肝脏离段联合门静脉结扎二期肝切除术的研究进展
|
摘要
术后肝功能衰竭一直是肝脏外科医生面临的一大难题,而术后肝功能衰竭往往与(FLR)不足直接相关。肝脏离段联合门静脉结扎二期肝切除术(ALPPS)作为能在短期内使FLR快速增长的一项革新技术,为因FLR不足而无法施行根治性手术的患者带来了希望。但在许多大型中心先后报道ALPPS的高病死率后,如何正确把握ALPPS手术适应证及对传统ALPPS术式的改进显得尤为重要。笔者对ALPPS促进FLR增生机制、ALPPS的病例选择、ALPPS术式的争议及目前基于经典ALPPS衍生术式的最新进展进行综述。
Postoperative liver failure has always been a difficult issue for liver surgeons, which is often directly related to the small volume of future liver remnant(FLR). The associating liver partition and portal vein ligation for staged hepatectomy(ALPPS) is an innovative technique for rapid growth of FLR in a short period of time, which brings hope to those who cannot withstand a radical surgery because of insufficient volume of FLR. However, after the high postoperative mortality rates of ALPPS reported by many large medical centers, how to correctly grasp the indications of ALPPS and improve the traditional ALPPS becomes particularly important. Here, the authors address the mechanism of ALPPS promoting FLR hyperplasia, the case selection for ALPPS, the controversies regarding ALPPS and the latest progress of the derivative procedures based on the classical ALPPS.
Postoperative liver failure has always been a difficult issue for liver surgeons, which is often directly related to the small volume of future liver remnant(FLR). The associating liver partition and portal vein ligation for staged hepatectomy(ALPPS) is an innovative technique for rapid growth of FLR in a short period of time, which brings hope to those who cannot withstand a radical surgery because of insufficient volume of FLR. However, after the high postoperative mortality rates of ALPPS reported by many large medical centers, how to correctly grasp the indications of ALPPS and improve the traditional ALPPS becomes particularly important. Here, the authors address the mechanism of ALPPS promoting FLR hyperplasia, the case selection for ALPPS, the controversies regarding ALPPS and the latest progress of the derivative procedures based on the classical ALPPS.
引文
[1]Tong YF,Meng N,Chen MQ,et al.Maturity of associating liver partition and portal vein ligation for staged hepatectomy-derived liver regeneration in a rat model[J].World J Gastroenterol,2018,24(10):1107-1119.doi:10.3748/wjg.v24.i10.1107.
[2]彭远飞,王征,周俭.联合肝脏离断和门静脉结扎的二步肝切除术的争议与发展[J].外科理论与实践,2018,23(3):185-190.doi:10.16139/j.1007-9610.2018.03.001.Peng YF,Wang Z,Zhou J.Controversy and development of associating liver partition and portal vein ligation for staged hepatectomy[J].Journal of Surgery Concepts&Practice,2018,23(3):185-190.doi:10.16139/j.1007-9610.2018.03.001.
[3]Kokudo N,Tada K,Seki M,et al.Proliferative activity of intrahepatic colorectal metastases after preoperative hemihepatic portal vein embolization[J].Hepatology,2001,34(2):267-272.doi:10.1053/jhep.2001.26513.
[4]Clavien PA,Petrowsky H,DeOliveira ML,et al.Strategies for safer liver surgery and partial liver transplantation[J].N Engl J Med,2007,356(15):1545-1559.doi:10.1056/NEJMra065156.
[5]Schnitzbauer AA,Lang SA,Goessmann H,et al.Right portal vein ligation combined with in situ splitting induces rapid left lateral liver lobe hypertrophy enabling 2-staged extended right hepatic resection in small-for-size settings[J].Ann Surg,2012,255(3):405-414.doi:10.1097/SLA.0b013e31824856f5.
[6]Stockmann M,Bednarsch J,Malinowski M,et al.Functional considerations in ALPPS-consequences for clinical management[J].HPB(Oxford),2017,19(11):1016-1025.doi:10.1016/j.hpb.2017.07.010.
[7]Bertens KA,Hawel J,Lung K,et al.ALPPS:challenging the concept of unresectability--a systematic review[J].Int J Surg,2015,13:280-287.doi:10.1016/j.ijsu.2014.12.008.
[8]Li J,Girotti P,K?nigsrainer I,et al.ALPP Sinright trisectionectomy:a safe procedure to avoid postoperative liver failure[J].J Gastrointest Surg,2013,17(5):956-961.doi:10.1007/s11605-012-2132-y.
[9]Takamoto T,Sugawara Y,Hashimoto T,et al.Associating liver partition and portal vein ligation(ALPPS):Taking a view of trails[J].Biosci Trends,2015,9(5):280-283.doi:10.5582/bst.2015.01131.
[10]Schadde E,Ardiles V,Robles-Campos R,et al.Early survival and safety of ALPPS:first report of the International ALPPSRegistry[J].Ann Surg,2014,260(5):829-836.doi:10.1097/SLA.0000000000000947.
[11]Nadalin S,Capobianco I,Li J,et al.Indications and limits for associating liver partition and portal vein ligation for staged hepatectomy(ALPPS).Lessons Learned from 15 cases at a single centre[J].Z Gastroenterol,2014,52(1):35-42.doi:10.1055/s-0033-1356364.
[12]Vivarelli M,Vincenzi P,Montalti R,et al.ALPPS Procedure for Extended Liver Resections:A Single Centre Experience and a Systematic Review[J].PLoS One,2015,10(12):e0144019.doi:10.1371/journal.pone.0144019.
[13]Alvarez FA,Ardiles V,de Santiba?es M,et al.Associating liver partition and portal vein ligation for staged hepatectomy offers high oncological feasibility with adequate patient safety:a prospective study at a single center[J].Ann Surg,2015,261(4):723-732.doi:10.1097/SLA.0000000000001046.
[14]Hasselgren K,Sandstr?m P,Bj?rnsson B.Role of associating liver partition and portal vein ligation for staged hepatectomy in colorectal liver metastases:a review[J].World J Gastroenterol,2015,21(15):4491-4498.doi:10.3748/wjg.v21.i15.4491.
[15]Yao L,Li C,Ge X,et al.Establishment of a rat model of portal vein ligation combined with in situ splitting[J].PLoS One,2014,9(8):e105511.doi:10.1371/journal.pone.0105511.
[16]Schadde E,Hertl M,Breitenstein S,et al.Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy(ALPPS)Procedure[J].J Vis Exp,2017,(126).doi:10.3791/55895.
[17]林为东,莫经刚.ALPPS促进剩余肝脏快速增生机制及相关因素研究进展[J].中国普通外科杂志,2017,26(8):1065-1070.doi:10.3978/j.issn.1005-6947.2017.08.016.Lin WD,Mo JG.Mechanisms of ALPPS promoting rapid hypertrophy of future liver remnant and relevant factors:recent advances[J].Chinese Journal of General Surgery,2017,26(8):1065-1070.doi:10.3978/j.issn.1005-6947.2017.08.016.
[18]Gall TM,Sodergren MH,Frampton AE,et al.Radio-frequencyassisted Liver Partition with Portal vein ligation(RALPP)for liver regeneration[J].Ann Surg,2015,261(2):e45-46.doi:10.1097/SLA.0000000000000607.
[19]Schlegel A,Lesurtel M,Melloul E,et al.ALPPS:from human to mice highlighting accelerated and novel mechanisms of liver regeneration[J].Ann Surg,2014,260(5):839-846.doi:10.1097/SLA.0000000000000949.
[20]Shi H,Yang G,Zheng T,et al.A preliminary study of ALPPSprocedure in a rat model[J].Sci Rep,2015,5:17567.doi:10.1038/srep17567.
[21]Dhar DK,Mohammad GH,Vyas S,et al.A novel rat model of liver regeneration:possible role of cytokine induced neutrophil chemoattractant-1 in augmented liver regeneration[J].Ann Surg Innov Res,2015,9:11.doi:10.1186/s13022-015-0020-3.
[22]黄民,黄粲宸,肖乐,等.ALPPS一期术后肝内干/祖细胞的变化及其与肝再生的关系[J].中国普通外科杂志,2018,27(2):210-218.doi:10.3978/j.issn.1005-6947.2018.02.013.Huang M,Huang CC,Xiao L,et al.Alteration in intrahepatic stem/progenitor cells after first stage of ALPPS and its relationship to liver regeneration[J].Chinese Journal of General Surgery,2018,27(2):210-218.doi:10.3978/j.issn.1005-6947.2018.02.013.
[23]Sala S,Ardiles V,Ulla M,et al.Our initial experience with ALPPStechnique:encouraging results[J].Updates Surg,2012,64(3):167-172.doi:10.1007/s13304-012-0175-y.
[24]Alvarez FA,Ardiles V,Sanchez CR,et al.Associating liver partition and portal vein ligation for staged hepatectomy(ALPPS):tips and tricks[J].J Gastrointest Surg,2013,17(4):814-821.doi:10.1007/s11605-012-2092-2.
[25]Torres OJ,Fernandes Ede S,Oliveira CV,et al.Associating liver partition and portal vein ligation for staged hepatectomy(ALPPS):the Brazilian experience[J].Arq Bras Cir Dig,2013,26(1):40-43.
[26]Buac S,Schadde E,Schnitzbauer AA,et al.The many faces of ALPPS:surgical indications and techniques among surgeons collaborating in the international registry[J].HPB(Oxford),2016,18(5):442-448.doi:10.1016/j.hpb.2016.01.547.
[27]Oldhafer KJ,Stavrou GA,van Gulik TM,et al.ALPPS--Where Do We Stand,Where Do We Go?:Eight Recommendations From the First International Expert Meeting[J].Ann Surg,2016,263(5):839-841.doi:10.1097/SLA.0000000000001633.
[28]Joechle K,Moser C,Ruemmele P,et al.ALPPS(associating liver partition and portal vein ligation for staged hepatectomy)does not affect proliferation,apoptosis,or angiogenesis as compared to standard liver resection for colorectal liver metastases[J].World JSurg Oncol,2017,15(1):57.doi:10.1186/s12957-017-1121-8.
[29]Fukami Y,Kurumiya Y,Kobayashi S.Associating liver partition and portal vein ligation for staged hepatectomy(ALPPS):an analysis of tumor activity[J].Updates Surg,2014,66(3):223-225.doi:10.1007/s13304-014-0256-1.
[30]Oldhafer KJ,Donati M,Jenner RM,et al.ALPPS for patients with colorectal liver metastases:effective liver hypertrophy,but early tumor recurrence[J].World J Surg,2014,38(6):1504-1509.doi:10.1007/s00268-013-2401-2.
[31]Xu J,Lu X,Zhang Y,Yet al.Laparoscopic associating liver tourniquet and portal ligation combined rescue transhepatic arterial embolization for staged hepatectomy:A case report[J].Medicine(Baltimore),2017,96(43):e8378.doi:10.1097/MD.0000000000008378.
[32]Li J,Ewald F,Gulati A,et al.Associating liver partition and portal vein ligation for staged hepatectomy:From technical evolution to oncological benefit[J].World J Gastrointest Surg,2016,8(2):124-133.doi:10.4240/wjgs.v8.i2.124.
[33]Donati M,Stavrou GA,Oldhafer KJ.Current position of ALPPSin the surgical landscape of CRLM treatment proposals[J].World J Gastroenterol,2013,19(39):6548-6554.doi:10.3748/wjg.v19.i39.6548.
[34]Ardiles V,Schadde E,Santibanes E,et al.Commentary on"Happy marriage or"dangerous liaison":ALPPS and the anterior approach"[J].Ann Surg,2014,260(2):e4.doi:10.1097/SLA.0000000000000735.
[35]Dokmak S,Belghiti J.Which limits to the"ALPPS"approach[J].Ann Surg,2012,256(3):e6.doi:10.1097/SLA.0b013e318265fd64.
[36]Torres OJ,Fernandes ES,Herman P.ALPPS:past,present and future[J].Arq Bras Cir Dig,2015,28(3):155-156.doi:10.1590/S0102-67202015000300001.
[37]Chaudhari P,Tian L,Deshmukh A,et al.Expression kinetics of hepatic progenitor markers in cellular models of human liver development recapitulating hepatocyte and biliary cell fate commitment[J].Exp Biol Med(Maywood),2016,241(15):1653-1662.doi:10.1177/1535370216657901.
[38]Serenari M,Collaud C,Alvarez FA,et al.Interstage Assessment of Remnant Liver Function in ALPPS Using Hepatobiliary Scintigraphy:Prediction of Posthepatectomy Liver Failure and Introduction of the HIBA Index[J].Ann Surg,2018,267(6):1141-1147.doi:10.1097/SLA.0000000000002150.
[39]Truant S,Baillet C,Deshorgue AC,et al.Contribution of hepatobiliary scintigraphy in assessing ALPPS most suited timing[J].Updates Surg,2017,69(3):411-419.doi:10.1007/s13304-017-0481-5.
[40]Sparrelid E,Jonas E,Tzortzakakis A,et al.Dynamic Evaluation of Liver Volume and Function in Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy[J].J Gastrointest Surg,2017,21(6):967-974.doi:10.1007/s11605-017-3389-y.
[41]Lau WY,Lai EC,Lau SH.Associating liver partition and portal vein ligation for staged hepatectomy:the current role and development[J].Hepatobiliary Pancreat Dis Int,2017,16(1):17-26.
[42]Uribe M,Uribe-Echevarría S,Mandiola C,et al.Insight on ALPPS-Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy-mechanisms:activation of mTOR pathway[J].HPB(Oxford),2018,pii:S1365-182X(18)30725-1.doi:10.1016/j.hpb.2018.02.636.[Epub ahead of print]
[43]Petrowsky H,Gy?ri G,de Oliveira M,et al.Is partial-ALPPSsafer than ALPPS?A single-center experience[J].Ann Surg,2015,261(4):e90-92.doi:10.1097/SLA.0000000000001087.
[44]Hernandez-Alejandro R,Bertens KA,Pineda-Solis K,et al.Can we improve the morbidity and mortality associated with the associating liver partition with portal vein ligation for staged hepatectomy(ALPPS)procedure in the management of colorectal liver metastases?[J].Surgery,2015,157(2):194-201.doi:10.1016/j.surg.2014.08.041.
[45]张国民,缪宁,郑徽,等.中国2005-2016年乙型病毒性肝炎报告发病的年龄和地区特征[J].中国疫苗和免疫,2018,24(2):121-126.Zhang GM,Miao N,Zheng H,et al.Incidence by age and region of hepatitis B reported in China from 2005 to 2016[J].Chinese Journal of Vaccines and Immunization,2018,24(2):121-126.
[46]彭驰涵,李川,文天夫,等.原发性肝癌行ALPPS的适应证与禁忌证初探(附15例报道)[J].中国普外基础与临床杂志,2015,22(10):1183-1186.Peng CH,Li C,Wen TF,et al.Discussion about The Indications and Contradictions of ALPPS for Primary Hepatoce-Uular Carcinoma Patients(Reports of 15 Cases)[J].Chinese Journal of Bases and Clinics In General Surgery,2015,22(10):1183-1186.
[47]Machado MA,Makdissi FF,Surjan RC,et al.Transition from open to laparoscopic ALPPS for patients with very small FLR:the initial experience[J].HPB(Oxford),2017,19(1):59-66.doi:10.1016/j.hpb.2016.10.004.
[48]Robles R,Parrilla P,López-Conesa A,et al.Tourniquet modification of the associating liver partition and portal ligation for staged hepatectomy procedure[J].Br J Surg,2014,101(9):1129-1134.doi:10.1002/bjs.9547.
[49]Li J,Kantas A,Ittrich H,et al.Avoid"All-Touch"by Hybrid ALPPSto Achieve Oncological Efficacy[J].Ann Surg,2016,263(1):e6-7.doi:10.1097/SLA.0000000000000845.
[50]彭淑牖,黄从云,李江涛,等.末梢门静脉栓塞术在计划性肝切除术中的应用初探[J].中华外科杂志,2016,54(9):664-668.doi:10.3760/cma.j.issn.0529-5815.2016.09.004.Peng SY,Huang CY,Li JT,et al.Terminal branches portal vein embolization for planed hepatectomy[J].Chinese Journal of Surgery,2016,54(9):664-668.doi:10.3760/cma.j.issn.0529-5815.2016.09.004.
[51]Reich H,McGlynn F,DeCaprio J,e al.Laparoscopic excision of benign liver lesions[J].Obstet Gynecol,1991,78(5 Pt 2):956-958.
[52]Cai X.Laparoscopic liver resection:the current status and the future[J].Hepatobiliary Surg Nutr,2018,7(2):98-104.doi:10.21037/hbsn.2018.02.07.
[53]Schelotto PB,Gondolesi G.Laparoscopy in ALPPS Procedure:When We Can Do It[J].Ann Surg,2017,265(4):e30-31.doi:10.1097/SLA.0000000000000834.
[54]Akyuz M,Yazici P,Yigitbas H,et al.Oncologic results of laparoscopic liver resection for malignant liver tumors[J].J Surg Oncol,2016,113(2):127-129.doi:10.1002/jso.24119.
[55]Tanaka K,Kikuchi Y,Kawaguchi D,et al.Modified ALPPSProcedures Avoiding Division of Portal Pedicles[J].Ann Surg,2017,265(2):e14-20.doi:10.1097/SLA.0000000000001967.
[56]Robles Campos R,Parrilla Paricio P,López Conesa A,et al.Anew surgical technique for extended right hepatectomy:tourniquet in the umbilical fissure and right portal vein occlusion(ALTPS).Clinical case[J].Cir Esp,2013,91(10):633-637.doi:10.1016/j.ciresp.2013.09.004.
[57]Robles Campos R,Brusadin R,López Conesa A,et al.Staged liver resection for perihilar liver tumors using a tourniquet in the umbilical fissure and sequential portal vein embolization on the fourth postoperative day(a modified ALTPS)[J].Cir Esp,2014,92(10):682-686.doi:10.1016/j.ciresp.2014.07.006.
[58]López-López V,Robles-Campos R,Brusadin R,et al.TourniquetALPPS is a promising treatment for very large hepatocellular carcinoma and intrahepatic cholangiocarcinoma[J].Oncotarget,2018,9(46):28267-28280.doi:10.18632/oncotarget.25538.
[59]Aloia TA,Vauthey JN.Associating liver partition and portal vein ligation for staged hepatectomy(ALPPS):what is gained and what is lost?[J].Ann Surg,2012,256(3):e9.doi:10.1097/SLA.0b013e318265fd3e.
[60]Cai YL,Song PP,Tang W,et al.An updated systematic review of the evolution of ALPPS and evaluation of its advantages and disadvantages in accordance with current evidence[J].Medicine(Baltimore),2016,95(24):e3941.doi:10.1097/MD.0000000000003941.
[61]Lai Q,Melandro F,Rossi M.Hybrid Partial ALPPS:a Feasible Approach in Case of Right Trisegmentectomy and Macrovascular Invasion[J].Ann Surg,2018,267(4):e80-82.doi:10.1097/SLA.0000000000002219.
[62]Peng SY,Wang XA,Huang CY,et al.Evolution of associating liver partition and portal vein ligation for staged hepatectomy:Simpler,safer and equally effective methods[J].World J Gastroenterol,2017,23(23):4140-4145.doi:10.3748/wjg.v23.i23.4140.
[63]Xiao N,Yu K,Yu S,et al.The paradigm of tumor shrinkage and rapid liver remnant hypertrophy for conversion of initially unresectable colorectal liver metastasis:a case report and literature review[J].World J Surg Oncol,2017,15(1):148.doi:10.1186/s12957-017-1212-6.
[2]彭远飞,王征,周俭.联合肝脏离断和门静脉结扎的二步肝切除术的争议与发展[J].外科理论与实践,2018,23(3):185-190.doi:10.16139/j.1007-9610.2018.03.001.Peng YF,Wang Z,Zhou J.Controversy and development of associating liver partition and portal vein ligation for staged hepatectomy[J].Journal of Surgery Concepts&Practice,2018,23(3):185-190.doi:10.16139/j.1007-9610.2018.03.001.
[3]Kokudo N,Tada K,Seki M,et al.Proliferative activity of intrahepatic colorectal metastases after preoperative hemihepatic portal vein embolization[J].Hepatology,2001,34(2):267-272.doi:10.1053/jhep.2001.26513.
[4]Clavien PA,Petrowsky H,DeOliveira ML,et al.Strategies for safer liver surgery and partial liver transplantation[J].N Engl J Med,2007,356(15):1545-1559.doi:10.1056/NEJMra065156.
[5]Schnitzbauer AA,Lang SA,Goessmann H,et al.Right portal vein ligation combined with in situ splitting induces rapid left lateral liver lobe hypertrophy enabling 2-staged extended right hepatic resection in small-for-size settings[J].Ann Surg,2012,255(3):405-414.doi:10.1097/SLA.0b013e31824856f5.
[6]Stockmann M,Bednarsch J,Malinowski M,et al.Functional considerations in ALPPS-consequences for clinical management[J].HPB(Oxford),2017,19(11):1016-1025.doi:10.1016/j.hpb.2017.07.010.
[7]Bertens KA,Hawel J,Lung K,et al.ALPPS:challenging the concept of unresectability--a systematic review[J].Int J Surg,2015,13:280-287.doi:10.1016/j.ijsu.2014.12.008.
[8]Li J,Girotti P,K?nigsrainer I,et al.ALPP Sinright trisectionectomy:a safe procedure to avoid postoperative liver failure[J].J Gastrointest Surg,2013,17(5):956-961.doi:10.1007/s11605-012-2132-y.
[9]Takamoto T,Sugawara Y,Hashimoto T,et al.Associating liver partition and portal vein ligation(ALPPS):Taking a view of trails[J].Biosci Trends,2015,9(5):280-283.doi:10.5582/bst.2015.01131.
[10]Schadde E,Ardiles V,Robles-Campos R,et al.Early survival and safety of ALPPS:first report of the International ALPPSRegistry[J].Ann Surg,2014,260(5):829-836.doi:10.1097/SLA.0000000000000947.
[11]Nadalin S,Capobianco I,Li J,et al.Indications and limits for associating liver partition and portal vein ligation for staged hepatectomy(ALPPS).Lessons Learned from 15 cases at a single centre[J].Z Gastroenterol,2014,52(1):35-42.doi:10.1055/s-0033-1356364.
[12]Vivarelli M,Vincenzi P,Montalti R,et al.ALPPS Procedure for Extended Liver Resections:A Single Centre Experience and a Systematic Review[J].PLoS One,2015,10(12):e0144019.doi:10.1371/journal.pone.0144019.
[13]Alvarez FA,Ardiles V,de Santiba?es M,et al.Associating liver partition and portal vein ligation for staged hepatectomy offers high oncological feasibility with adequate patient safety:a prospective study at a single center[J].Ann Surg,2015,261(4):723-732.doi:10.1097/SLA.0000000000001046.
[14]Hasselgren K,Sandstr?m P,Bj?rnsson B.Role of associating liver partition and portal vein ligation for staged hepatectomy in colorectal liver metastases:a review[J].World J Gastroenterol,2015,21(15):4491-4498.doi:10.3748/wjg.v21.i15.4491.
[15]Yao L,Li C,Ge X,et al.Establishment of a rat model of portal vein ligation combined with in situ splitting[J].PLoS One,2014,9(8):e105511.doi:10.1371/journal.pone.0105511.
[16]Schadde E,Hertl M,Breitenstein S,et al.Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy(ALPPS)Procedure[J].J Vis Exp,2017,(126).doi:10.3791/55895.
[17]林为东,莫经刚.ALPPS促进剩余肝脏快速增生机制及相关因素研究进展[J].中国普通外科杂志,2017,26(8):1065-1070.doi:10.3978/j.issn.1005-6947.2017.08.016.Lin WD,Mo JG.Mechanisms of ALPPS promoting rapid hypertrophy of future liver remnant and relevant factors:recent advances[J].Chinese Journal of General Surgery,2017,26(8):1065-1070.doi:10.3978/j.issn.1005-6947.2017.08.016.
[18]Gall TM,Sodergren MH,Frampton AE,et al.Radio-frequencyassisted Liver Partition with Portal vein ligation(RALPP)for liver regeneration[J].Ann Surg,2015,261(2):e45-46.doi:10.1097/SLA.0000000000000607.
[19]Schlegel A,Lesurtel M,Melloul E,et al.ALPPS:from human to mice highlighting accelerated and novel mechanisms of liver regeneration[J].Ann Surg,2014,260(5):839-846.doi:10.1097/SLA.0000000000000949.
[20]Shi H,Yang G,Zheng T,et al.A preliminary study of ALPPSprocedure in a rat model[J].Sci Rep,2015,5:17567.doi:10.1038/srep17567.
[21]Dhar DK,Mohammad GH,Vyas S,et al.A novel rat model of liver regeneration:possible role of cytokine induced neutrophil chemoattractant-1 in augmented liver regeneration[J].Ann Surg Innov Res,2015,9:11.doi:10.1186/s13022-015-0020-3.
[22]黄民,黄粲宸,肖乐,等.ALPPS一期术后肝内干/祖细胞的变化及其与肝再生的关系[J].中国普通外科杂志,2018,27(2):210-218.doi:10.3978/j.issn.1005-6947.2018.02.013.Huang M,Huang CC,Xiao L,et al.Alteration in intrahepatic stem/progenitor cells after first stage of ALPPS and its relationship to liver regeneration[J].Chinese Journal of General Surgery,2018,27(2):210-218.doi:10.3978/j.issn.1005-6947.2018.02.013.
[23]Sala S,Ardiles V,Ulla M,et al.Our initial experience with ALPPStechnique:encouraging results[J].Updates Surg,2012,64(3):167-172.doi:10.1007/s13304-012-0175-y.
[24]Alvarez FA,Ardiles V,Sanchez CR,et al.Associating liver partition and portal vein ligation for staged hepatectomy(ALPPS):tips and tricks[J].J Gastrointest Surg,2013,17(4):814-821.doi:10.1007/s11605-012-2092-2.
[25]Torres OJ,Fernandes Ede S,Oliveira CV,et al.Associating liver partition and portal vein ligation for staged hepatectomy(ALPPS):the Brazilian experience[J].Arq Bras Cir Dig,2013,26(1):40-43.
[26]Buac S,Schadde E,Schnitzbauer AA,et al.The many faces of ALPPS:surgical indications and techniques among surgeons collaborating in the international registry[J].HPB(Oxford),2016,18(5):442-448.doi:10.1016/j.hpb.2016.01.547.
[27]Oldhafer KJ,Stavrou GA,van Gulik TM,et al.ALPPS--Where Do We Stand,Where Do We Go?:Eight Recommendations From the First International Expert Meeting[J].Ann Surg,2016,263(5):839-841.doi:10.1097/SLA.0000000000001633.
[28]Joechle K,Moser C,Ruemmele P,et al.ALPPS(associating liver partition and portal vein ligation for staged hepatectomy)does not affect proliferation,apoptosis,or angiogenesis as compared to standard liver resection for colorectal liver metastases[J].World JSurg Oncol,2017,15(1):57.doi:10.1186/s12957-017-1121-8.
[29]Fukami Y,Kurumiya Y,Kobayashi S.Associating liver partition and portal vein ligation for staged hepatectomy(ALPPS):an analysis of tumor activity[J].Updates Surg,2014,66(3):223-225.doi:10.1007/s13304-014-0256-1.
[30]Oldhafer KJ,Donati M,Jenner RM,et al.ALPPS for patients with colorectal liver metastases:effective liver hypertrophy,but early tumor recurrence[J].World J Surg,2014,38(6):1504-1509.doi:10.1007/s00268-013-2401-2.
[31]Xu J,Lu X,Zhang Y,Yet al.Laparoscopic associating liver tourniquet and portal ligation combined rescue transhepatic arterial embolization for staged hepatectomy:A case report[J].Medicine(Baltimore),2017,96(43):e8378.doi:10.1097/MD.0000000000008378.
[32]Li J,Ewald F,Gulati A,et al.Associating liver partition and portal vein ligation for staged hepatectomy:From technical evolution to oncological benefit[J].World J Gastrointest Surg,2016,8(2):124-133.doi:10.4240/wjgs.v8.i2.124.
[33]Donati M,Stavrou GA,Oldhafer KJ.Current position of ALPPSin the surgical landscape of CRLM treatment proposals[J].World J Gastroenterol,2013,19(39):6548-6554.doi:10.3748/wjg.v19.i39.6548.
[34]Ardiles V,Schadde E,Santibanes E,et al.Commentary on"Happy marriage or"dangerous liaison":ALPPS and the anterior approach"[J].Ann Surg,2014,260(2):e4.doi:10.1097/SLA.0000000000000735.
[35]Dokmak S,Belghiti J.Which limits to the"ALPPS"approach[J].Ann Surg,2012,256(3):e6.doi:10.1097/SLA.0b013e318265fd64.
[36]Torres OJ,Fernandes ES,Herman P.ALPPS:past,present and future[J].Arq Bras Cir Dig,2015,28(3):155-156.doi:10.1590/S0102-67202015000300001.
[37]Chaudhari P,Tian L,Deshmukh A,et al.Expression kinetics of hepatic progenitor markers in cellular models of human liver development recapitulating hepatocyte and biliary cell fate commitment[J].Exp Biol Med(Maywood),2016,241(15):1653-1662.doi:10.1177/1535370216657901.
[38]Serenari M,Collaud C,Alvarez FA,et al.Interstage Assessment of Remnant Liver Function in ALPPS Using Hepatobiliary Scintigraphy:Prediction of Posthepatectomy Liver Failure and Introduction of the HIBA Index[J].Ann Surg,2018,267(6):1141-1147.doi:10.1097/SLA.0000000000002150.
[39]Truant S,Baillet C,Deshorgue AC,et al.Contribution of hepatobiliary scintigraphy in assessing ALPPS most suited timing[J].Updates Surg,2017,69(3):411-419.doi:10.1007/s13304-017-0481-5.
[40]Sparrelid E,Jonas E,Tzortzakakis A,et al.Dynamic Evaluation of Liver Volume and Function in Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy[J].J Gastrointest Surg,2017,21(6):967-974.doi:10.1007/s11605-017-3389-y.
[41]Lau WY,Lai EC,Lau SH.Associating liver partition and portal vein ligation for staged hepatectomy:the current role and development[J].Hepatobiliary Pancreat Dis Int,2017,16(1):17-26.
[42]Uribe M,Uribe-Echevarría S,Mandiola C,et al.Insight on ALPPS-Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy-mechanisms:activation of mTOR pathway[J].HPB(Oxford),2018,pii:S1365-182X(18)30725-1.doi:10.1016/j.hpb.2018.02.636.[Epub ahead of print]
[43]Petrowsky H,Gy?ri G,de Oliveira M,et al.Is partial-ALPPSsafer than ALPPS?A single-center experience[J].Ann Surg,2015,261(4):e90-92.doi:10.1097/SLA.0000000000001087.
[44]Hernandez-Alejandro R,Bertens KA,Pineda-Solis K,et al.Can we improve the morbidity and mortality associated with the associating liver partition with portal vein ligation for staged hepatectomy(ALPPS)procedure in the management of colorectal liver metastases?[J].Surgery,2015,157(2):194-201.doi:10.1016/j.surg.2014.08.041.
[45]张国民,缪宁,郑徽,等.中国2005-2016年乙型病毒性肝炎报告发病的年龄和地区特征[J].中国疫苗和免疫,2018,24(2):121-126.Zhang GM,Miao N,Zheng H,et al.Incidence by age and region of hepatitis B reported in China from 2005 to 2016[J].Chinese Journal of Vaccines and Immunization,2018,24(2):121-126.
[46]彭驰涵,李川,文天夫,等.原发性肝癌行ALPPS的适应证与禁忌证初探(附15例报道)[J].中国普外基础与临床杂志,2015,22(10):1183-1186.Peng CH,Li C,Wen TF,et al.Discussion about The Indications and Contradictions of ALPPS for Primary Hepatoce-Uular Carcinoma Patients(Reports of 15 Cases)[J].Chinese Journal of Bases and Clinics In General Surgery,2015,22(10):1183-1186.
[47]Machado MA,Makdissi FF,Surjan RC,et al.Transition from open to laparoscopic ALPPS for patients with very small FLR:the initial experience[J].HPB(Oxford),2017,19(1):59-66.doi:10.1016/j.hpb.2016.10.004.
[48]Robles R,Parrilla P,López-Conesa A,et al.Tourniquet modification of the associating liver partition and portal ligation for staged hepatectomy procedure[J].Br J Surg,2014,101(9):1129-1134.doi:10.1002/bjs.9547.
[49]Li J,Kantas A,Ittrich H,et al.Avoid"All-Touch"by Hybrid ALPPSto Achieve Oncological Efficacy[J].Ann Surg,2016,263(1):e6-7.doi:10.1097/SLA.0000000000000845.
[50]彭淑牖,黄从云,李江涛,等.末梢门静脉栓塞术在计划性肝切除术中的应用初探[J].中华外科杂志,2016,54(9):664-668.doi:10.3760/cma.j.issn.0529-5815.2016.09.004.Peng SY,Huang CY,Li JT,et al.Terminal branches portal vein embolization for planed hepatectomy[J].Chinese Journal of Surgery,2016,54(9):664-668.doi:10.3760/cma.j.issn.0529-5815.2016.09.004.
[51]Reich H,McGlynn F,DeCaprio J,e al.Laparoscopic excision of benign liver lesions[J].Obstet Gynecol,1991,78(5 Pt 2):956-958.
[52]Cai X.Laparoscopic liver resection:the current status and the future[J].Hepatobiliary Surg Nutr,2018,7(2):98-104.doi:10.21037/hbsn.2018.02.07.
[53]Schelotto PB,Gondolesi G.Laparoscopy in ALPPS Procedure:When We Can Do It[J].Ann Surg,2017,265(4):e30-31.doi:10.1097/SLA.0000000000000834.
[54]Akyuz M,Yazici P,Yigitbas H,et al.Oncologic results of laparoscopic liver resection for malignant liver tumors[J].J Surg Oncol,2016,113(2):127-129.doi:10.1002/jso.24119.
[55]Tanaka K,Kikuchi Y,Kawaguchi D,et al.Modified ALPPSProcedures Avoiding Division of Portal Pedicles[J].Ann Surg,2017,265(2):e14-20.doi:10.1097/SLA.0000000000001967.
[56]Robles Campos R,Parrilla Paricio P,López Conesa A,et al.Anew surgical technique for extended right hepatectomy:tourniquet in the umbilical fissure and right portal vein occlusion(ALTPS).Clinical case[J].Cir Esp,2013,91(10):633-637.doi:10.1016/j.ciresp.2013.09.004.
[57]Robles Campos R,Brusadin R,López Conesa A,et al.Staged liver resection for perihilar liver tumors using a tourniquet in the umbilical fissure and sequential portal vein embolization on the fourth postoperative day(a modified ALTPS)[J].Cir Esp,2014,92(10):682-686.doi:10.1016/j.ciresp.2014.07.006.
[58]López-López V,Robles-Campos R,Brusadin R,et al.TourniquetALPPS is a promising treatment for very large hepatocellular carcinoma and intrahepatic cholangiocarcinoma[J].Oncotarget,2018,9(46):28267-28280.doi:10.18632/oncotarget.25538.
[59]Aloia TA,Vauthey JN.Associating liver partition and portal vein ligation for staged hepatectomy(ALPPS):what is gained and what is lost?[J].Ann Surg,2012,256(3):e9.doi:10.1097/SLA.0b013e318265fd3e.
[60]Cai YL,Song PP,Tang W,et al.An updated systematic review of the evolution of ALPPS and evaluation of its advantages and disadvantages in accordance with current evidence[J].Medicine(Baltimore),2016,95(24):e3941.doi:10.1097/MD.0000000000003941.
[61]Lai Q,Melandro F,Rossi M.Hybrid Partial ALPPS:a Feasible Approach in Case of Right Trisegmentectomy and Macrovascular Invasion[J].Ann Surg,2018,267(4):e80-82.doi:10.1097/SLA.0000000000002219.
[62]Peng SY,Wang XA,Huang CY,et al.Evolution of associating liver partition and portal vein ligation for staged hepatectomy:Simpler,safer and equally effective methods[J].World J Gastroenterol,2017,23(23):4140-4145.doi:10.3748/wjg.v23.i23.4140.
[63]Xiao N,Yu K,Yu S,et al.The paradigm of tumor shrinkage and rapid liver remnant hypertrophy for conversion of initially unresectable colorectal liver metastasis:a case report and literature review[J].World J Surg Oncol,2017,15(1):148.doi:10.1186/s12957-017-1212-6.