扁担藤化学成分的研究
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摘要
目的研究扁担藤Tetrastigma planule(Hook.) Gagnep.的化学成分。方法扁担藤80%乙醇提取物采用硅胶、大孔吸附树脂、Sephadex LH-20进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到16个化合物,分别鉴定为coelarthenol (1)、ethyl 3β-hydroxy-5-cholen-26-oate (2)、蒲公英赛酮(3)、 dennettine (4)、3-β(stearyolxy)olean-12-ene (5)、棕榈酸(6)、水杨酸(7)、β-谷甾醇油酸酯(8)、香草酸(9)、豆甾醇(10)、12-methyltridecan-1-ol(11)、异东莨菪内酯(12)、estigmast-4-en-6β-ol-3-one (13)、stigmast-4,2 2-dien-3-one (14)、D-葡萄糖(15)、D-甘露醇(16)。结论化合物1～5、8、11～16为首次从该植物中分离得到。
AIM To study the chemical constituents from Tetrastigma planicaul(Hook.) Gagnep.METHODS The 80% ethanol extract from T. planicaul was isolated and purified by silica,macroporous adsorbent resin and Sephadex LH-20,then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Sixteen compounds were isolated and identified as coelarthenol(1), ethyl 3β-hydroxy-5-cholen-26-oate(2), taraxerone(3),dennettine(4), 3-β(stearyolxy)olean-12-ene(5), palmitic acid(6), salicy-lic acid(7), β-sitosteryl oleate(8), vanillic acid(9), stigmasterol(10),12-methyltridecan-1-ol(11),isoscopletin(12), estigmast-4-en-6β-ol-3-one(13),stigmast-4,2, 2-dien-3-one(14), D-glucose(15), D-mannitol(16).CONCLUSION Compounds 1-5,8,11-16 are isolated from this plant for the first time.
AIM To study the chemical constituents from Tetrastigma planicaul(Hook.) Gagnep.METHODS The 80% ethanol extract from T. planicaul was isolated and purified by silica,macroporous adsorbent resin and Sephadex LH-20,then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Sixteen compounds were isolated and identified as coelarthenol(1), ethyl 3β-hydroxy-5-cholen-26-oate(2), taraxerone(3),dennettine(4), 3-β(stearyolxy)olean-12-ene(5), palmitic acid(6), salicy-lic acid(7), β-sitosteryl oleate(8), vanillic acid(9), stigmasterol(10),12-methyltridecan-1-ol(11),isoscopletin(12), estigmast-4-en-6β-ol-3-one(13),stigmast-4,2, 2-dien-3-one(14), D-glucose(15), D-mannitol(16).CONCLUSION Compounds 1-5,8,11-16 are isolated from this plant for the first time.
引文
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[13] 刘睿. 中草药长叶水麻(Debregeasia Longifolia)和密脉鹅掌柴(Schefflera Venulosa)的抗癌活性成分研究[D]. 青岛:中国海洋大学, 2003.
[2] Ali M S, Jahangir M, Saleem M, et al. Metabolites of marine algae collected from Karachi-coasts of Arabian Sea[J]. Nat Prodt Sci, 2000, 6(2):61-65.
[3] Sepe V, Leva F S D, D’Amore C, et al. Marine and semisynthetic hydroxysteroids as new scaffolds for pregnane X receptor modulation[J]. Marine Drugs, 2014, 12(6):3091-3115.
[4] 王金兰, 姚佳, 刘继梅, 等. 柞树皮化学成分研究[J]. 中草药, 2014, 45(21):3062-3066.
[5] Lopez-Martin J, Anam E M, Boira H, et al. Chromone and phenanthrene alkaloids from Dennettia tripetala[J]. Chem Pharm Bull (Tokyo), 2002, 50(12):1613-1615.
[6] Vieira Filho S A, Duarte L P, Silva G D F. 3β-(Stearyloxy)ole—an-12-ene from austroplenckia populnea: structure elucidation by 2D-NMR and quantitative 13C-NMR spectroscopy[J]. Helv Chim Acta, 2003, 86(10):3445-3449.
[7] 刘桂艳, 马双成, 郑健, 等. 深绿山龙眼种子化学成分研究(Ⅰ)[J]. 中草药, 2005, 36(6):814-817.
[8] 郭良君, 谭兴起, 郑巍, 等. 地瓜藤化学成分研究[J].中草药, 2011,42(9):1709-1711.
[9] Abuzer A, Mohammad J,Mohammed A. New naphthyl esters from the bark of Ficus religiosa Linn[J]. Nat Prod J,2014, 4(4):248-253.
[10] Dickschat J S, Helmke E, Schulz S.Volatile organic compounds from arctic bacteria of the cytophaga-flavobacterium-bacteroides group: A retrobiosynthetic approach in chemotaxono—mic investigations[J]. Chem Biodivers, 2005, 2(3):318.
[11] 李慧慧. 刺五加浸膏化学成分及活性研究[D]. 齐齐哈尔:齐齐哈尔大学,2015.
[12] Correia, David S D J, David J P, et al. Constituintes das casde Tapirira guianensis (Anacardiaceae)[J]. Quím Nova, 2003, 26(1): 36-38.
[13] 刘睿. 中草药长叶水麻(Debregeasia Longifolia)和密脉鹅掌柴(Schefflera Venulosa)的抗癌活性成分研究[D]. 青岛:中国海洋大学, 2003.