结肠癌早期诊断及预防措施
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摘要
<正>结肠癌(colon cancer)是消化道最常见的恶性肿瘤之一,全世界每年有110万新发病例,约50万人因此死亡~([1]),从全球范围看,欧洲和北美发病率较高~([2])。但是随着我国人口老龄化、饮食结构脂肪成分增多以及结肠癌普查工作的开展,结肠癌在我国的发病率呈逐年上升的趋势,发病年龄也有年轻化趋势~([3])。因此,降低我国结肠癌的发病率和死亡率是亟待解决的公共卫生问题。研究发现,结肠癌的预后与诊治时机密切相关,早
引文
[1]Aquina CT,Mohile SG,Tejani MA,et al.The impact of age on complications,survival,and cause of death following colon cancer surgery[J].Br J Cancer,2017,116(3):389-397.
[2]中华医学会消化内镜学会消化系早癌内镜诊断与治疗协作组,中华医学会消化病学分会消化道肿瘤协作组,中华医学会消化内镜学分会肠道学组,等.中国早期结直肠癌及癌前病变筛查与诊治共识意见[J].中华内科杂志,2015,54(4):375-385.
[3]Manjelievskaia J,Brown D,McGlynn KA,et al.Chemotherapy use and survival among young and middle-aged patients with colon cancer[J].JAMA Surg,2017,152(5):452-459.
[4]Kontovounisios C,Tan E,Pawa N,et al.The selection process can improve the outcome in locally advanced and recurrent colorectal cancer:activity and results of a dedicated multidisciplinary colorectal cancer centre[J].Colorectal Dis,2017,19(4):331-338.
[5]杨海芸,戈之铮,戴军,等.免疫法和化学粪便隐血试验对下消化道易出血疾病筛查价值的对照研究[J].中华消化内镜杂志,2008,25(1):26-30.
[6]王莉,赵亚楠,李志燕.CEA、CA199、细胞角质素片段19和CK联合检测对结肠癌的诊断价值[J].标记免疫分析与临床,2013,20(1):13-16.
[7]Watanabe T.Biomarker for high-risk patients with stage II colon cancer[J].Lancet Oncol,2013,14(13):1247-1248.
[8]Kim Y,Lee S,Park S,et al.Gastrointestinal tract cancer screening using fecal carcinoembryonic antigen[J].Ann Clin Lab Sci,2003,33(11):32-38.
[9]Steward WP,Brown K.Cancer chemoprevention:a rapidly evolving field[J].Br J Cancer,2013,109(1):1-7.
[10]郭巍,赵岩峰.七种肿瘤标志物联检在结直肠癌诊断中的应用体会[J].标记免疫分析与临床,2013,20(6):473-474.
[11]张世才,孙霞.血清CEA和CA199检测对结直肠癌早期诊断的价值研究[J].医学检验与临床,2009,20(6):101-102.
[12]张巨彪,苏秀兰,欧阳晓晖.联合检测血清肿瘤标志物对结肠癌的诊断价值[J].医学综述,2015,21(20):3800-3801.
[13]Attallah AM,El-Far M,Ibrahim AR,et al.Clinical value of a diagnostic score for colon cancer based on serum CEA,CA19-9,cytokeratin-1 and mucin-1[J].Br J Biomed Sci,2018,75(3):122-127.
[14]Kanaoka S,Yoshida K,Miura N,et al.Potential usefulness of detecting cyclooxygenase 2 messenger RNA in feces for colorectal cancer screening[J].Gastroenterology,2004,127(2):422-427.
[15]Shastri YM,Naumann M,Oremek GM,et al.Prospective multicenter evaluation of fecal tumor pyruvate kinase type M2(M2-PK)as a screening biomarker for colorectal neoplasia[J].Int J Cancer,2006,119(11):2651-2656.
[16]张波,陈剑英,王国斌.肿瘤M2型丙酮酸激酶在结直肠癌粪便筛查中的临床价值[J].世界华人消化杂志,2007,15(2):193-196.
[17]潘胜武,孙安乐,刘变英,等.大肠癌相关基因表达的早期诊断意义[J].世界华人消化杂志,2000,8(12):1431-1432.
[18]Fang RH,Ji XB.Advances in the research of the relationship between miRNA-29c and cancer[J].Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi,2018,32(4):312-317.
[19]Smith-Ravin J,England J,Talbot IC,et al.Detection of c-Ki-ras mutations in faecal samples from sporadic colorectal cancer patients[J].Gut,1995,36(1):81-86.
[20]Doolittle BR,Emanuel J,Tuttle C,et al.Detection of the mutated K-Ras biomarker in colorectal carcinoma[J].Exp Mol Patbol,2001,70(3):289-301.
[21]马文华,李娜,赵利平,等.结直肠癌组织与血液KRAS/BRAF基因突变表达一致性检测分析[J].河北医药,2014,36(7):1048-1050.
[22]张曹,杨银学,杜勇,等.大肠癌患者便与癌组织APC基因突变检测的一致性研究[J].宁夏医科大学学报,2014,36(4):364-367.
[23]Moridikia A,Mirzaei H,Sahebkar A,et al.MicroRNAs:potential candidates for diagnosis and treatment of colorectal cancer[J].J Cell Physiol,2018,233(2):901-913.
[24]Ahlquist DA,Skoletsky JE,Boynton KA,et al.Colorectal cancer screening by detection of altered human DNA in stool:feasibility of a multitarget assay panel[J].Gasrtroenteorology,2000,119(5):1219-1227.
[25]马丽,崔涛.结直肠癌内镜检出率及早诊筛查临床研究[J].北华大学学报(自然科学版),2016,17(3):377-379.
[26]李志霞,安大立,王烨,等.早期结直肠癌的诊断方法与微创治疗[J].中华胃肠外科杂志,2004,7(5):381-383.
[27]Kulikov AV,Luchkina EA,Gogvadze V,et al.Mitophagy:link to cancer development and therapy[J].Biochem Biophys Res Commun,2017,482(3):432-439.
[28]Fidler MM,Gupta S,Soerjomataram I,et al.Cancer incidence and mortality among young adults aged 20~39 years worldwide in 2012:a population-based study[J].Lancet Oncol,2017,18(12):1579-1589.
[29]Doaei S,Hajiesmaeil M,Aminifard A,et al.Effects of gene polymorphisms of metabolic enzymes on the association between red and processed meat consumption and the development of colon cancer:a literature review[J].J Nutr Sci,2018,7:e26.DOI:10.1017/jns.2018.17.
[30]Afrin S,Giampieri F,Gasparrini M,et al.Chemopreventive and therapeutic effects of edible berries:a focus on colon cancer prevention and treatment[J].Molecules,2016,21(2):169.
[31]Risio M,Lipkin M,Newmark H,et al.Apoptosis,cell replication,and Western-style diet-induced tumorigenesis in mouse colon[J].Cancer Res,1996,56(21):4910-4916.
[32]Johnson IT.New approaches to the role of diet in the prevention of cancers of the alimentary tract[J].Mutat Res,2004,551(1-2):9-28.
[33]Crosara Teixeira M,Braghiroli MI,Sabbaga J,et al.Primary prevention of colorectal cancer:myth or reality?[J].World JGastroenterol,2014,20(41):15060-15069.
[34]Jaganathan SK,Vellayappan MV,Narasimhan G,et al.Role of pomegranate and citrus fruit juices in colon cancer prevention[J].World J Gastroenterol,2014,20(16):4618-4625.
[35]Larsson SC,Rutegard J,Bergkvist L,et al.Physical activity,obesity,and risk of colon and rectal cancer in a cohort of Swedish men[J].Eur J Cancer,2006,42(15):2590-2597.
[36]从甲荣.结肠癌的早期诊断及预后[J].河南外科学杂志,2014,20(1):94-95.
[37]Saxena A,Baliga MS,Ponemone V,et al.Mucus and adiponectin deficiency:role in chronic inflammation-induced colon cancer[J].Int JColorectal Dis,2013,28(9):1267-1279.
[38]Halfvarson J,Brislawn CJ,Lamendella R,et al.Dynamics of the human gut microbiome in inflammatory bowel disease[J].Nat Microbiol,2017,2:17004.DOI:10.1038/nmicrobiol.2017.4.
[39]Zinatizadeh N,Khalili F,Fllah P,et al.Potential preventive effect of lactobacillus acidophilus and lactobacillus plantarumin patients with polyps or colorectal cancer[J].Arq Gastroenterol,2018,55(4):407-411.
[40]Browne AS,Kellv CR.Fecal transplant in inflammatory bowel disease[J].Gastroenterol Clin North Am,2017,46(4):825-837.
[41]Chen J,Vitetta L.Inflammation-modulating effect of butyrate in the prevention of colon cancer by dietary fiber[J].Clin Colorectal Cancer,2018,17(3):e541-e544.
[42]Ranji P,Akbarzadeh A,Rahmati-Yamchi M.Associations of probiotics with Vitamin D and Leptin receptors and their effects on colon cancer[J].Asian Pac J Cancer Prev,2015,16(9):3621-3627.
[43]Geraldino TH,Modiano P,Veronez LC,et al.Jacalin has chemopreventive effects on colon cancer development[J].Biomed Res Int.,2017;2017:4614357.DOI:10.1155/2017/4614357.
[44]胡义亭,张建,贾桂丛,等.精神心理因素与炎症性肠病关系的研究现状[J].医学综述,2017,23(24):4900-4904.
[2]中华医学会消化内镜学会消化系早癌内镜诊断与治疗协作组,中华医学会消化病学分会消化道肿瘤协作组,中华医学会消化内镜学分会肠道学组,等.中国早期结直肠癌及癌前病变筛查与诊治共识意见[J].中华内科杂志,2015,54(4):375-385.
[3]Manjelievskaia J,Brown D,McGlynn KA,et al.Chemotherapy use and survival among young and middle-aged patients with colon cancer[J].JAMA Surg,2017,152(5):452-459.
[4]Kontovounisios C,Tan E,Pawa N,et al.The selection process can improve the outcome in locally advanced and recurrent colorectal cancer:activity and results of a dedicated multidisciplinary colorectal cancer centre[J].Colorectal Dis,2017,19(4):331-338.
[5]杨海芸,戈之铮,戴军,等.免疫法和化学粪便隐血试验对下消化道易出血疾病筛查价值的对照研究[J].中华消化内镜杂志,2008,25(1):26-30.
[6]王莉,赵亚楠,李志燕.CEA、CA199、细胞角质素片段19和CK联合检测对结肠癌的诊断价值[J].标记免疫分析与临床,2013,20(1):13-16.
[7]Watanabe T.Biomarker for high-risk patients with stage II colon cancer[J].Lancet Oncol,2013,14(13):1247-1248.
[8]Kim Y,Lee S,Park S,et al.Gastrointestinal tract cancer screening using fecal carcinoembryonic antigen[J].Ann Clin Lab Sci,2003,33(11):32-38.
[9]Steward WP,Brown K.Cancer chemoprevention:a rapidly evolving field[J].Br J Cancer,2013,109(1):1-7.
[10]郭巍,赵岩峰.七种肿瘤标志物联检在结直肠癌诊断中的应用体会[J].标记免疫分析与临床,2013,20(6):473-474.
[11]张世才,孙霞.血清CEA和CA199检测对结直肠癌早期诊断的价值研究[J].医学检验与临床,2009,20(6):101-102.
[12]张巨彪,苏秀兰,欧阳晓晖.联合检测血清肿瘤标志物对结肠癌的诊断价值[J].医学综述,2015,21(20):3800-3801.
[13]Attallah AM,El-Far M,Ibrahim AR,et al.Clinical value of a diagnostic score for colon cancer based on serum CEA,CA19-9,cytokeratin-1 and mucin-1[J].Br J Biomed Sci,2018,75(3):122-127.
[14]Kanaoka S,Yoshida K,Miura N,et al.Potential usefulness of detecting cyclooxygenase 2 messenger RNA in feces for colorectal cancer screening[J].Gastroenterology,2004,127(2):422-427.
[15]Shastri YM,Naumann M,Oremek GM,et al.Prospective multicenter evaluation of fecal tumor pyruvate kinase type M2(M2-PK)as a screening biomarker for colorectal neoplasia[J].Int J Cancer,2006,119(11):2651-2656.
[16]张波,陈剑英,王国斌.肿瘤M2型丙酮酸激酶在结直肠癌粪便筛查中的临床价值[J].世界华人消化杂志,2007,15(2):193-196.
[17]潘胜武,孙安乐,刘变英,等.大肠癌相关基因表达的早期诊断意义[J].世界华人消化杂志,2000,8(12):1431-1432.
[18]Fang RH,Ji XB.Advances in the research of the relationship between miRNA-29c and cancer[J].Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi,2018,32(4):312-317.
[19]Smith-Ravin J,England J,Talbot IC,et al.Detection of c-Ki-ras mutations in faecal samples from sporadic colorectal cancer patients[J].Gut,1995,36(1):81-86.
[20]Doolittle BR,Emanuel J,Tuttle C,et al.Detection of the mutated K-Ras biomarker in colorectal carcinoma[J].Exp Mol Patbol,2001,70(3):289-301.
[21]马文华,李娜,赵利平,等.结直肠癌组织与血液KRAS/BRAF基因突变表达一致性检测分析[J].河北医药,2014,36(7):1048-1050.
[22]张曹,杨银学,杜勇,等.大肠癌患者便与癌组织APC基因突变检测的一致性研究[J].宁夏医科大学学报,2014,36(4):364-367.
[23]Moridikia A,Mirzaei H,Sahebkar A,et al.MicroRNAs:potential candidates for diagnosis and treatment of colorectal cancer[J].J Cell Physiol,2018,233(2):901-913.
[24]Ahlquist DA,Skoletsky JE,Boynton KA,et al.Colorectal cancer screening by detection of altered human DNA in stool:feasibility of a multitarget assay panel[J].Gasrtroenteorology,2000,119(5):1219-1227.
[25]马丽,崔涛.结直肠癌内镜检出率及早诊筛查临床研究[J].北华大学学报(自然科学版),2016,17(3):377-379.
[26]李志霞,安大立,王烨,等.早期结直肠癌的诊断方法与微创治疗[J].中华胃肠外科杂志,2004,7(5):381-383.
[27]Kulikov AV,Luchkina EA,Gogvadze V,et al.Mitophagy:link to cancer development and therapy[J].Biochem Biophys Res Commun,2017,482(3):432-439.
[28]Fidler MM,Gupta S,Soerjomataram I,et al.Cancer incidence and mortality among young adults aged 20~39 years worldwide in 2012:a population-based study[J].Lancet Oncol,2017,18(12):1579-1589.
[29]Doaei S,Hajiesmaeil M,Aminifard A,et al.Effects of gene polymorphisms of metabolic enzymes on the association between red and processed meat consumption and the development of colon cancer:a literature review[J].J Nutr Sci,2018,7:e26.DOI:10.1017/jns.2018.17.
[30]Afrin S,Giampieri F,Gasparrini M,et al.Chemopreventive and therapeutic effects of edible berries:a focus on colon cancer prevention and treatment[J].Molecules,2016,21(2):169.
[31]Risio M,Lipkin M,Newmark H,et al.Apoptosis,cell replication,and Western-style diet-induced tumorigenesis in mouse colon[J].Cancer Res,1996,56(21):4910-4916.
[32]Johnson IT.New approaches to the role of diet in the prevention of cancers of the alimentary tract[J].Mutat Res,2004,551(1-2):9-28.
[33]Crosara Teixeira M,Braghiroli MI,Sabbaga J,et al.Primary prevention of colorectal cancer:myth or reality?[J].World JGastroenterol,2014,20(41):15060-15069.
[34]Jaganathan SK,Vellayappan MV,Narasimhan G,et al.Role of pomegranate and citrus fruit juices in colon cancer prevention[J].World J Gastroenterol,2014,20(16):4618-4625.
[35]Larsson SC,Rutegard J,Bergkvist L,et al.Physical activity,obesity,and risk of colon and rectal cancer in a cohort of Swedish men[J].Eur J Cancer,2006,42(15):2590-2597.
[36]从甲荣.结肠癌的早期诊断及预后[J].河南外科学杂志,2014,20(1):94-95.
[37]Saxena A,Baliga MS,Ponemone V,et al.Mucus and adiponectin deficiency:role in chronic inflammation-induced colon cancer[J].Int JColorectal Dis,2013,28(9):1267-1279.
[38]Halfvarson J,Brislawn CJ,Lamendella R,et al.Dynamics of the human gut microbiome in inflammatory bowel disease[J].Nat Microbiol,2017,2:17004.DOI:10.1038/nmicrobiol.2017.4.
[39]Zinatizadeh N,Khalili F,Fllah P,et al.Potential preventive effect of lactobacillus acidophilus and lactobacillus plantarumin patients with polyps or colorectal cancer[J].Arq Gastroenterol,2018,55(4):407-411.
[40]Browne AS,Kellv CR.Fecal transplant in inflammatory bowel disease[J].Gastroenterol Clin North Am,2017,46(4):825-837.
[41]Chen J,Vitetta L.Inflammation-modulating effect of butyrate in the prevention of colon cancer by dietary fiber[J].Clin Colorectal Cancer,2018,17(3):e541-e544.
[42]Ranji P,Akbarzadeh A,Rahmati-Yamchi M.Associations of probiotics with Vitamin D and Leptin receptors and their effects on colon cancer[J].Asian Pac J Cancer Prev,2015,16(9):3621-3627.
[43]Geraldino TH,Modiano P,Veronez LC,et al.Jacalin has chemopreventive effects on colon cancer development[J].Biomed Res Int.,2017;2017:4614357.DOI:10.1155/2017/4614357.
[44]胡义亭,张建,贾桂丛,等.精神心理因素与炎症性肠病关系的研究现状[J].医学综述,2017,23(24):4900-4904.