血清S100B及IL-6水平与2型糖尿病合并慢性阻塞性肺疾病的关系研究
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摘要
目的探讨血清S100B及白细胞介素-6(IL-6)水平与2型糖尿病合并慢性阻塞性肺疾病的关系。方法选择314例患者行肺功能检查,其中2型糖尿病合并慢性阻塞性肺疾病患者102例,单纯性慢性阻塞性肺疾病患者78例,选择134例单纯性糖尿病患者作为对照组,比较3组患者S100B及IL-6水平变化。结果 2型糖尿病合并慢性阻塞性肺疾病较单纯性糖尿病组S100B [(81.60±5.713) ng/L比(61.60±7.52)ng/L]及IL-6 (94.76±8.096)pmol/L比(70.83±12.964)pmol/L]显著升高(P<0.05);进一步研究发现,2型糖尿病合并慢性阻塞性肺疾病较单纯性慢性阻塞性肺疾病S100B [(81.60±5.713)ng/L比(75.32±13.249)ng/L]及IL-6 (94.76±8.096)pmol/L比(73.62±13.572)pmol/L]亦明显升高(P<0.05)。结论血清S100B及IL-6水平在2型糖尿病合并慢性阻塞性肺疾病患者发病中具有重要作用。
Objective To explore the association of S100 B and IL-6 levels in chronic obstructive pulmonary disease patients with type 2 diabetes mellitus(T2 DM). Methods A total of 314 patients were selected for pulmonary function examination,including 102 patients with T2 DM complicated with chronic obstructive pulmonary disease(COPD) and 78 patients with simple COPD. 134 patients with simple diabetes were selected as the control group to compare the changes of S100 B and IL-6 levels in three groups.Results S100 B was(81.60±5.713) ng/L in patients with T2 DM complicated with COPD and(61.60±7.52) ng/L in patients with simple COPD(P<0.05).And IL-6(94.76±8.096) in patients with T2 DM complicated with COPD and(70.83±12.964) pmol/L in patients with simple COPD(P<0.05). Further studies showed that the ratio of S100 B [(81.60±5.713) vs(75.32±13.249) ng/L]and the ratio of IL-6(94.76±8.096) to(73.62±13.572) pmol/L of T2 DM was significantly higher than that of simple COPD(P<0.05).Conclusion The serum S100 B and Il-6 levels may play an important role in the development of chronic obstructive pulmonary disease in patients with T2 DM.
Objective To explore the association of S100 B and IL-6 levels in chronic obstructive pulmonary disease patients with type 2 diabetes mellitus(T2 DM). Methods A total of 314 patients were selected for pulmonary function examination,including 102 patients with T2 DM complicated with chronic obstructive pulmonary disease(COPD) and 78 patients with simple COPD. 134 patients with simple diabetes were selected as the control group to compare the changes of S100 B and IL-6 levels in three groups.Results S100 B was(81.60±5.713) ng/L in patients with T2 DM complicated with COPD and(61.60±7.52) ng/L in patients with simple COPD(P<0.05).And IL-6(94.76±8.096) in patients with T2 DM complicated with COPD and(70.83±12.964) pmol/L in patients with simple COPD(P<0.05). Further studies showed that the ratio of S100 B [(81.60±5.713) vs(75.32±13.249) ng/L]and the ratio of IL-6(94.76±8.096) to(73.62±13.572) pmol/L of T2 DM was significantly higher than that of simple COPD(P<0.05).Conclusion The serum S100 B and Il-6 levels may play an important role in the development of chronic obstructive pulmonary disease in patients with T2 DM.
引文
[1] 盛乐智,陶魁林,蔡振荣,等.2型糖尿病合并急性冠状动脉综合征患者血清S100B、S100A6、S100P水平回顾性分析[J].心脑血管病防治,2018,4(11):285-288.
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[5] 盛乐智,程英平,王树云,等.血清S100B蛋白、S100A6蛋白、S100P蛋白及C反应蛋白水平对急性冠脉综合征患者短期预后的预测价值研究[J].实用心脑肺血管病杂志,2018,26(4):15-18.
[6] 盛乐智,陈秋静,张奇,等.血清S100B、S100A6、S100P水平升高与急性冠脉综合征的相关性研究[J].国际心血管病杂志,2016,43(2):115-119.
[7] 徐继勋,徐维利.慢性阻塞性肺疾病患者lep-tin、IL-6的表达变化及其意义[J].临床肺科杂志,2016,21(8):1445-1448.
[2] 蔡柏蔷.慢性阻塞性肺疾病诊断、处理和预防全球策略(2017GOLD报告)解读[J].国际呼吸杂志,2017,37(1):6-17.
[3] 中华医学会糖尿病学分会.中国2型糖尿病防治指南(2013年版)[J].中国糖尿病杂志,2014,10(8):2-42.
[4] 顾天伟,钮清,朱大龙,等.中美指南推荐的糖尿病风险评估量表在中国人群中筛查糖尿病的效能评估[J].临床内科杂志,2018,35(8):531-534.
[5] 盛乐智,程英平,王树云,等.血清S100B蛋白、S100A6蛋白、S100P蛋白及C反应蛋白水平对急性冠脉综合征患者短期预后的预测价值研究[J].实用心脑肺血管病杂志,2018,26(4):15-18.
[6] 盛乐智,陈秋静,张奇,等.血清S100B、S100A6、S100P水平升高与急性冠脉综合征的相关性研究[J].国际心血管病杂志,2016,43(2):115-119.
[7] 徐继勋,徐维利.慢性阻塞性肺疾病患者lep-tin、IL-6的表达变化及其意义[J].临床肺科杂志,2016,21(8):1445-1448.