碘对甲状腺疾病影响及机制的研究进展
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摘要
碘参与人体内代谢,影响人体的生长发育。近年来,甲状腺疾病的诊断率和治疗水平逐渐提高。碘在甲状腺疾病的发生、发展中发挥重要作用。研究碘在甲状腺疾病中的代谢路径、病因机制,对甲状腺疾病和其他碘代谢疾病的预防、治疗均有一定作用。本文就碘对甲状腺疾病的影响及机制的研究进展作一综述。
Iodine participates in the metabolism in human body,which is involved in the growth and development of human body.In recent years,the diagnostic rate of thyroid diseases and the treatment results have been improved gradually.Iodine plays an essential role in the occurrence and development of thyroid diseases.Therefore,the study of the metabolic pathway and the mechanism of iodine in thyroid diseases is of significance in the prevention and treatment of thyroid diseases and other metabolic diseases.This paper reviews the influence of iodine on thyroid diseases and its mechanism.
Iodine participates in the metabolism in human body,which is involved in the growth and development of human body.In recent years,the diagnostic rate of thyroid diseases and the treatment results have been improved gradually.Iodine plays an essential role in the occurrence and development of thyroid diseases.Therefore,the study of the metabolic pathway and the mechanism of iodine in thyroid diseases is of significance in the prevention and treatment of thyroid diseases and other metabolic diseases.This paper reviews the influence of iodine on thyroid diseases and its mechanism.
引文
[1]Zimmermann MB.Thyroid gland:iodine deficiency and thyroid nodules[J].Nat Rev Endocrinol,2014,10(12):707-708.
[2]张博,苏俊平,陈云霞.结节性甲状腺肿患者碘摄入量与自身免疫功能的相关性研究[J].中国全科医学,2013,16(5):487-489.
[3]章阳,解磐磐,丁洁,等.碘与甲状腺常见疾病相关性研究[J].中华肿瘤防治杂志,2015,22(9):687-691.
[4]Yazbeck CF,Sullivan SD.Thyroid disorders during pregnancy[J].Med Clin North Am,2012,96(2):235-256.
[5]高倩倩,孙丹丹,赵岩,等.妊娠早期孕妇母体碘营养与甲状腺功能异常的初步研究[J].中国医科大学学报,2013,42(4):330-333.
[6]Kumar A.Immunomodulation in recurrent miscarriage[J].J Obstet Gynaecol India,2014,64(3):165-168.
[7]Tada H,Mizuta 1,Takano T.Blocking-type anti-TSH receptor antibodies and relation to responsiveness to antithyroid drug therapy and remission in Graves'disease[J].Clin Endocrinol(Oxf),2003,58(4):403-408.
[8]肖碧如,薛向阳,胡飞红,等.微小RNA155在不明原因复发性流产患者绒毛组织中的表达变化及其调控机制[J].中华妇产科杂志,2014,49(2):130-134.
[9]Pearce EN.effects of iodine deficiency in pregnancy[J].J Ttrace Elem Med Biol,2012,26(23):131-133.
[10]Corso C,Gomez X,Sanabria A,et al.Total thyroidectomy versus hemithyroidectomy for patients with follicular neoplasm:a cost-utility analysis[J].Int J Surg,2014,12(8):837-842.
[11]Carle A,Krejbjerg A,Laurberg P.Epidemiology of nodular goiter:influence of iodine intake[J].Best Pract Res Clin Endocrinol Metab,2014,28(4):465-479.
[12]Michael B.Zimmermann MB,Galetti V.Iodine intake as a risk factor for thyroid cancer:a comprehensive review of animal and human studies[J].Thyroid Res,2015,8:8.
[13]闰慧娴,谷伟军,吕朝晖.结节大小与甲状腺癌风险的临床研究[J].中华内分泌代谢杂志,2015,31(1):10-13.
[14]Aghini LF,Fiore E,Tonacchera M,et al.The effect of voluntary iodine prophylaxis in a small rural community:the Pescopagano survey 15 years later[J].J Clin Endocrinol Metab,2013,98(3):1031-1039.
[15]Pedersen IB,Knudsen N,CarléA.A cautious iodization program bringing iodine intake to a low recommended level is associated with an increase in the prevalence of thyroid autoantibodies in the population[J].Clin Endocrinol(Oxf),2011,75(1):120-126.
[16]李晓玲,王存丰,翟亚萍,等.桥本甲状腺炎和格雷夫斯病甲状腺组织中淋巴细胞亚群分布及临床意义[J].中华实用诊断与治疗杂志,2013,27(12):1156-1158.
[17]马跃华,王存丰,徐丹丹,等.甲状腺自身抗体及淋巴细胞浸润对桥本病甲状腺肿大程度的影响[J].中华实用诊断与治疗杂志,2013,27(9):842-844.
[18]Wang LQ,Wang TY,Sun QL,et al.Correlation between thyroglobulin gene polymorphisms and autoimmune thyroid disease[J].Mol Med Rep,2015,12(3):4469-4475.
[19]Camargo RY,Tomimori EK,Neves SC,et al.Thyroid and the environment:exposure to excessive nutritional iodine increases the prevalence of thyroid disorders in SaPaulo,Brazil[J].Eur J Endocrinol,2008,159(3):293-299.
[2]张博,苏俊平,陈云霞.结节性甲状腺肿患者碘摄入量与自身免疫功能的相关性研究[J].中国全科医学,2013,16(5):487-489.
[3]章阳,解磐磐,丁洁,等.碘与甲状腺常见疾病相关性研究[J].中华肿瘤防治杂志,2015,22(9):687-691.
[4]Yazbeck CF,Sullivan SD.Thyroid disorders during pregnancy[J].Med Clin North Am,2012,96(2):235-256.
[5]高倩倩,孙丹丹,赵岩,等.妊娠早期孕妇母体碘营养与甲状腺功能异常的初步研究[J].中国医科大学学报,2013,42(4):330-333.
[6]Kumar A.Immunomodulation in recurrent miscarriage[J].J Obstet Gynaecol India,2014,64(3):165-168.
[7]Tada H,Mizuta 1,Takano T.Blocking-type anti-TSH receptor antibodies and relation to responsiveness to antithyroid drug therapy and remission in Graves'disease[J].Clin Endocrinol(Oxf),2003,58(4):403-408.
[8]肖碧如,薛向阳,胡飞红,等.微小RNA155在不明原因复发性流产患者绒毛组织中的表达变化及其调控机制[J].中华妇产科杂志,2014,49(2):130-134.
[9]Pearce EN.effects of iodine deficiency in pregnancy[J].J Ttrace Elem Med Biol,2012,26(23):131-133.
[10]Corso C,Gomez X,Sanabria A,et al.Total thyroidectomy versus hemithyroidectomy for patients with follicular neoplasm:a cost-utility analysis[J].Int J Surg,2014,12(8):837-842.
[11]Carle A,Krejbjerg A,Laurberg P.Epidemiology of nodular goiter:influence of iodine intake[J].Best Pract Res Clin Endocrinol Metab,2014,28(4):465-479.
[12]Michael B.Zimmermann MB,Galetti V.Iodine intake as a risk factor for thyroid cancer:a comprehensive review of animal and human studies[J].Thyroid Res,2015,8:8.
[13]闰慧娴,谷伟军,吕朝晖.结节大小与甲状腺癌风险的临床研究[J].中华内分泌代谢杂志,2015,31(1):10-13.
[14]Aghini LF,Fiore E,Tonacchera M,et al.The effect of voluntary iodine prophylaxis in a small rural community:the Pescopagano survey 15 years later[J].J Clin Endocrinol Metab,2013,98(3):1031-1039.
[15]Pedersen IB,Knudsen N,CarléA.A cautious iodization program bringing iodine intake to a low recommended level is associated with an increase in the prevalence of thyroid autoantibodies in the population[J].Clin Endocrinol(Oxf),2011,75(1):120-126.
[16]李晓玲,王存丰,翟亚萍,等.桥本甲状腺炎和格雷夫斯病甲状腺组织中淋巴细胞亚群分布及临床意义[J].中华实用诊断与治疗杂志,2013,27(12):1156-1158.
[17]马跃华,王存丰,徐丹丹,等.甲状腺自身抗体及淋巴细胞浸润对桥本病甲状腺肿大程度的影响[J].中华实用诊断与治疗杂志,2013,27(9):842-844.
[18]Wang LQ,Wang TY,Sun QL,et al.Correlation between thyroglobulin gene polymorphisms and autoimmune thyroid disease[J].Mol Med Rep,2015,12(3):4469-4475.
[19]Camargo RY,Tomimori EK,Neves SC,et al.Thyroid and the environment:exposure to excessive nutritional iodine increases the prevalence of thyroid disorders in SaPaulo,Brazil[J].Eur J Endocrinol,2008,159(3):293-299.