早期应用清热化痰解毒法治疗脑梗死后相关肺炎的临床观察
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摘要
目的观察早期应用清热化痰解毒法治疗脑梗死后相关肺炎的临床疗效。方法将146例急性脑梗死患者按照随机方法分为治疗组及对照组,各73例,治疗组在西医常规治疗基础上加用清热化痰解毒汤,对照组西医常规治疗, 7 d后观察2组的差异。同时观察2组CPIS评分以及炎性因子如TNF-α、 PCT、 CRP指标的变化。结果治疗组对梗死后肺炎的疗效优于对照组,差异有统计学意义(P<0.05或P<0.01)。结论早期应用清热化痰解毒法可以很好地治疗脑梗死后的相关肺炎,改善患者的生活质量。
ObjectiveTo observe the clinical effects of early application of the detoxification method in the treatment of pneumonia after cerebral infarction.Methods146 patients with cerebral infarction were randomly dividedinto treatment group and control group(n= 73), then, the differences between the treatment group and the control group after 7 days of treatment were compared. In the treatment group, western medical treatment and Qingrehuatanjiedutang were applied simultaneously. The patients of the control group were treated only by westernmedicine. The changes of inflammatory factors such as CPIS score, TNF-α, PCT and CRP in the two groupswere observed.ResultsAfter statistical analysis, the effects of the treatment group on post-stroke pneumoniawere statistically significant,P<0. 05 orP<0. 01.ConclusionEarly application of the detoxification method canbe used to treat the pneumonia associated with cerebral infarction and improve the quality of life of patients.
ObjectiveTo observe the clinical effects of early application of the detoxification method in the treatment of pneumonia after cerebral infarction.Methods146 patients with cerebral infarction were randomly dividedinto treatment group and control group(n= 73), then, the differences between the treatment group and the control group after 7 days of treatment were compared. In the treatment group, western medical treatment and Qingrehuatanjiedutang were applied simultaneously. The patients of the control group were treated only by westernmedicine. The changes of inflammatory factors such as CPIS score, TNF-α, PCT and CRP in the two groupswere observed.ResultsAfter statistical analysis, the effects of the treatment group on post-stroke pneumoniawere statistically significant,P<0. 05 orP<0. 01.ConclusionEarly application of the detoxification method canbe used to treat the pneumonia associated with cerebral infarction and improve the quality of life of patients.
引文
[1]DIRNAGL U.Stroke-induced immuunodepression:experimental evidence and clinical relevance[J].Stroke,2007,38(2):770-775.
[2]中华神经科学会.各类脑血管疾病诊断要点[J].中华神经科杂志,1996,29(6):379.
[3]国家中医药管理局脑病急症协作组.中风病诊断与疗效评定标准[J].北京中医药大学学报,1996,19(1):55.
[4]卒中相关性肺炎诊治中国专家共识组.卒中相关性肺炎诊治中国专家共识[J].中华内科学杂志,2010,89(12):1075-1078.DOI:10.3760/cma.j.issn.0578-1426.2010.12.031.
[5]张道培,闫福岭.卒中相关性肺炎及其发病机制[J].国际脑血管病杂志,2007,15(1):63-66.DOI:10.3760/cma.j.issn.1673-4165.2007.01.012.
[6]李辉.临床肺部感染评分和C-反应蛋白在老年社区获得性肺炎预后评估中的应用[J].临床肺科杂志,2010,15(6):843-844.DOI:10.3969/j.issn.1009-6663.2010.06.048.
[7]李洁,张岱州,高丽霞.中药郁金的现代药理研究概况[J].内蒙古中医药,2001,1(2):37-38.DOI:10.3969/j.issn.1006-0979.2001.01.035.
[8]杨晓燕,陈发奎.菖蒲的化学成分研究概况[J].沈阳药科大学学报,1999,16(1):71.DOI:10.3969/j.issn.1006-2858.1999.01.019.
[9]滕勇荣,王连侠,张永清.瓜蒌药理研究进展[J].齐鲁药事,2010,29(7):417-419.DOI:10.3969/j.issn.1672-7738.2010.07.017.
[10]张明发,沈雅琴.射干药理研究进展[J].中国执业药师,2010,7(1):14-18.DOI:10.3969/j.issn.1672-5433.2010.01.005.
[11]姚丽娜.湖北贝母、鄂北贝母、紫花鄂北贝母生物总碱对呼吸系统的药理作用[J].同济医科大学学报,1993,22(1):47.
[12]肖灿鹏.中药贝母几种主要成分的体外抗菌活性[J].中国药科大学学报,1992,23(3):188.
[13]路保通,张鸯,胡新安,等.蒲公英有效成分提取及其抑菌活性作用[J].中国兽医杂志,2008,44(5):45-46.DOI:10.3969/j.issn.0529-6005.2008.05.024.
[14]于新慧,石学魁,张晓莉,等.蒲公英对小鼠免疫功能的调节作用[J].中国医药导刊,2008,10(6):920-921.DOI:10.3969/j.issn.1009-0959.2008.06.061.
[15]侯艳宁,朱秀媛,程桂芳,等.黄芩苷的抗炎机理[J].药学学报,2000,35(3):161-164.DOI:10.3321/j.issn:0513-4870.2000.03.001.
[16]刘庆林.浅谈桔梗药对的临床应用[J].国医论坛,2005,20(5):49-50.DOI:10.3969/j.issn.1002-1078.2005.05.049.
[17]何美莲,程小卫,陈家宽,等.桔梗皂苷类成分及其质量分析[J].中药新药与临床药理,2005,16(6):457-460.DOI:10.3321/j.issn:1003-9783.2005.06.025.
[18]利仕伟.杏仁的加工炮制及现代药理研究[J].内蒙古中医药,2014,33(1):84.DOI:10.16040/j.cnki.cn15-1101.2014.01.187.
[19]王涛,刘宏祥,王颖,等.清热化痰解毒汤对急性脑梗死患者缺损神经功能修复的影响[J].河北医药,2018,40(10):1558-1560.DOI:10.3969/j.issn.1002-7386.2018.10.030.
[2]中华神经科学会.各类脑血管疾病诊断要点[J].中华神经科杂志,1996,29(6):379.
[3]国家中医药管理局脑病急症协作组.中风病诊断与疗效评定标准[J].北京中医药大学学报,1996,19(1):55.
[4]卒中相关性肺炎诊治中国专家共识组.卒中相关性肺炎诊治中国专家共识[J].中华内科学杂志,2010,89(12):1075-1078.DOI:10.3760/cma.j.issn.0578-1426.2010.12.031.
[5]张道培,闫福岭.卒中相关性肺炎及其发病机制[J].国际脑血管病杂志,2007,15(1):63-66.DOI:10.3760/cma.j.issn.1673-4165.2007.01.012.
[6]李辉.临床肺部感染评分和C-反应蛋白在老年社区获得性肺炎预后评估中的应用[J].临床肺科杂志,2010,15(6):843-844.DOI:10.3969/j.issn.1009-6663.2010.06.048.
[7]李洁,张岱州,高丽霞.中药郁金的现代药理研究概况[J].内蒙古中医药,2001,1(2):37-38.DOI:10.3969/j.issn.1006-0979.2001.01.035.
[8]杨晓燕,陈发奎.菖蒲的化学成分研究概况[J].沈阳药科大学学报,1999,16(1):71.DOI:10.3969/j.issn.1006-2858.1999.01.019.
[9]滕勇荣,王连侠,张永清.瓜蒌药理研究进展[J].齐鲁药事,2010,29(7):417-419.DOI:10.3969/j.issn.1672-7738.2010.07.017.
[10]张明发,沈雅琴.射干药理研究进展[J].中国执业药师,2010,7(1):14-18.DOI:10.3969/j.issn.1672-5433.2010.01.005.
[11]姚丽娜.湖北贝母、鄂北贝母、紫花鄂北贝母生物总碱对呼吸系统的药理作用[J].同济医科大学学报,1993,22(1):47.
[12]肖灿鹏.中药贝母几种主要成分的体外抗菌活性[J].中国药科大学学报,1992,23(3):188.
[13]路保通,张鸯,胡新安,等.蒲公英有效成分提取及其抑菌活性作用[J].中国兽医杂志,2008,44(5):45-46.DOI:10.3969/j.issn.0529-6005.2008.05.024.
[14]于新慧,石学魁,张晓莉,等.蒲公英对小鼠免疫功能的调节作用[J].中国医药导刊,2008,10(6):920-921.DOI:10.3969/j.issn.1009-0959.2008.06.061.
[15]侯艳宁,朱秀媛,程桂芳,等.黄芩苷的抗炎机理[J].药学学报,2000,35(3):161-164.DOI:10.3321/j.issn:0513-4870.2000.03.001.
[16]刘庆林.浅谈桔梗药对的临床应用[J].国医论坛,2005,20(5):49-50.DOI:10.3969/j.issn.1002-1078.2005.05.049.
[17]何美莲,程小卫,陈家宽,等.桔梗皂苷类成分及其质量分析[J].中药新药与临床药理,2005,16(6):457-460.DOI:10.3321/j.issn:1003-9783.2005.06.025.
[18]利仕伟.杏仁的加工炮制及现代药理研究[J].内蒙古中医药,2014,33(1):84.DOI:10.16040/j.cnki.cn15-1101.2014.01.187.
[19]王涛,刘宏祥,王颖,等.清热化痰解毒汤对急性脑梗死患者缺损神经功能修复的影响[J].河北医药,2018,40(10):1558-1560.DOI:10.3969/j.issn.1002-7386.2018.10.030.