孟鲁斯特钠联合布地奈德治疗支气管哮喘的临床效果研究
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摘要
目的观察支气管哮喘者接受孟鲁斯特钠联合布地奈德治疗的效果。方法选择笔者所在科室于2018年1—年10月期间收治的128例支气管哮喘患者,等分为(甲组、乙组)两组,分别接受布地奈德与布地奈德+孟鲁斯特钠治疗,比较两组疗效。结果乙组治疗总有效率为95.3%,明显高于甲组75.0%(48例)(P<0.01);治疗后,两组患者嗜酸性粒细胞计数均有所降低,乙组下降比甲组更为明显(P<0.05);两组患者在用药治疗期间均未出现明显不良反应。结论孟鲁斯特钠与布地奈德联合疗法用于支气管哮喘临床治疗,有助于降低嗜酸性粒细胞计数,疗效优良且具有较高安全性,值得推广。
Objective To observe the effect of treatment of bronchial asthma with montelukast sodium combined with budesonide. Methods A total of 128 patients with bronchial asthma who were admitted to the department from January to October 2018 were enrolled in the two groups(group A and group B). They were treated with budesonide and budesonide + montelukast. The efficacy of the two groups was compared. Results The total effective rate of treatment in group B was 95.3%, which was significantly higher than that in group A 75.0%(48 case)(P<0.01). After treatment, the eosinophil counts were decreased in both groups, and group B decreased more than group A(P<0.05); no significant adverse effects occurred during the treatment of the two groups of patients. Conclusion The combination of montelukast sodium and budesonide for the clinical treatment of bronchial asthma can help reduce eosinophil count, with excellent curative effect and high safety. It is worthy of promotion.
Objective To observe the effect of treatment of bronchial asthma with montelukast sodium combined with budesonide. Methods A total of 128 patients with bronchial asthma who were admitted to the department from January to October 2018 were enrolled in the two groups(group A and group B). They were treated with budesonide and budesonide + montelukast. The efficacy of the two groups was compared. Results The total effective rate of treatment in group B was 95.3%, which was significantly higher than that in group A 75.0%(48 case)(P<0.01). After treatment, the eosinophil counts were decreased in both groups, and group B decreased more than group A(P<0.05); no significant adverse effects occurred during the treatment of the two groups of patients. Conclusion The combination of montelukast sodium and budesonide for the clinical treatment of bronchial asthma can help reduce eosinophil count, with excellent curative effect and high safety. It is worthy of promotion.
引文
[1]莫健平.平喘汤联合孟鲁斯特钠治疗支气管哮喘随机平行对照研究[J].实用中医内科杂志, 2015,12(4):102-104.
[2]陆薇薇.布地奈德联合孟鲁司特钠治疗小儿支气管哮喘的疗效观察[J].浙江临床医学, 2015,14(2):243-244.
[3]陈琳,唐聪,吴蕾.孟鲁司特治疗支气管哮喘的疗效及对患者免疫状态的影响[J].中国生化药物杂志, 2017, 37(2):249-251.
[4]高小英.孟鲁司特钠联合布地奈德治疗儿童支气管哮喘的临床疗效[J].医学综述, 2016, 22(18):3712-3714.
[5]黎剑泉,徐小琳,邹云新.孟鲁司特钠联合舒利迭治疗支气管哮喘的临床分析[J].中国医学创新,2015,12(14):148-149.
[6]张雨星.布地奈德联合孟鲁司特钠治疗支气管哮喘临床观察[J].临床合理用药杂志, 2015,4(16):28-29.
[7]宋瑞红,张华伟,鲁立文.孟鲁司特钠联合信必可都保对支气管哮喘的疗效及对血清EOS影响[J].临床肺科杂志, 2016, 21(10):1909-1911.
[8]郭彩云,杨帆.孟鲁斯特钠联合布地奈德治疗支气管哮喘临床疗效观察[J].饮食保健, 2016, 3(12):123-124.
[9]任晋茹.孟鲁斯特钠联合布地奈德治疗支气管哮喘临床效果分析[J].中国处方药, 2015(2):44-45.
[10]白青好.孟鲁司特钠联合布地奈德治疗支气管哮喘临床疗效观察[J].吉林医学, 2015(10):2107.
[2]陆薇薇.布地奈德联合孟鲁司特钠治疗小儿支气管哮喘的疗效观察[J].浙江临床医学, 2015,14(2):243-244.
[3]陈琳,唐聪,吴蕾.孟鲁司特治疗支气管哮喘的疗效及对患者免疫状态的影响[J].中国生化药物杂志, 2017, 37(2):249-251.
[4]高小英.孟鲁司特钠联合布地奈德治疗儿童支气管哮喘的临床疗效[J].医学综述, 2016, 22(18):3712-3714.
[5]黎剑泉,徐小琳,邹云新.孟鲁司特钠联合舒利迭治疗支气管哮喘的临床分析[J].中国医学创新,2015,12(14):148-149.
[6]张雨星.布地奈德联合孟鲁司特钠治疗支气管哮喘临床观察[J].临床合理用药杂志, 2015,4(16):28-29.
[7]宋瑞红,张华伟,鲁立文.孟鲁司特钠联合信必可都保对支气管哮喘的疗效及对血清EOS影响[J].临床肺科杂志, 2016, 21(10):1909-1911.
[8]郭彩云,杨帆.孟鲁斯特钠联合布地奈德治疗支气管哮喘临床疗效观察[J].饮食保健, 2016, 3(12):123-124.
[9]任晋茹.孟鲁斯特钠联合布地奈德治疗支气管哮喘临床效果分析[J].中国处方药, 2015(2):44-45.
[10]白青好.孟鲁司特钠联合布地奈德治疗支气管哮喘临床疗效观察[J].吉林医学, 2015(10):2107.