RUBIANO J C,VELEZ REYES F A,et al.In vitro antiviral activity of Lactobacillus casei and Bifidobacterium adolescentis against rotavirus infection monitored by NSP4 protein production[J].J Appl Microbiol,2016,120(4):1041-1051.
[39] PARK S,KIM J I,BAE J,et al.Effects of heat-killed Lactobacillus plantarum against influenza viruses in mice[J].J Microbiol,2018,56(2):145-149.
[40] ZIMMERMANN P,CURTIS N.The influence of probiotics on vaccine responses-A systematic review[J].Vaccine,2017,36(2):207-213.
[41] LAMOUSé-SMITH E S,ALICE T,STARNBACH M N.The intestinal flora is required to support antibody responses to systemic immunization in infant and germ free mice[J].PLoS One,2011,6(11):e27662.
[42] OH J Z,RAVINDRAN R,CHASSAING B,et al.TLR5-mediated sensing of gut microbiota is necessary for antibody responses to seasonal influenza vaccination[J].Immunity,2014,41(3):478-492.
[43] HUDA M N,LEWIS Z,KALANETRA K M,et al.Stool microbiota and vaccine responses of infants[J].Pediatrics,2014,134(2):e362.
[44] HARRIS V C,ARMAH G,FUENTES S,et al.Significant correlation between the infant gut microbiome and rotavirus vaccine response in rural Ghana[J].J Infect Dis,2017,215(1):34-41.
[45] VATANEN T,KOSTIC A D,HENNEZEL E,et al.Variation in microbiome LPS immunogenicity contributes to autoimmunity in humans[J].Cell,2016,165(4):842-853.
[46] DAVIDSON L E,FIORINO A,SNYDMAN D R,et al.Lactobacillus GG as an immune adjuvant for live-attenuated influenza vaccine in healthy adults:a randomized double-blind placebo-controlled trial[J].Eur J Clin Nutr,2011,65(4):501-507.
[47] GILL H,PRASAD J.Probiotics,immunomodulation,and health benefits[J].Adv Exp Med Biol,2008,606:423-454.
[48] VALDEZ Y,BROWN E M,FINLAY B B.Influence of the microbiota on vaccine effectiveness[J].Trends Immunol,2014,35(11):526-537.
[49] MOAYYEDI P,YUAN Y,BAHARITH H,et al.Faecal microbiota transplantation for Clostridium difficile-associated diarrhoea:a systematic review of randomised controlled trials[J].Med J Aust,2017,207(4):166-172.
[50] MONEDERO V,COLLADO M C,RODRíGUEZ-DíAZ J.Therapeutic opportunities in intestinal microbiota-virus interactions[J].Trends Biotechnol,2018,36(7):645-648.