Th17细胞在牙周炎中的研究进展
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摘要
牙周炎是以牙周组织炎症和牙槽骨破坏为主要特征的慢性炎症性破坏性疾病。近来研究发现Th17细胞存在于牙周炎的病变牙周组织中,提示Th17细胞参与牙周炎的发病过程。本文就Th17细胞在牙周炎发病中的作用进行综述。
Periodontitis is a chronic inflammatory disease characterized by periodontal tissue inflammation and alveolar bone destruction. Researchers have detected Th17 cells at different stages of periodontitis,suggesting that Th17 cells participate in the progress of periodontitis. This article reviews the role of Th17 cells in the development of periodontitis.
Periodontitis is a chronic inflammatory disease characterized by periodontal tissue inflammation and alveolar bone destruction. Researchers have detected Th17 cells at different stages of periodontitis,suggesting that Th17 cells participate in the progress of periodontitis. This article reviews the role of Th17 cells in the development of periodontitis.
引文
[1]王琳源,林晓萍,靳赢.适应性免疫应答在牙周炎中的作用[J].中华口腔医学,2013,48(2):115-118.
[2]王琳源,林晓萍,靳赢. CD4+T细胞在不同菌株诱导小鼠牙周炎中的表达[J].上海口腔医学,2014,23(1):20-25.
[3] Cheng WC,Hughes FJ,Taams LS. The presence,function and regulation of IL-17 and Th17 cells in periodontitis[J].J Clin Periodontol,2014,41(6):541-549.
[4] Lee W,Lee GR. Transcriptional regulation and development of regulatory T cells[J]. Exp Mol Med,2018,50(3):e456.
[5] Harrington LE,Hatton RD,Mangan PR,et al. Interleukin 17-producing CD4+effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages[J]. Nat Immunol,2005,6(11):1123-1132.
[6] Park H,Li Z,Yang XO,et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17[J]. Nat Immunol,2005,6(11):1133-1141.
[7] Wacleche VS,Landay A,Routy JP,et al. The Th17 lineage:from barrier surfaces homeostasis to autoimmunity,cancer,and HIV-1 pathogenesis[J].Viruses,2017,9(10):pii:E303.
[8] Harrington LE,Hatton RD,Mangan PR. Interlenkin 17-producing CD4+effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages[J]. Nat Immunol,2005,6(11):1123-1132.
[9] Korn T,Bettelli E,Gao W,et al. IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells[J]. Nature,2007,448(7152):484-487.
[10] Bettelli E,Carrier Y,Gao W,et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells[J].Nature,2006,441(7090):235-238.
[11] Imamura E,Taguchi K,Sasaki-Iwaoka H,et al. Anti-IL-23 receptor monoclonal antibody prevents CD4+T cell-mediated colitis in association with decreased systemic Th1 and Th17 responses[J].Eur J Pharmacol,2018,824:163-169.
[12] Mc Geachy MJ,Bak-Jensen KS,Chen Y,et al. TGF-beta and IL-6drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology[J].Nat Immunol,2007,8(12):1390-1397.
[13]王琳源,林晓萍,靳赢.适应性免疫应答在牙周炎中的作用[J].中华口腔医学,2013,48(2):115-118.
[14] Bittner-Eddy PD,Fischer LA,Kaplan DH,et al. Mucosal langerhans cells promote differentiation of Th17 cells in a murine model of periodontitis but are not required for porphyromonas gingivalisdriven alveolar bone destruction[J]. J Immunol,2016,197(4):1435-1446.
[15] Cheng WC,van Asten SD,Burns LA,et al. Periodontitis-associated pathogens P. gingivalis and A. actinomycetemcomitans activate human CD14(+)monocytes leading to enhanced Th17/IL-17 responses[J].Eur J Immunol,2016,46(9):2211-2221.
[16] Song X,Qian Y. The activation and regulation of IL-17 receptor mediated signaling[J].Cytokine,2013,62(2):175-182.
[17] Takahashi N,Okui T,Tabeta K,et al. Effect of interleukin-17 on the expression of chemokines in gingival epithelialcells[J]. Eur J Oral Sci,2011,119(5):339-344.
[18]王琳源,关宁,林晓萍.辅助性T17细胞在牙周炎小鼠中的免疫状态研究[J].华西口腔医学,2015,33(2):125-129.
[19] Mitani A,Niedbala W,Fujimura T,et al. Increased expression of interleukin(IL)-35 and IL-17,but not IL-27,in gingival tissues with chronic periodontitis[J]. J Periodontol,2015,86(2):301-309.
[20] Chen XT,Chen LL,Tan JY,et al. Th17 and Th1 lymphocytes are correlated with chronic periodontitis[J].Immunol Invest,2016,45(3):243-254.
[21] Zhao L,Zhou Y,Xu Y,et al. Effect of non-surgical periodontal therapy on the levels of Th17/Th1/Th2 cytokines and their transcription factors in Chinese chronic periodontitis patients[J]. J clin Periodontal,2011,38(6):509-516.
[22]王琳源,林晓萍. RANKL在牙周炎骨吸收中的研究进展[J].口腔医学,2013,33(7):493-495.
[23] Dutzan N,Gamonal J,Silva A,et al. Over-expression of forkhead box P3 and its association with receptor activator of nuclear factorkappa B ligand,interleukin(IL)-17,IL-10 and transforming growth factor-beta during the progression of chronic periodontitis[J].J Clin Periodontol,2009,36(5):396-403.
[24] Kuritani M,Sakai N,Karakawa A,et al. Anti-mouse RANKL antibodies inhibit alveolar bone destruction in periodontitis model mice[J].Biol Pharm Bull,2018,41(4):637-643.
[25] Peters A,Lee Y,Kuchroo VK. The many faces of Th17 cells[J].Curr Opin Immunol,2011,23(6):702-706.
[26] Pacifici R. The role of IL-17 and TH17 cells in the bone catabolic activity of PTH[J].Front Immunol,2016,7:57.
[27] P9llinger B,Junt T,Metzler B,et al. Th17 cells,not IL-17+γδT cells,drive arthritic bone destruction in mice and humans[J]. J Immunol,2011,186(4):2602-2612.
[28] Cardoso CR,Garlet GP,Crippa GE,et al. Evidence of the presence of T helper type 17 cells in chronic lesions of human periodontal disease[J].Oral Microbiol Immunol,2009,24(1):1-6.
[29] Mc Govern JL,Wright GP,Stauss HJ. Engineering specificity and function of therapeutic regulatory T cells[J].Front Immunol,2017,8:1517.
[30]王琳源,关宁,林晓萍. Treg细胞介导的免疫应答在牙周炎小鼠中的研究[J].实用口腔医学,2015,31(3):318-322.
[31] Araujo-Pires AC,Vieira AE,Francisconi CF,et al. IL-4/CCL22/CCR4 axis controls regulatory T-cell migration that suppresses inflammatory bone loss in murine experimental periodontitis[J]. J Bone Miner Res,2015,30(3):412-422.
[32] Keswani T,Sarkar S,Sengupta A,et al. Role of TGF-βand IL-6in dendritic cells, Treg and Th17 mediated immune response during experimental cerebral malaria[J]. Cytokine,2016,88:154-166.
[33] Cortes-Perez NG,Lozano-Ojalvo D,Maiga MA,et al. Intragastric administration of Lactobacillus casei BL23 induces regulatory Fox P3+RORγt+T cells subset in mice[J].Benef Microbes,2017,8(3):433-438.
[34] Ren J,Li B. The Functional stability of FOXP3 and RORγt in Treg and Th17 and their therapeutic applications[J]. Adv Protein Chem Struct Biol,2017,107:155-189.
[35] Kluger MA,Nosko A,Ramcke T,et al. RORγt expression in Tregs promotes systemic lupus erythematosus via IL-17 secretion,alteration of Treg phenotype and suppression of Th2 responses[J].Clin Exp Immunol,2017,188(1):63-78.
[36] Weitzmann MN. Bone and the immune system[J].Toxicol Pathol,2017,45(7):911-924.
[37] Ozaki Y,Koide M,Furuya Y,et al. Treatment of OPG-deficient mice with WP9QY,a RANKL-binding peptide,recovers alveolar bone loss by suppressing osteoclastogenesis and enhancing osteoblastogenesis[J].PLoS One,2017,12(9):e0184904.
[2]王琳源,林晓萍,靳赢. CD4+T细胞在不同菌株诱导小鼠牙周炎中的表达[J].上海口腔医学,2014,23(1):20-25.
[3] Cheng WC,Hughes FJ,Taams LS. The presence,function and regulation of IL-17 and Th17 cells in periodontitis[J].J Clin Periodontol,2014,41(6):541-549.
[4] Lee W,Lee GR. Transcriptional regulation and development of regulatory T cells[J]. Exp Mol Med,2018,50(3):e456.
[5] Harrington LE,Hatton RD,Mangan PR,et al. Interleukin 17-producing CD4+effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages[J]. Nat Immunol,2005,6(11):1123-1132.
[6] Park H,Li Z,Yang XO,et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17[J]. Nat Immunol,2005,6(11):1133-1141.
[7] Wacleche VS,Landay A,Routy JP,et al. The Th17 lineage:from barrier surfaces homeostasis to autoimmunity,cancer,and HIV-1 pathogenesis[J].Viruses,2017,9(10):pii:E303.
[8] Harrington LE,Hatton RD,Mangan PR. Interlenkin 17-producing CD4+effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages[J]. Nat Immunol,2005,6(11):1123-1132.
[9] Korn T,Bettelli E,Gao W,et al. IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells[J]. Nature,2007,448(7152):484-487.
[10] Bettelli E,Carrier Y,Gao W,et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells[J].Nature,2006,441(7090):235-238.
[11] Imamura E,Taguchi K,Sasaki-Iwaoka H,et al. Anti-IL-23 receptor monoclonal antibody prevents CD4+T cell-mediated colitis in association with decreased systemic Th1 and Th17 responses[J].Eur J Pharmacol,2018,824:163-169.
[12] Mc Geachy MJ,Bak-Jensen KS,Chen Y,et al. TGF-beta and IL-6drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology[J].Nat Immunol,2007,8(12):1390-1397.
[13]王琳源,林晓萍,靳赢.适应性免疫应答在牙周炎中的作用[J].中华口腔医学,2013,48(2):115-118.
[14] Bittner-Eddy PD,Fischer LA,Kaplan DH,et al. Mucosal langerhans cells promote differentiation of Th17 cells in a murine model of periodontitis but are not required for porphyromonas gingivalisdriven alveolar bone destruction[J]. J Immunol,2016,197(4):1435-1446.
[15] Cheng WC,van Asten SD,Burns LA,et al. Periodontitis-associated pathogens P. gingivalis and A. actinomycetemcomitans activate human CD14(+)monocytes leading to enhanced Th17/IL-17 responses[J].Eur J Immunol,2016,46(9):2211-2221.
[16] Song X,Qian Y. The activation and regulation of IL-17 receptor mediated signaling[J].Cytokine,2013,62(2):175-182.
[17] Takahashi N,Okui T,Tabeta K,et al. Effect of interleukin-17 on the expression of chemokines in gingival epithelialcells[J]. Eur J Oral Sci,2011,119(5):339-344.
[18]王琳源,关宁,林晓萍.辅助性T17细胞在牙周炎小鼠中的免疫状态研究[J].华西口腔医学,2015,33(2):125-129.
[19] Mitani A,Niedbala W,Fujimura T,et al. Increased expression of interleukin(IL)-35 and IL-17,but not IL-27,in gingival tissues with chronic periodontitis[J]. J Periodontol,2015,86(2):301-309.
[20] Chen XT,Chen LL,Tan JY,et al. Th17 and Th1 lymphocytes are correlated with chronic periodontitis[J].Immunol Invest,2016,45(3):243-254.
[21] Zhao L,Zhou Y,Xu Y,et al. Effect of non-surgical periodontal therapy on the levels of Th17/Th1/Th2 cytokines and their transcription factors in Chinese chronic periodontitis patients[J]. J clin Periodontal,2011,38(6):509-516.
[22]王琳源,林晓萍. RANKL在牙周炎骨吸收中的研究进展[J].口腔医学,2013,33(7):493-495.
[23] Dutzan N,Gamonal J,Silva A,et al. Over-expression of forkhead box P3 and its association with receptor activator of nuclear factorkappa B ligand,interleukin(IL)-17,IL-10 and transforming growth factor-beta during the progression of chronic periodontitis[J].J Clin Periodontol,2009,36(5):396-403.
[24] Kuritani M,Sakai N,Karakawa A,et al. Anti-mouse RANKL antibodies inhibit alveolar bone destruction in periodontitis model mice[J].Biol Pharm Bull,2018,41(4):637-643.
[25] Peters A,Lee Y,Kuchroo VK. The many faces of Th17 cells[J].Curr Opin Immunol,2011,23(6):702-706.
[26] Pacifici R. The role of IL-17 and TH17 cells in the bone catabolic activity of PTH[J].Front Immunol,2016,7:57.
[27] P9llinger B,Junt T,Metzler B,et al. Th17 cells,not IL-17+γδT cells,drive arthritic bone destruction in mice and humans[J]. J Immunol,2011,186(4):2602-2612.
[28] Cardoso CR,Garlet GP,Crippa GE,et al. Evidence of the presence of T helper type 17 cells in chronic lesions of human periodontal disease[J].Oral Microbiol Immunol,2009,24(1):1-6.
[29] Mc Govern JL,Wright GP,Stauss HJ. Engineering specificity and function of therapeutic regulatory T cells[J].Front Immunol,2017,8:1517.
[30]王琳源,关宁,林晓萍. Treg细胞介导的免疫应答在牙周炎小鼠中的研究[J].实用口腔医学,2015,31(3):318-322.
[31] Araujo-Pires AC,Vieira AE,Francisconi CF,et al. IL-4/CCL22/CCR4 axis controls regulatory T-cell migration that suppresses inflammatory bone loss in murine experimental periodontitis[J]. J Bone Miner Res,2015,30(3):412-422.
[32] Keswani T,Sarkar S,Sengupta A,et al. Role of TGF-βand IL-6in dendritic cells, Treg and Th17 mediated immune response during experimental cerebral malaria[J]. Cytokine,2016,88:154-166.
[33] Cortes-Perez NG,Lozano-Ojalvo D,Maiga MA,et al. Intragastric administration of Lactobacillus casei BL23 induces regulatory Fox P3+RORγt+T cells subset in mice[J].Benef Microbes,2017,8(3):433-438.
[34] Ren J,Li B. The Functional stability of FOXP3 and RORγt in Treg and Th17 and their therapeutic applications[J]. Adv Protein Chem Struct Biol,2017,107:155-189.
[35] Kluger MA,Nosko A,Ramcke T,et al. RORγt expression in Tregs promotes systemic lupus erythematosus via IL-17 secretion,alteration of Treg phenotype and suppression of Th2 responses[J].Clin Exp Immunol,2017,188(1):63-78.
[36] Weitzmann MN. Bone and the immune system[J].Toxicol Pathol,2017,45(7):911-924.
[37] Ozaki Y,Koide M,Furuya Y,et al. Treatment of OPG-deficient mice with WP9QY,a RANKL-binding peptide,recovers alveolar bone loss by suppressing osteoclastogenesis and enhancing osteoblastogenesis[J].PLoS One,2017,12(9):e0184904.