组织工程化牙齿的相关研究进展
摘要
目前临床上大多采用活动义齿、固定义齿以及种植体来修复缺失的牙齿,这些传统的修复方式存在生物相容性差、无法获得生理性牙周膜的缺陷。近年来,牙齿组织工程领域的大量研究实验使得采用组织工程技术修复牙齿缺失成为可能。牙齿组织工程学的定义是利用体外和体内单细胞,通过培养的方式获得整个牙齿的组织工程手段。该方法的关键是需要获得具有较强生长和分化潜能的种子细胞、合适的生物支架材料,进而构建有较强再生能力的细胞—支架复合体。
引文
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[2]Duailibi MT,Duailibi SE,Young CS,et al.Bioengineered teeth from cultured rat tooth bud cells[J].J Dent Res,2004,83(7):523-528.
[3]Honda MJ,Tsuchiya S,Sumita Y,et al.The sequential seeding of epithelial and mesenchymal cells for tissue-engineered tooth regeneration[J].Biomaterials,2007,28(4):680-689.
[4]Nakao K,Morita R,Saji Y,et al.The development of a bioengineered organ germ method[J].Nat Methods,2007,4(3):227-230.
[5]Gronthos S,Mankani M,Brahim J,et al.Postnatal human dental pulp stem cells(DPSCs)in vitro and in vivo[J].Proc Natl Acad Sci U S A,2000,97(25):13625-13630.
[6]Miura M,Gronthos S,Zhao M,et al.SHED:stem cells from human exfoliated deciduous teeth[J].Proc Natl Acad Sci U S A,2003,100(10):5807-5812.
[7]Sonoyama W,Liu Y,Fang D,et al.Mesenchymal stem cellmediated functional tooth regeneration in swine[J].PLoS ONE,2006,1:e79.
[8]Kikuchi A,Okano T.Nanostructured designs of biomedical materials:applications of cell sheet engineering to functional regenerative tissues and organs[J].J Control Release,2005,101(1-3):69-84.
[9]Masuda S,Shimizu T,Yamato M,et al.Cell sheet engineering for heart tissue repair[J].Adv Drug Deliv Rev,2008,60(2):277-285.
[10]Hu B,Unda F,Bopp-Kuchler S,et al.Bone marrow cells can give rise to ameloblast-like cells[J].J Dent Res,2006,85(5):416-421.
[11]Hu B,Nadiri A,Kuchler-Bopp S,et al.Tissue engineering of tooth crown,root,and periodontium[J].Tissue Eng,2006,12(8):2069-2075.
[12]Handa K,Saito M,Yamauchi M,et al.Cementum matrix formation in vivo by cultured dental follicle cells[J].Bone,2002,31(5):606-611.
[13]Morsczeck C,Gotz W,Schierholz J,et al.Isolation of precursor cells(PCs)from human dental follicle of wisdom teeth[J].Matrix Biol,2005,24(2):155-165.
[14]Morsczeck C,Moehl C,Gotz W,et al.In vitro differentiation of human dental follicle cells with dexamethasone and insulin[J].Cell Biol Int,2005,29(7):567-575.
[15]Seo BM,Miura M,Gronthos S,et al.Investigation of multipotent postnatal stem cells from human periodontal ligament[J].Lancet,2004,364(9429):149-55.
[16]Kramer PR,Nares S,Kramer SF,et al.Mesenchymal stem cells acquire characteristics of cells in the periodontal ligament in vitro[J].JDent Res,2004,83(1):27-34.
[17]Kawaguchi H,Hirachi A,Hasegawa N,et al.Enhancement of periodontal tissue regeneration by transplantation of bone marrow mesenchymal stem cells[J].J Periodontol,2004,75(9):1281-1287.
[18]Carmona-Rodriguez B,Alvarez-Perez MA,Narayanan AS,et al.Human Cementum Protein 1 induces expression of bone and cementum proteins by human gingival fibroblasts[J].Biochem Biophys Res Commun,2007,358(3):763-769.
[19]Flores MG,Hasegawa M,Yamato M,et al.Cementumperiodontal ligament complex regeneration using the cell sheet technique[J].J Periodontal Res,2008,43(3):364-371.
[20]Iwata T,Yamato M,Tsuchioka H,et al.Periodontal regeneration with multi-layered periodontal ligament-derived cell sheets in a canine model[J].Biomaterials,2009,30(14):2716-2723.
[21]Mitsiadis TA,Cheraud Y,Sharpe P,et al.Development of teeth in chick embryos after mouse neural crest transplantations[J].Proc Natl Acad Sci U S A,2003,100(11):6541-6545.
[22]Kim SH,Turnbull J,Guimond S.Extracellular matrix and cell signalling:the dynamic cooperation of integrin,proteo-glycan and growth factor receptor[J].J Endocrinol,2011,209(2):139-151.
[23]Nerem RM,Sambanis A.Tissue engineering:from biology to biological substitutes[J].Tissue Eng,1995,1(1):3-13.