MicroRNA与室性心律失常关系的研究进展
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摘要
微小RNA(microRNA,简称miRNA)是长约22个核苷酸的小的非编码RNA,在各种生物过程中发挥重要作用,包括发育、分化、凋亡、细胞增殖和细胞衰老。近年研究发现,miRNA是心脏生理和病理条件的重要调节剂,多个miRNA与室性心律失常密切相关,包括miRNA-1(miR-1)、miR-21、miR-130a、miR-133、miR-208等。
引文
[1]Hsueh CH,Chen NX,Lin SF,et al.Pathogenesis of arrhythmias in a model of CKD[J].J Am Soc Nephrol,2014,25(12):2812-2821.
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[3]Heidersbach A,Saxby C,Carver-Moore K,et al.microRNA-1regulates sarcomere formation and suppresses smooth muscle gene expression in the mammalian heart[J].Elife,2013,2:e01323.
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[7]Curcio A,Torella D,Iaconetti C,et al.MicroRNA-1 downregulation increases connexin 43 displacement and induces ventricular tachyarrhythmias in rodent hypertrophic hearts[J].PLo S One,2013,8(7):e70158.
[8]Yang B,Lin H,Xiao J,et al.The muscle-specific microRNAmiR-1 regulates cardiac arrhythmogenic potential by targeting GJA1and KCNJ2[J].Nat Med,2007,13(4):486-491.
[9]Lu Y,Zhang Y,Shan H,et al.MicroRNA-1 downregulation by propranolol in a rat model of myocardial infarction:a new mechanism for ischaemic cardioprotection[J].Cardiovasc Res,2009,84(3):434-441.
[10]NeckáJ,BoudíkováA,MandíkováP,et al.Protective effects of dexrazoxane against acute ischaemia/reperfusion injury of rat hearts[J].Can J Physiol Pharmacol,2012,90(9):1303-1310.
[11]Han Q,Zhang HY,Zhong BL,et al.Antiapoptotic effect of recombinant HMGB1 A-box protein via regulation of microrna-21 in myocardial ischemia-reperfusion injury model in rats[J].DNACell Biol,2016,35(4):192-202.
[12]Yang L,Wang B,Zhou Q,et al.MicroRNA-21 prevents excessive inflammation and cardiac dysfunction after myocardial infarction through targeting KBTBD7[J].Cell Death Dis,2018,9(7):769.
[13]Zhang HD,Jiang LH,Sun DW,et al.The role of miR-130a in cancer[J].Breast Cancer,2017,24(4):521-527.
[14]Matkovich SJ,Van Booven DJ,Youker KA,et al.Reciprocal regulation of myocardial microRNAs and messenger RNA in human cardiomyopathy and reversal of the microRNA signature by biomechanical support[J].Circulation,2009,119(9):1263-1271.
[15]Osbourne A,Calway T,Broman M,et al.Downregulation of connexin43 by microRNA-130a in cardiomyocytes results in cardiac arrhythmias[J].J Mol Cell Cardiol,2014,74:53-63.
[16]Mazurek SR,Calway T,Harmon C,et al.MicroRNA-130a regulation of desmocollin 2 in a novel model of arrhythmogenic cardiomyopathy[J].Microrna,2017,6(2):143-150.
[17]Yu H,Lu Y,Li Z,et al.microRNA-133:expression,function and therapeutic potential in muscle diseases and cancer[J].Curr Drug Targets,2014,15(9):817-828.
[18]Chistiakov DA,Orekhov AN,Bobryshev YV.Cardiac-specific miRNA in cardiogenesis,heart function,and cardiac pathology(with focus on myocardial infarction)[J].J Mol Cell Cardiol,2016,94:107-121.
[19]Xiao L,Xiao J,Luo X,et al.Feedback remodeling of cardiac potassium current expression:a novel potential mechanism for control of repolarization reserve[J].Circulation,2008,118(10):983-992.
[20]Li YD,Hong YF,Yusufuaji Y,et al.Altered expression of hyperpolarization-activated cyclic nucleotide-gated channels and microR-NA-1 and-133 in patients with age-associated atrial fibrillation[J].Mol Med Rep,2015,12(3):3243-3248.
[21]Chen Y,Zhao Y,Chen W,et al.MicroRNA-133 overexpression promotes the therapeutic efficacy of mesenchymal stem cells on acute myocardial infarction[J].Stem Cell Res Ther,2017,8(1):268.
[22]Liu Y,Liang Y,Zhang JF,et al.MicroRNA-133 mediates cardiac diseases:Mechanisms and clinical implications[J].Exp Cell Res,2017,354(2):65-70.
[23]Huang Y,Li J.MicroRNA208 family in cardiovascular diseases:therapeutic implication and potential biomarker[J].J Physiol Biochem,2015,71(3):479-486.
[24]Callis TE,Pandya K,Seok HY,et al.MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice[J].J Clin Invest,2009,119(9):2772-2786.
[25]Bostjancic E,Zidar N,Stajer D,et al.MicroRNAs miR-1,miR-133a,miR-133b and miR-208 are dysregulated in human myocardial infarction[J].Cardiology,2010,115(3):163-169.
[26]Li C,Fang Z,Jiang T,et al.Serum microRNAs profile from genome-wide serves as a fingerprint for diagnosis of acute myocardial infarction and angina pectoris[J].BMC Med Genomics,2013,6:16.
[27]van Rooij E,Sutherland LB,Thatcher JE,et al.Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis[J].Proc Natl Acad Sci USA,2008,105(35):13027-13032.
[28]Liu X,Zhang Y,Du W,et al.MiR-223-3p as a novel MicroRNAregulator of expression of voltage-gated K+channel Kv4.2 in acute myocardial infarction[J].Cell Physiol Biochem,2016,39(1):102-114.
[29]Zhang Y,Wang R,Du W,et al.Downregulation of miR-151-5p contributes to increased susceptibility to arrhythmogenesis during myocardial infarction with estrogen deprivation[J].PLo S One,2013,8(9):e72985.
[30]Blanco RR,Austin H,Vest RN 3rd,et al.Angiotensin receptor type 1 single nucleotide polymorphism 1166A/C is associated with malignant arrhythmias and altered circulating miR-155 levels in patients with chronic heart failure[J].J Card Fail,2012,18(9):717-723.
[31]Jin Y,Zhou TY,Cao JN,et al.MicroRNA-206 downregulates connexin43 in cardiomyocytes to induce cardiac arrhythmias in a transgenic mouse model[J].Heart Lung Circ,2018,S1443-9506(18):31917.
[32]Sommariva E,D'Alessandra Y,Farina FM,et al.MiR-320a as a potential novel circulating biomarker of arrhythmogenic cardiomyopathy[J].Sci Rep,2017,7(1):4802.
[33]Yamada S,Hsiao YW,Chang SL,et al.Circulating microRNAs in arrhythmogenic right ventricular cardiomyopathy with ventricular arrhythmia[J].Europace,2018,20(FI1):f37-f45.
[2]Hedley PL,Carlsen AL,Christiansen KM,et al.MicroRNAs in cardiac arrhythmia:DNA sequence variation of MiR-1 and MiR-133A in long QT syndrome[J].Scand J Clin Lab Invest,2014,74(6):485-491.
[3]Heidersbach A,Saxby C,Carver-Moore K,et al.microRNA-1regulates sarcomere formation and suppresses smooth muscle gene expression in the mammalian heart[J].Elife,2013,2:e01323.
[4]Duan L,Xiong X,Liu Y,et al.miRNA-1:functional roles and dysregulation in heart disease[J].Mol Biosyst,2014,10(11):2775-2782.
[5]Curcio A,Torella D,Iaconetti C,et al.MicroRNA-1 downregulation increases connexin 43 displacement and induces ventricular tachyarrhythmias in rodent hypertrophic hearts[J].PLo S One,2013,8(7):e70158.
[6]Sovari A A,Iravanian S,Dolmatova E,et al.Inhibition of c-Src tyrosine kinase prevents angiotensinⅡ-mediated connexin-43 remodeling and sudden cardiac death[J].J Am Coll Cardiol,2011,58(22):2332-2339.
[7]Curcio A,Torella D,Iaconetti C,et al.MicroRNA-1 downregulation increases connexin 43 displacement and induces ventricular tachyarrhythmias in rodent hypertrophic hearts[J].PLo S One,2013,8(7):e70158.
[8]Yang B,Lin H,Xiao J,et al.The muscle-specific microRNAmiR-1 regulates cardiac arrhythmogenic potential by targeting GJA1and KCNJ2[J].Nat Med,2007,13(4):486-491.
[9]Lu Y,Zhang Y,Shan H,et al.MicroRNA-1 downregulation by propranolol in a rat model of myocardial infarction:a new mechanism for ischaemic cardioprotection[J].Cardiovasc Res,2009,84(3):434-441.
[10]NeckáJ,BoudíkováA,MandíkováP,et al.Protective effects of dexrazoxane against acute ischaemia/reperfusion injury of rat hearts[J].Can J Physiol Pharmacol,2012,90(9):1303-1310.
[11]Han Q,Zhang HY,Zhong BL,et al.Antiapoptotic effect of recombinant HMGB1 A-box protein via regulation of microrna-21 in myocardial ischemia-reperfusion injury model in rats[J].DNACell Biol,2016,35(4):192-202.
[12]Yang L,Wang B,Zhou Q,et al.MicroRNA-21 prevents excessive inflammation and cardiac dysfunction after myocardial infarction through targeting KBTBD7[J].Cell Death Dis,2018,9(7):769.
[13]Zhang HD,Jiang LH,Sun DW,et al.The role of miR-130a in cancer[J].Breast Cancer,2017,24(4):521-527.
[14]Matkovich SJ,Van Booven DJ,Youker KA,et al.Reciprocal regulation of myocardial microRNAs and messenger RNA in human cardiomyopathy and reversal of the microRNA signature by biomechanical support[J].Circulation,2009,119(9):1263-1271.
[15]Osbourne A,Calway T,Broman M,et al.Downregulation of connexin43 by microRNA-130a in cardiomyocytes results in cardiac arrhythmias[J].J Mol Cell Cardiol,2014,74:53-63.
[16]Mazurek SR,Calway T,Harmon C,et al.MicroRNA-130a regulation of desmocollin 2 in a novel model of arrhythmogenic cardiomyopathy[J].Microrna,2017,6(2):143-150.
[17]Yu H,Lu Y,Li Z,et al.microRNA-133:expression,function and therapeutic potential in muscle diseases and cancer[J].Curr Drug Targets,2014,15(9):817-828.
[18]Chistiakov DA,Orekhov AN,Bobryshev YV.Cardiac-specific miRNA in cardiogenesis,heart function,and cardiac pathology(with focus on myocardial infarction)[J].J Mol Cell Cardiol,2016,94:107-121.
[19]Xiao L,Xiao J,Luo X,et al.Feedback remodeling of cardiac potassium current expression:a novel potential mechanism for control of repolarization reserve[J].Circulation,2008,118(10):983-992.
[20]Li YD,Hong YF,Yusufuaji Y,et al.Altered expression of hyperpolarization-activated cyclic nucleotide-gated channels and microR-NA-1 and-133 in patients with age-associated atrial fibrillation[J].Mol Med Rep,2015,12(3):3243-3248.
[21]Chen Y,Zhao Y,Chen W,et al.MicroRNA-133 overexpression promotes the therapeutic efficacy of mesenchymal stem cells on acute myocardial infarction[J].Stem Cell Res Ther,2017,8(1):268.
[22]Liu Y,Liang Y,Zhang JF,et al.MicroRNA-133 mediates cardiac diseases:Mechanisms and clinical implications[J].Exp Cell Res,2017,354(2):65-70.
[23]Huang Y,Li J.MicroRNA208 family in cardiovascular diseases:therapeutic implication and potential biomarker[J].J Physiol Biochem,2015,71(3):479-486.
[24]Callis TE,Pandya K,Seok HY,et al.MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice[J].J Clin Invest,2009,119(9):2772-2786.
[25]Bostjancic E,Zidar N,Stajer D,et al.MicroRNAs miR-1,miR-133a,miR-133b and miR-208 are dysregulated in human myocardial infarction[J].Cardiology,2010,115(3):163-169.
[26]Li C,Fang Z,Jiang T,et al.Serum microRNAs profile from genome-wide serves as a fingerprint for diagnosis of acute myocardial infarction and angina pectoris[J].BMC Med Genomics,2013,6:16.
[27]van Rooij E,Sutherland LB,Thatcher JE,et al.Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis[J].Proc Natl Acad Sci USA,2008,105(35):13027-13032.
[28]Liu X,Zhang Y,Du W,et al.MiR-223-3p as a novel MicroRNAregulator of expression of voltage-gated K+channel Kv4.2 in acute myocardial infarction[J].Cell Physiol Biochem,2016,39(1):102-114.
[29]Zhang Y,Wang R,Du W,et al.Downregulation of miR-151-5p contributes to increased susceptibility to arrhythmogenesis during myocardial infarction with estrogen deprivation[J].PLo S One,2013,8(9):e72985.
[30]Blanco RR,Austin H,Vest RN 3rd,et al.Angiotensin receptor type 1 single nucleotide polymorphism 1166A/C is associated with malignant arrhythmias and altered circulating miR-155 levels in patients with chronic heart failure[J].J Card Fail,2012,18(9):717-723.
[31]Jin Y,Zhou TY,Cao JN,et al.MicroRNA-206 downregulates connexin43 in cardiomyocytes to induce cardiac arrhythmias in a transgenic mouse model[J].Heart Lung Circ,2018,S1443-9506(18):31917.
[32]Sommariva E,D'Alessandra Y,Farina FM,et al.MiR-320a as a potential novel circulating biomarker of arrhythmogenic cardiomyopathy[J].Sci Rep,2017,7(1):4802.
[33]Yamada S,Hsiao YW,Chang SL,et al.Circulating microRNAs in arrhythmogenic right ventricular cardiomyopathy with ventricular arrhythmia[J].Europace,2018,20(FI1):f37-f45.