季铵盐抗菌剂在口腔材料中的应用现状与发展趋势概述
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摘要
季铵盐抗菌剂是一种阳离子表面活性剂类的广谱抗菌剂,广泛应用于人民群众生产生活的各个领域,如水处理、纺织业、食品、油漆涂料等,在医疗领域也有应用。近年来,越来越多的口腔医学工作者开始关注季铵盐抗菌剂。本文针对季铵盐抗菌单体应用于牙髓牙体、口腔修复、口腔种植及口腔正畸等口腔医学领域的研究进展进行综述,并展望了季铵盐抗菌单体的未来发展趋势。
Quaternary ammonium salt antibacterial agent is a kind of broad spectrum antibacterial agent of cationic surfactant, which is widely used in various fields of people's production and life, such as water treatment,textile industry, food, paint and coating, etc., as well as in medical field. In recent years, more and more stomatologists began to pay attention to quaternary ammonium antibacterial agents. In this paper, the application of quaternary ammonium antibacterial monomers in endodontics, dental prosthodontics, oral implantation, orthodontics and other fields of stomatology was reviewed, and the future development trend of quaternary ammonium antibacterial monomers was prospected.
Quaternary ammonium salt antibacterial agent is a kind of broad spectrum antibacterial agent of cationic surfactant, which is widely used in various fields of people's production and life, such as water treatment,textile industry, food, paint and coating, etc., as well as in medical field. In recent years, more and more stomatologists began to pay attention to quaternary ammonium antibacterial agents. In this paper, the application of quaternary ammonium antibacterial monomers in endodontics, dental prosthodontics, oral implantation, orthodontics and other fields of stomatology was reviewed, and the future development trend of quaternary ammonium antibacterial monomers was prospected.
引文
[1]陈德英,胡格,周传健,葛建华,吴峻岭.含纳米抗菌无机填料树脂粘接剂的合成及相关性能研究[J].华西口腔医学杂志,2018,36(1):46-51.
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[4]张宁,马雁崧,徐华焜,白玉兴.季铵盐单体对正畸粘接剂粘接强度和抗菌性能的影响[J].北京口腔医学,2017,25(6):301-304.
[5]吴峻岭,张强,孙睿男,朱婷,葛建华,周传健.含长链烷基季铵盐纳米抗菌无机填料的复合树脂对人牙菌斑生物膜的影响[J].华西口腔医学杂志,2015,33(6):565-569.
[6]王晓曚,张宁,白玉兴.季铵盐类抗菌单体在口腔材料中的应用[J].北京口腔医学,2018,26(1):53-56.
[7]Murata H,Koepsel R R,Matyjaszewski K,et al.Permanent nonleaching antibacterial surface-2:how high density cationic surfaces kill bacterial cells[J].Biomateria ls,2007,28(32):4870-4879.
[8]Beyth N,Yudovin-Farber I,Bahir R,et al.Antibacterial activity of dental composites containing quaternary ammoniumpolye thylenimine nanoparticles against Streptococcusmutans[J].Biomaterials,2006,27(21):3995-4002.
[9]Imazato S,Kuramoto A,Takahashi Y,et al.In vitro antibacterial effects of the dentin primer of Clearfil Protect Bond[J].Dent Mater,2006,22(6):527-532.
[10]Ozer F,Karakaya S,UnlüN,et al.Comparison of antibacterial activity of two dentin bonding systems using agar well technique and tooth cavity model[J].J Dent2003,31(2):111-116.
[11]Melo MA,Wu J,Weir MD,et al.A novel antibacteria orthodontic cement containing a quaternary ammonium monomer dimethylaminododecyl methacrylate[J].JDent,2014,42(9):1193-1201.
[12]李锋,陈吉华,吴丹,等.季铵盐单体改性窝沟封闭剂的抗菌性能研究[J].牙体牙髓牙周病学杂志,2011,21(3):158-162.
[13]Waβmann M,Winkel A,Haak K,et al.Influence of quaternization of ammonium on antibacterial activity and cytocompatibility of thin copolymer layers on titanium[J].JBiomater Sci Polym Ed,2016,27(15):1507-1519.
[14]Stopiglia CD,Collares FM,Ogliari FA,et al.Antimicrobia activity of[2-(methacryloyloxy)ethyl]trimethylammonium chlorideagainst Candidaspp[J].Rev Iberoame Micol,2012,29(1):20-23.
[2]Kourai H.Syntheses and antimicrobial activities of a series of new bis-quaternary ammonium compounds[J].Eur J Med Chem,2006,41(4):437-444.
[3]Thorsteinsson T,Másson M,Kristinsson KG,et al.Soft antimicrobial agents:synthesis and activity of labile environmentally friendly long chain quaternary ammonium compounds[J].J Med Chem,2003,46(19):4173-4181.
[4]张宁,马雁崧,徐华焜,白玉兴.季铵盐单体对正畸粘接剂粘接强度和抗菌性能的影响[J].北京口腔医学,2017,25(6):301-304.
[5]吴峻岭,张强,孙睿男,朱婷,葛建华,周传健.含长链烷基季铵盐纳米抗菌无机填料的复合树脂对人牙菌斑生物膜的影响[J].华西口腔医学杂志,2015,33(6):565-569.
[6]王晓曚,张宁,白玉兴.季铵盐类抗菌单体在口腔材料中的应用[J].北京口腔医学,2018,26(1):53-56.
[7]Murata H,Koepsel R R,Matyjaszewski K,et al.Permanent nonleaching antibacterial surface-2:how high density cationic surfaces kill bacterial cells[J].Biomateria ls,2007,28(32):4870-4879.
[8]Beyth N,Yudovin-Farber I,Bahir R,et al.Antibacterial activity of dental composites containing quaternary ammoniumpolye thylenimine nanoparticles against Streptococcusmutans[J].Biomaterials,2006,27(21):3995-4002.
[9]Imazato S,Kuramoto A,Takahashi Y,et al.In vitro antibacterial effects of the dentin primer of Clearfil Protect Bond[J].Dent Mater,2006,22(6):527-532.
[10]Ozer F,Karakaya S,UnlüN,et al.Comparison of antibacterial activity of two dentin bonding systems using agar well technique and tooth cavity model[J].J Dent2003,31(2):111-116.
[11]Melo MA,Wu J,Weir MD,et al.A novel antibacteria orthodontic cement containing a quaternary ammonium monomer dimethylaminododecyl methacrylate[J].JDent,2014,42(9):1193-1201.
[12]李锋,陈吉华,吴丹,等.季铵盐单体改性窝沟封闭剂的抗菌性能研究[J].牙体牙髓牙周病学杂志,2011,21(3):158-162.
[13]Waβmann M,Winkel A,Haak K,et al.Influence of quaternization of ammonium on antibacterial activity and cytocompatibility of thin copolymer layers on titanium[J].JBiomater Sci Polym Ed,2016,27(15):1507-1519.
[14]Stopiglia CD,Collares FM,Ogliari FA,et al.Antimicrobia activity of[2-(methacryloyloxy)ethyl]trimethylammonium chlorideagainst Candidaspp[J].Rev Iberoame Micol,2012,29(1):20-23.